The invention provides a wine for dispelling rheumatism, capable of promoting blood circulation by removing blood stasis, and relaxing muscles and tendons and removing obstructionfrom meridians. The wine is prepared by: 10-15% liquorice , 20-30% whole angelica, 10-20% leatherleaf milletia, 15-30% radix dipsaci, 10-20% pawpaw, 20-30% eucommia bark , 10-15% rhizoma drynariae, 10-15% cibotium barometz, 10-20% semen persicae, 15-30% heracleum hemsleyanum michaux, 20-30% autoeciousness, 10-20% rhododendron dauricum, 10-15% white muscardine silkworm, 10-15% menispermaceae, 15-30% long-noded pit viper and 10-30% radix puerariae, based on weight ratio. The invention has remarkable curative effect for diseases of ache of waist and knee, pain of rheumatic articulation, stagnation of liver and kidney, impediment of qi and blood circulation, abdominal distention and adynamia, cold in foot and hand, sciatica, etc., thus has advantages of taking effect quickly, rapidly stopping pain, pure nature, without toxic and side effect, and the like.