The invention discloses rose-grape wine and a preparation method thereof. The rose-grape wine is prepared from the following raw materials: 10-12 parts of rose, 8-10 parts of chamomile, 60-80 parts of grape, 30-40 parts of mulberry, 20-30 parts of leaves of rhizoma fagopyri cymosi, 10-12 parts of lotus leaf, 60-80 parts of glutinous rice juice, 2-4 parts of grape-fruit flower, 3-4 parts of vaccinium bracteatum thunb leaf, 3-5 parts of fructus rosae, 2-3 parts of ginseng leaf, 2-3 parts of sanchi flower, 2-3 parts of motherwort and 8-10 parts of honey. The rose-grape wine prepared by the invention integrates the nutritional and functional components of the leaves of rhizoma fagopyri cymosi, and through fermentation for several times, the dissolution rate of active ingredients of a finished product is enhanced, so that the product is easy to be digested and absorbed by human body; and meanwhile, taste is improved and palatability is enhanced; the rose-grape wine is yellow-red and bright in color, sweet and mellow in taste, and is smooth and palatable; at the same time, by blending traditional Chinese medicinal components to the formula of the raw materials, unpalatable medicine flavor caused by conventional extraction is eliminated, and health care value is also improved; and the rose-grape wine has the functions of enriching blood and promoting blood circulation, tranquilizing and calming nerves, preserving health and resisting aging, etc., and the rose-grape wine is capable of regulating and improving sleep quality, losing weight and keeping fit.