The present invention relates to a fruit tree cultivation technology, particularly to a nuisance-free cultivation technology of grapes, and belongs to the cultivation technical field of agriculture. A centennial seedless variety is selected for field planting, in late December, grape plants are trimmed in winter, lime nitrogen is used for preparing liquid to be applied to twigs, and a small simple arched shed is adopted as a facility for promoting the early cultivation of grapes; after the grape plants fructify, pure white paper bags are used for covering ears, and when the particle diameter of each grape is 2-3mm, 20000 times of gibberellin liquid is used for spraying the ears; reasonable trimming in winter, thinning of trees and thinning of ears are performed, assistant ears are removed, ear points are pinched off, grains are thinned, and the yield of per hectare is controlled to be 18-22.5t; improving the fruit positions of the plants needs to be paid attention, favorable ventilation and transmittance conditions are maintained, and the grapes are promoted to ripen in advance. The peel of the grapes cultivated by the culturing technology disclosed by the invention is green in bottom color, while maturity, the grapes are pistachio in bottom color, the peels are thin, the toughness is good, the grapes are indehiscent, the flesh of the grapes is thick, the grain is hard and crisp, the content of soluble solid contents achieves as high as 18%, the taste is sweet, the grapes have delicate fragrance, and the grapes are good in mouth feel, good in quality, and resistant to storage and transportation. The trees of the grapes are strong, branches are robust, the fructifying degree is high, the yield is high, and the disease resistance is stronger.