35 results about "Honokiol" patented technology

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

The invention relates to the technical field of anti-cancer drugs, and provides a traditional Chinese medicine multi-component nano drug delivery system as well as a preparation method and application thereof. According to the invention, honokiol (HN) is entrapped by adopting lipid nanoparticles formed by a berberine (BR)-disulfide bond-caprylic capric triglyceride compound, the surface of the lipid nanoparticles is coated with a gelatin layer, and quercetin (QE) is entrapped in the gelatin layer, so that simultaneous delivery of HN, BR and QE and programmed release outside and inside cells are realized. Furthermore, the surface of the gelatin layer is modified with PEG, so that the long circulation of the drug delivery system in blood is improved; furthermore, cRGD is connected to PEG, and the synergistic lung cancer resisting effect of HN, BR and QE is greatly improved through the targeting effect of cRGD. In conclusion, the drug delivery system provided by the invention can give full play to the effect of synergistically treating lung cancer by HN, QE and BR, and has a wide application prospect.

The invention relates to the technical field of biomedical materials, in particular to a COF heterojunction nanosphere with biomimetic mineralization and antibacterial functions and a preparation method and application thereof. The preparation method comprises the following steps: mixing a magnolol solution, a 1, 3, 5-tris (4-aminophenyl) benzene solution, a polyvinylpyrrolidone solution, a 2, 5-dimethoxybenzene-1, 4-dicarboxaldehyde solution and acetic acid, so as to obtain COFDMTP-coated Honokiol nanospheres; the preparation method comprises the following steps: mixing 4, 4 '-((2, 5-diformyl-1, 4-phenylene) bis (oxy)) dibutyric acid, COFDMTP (at) Honokiol nanospheres, acetonitrile and an acetic acid solution, and reacting to obtain the COFFPBA (at) Honokiol heterojunction nanospheres. The heterojunction nanosphere provided by the invention not only can promote the mineralization of acid-etched enamel, but also can effectively inhibit the growth of oral bacteria and reduce the occurrence of decayed teeth.

The invention belongs to the technical field of organic synthesis, and discloses a dialkylated cationic derivative based on honokiol mother nucleus as well as a preparation method and antibacterial application of the dialkylated cationic derivative. The preparation method comprises the following steps: mixing honokiol, potassium carbonate, dibromoalkane and acetone, and carrying out first reaction to obtain an intermediate product; and mixing the intermediate product, a compound R1H and acetonitrile, and carrying out a second reaction to obtain the honokiol mother nucleus-based dialkylated cationic derivative. A series of novel amphiphilic derivatives are designed and synthesized by reasonably modifying a natural product honokiol, and the novel amphiphilic derivatives show effective in-vitro antibacterial activity on gram-positive bacteria.

The invention discloses a bacteriostatic liposome with lipase responsiveness, a preparation method and application thereof and a product, and belongs to the technical field of cosmetics. The invention aims to solve the technical problems of drug resistance, high skin irritation and the like of the existing acne treatment means. Meanwhile, antibacterial core materials such as totarol and the like have the problems of poor solubility, poor transdermal absorption, burst release stimulation and the like. According to the key point of the technical scheme, the bacteriostatic liposome with lipase responsiveness is provided, and a wall material of the bacteriostatic liposome comprises soybean phosphatidylcholine, hydrogenated phosphatidylcholine, cholesterol, PEG-7 olivate, glyceryl stearate and ceramide NP, the inner core material is prepared from at least one of totarol, paeonol, honokiol, capryloyl glycine, glabridin, ascorbyl tetraisopalmitate, tetrahydrocurcumin or pterostilbene. Through a specific preparation method, the release speed of the core material is regulated and controlled by utilizing the reaction of lipase and the wall material, the slow release and controlled release effects are achieved, and industrial production is easy.

The present application relates to a high-refractive material based on biomass magnolol and honokiol. Specifically, the high-refractive material of the present application can be obtained by photo-curing reaction of a photo-curable monomer and a plurality of mercaptans / mercaptanols under photo-initiation, wherein the photo-curable monomer is derived from a monomer containing an allyl functional group derived from biomass magnolol and honokiol. The high-refractive material provided by the present application has good optical performance, in particular, it not only has a high refractive index (1.67-1.71) but also has a relatively high Abbe number (35-24).

The application belongs to the technical field of disease prevention and treatment of aquaculture, and particularly relates to application of honokiol combined with sulfisoxazole sodium in preparation of a Vibrio parahaemolyticus inhibitor, characterized by that the mass ratio of honokiol to sulfisoxazole sodium in the composition is 1:0.5-2, the concentration of honokiol in the composition is 32-64 µg / mL, and the concentration of sulfisoxazole sodium in the composition is 32-128 µg / mL, and the application further provides a medicine for improving sensitivity of Vibrio parahaemolyticus to sulfisoxazole sodium and treating acute hepatopancreas necrosis disease of prawns, and the mass ratio of honokiol to sulfisoxazole sodium in the medicine is 1:0.125-0.5; the composition can significantly reverse drug resistance of Vibrio parahaemolyticus to SMM-Na, reduce the use amount of SMM-Na, and produce a rapid sterilization effect through combined action, and meanwhile, the composition exhibits excellent protection efficacy in prawn bodies.

This invention belongs to the field of pharmaceutical technology and relates to a preparation process of a modified Huoxiang Zhengqi compound. The preparation process is as follows: Pinellia ternata and Angelica dahurica are percolated; Pogostemon cablin, Perilla frutescens, Citrus reticulata peel, Magnolia officinalis, and Atractylodes macrocephala are extracted in groups for 2-5 hours, and the total volatile oil is collected. The residues of each group are decocted with water, and the decoctions of each group are collected; Poria cocos, Platycodon grandiflorus, Glycyrrhiza uralensis, Areca catechu peel, Ziziphus jujuba, and Zingiber officinale are decocted with water to obtain a decoction; the total volatile oil is added to an inclusion material, and inclusion is obtained using an ultrasonic-assisted method; the percolation and decoctions are combined, concentrated, and centrifuged to obtain a supernatant; a preservative is added to the supernatant and the inclusion material to obtain the final product. This invention extracts medicinal materials containing volatile oils in groups and uses a cyclodextrin inclusion complexation process, which not only improves the total extraction rate of volatile oils, but also increases the content of hesperidin, hydrated oxypenicillin, magnolol, honokiol, patchouli flavonol, and baicalein, while improving the taste and flavor of the flavored patchouli flavonoid compound.

The present invention relates to an anti-aging composition containing a Magnolia officinalis extract or magnolol, honokiol and 4-O-methlyhonokiol compounds. The extract or compound restores mitochondrial functions of senescent cells, reduces damaged DNA in cells, and restores senescent cells to a youthful cell state, and thus can be effectively used as a multifunctional cosmetic composition, a pharmaceutical composition, or a health functional food for inhibiting aging.

The invention belongs to the technical field of honokiol derivatives, and particularly discloses a honokiol derivative with a cationic group, a preparation method of the honokiol derivative and application of the honokiol derivative in preparation of anti-infection drugs. The preparation method comprises the following steps: carrying out amide coupling reaction on a compound 1 and a compound 2 to obtain a compound 3; then carrying out hydrolysis reaction on the compound 3 to obtain a compound 4; performing bromination reaction on the compound 4 to obtain a compound 5; and carrying out nucleophilic substitution reaction on the compound 5 and H-R2 to obtain the honokiol derivative with the cationic group. The micromolecular stimulant prepared by the invention can replicate the core physicochemical and biological characteristics of the antibacterial peptide, also can optimize the pharmacological characteristics, and solves many problems existing when the antibacterial peptide is used as an anti-infective drug.

The present invention relates to a cosmetic composition comprising a glutathione precursor and a lignan-based compound derived from magnolia, and provides a cosmetic composition having an excellent antioxidant effect by securing the efficiency of a complex synergistic combination of honokiol and an antioxidant amino acid.

The invention belongs to the technical field of organic synthesis, and provides a honokiol phosphine salt derivative as well as a preparation method and application thereof, and a novel magnolol derivative is designed and synthesized by integrating a cationic head group and a hydrophobic chain. The compound shows potent activity (MIC = 1-4 [mu] g / mL) on a series of gram-positive bacteria, meanwhile, the hemolytic activity is extremely low (HC50 = 106.9 [mu] g / mL), and the cytotoxicity is also low (CC50 = 19.25 [mu] g / mL). In addition, the derivative also has the capabilities of rapid sterilization, low drug resistance, good plasma stability and capability of inhibiting biofilm formation and destroying mature biofilms. And compared with vancomycin, the vancomycin-containing antibacterial peptide has the advantage that the bacterial load can be obviously reduced.

The invention relates to the technical field of medicinal chemistry, in particular to a preparation method of a lung-targeting tertiary amine modified honokiol derivative, which is characterized in that a series of novel derivatives are synthesized by introducing a tertiary amine ligand into honokiol molecules and adopting an ester bond, carbamate bond or ether bond covalent linkage mode. The water solubility and metabolic stability of honokiol are effectively improved, the in-vivo half-life period of honokiol is remarkably prolonged, the lung tissue targeting characteristic of the tertiary amine ligand is utilized, selective enrichment of the derivative in the lung is achieved, and the selectivity of the derivative in the lung is improved. Therefore, the technical problem that honokiol is difficult to reach and maintain an effective treatment concentration at a target site due to poor pharmacokinetic properties is solved. Wherein the ether bond connected derivative HM-16 shows excellent anti-tumor activity, good tolerance and prolonged in-lung residence time, and a potential candidate drug is provided for targeted therapy of lung cancer.

The application discloses a preparation method of honokiol-tetramethylpyrazine eutectic crystal, which comprises the following steps: mixing honokiol and tetramethylpyrazine, ball milling / stirring, and drying to obtain honokiol-tetramethylpyrazine eutectic crystal. The application further discloses honokiol-tetramethylpyrazine eutectic crystal prepared by the above method. The application further discloses a composition comprising the above honokiol-tetramethylpyrazine eutectic crystal and honey. The application further discloses the use of the above honokiol-tetramethylpyrazine eutectic crystal or the above composition in the preparation of drugs for treating cardiovascular and cerebrovascular diseases, resisting platelet aggregation and resisting tumors.

This invention provides a method for separating magnolol and honokiol, relating to the field of separation technology. The invention involves mixing total magnolol (including magnolol and honokiol) with an organic solvent; extracting the resulting organic phase solution using an extractant (an aqueous solution of 1,3-dimethylurea) to obtain an organic phase (including magnolol and the organic solvent) and an aqueous phase (including honokiol and the extractant). This invention is the first to utilize a single extractant and hydrogen-bonded molecular recognition mechanism to achieve highly selective separation of magnolol isomers. Furthermore, by integrating multi-stage extraction and variable-concentration back-extraction, the purity and recovery rate of magnolol and honokiol can both reach over 99%. The entire process operates under mild conditions, is energy-efficient and economical, and ensures the activity and stability of the product. Through concentration, complete recovery and recycling of the extractant and process water are achieved, realizing a closed-loop cycle that is environmentally friendly.

The application provides a Sanhua decoction reference sample freeze-dried powder and a preparation method and a quality detection method thereof. The preparation method of the Sanhua decoction reference sample freeze-dried powder is optimized to prepare the freeze-dried powder, so that the modern process parameters of the classical famous prescription reference sample are obtained, and subsequent pilot production and industrialized production are facilitated. The quality of the Sanhua decoction reference sample freeze-dried powder is detected by two technical means of thin layer chromatography and high-phase liquid chromatography. The thin layer chromatography is used for identification of all medicinal materials, and according to the differences of different medicinal material components, a separate TLC detection means is formulated for the medicinal materials, and the detection of rhubarb glycoside is increased for the anti-counterfeiting of the rhubarb medicinal material. Compared with the prior art, the method is more intuitive and clear. The total content of magnolol and honokiol is determined by high-performance liquid chromatography, and a quantitative monitoring means is provided.

The invention belongs to the technical field of nano-drugs, and particularly relates to multifunctional honokiol nano-particles and a preparation method and application thereof.The honokiol nano-particles are prepared by using rhamnolipid modified chitosan as a carrier and loading honokiol; according to the nano-particles, an amido bond formed between rhamnolipid and chitosan can be subjected to targeted decomposition under the acidic condition of a bacterial infection part, and the released rhamnolipid can destroy a bacterial biofilm; further, permeation of the natural antibacterial agent honokiol and chitosan at the infected part is enhanced, and synergistic sterilization is realized; meanwhile, the planktonic bacteria re-adhesion resistance characteristic of rhamnolipid can inhibit the re-formation of a biofilm, the full-stage sterilization of'destroying the biofilm, killing bacteria in the film and inhibiting the re-adhesion of residual bacteria 'of the nanoparticles is finally realized, and the multifunctional honokiol nano platform is suitable for preventing and treating infectious diseases such as wound infection and bacterial peritonitis.

The application belongs to the technical field of natural medicine chemistry, and particularly relates to a method for extracting compounds in Magnolia officinalis by using a low eutectic solvent and a detection method. Magnolia officinalis powder and a low eutectic solvent are mixed, and then soaking and ultrasonic extraction are sequentially performed to obtain an extraction liquid containing target compounds; the target compounds are magnoliabine, syringin, magnolol and honokiol. The low eutectic solvent is used to assist ultrasonic extraction of the Magnolia officinalis powder, and strong hydrogen bond interaction is formed between the low eutectic solvent and the target compounds, which is beneficial to the extraction of the target compounds, so that the extraction rate of the four target compounds in the Magnolia officinalis powder is improved.

The present application relates to a method for inhibiting PRRSV infection in vitro by honokiol and application thereof, and experiments show that honokiol can be used for preparing a medicine for inhibiting PRRSV infection. In the process of PRRSV infection in MARC-145 cells in vitro, honokiol with a concentration of 2.5, 5 and 10 micromoles / L is added, and compared with a control group without honokiol, the PRRSV RNA content, protein abundance and titer of the treatment group with honokiol are obviously reduced in a dose-dependent manner, indicating that honokiol can be used for inhibiting PRRSV infection in vitro.

The invention provides application of honokiol in preparation of a medicine for treating mutated drug-resistant solid tumors and / or brain metastatic tumors of the drug-resistant solid tumors. Researches find that honokiol can generate an obvious inhibition effect on a mutant drug-resistant strain, and can simultaneously have an obvious inhibition effect on in-situ and brain metastases of the drug-resistant strain. Therefore, honokiol has an obvious treatment effect on the drug-resistant solid tumor and the brain metastasis tumor of the drug-resistant solid tumor, the lifetime of a patient is prolonged, and a new and effective treatment choice is provided for the drug-resistant solid tumor and the brain metastasis tumor of the drug-resistant solid tumor.

The application discloses a bacteriostatic liposome with lipase responsiveness, a preparation method and application thereof and a product, and belongs to the technical field of cosmetics. The technical problems to be solved are that existing means for treating acne are faced with problems such as drug resistance, high skin irritation and the like. Meanwhile, bacteriostatic core materials such as paeonol have problems such as poor solubility, poor transdermal absorption, burst stimulation and the like. The technical solution is characterized by providing a bacteriostatic liposome with lipase responsiveness, wherein wall materials include soybean phosphatidylcholine, hydrogenated phosphatidylcholine, cholesterols, PEG-7 olive oil acid ester, glycerol stearate and ceramide NP; and internal core materials include at least one of paeonol, paeonol, honokiol, caprylyl glycine, glabridin, ascorbic acid tetraisopalmitate, tetrahydrocurcumin or pterostilbene. Through a specific preparation method, the release speed of the core materials is regulated by using the reaction between lipase and the wall materials, a slow-release and controlled-release effect is achieved, and the product is easy to be produced industrially.

Use of a small-molecule drug combination composition in enhancing the metabolic and killing abilities of NK cells under hypoxic conditions. The combination composition comprises honokiol and nicotinamide nucleoside. A combination of honokiol and nicotinamide nucleoside has a synergistic effect on the regulation of NK cells under hypoxic conditions, and can significantly enhance the metabolic and killing abilities of NK cells under hypoxic conditions. Thus, the present invention provides a new drug combination strategy for the treatment of tumors.

The invention provides silver-containing hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel. The preparation method of the silver-containing hydrogel comprises the following steps: sequentially carrying out ultrasonic treatment, stirring and standing on glycyrrhizic acid, honokiol and water to obtain a hydrogel matrix; the levodopa solution and the silver nitrate solution are mixed and then subjected to an illumination reaction, and a silver nanoparticle solution is obtained; and mixing the hydrogel matrix and the silver nanoparticle solution, and standing to obtain the silver-containing hydrogel. The particle size distribution of AgNPs in the prepared silver-containing hydrogel is uniform (164-531 nm), the hydrogel has excellent injectability, slow release performance and biocompatibility, and the hydrogel shows remarkable synergistic antibacterial activity on common pathogenic bacteria such as staphylococcus aureus and escherichia coli, especially gram-positive bacteria.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a mangnolia officinalis extract or a structural analogue thereof in preparation of a medicament for treating hyperinsulinemia / hyperamminemia syndrome. The invention provides a new application of a mangnolia officinalis extract represented by honokiol. Research shows that the mangnolia officinalis extract or the structural analogue thereof can well inhibit the activity of glutamate dehydrogenase (GDH), including wild type GDH and GDH capable of causing acquisition function mutation of the hyperinsulinemia / hyperamminemia (HI / HA) syndrome, so that the effect of the mangnolia officinalis extract or the structural analogue thereof as a GDH inhibitor in treatment of the HI / HA syndrome is expanded, and the application of the mangnolia officinalis extract or the structural analogue thereof in treatment of the HI / HA syndrome is promoted. Effective attempts are made for solving the problem that existing medicines for treating the rare HI / HA syndrome are rare, the current situation of treating the HI / HA syndrome can be remarkably improved, the situation of lack of targeted medicines is broken through, the life quality of patients is improved, and the family and social burden of the patients is greatly relieved.

The present invention provides compositions and methods for treating a subject diagnosed with ASD. In preferred embodiments, the subject compositions comprise tellimagrandin II, glycyrrhizin, monolaurin, selenium, honokiol, a probiotic, and one or more biological amphiphilic molecules, which when administered to a subject, can support immune and / or digestive health, and suppress and / or disable viral pathogenic agents in the body.

The present application relates to an anti-aging composition for improving cardiovascular function and a preparation method and application thereof, and the composition comprises L-ergothioneine, honokiol, quercetin and coenzyme Q10. The present application creatively designs an anti-aging composition for improving cardiovascular aging, which improves cardiovascular aging from four dimensions of "myocardial energy supply + anti-hypertrophy + endothelial protection + anti-oxidation". Coenzyme Q10 can restore myocardial mitochondrial ATP production, honokiol can reverse myocardial hypertrophy through NAD+ deacetylase, quercetin can improve endothelial function and reduce blood pressure, and L-ergothioneine can protect vascular endothelial cells from oxidative damage and inhibit the formation of ox-LDL. Through research, it is found that the four can cooperate and synergize with each other, and can jointly play an excellent role in improving cardiovascular aging, and achieve multiple protection for cardiovascular aging.

The present invention relates to a cosmetic composition for skin improvement and a pharmaceutical composition for the prevention or treatment of skin damage, comprising honokiol and a polyol. When honokiol is dissolved in a polyol, the effects of wrinkle improvement, elasticity improvement, moisturizing improvement, barrier improvement, inflammation suppression, and antioxidant activity are synergistically enhanced, making it effective for the production of cosmetic compositions for skin improvement or pharmaceutical compositions for the prevention or treatment of skin damage.

The invention discloses a preparation method and antibacterial application of honokiol derivatives with antibacterial activity. The structure of the honokiol derivatives is shown as a general formula I. The natural product honokiol is taken as a starting raw material, the amine functional group is introduced through Mannich reaction to prepare the novel derivative, and the synthesis method is simple and convenient to operate, few in steps and easy for large-scale production. In-vitro activity evaluation shows that the derivative not only has good antibacterial activity on gram-positive and gram-negative bacteria, but also can effectively inhibit the formation of a biofilm, and the water solubility of the derivative is also improved. The invention is of great significance to development and research of new antibacterial drugs.

The invention provides a nursing pharmaceutical composition for preventing pressure sores and a preparation method thereof, and the composition is composed of an active component, a liquid absorption component and pharmaceutically acceptable auxiliary materials, active components of the composition comprise an astragalus extract, an angelica sinensis extract, a lithospermum extract, a recombinant human epidermal growth factor, pentoxifylline, polyhexamethylene biguanide hydrochloride, beta-glucan, asiaticoside and magnolol, and the effects of improving microcirculation, resisting inflammation and bacteria and promoting tissue repair are comprehensively achieved through a multi-target synergistic effect; luminan microspheres or calcium alginate fibers are adopted as liquid absorption components, wound exudate is effectively managed, a wet environment is maintained, a split-phase preparation and low-temperature integration process is adopted in the preparation method, the compatibility problem of complex components is solved, and the stability and effectiveness of the product are ensured; the device integrates active treatment and protection, is suitable for preventing and treating pressure sores in all stages, and has the advantages of being remarkable in effect and safe to use.