62 results about "Honokiol" patented technology

The invention belongs to the technical field of agricultural biology, and particularly discloses application of honokiol in preparation of a bactericide for preventing and treating fungal diseases of plants, and honokiol is derived from plants, is a green, environment-friendly and high-safety small molecule compound, is wide in antibacterial spectrum and long in lasting period, and can be applied to prevention and treatment of fungal diseases of plants. The bactericidal composition can be used for effectively preventing and treating plant diseases of peanuts, corns, wheat, Chinese chives, soybeans, peppers, tomatoes and the like, can be applied to industrial crops such as various grains, melons and fruits, vegetables and the like, is safe to non-target organisms, meets the requirements of green sustainable development, and has a wide application value.

The present invention relates to a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, a feed composition for improving brain cognitive function, and a method for preparing same and, specifically, to: a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredients, extracts of Atractylodes lancea, Eclipta prostrata, and Magnolia officinalis, and a method for preparing same; and a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredient(s), atractylodin, wedelolactone, and / or honokiol, and a method for preparing same.

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

The present application relates to a kind of composition capable of relieving fatigue-related emotional fluctuation and anxiety and its application.The composition includes: and magnolol, ergothioneine, ginsenoside and plant extract;The plant source of the plant extract includes eucommia leaf and schisandra chinensis.The above components cooperate with each other, and have significant synergistic effect in relieving tension, anxious mood and anti-depression.

The invention relates to the technical field of anti-cancer drugs, and provides a traditional Chinese medicine multi-component nano drug delivery system as well as a preparation method and application thereof. According to the invention, honokiol (HN) is entrapped by adopting lipid nanoparticles formed by a berberine (BR)-disulfide bond-caprylic capric triglyceride compound, the surface of the lipid nanoparticles is coated with a gelatin layer, and quercetin (QE) is entrapped in the gelatin layer, so that simultaneous delivery of HN, BR and QE and programmed release outside and inside cells are realized. Furthermore, the surface of the gelatin layer is modified with PEG, so that the long circulation of the drug delivery system in blood is improved; furthermore, cRGD is connected to PEG, and the synergistic lung cancer resisting effect of HN, BR and QE is greatly improved through the targeting effect of cRGD. In conclusion, the drug delivery system provided by the invention can give full play to the effect of synergistically treating lung cancer by HN, QE and BR, and has a wide application prospect.

The invention relates to the technical field of biomedical materials, in particular to a COF heterojunction nanosphere with biomimetic mineralization and antibacterial functions and a preparation method and application thereof. The preparation method comprises the following steps: mixing a magnolol solution, a 1, 3, 5-tris (4-aminophenyl) benzene solution, a polyvinylpyrrolidone solution, a 2, 5-dimethoxybenzene-1, 4-dicarboxaldehyde solution and acetic acid, so as to obtain COFDMTP-coated Honokiol nanospheres; the preparation method comprises the following steps: mixing 4, 4 '-((2, 5-diformyl-1, 4-phenylene) bis (oxy)) dibutyric acid, COFDMTP (at) Honokiol nanospheres, acetonitrile and an acetic acid solution, and reacting to obtain the COFFPBA (at) Honokiol heterojunction nanospheres. The heterojunction nanosphere provided by the invention not only can promote the mineralization of acid-etched enamel, but also can effectively inhibit the growth of oral bacteria and reduce the occurrence of decayed teeth.

The invention discloses a method for determining four mangnolia officinalis extracts in import and export cosmetics, which is used for detecting magnolol, honokiol, magnoflorine and magnoliavine, and comprises the following steps: S1, uniformly mixing a cosmetic sample with a solvent; s2, after uniform mixing, carrying out vortex oscillation treatment on the sample; s3, after vortex oscillation treatment, carrying out ultrasonic extraction on the sample at room temperature to obtain an extracting solution; s4, mixing the extracting solution with an adsorbent to obtain a purified to-be-detected solution; and S5, filtering the to-be-detected liquid, and determining the to-be-detected liquid through LC-MS / MS to obtain a detection result. According to the present invention, the target object in the cosmetics with different matrix types can be effectively represented, the core functional components such as magnolol and honokiol in the cortex magnoliae officinalis extract can be detected, the qualitative and quantitative analysis can be further performed on the potential supervision risk substance, and the dual functions of quality evaluation and safety supervision can be provided for the cosmetics.

The invention discloses a nano composition of pterostilbene, a preparation method of the nano composition, and application of the pterostilbene in preparation of an anti-hair loss product. Comprising the following components in percentage by mass: 0.1-25% of pterostilbene, 0.1-30% of polyol ether, 0.1-8% of terpene essential oil, 0.5-30% of a flexible agent, 0.1-20% of phospholipid and / or phospholipid derivative, 0-2% of honokiol, 0-3% of cinnamic acid, 0-35% of an additive and the balance of water. The invention proves that the pterostilbene has an excellent anti-hair loss effect and has relatively strong 5 alpha-reductase inhibitory activity, and the nano composition containing the pterostilbene, honokiol and cinnamic acid can synergistically enhance the 5 alpha-reductase inhibitory and anti-hair loss effects of the pterostilbene, and meanwhile, the nano composition enhances the solubility and stability of the pterostilbene, so that the anti-hair loss effect of the pterostilbene is improved, and the anti-hair loss effect of the pterostilbene is improved. The application of the pterostilbene is expanded.

Provided are a honokiol liposome lyophilized agent and a preparation method therefor, belonging to the technical field of the preparation of liposome formulations. Provided is a honokiol liposome lyophilized agent. The active ingredient of the lyophilized agent is honokiol, and a protective agent povidone is contained. Further, the lyophilized agent is prepared from 1 part of honokiol, 2-8 parts of phospholipid, 0.3-2.2 parts of cholesterol, 0.1-1.5 parts of polyethylene glycol or phospholipid treated by polyethylene glycol, and 30-300 parts of a protective agent. The liposome lyophilized agent has low impurity content, better stability, and lower requirements on the storage environment.

The present invention relates to a honokiol derivative represented by the following formula I or formula II, a preparation method therefor, and use thereof. The compound according to the present invention can serve as a prodrug of honokiol, greatly improving the bioavailability of honokiol, overcoming the problem that honokiol monomer cannot be developed into a drug due to its low bioavailability in vivo, and making the clinical development of honokiol possible.

The invention belongs to the technical field of organic synthesis, and discloses a dialkylated cationic derivative based on honokiol mother nucleus as well as a preparation method and antibacterial application of the dialkylated cationic derivative. The preparation method comprises the following steps: mixing honokiol, potassium carbonate, dibromoalkane and acetone, and carrying out first reaction to obtain an intermediate product; and mixing the intermediate product, a compound R1H and acetonitrile, and carrying out a second reaction to obtain the honokiol mother nucleus-based dialkylated cationic derivative. A series of novel amphiphilic derivatives are designed and synthesized by reasonably modifying a natural product honokiol, and the novel amphiphilic derivatives show effective in-vitro antibacterial activity on gram-positive bacteria.

The invention belongs to the technical field of biopesticides, and particularly relates to a microbial biopesticide for preventing and treating wheat scab. The invention relates to a microbial biopesticide. The microbial biopesticide is prepared by binary compounding of ceriporia lacerata, physcion, L-alkannin or honokiol according to a certain mass ratio. According to the invention, the ceriporia lacerata GXMS1 is compounded with the existing bioactive bactericidal component physcion, L-alkannin or honokiol, and compared with the single use of the ceriporia lacerata GXMS1, the control effect on the wheat scab can be improved. The microbial biopesticide provided by the invention is environment-friendly, and compared with the use of chemical agents, the microbial biopesticide provided by the invention can reduce adverse effects such as drug resistance, environmental pollution and the like caused by chemical prevention and treatment, conforms to the ideas of green and sustainable development of agriculture, and can provide support for developing biopesticides for preventing and treating gibberellic disease.

The invention discloses a bacteriostatic liposome with lipase responsiveness, a preparation method and application thereof and a product, and belongs to the technical field of cosmetics. The invention aims to solve the technical problems of drug resistance, high skin irritation and the like of the existing acne treatment means. Meanwhile, antibacterial core materials such as totarol and the like have the problems of poor solubility, poor transdermal absorption, burst release stimulation and the like. According to the key point of the technical scheme, the bacteriostatic liposome with lipase responsiveness is provided, and a wall material of the bacteriostatic liposome comprises soybean phosphatidylcholine, hydrogenated phosphatidylcholine, cholesterol, PEG-7 olivate, glyceryl stearate and ceramide NP, the inner core material is prepared from at least one of totarol, paeonol, honokiol, capryloyl glycine, glabridin, ascorbyl tetraisopalmitate, tetrahydrocurcumin or pterostilbene. Through a specific preparation method, the release speed of the core material is regulated and controlled by utilizing the reaction of lipase and the wall material, the slow release and controlled release effects are achieved, and industrial production is easy.

The present application relates to a high-refractive material based on biomass magnolol and honokiol. Specifically, the high-refractive material of the present application can be obtained by photo-curing reaction of a photo-curable monomer and a plurality of mercaptans / mercaptanols under photo-initiation, wherein the photo-curable monomer is derived from a monomer containing an allyl functional group derived from biomass magnolol and honokiol. The high-refractive material provided by the present application has good optical performance, in particular, it not only has a high refractive index (1.67-1.71) but also has a relatively high Abbe number (35-24).

The application belongs to the technical field of disease prevention and treatment of aquaculture, and particularly relates to application of honokiol combined with sulfisoxazole sodium in preparation of a Vibrio parahaemolyticus inhibitor, characterized by that the mass ratio of honokiol to sulfisoxazole sodium in the composition is 1:0.5-2, the concentration of honokiol in the composition is 32-64 µg / mL, and the concentration of sulfisoxazole sodium in the composition is 32-128 µg / mL, and the application further provides a medicine for improving sensitivity of Vibrio parahaemolyticus to sulfisoxazole sodium and treating acute hepatopancreas necrosis disease of prawns, and the mass ratio of honokiol to sulfisoxazole sodium in the medicine is 1:0.125-0.5; the composition can significantly reverse drug resistance of Vibrio parahaemolyticus to SMM-Na, reduce the use amount of SMM-Na, and produce a rapid sterilization effect through combined action, and meanwhile, the composition exhibits excellent protection efficacy in prawn bodies.

The present disclosure relates to a pharmaceutical composition for treatment of muscle disease, comprising a Magnolia officinalis extract. The Magnolia officinalis extract contains various ingredients other than magnolol and honokiol, and inhibits cisplatin-induced weight loss, muscle mass reduction, grip strength reduction, and muscle fiber damage, and promotes the repair of damaged muscle fibers through macrophage polarization from M1 to M2 without interfering with an antitumor function of cisplatin, and thus can be effectively used for prevention and treatment of muscle disease, especially, anticancer drug-induced muscle disease.

The application belongs to the technical field of content detection, and discloses a kind of HPLC detection methods for simultaneously determining the content of multiple components in semen Cannabis capsules.The detection method includes mixing reference solution, chrysophanol and methanol to obtain mixed reference solution.The reference solution includes physcion solution, magnolol solution, houpo chrysophanol solution, emodin solution, rhein solution, nobiletin solution, aloe emodin solution, hesperidin solution and paeoniflorin solution;The contents of semen Cannabis capsules are mixed with methanol, and the test solution is obtained after heating and refluxing;The mixed reference solution and test solution are respectively sucked and injected into high performance liquid chromatograph.The detection method can simultaneously determine the content of multiple index components, can comprehensively reflect the quality of the preparation, and the test method has excellent precision, repeatability, stability and high sample recovery rate.

This invention belongs to the field of pharmaceutical technology and relates to a preparation process of a modified Huoxiang Zhengqi compound. The preparation process is as follows: Pinellia ternata and Angelica dahurica are percolated; Pogostemon cablin, Perilla frutescens, Citrus reticulata peel, Magnolia officinalis, and Atractylodes macrocephala are extracted in groups for 2-5 hours, and the total volatile oil is collected. The residues of each group are decocted with water, and the decoctions of each group are collected; Poria cocos, Platycodon grandiflorus, Glycyrrhiza uralensis, Areca catechu peel, Ziziphus jujuba, and Zingiber officinale are decocted with water to obtain a decoction; the total volatile oil is added to an inclusion material, and inclusion is obtained using an ultrasonic-assisted method; the percolation and decoctions are combined, concentrated, and centrifuged to obtain a supernatant; a preservative is added to the supernatant and the inclusion material to obtain the final product. This invention extracts medicinal materials containing volatile oils in groups and uses a cyclodextrin inclusion complexation process, which not only improves the total extraction rate of volatile oils, but also increases the content of hesperidin, hydrated oxypenicillin, magnolol, honokiol, patchouli flavonol, and baicalein, while improving the taste and flavor of the flavored patchouli flavonoid compound.

The present invention relates to an anti-aging composition containing a Magnolia officinalis extract or magnolol, honokiol and 4-O-methlyhonokiol compounds. The extract or compound restores mitochondrial functions of senescent cells, reduces damaged DNA in cells, and restores senescent cells to a youthful cell state, and thus can be effectively used as a multifunctional cosmetic composition, a pharmaceutical composition, or a health functional food for inhibiting aging.

The invention belongs to the technical field of fluorocarbon finish paint, and particularly relates to a preparation method of metal fluorocarbon finish paint. The invention relates to a preservative. The preservative is prepared by compounding murrayone and polyhexamethylene biguanide hydrochloride. The preservative prepared by compounding the murrayone and the polyhexamethylene biguanide hydrochloride has a synergistic effect on various moulds, and compared with single polyhexamethylene biguanide hydrochloride, the preservative can improve the inhibition effect on mould growth and resist the influence of microorganisms on the finish paint, so that the preservative effect of the finish paint is further improved.

The invention belongs to the technical field of honokiol derivatives, and particularly discloses a honokiol derivative with a cationic group, a preparation method of the honokiol derivative and application of the honokiol derivative in preparation of anti-infection drugs. The preparation method comprises the following steps: carrying out amide coupling reaction on a compound 1 and a compound 2 to obtain a compound 3; then carrying out hydrolysis reaction on the compound 3 to obtain a compound 4; performing bromination reaction on the compound 4 to obtain a compound 5; and carrying out nucleophilic substitution reaction on the compound 5 and H-R2 to obtain the honokiol derivative with the cationic group. The micromolecular stimulant prepared by the invention can replicate the core physicochemical and biological characteristics of the antibacterial peptide, also can optimize the pharmacological characteristics, and solves many problems existing when the antibacterial peptide is used as an anti-infective drug.

The invention relates to a composition with tooth repairing and whitening effects and application thereof. The composition is prepared from paeonol, honokiol, allantoin and a crocus sativus extract. The invention creatively discovers that paeonol, honokiol, allantoin and crocus sativus extract have a remarkable synergistic effect in the aspects of repairing and whitening the teeth. The four components are compounded for use, so that dental plaque bacteria can be remarkably reduced, gingival inflammation can be relieved, and meanwhile, the tooth whitening effect can be improved.

The invention provides an application of 4-O-Methyl honokiol in targeted inhibition of TKI drug resistance of non-small cell lung cancer, and particularly provides an application of a compound (I) or a pharmaceutically acceptable salt thereof in treatment of drug-resistant tumors. The compound (I) is an effective novel APOBEC3A inhibitor, can significantly inhibit the increase of the expression level of APOBEC3A induced by TKI, and can effectively inhibit tumor drug resistance.

The present invention relates to a cosmetic composition comprising a glutathione precursor and a lignan-based compound derived from magnolia, and provides a cosmetic composition having an excellent antioxidant effect by securing the efficiency of a complex synergistic combination of honokiol and an antioxidant amino acid.

The invention belongs to the technical field of organic synthesis, and provides a honokiol phosphine salt derivative as well as a preparation method and application thereof, and a novel magnolol derivative is designed and synthesized by integrating a cationic head group and a hydrophobic chain. The compound shows potent activity (MIC = 1-4 [mu] g / mL) on a series of gram-positive bacteria, meanwhile, the hemolytic activity is extremely low (HC50 = 106.9 [mu] g / mL), and the cytotoxicity is also low (CC50 = 19.25 [mu] g / mL). In addition, the derivative also has the capabilities of rapid sterilization, low drug resistance, good plasma stability and capability of inhibiting biofilm formation and destroying mature biofilms. And compared with vancomycin, the vancomycin-containing antibacterial peptide has the advantage that the bacterial load can be obviously reduced.

The invention relates to the technical field of medicinal chemistry, in particular to a preparation method of a lung-targeting tertiary amine modified honokiol derivative, which is characterized in that a series of novel derivatives are synthesized by introducing a tertiary amine ligand into honokiol molecules and adopting an ester bond, carbamate bond or ether bond covalent linkage mode. The water solubility and metabolic stability of honokiol are effectively improved, the in-vivo half-life period of honokiol is remarkably prolonged, the lung tissue targeting characteristic of the tertiary amine ligand is utilized, selective enrichment of the derivative in the lung is achieved, and the selectivity of the derivative in the lung is improved. Therefore, the technical problem that honokiol is difficult to reach and maintain an effective treatment concentration at a target site due to poor pharmacokinetic properties is solved. Wherein the ether bond connected derivative HM-16 shows excellent anti-tumor activity, good tolerance and prolonged in-lung residence time, and a potential candidate drug is provided for targeted therapy of lung cancer.

The invention provides application of tetrahydrohonokiol in preparation of a medicine for preventing and / or treating tumors. Tetrahydrohonokiol has relatively strong anti-cancer activity on cells of malignant tumors such as esophageal cancer, bladder cancer, brain glioma, liver cancer, colorectal cancer, lung cancer, pancreatic cancer and breast cancer. Therefore, the tetrahydrohonokiol can be used for preparing the anti-tumor medicine.

The application discloses a preparation method of honokiol-tetramethylpyrazine eutectic crystal, which comprises the following steps: mixing honokiol and tetramethylpyrazine, ball milling / stirring, and drying to obtain honokiol-tetramethylpyrazine eutectic crystal. The application further discloses honokiol-tetramethylpyrazine eutectic crystal prepared by the above method. The application further discloses a composition comprising the above honokiol-tetramethylpyrazine eutectic crystal and honey. The application further discloses the use of the above honokiol-tetramethylpyrazine eutectic crystal or the above composition in the preparation of drugs for treating cardiovascular and cerebrovascular diseases, resisting platelet aggregation and resisting tumors.

The invention belongs to the field of agricultural chemistry, and particularly relates to a biological source bactericide and application thereof. The active ingredients of the bactericidal composition comprise zhongshengmycin and magnolol, and the weight ratio of zhongshengmycin to magnolol is (1: 20)-(5: 1). The bactericide provided by the invention belongs to a biological source bactericide and is environment-friendly, and the combination of the active components has an obvious synergistic effect, so that the dosage of the bactericide can be reduced, and the generation of drug resistance of diseases can be delayed.

This invention provides a method for separating magnolol and honokiol, relating to the field of separation technology. The invention involves mixing total magnolol (including magnolol and honokiol) with an organic solvent; extracting the resulting organic phase solution using an extractant (an aqueous solution of 1,3-dimethylurea) to obtain an organic phase (including magnolol and the organic solvent) and an aqueous phase (including honokiol and the extractant). This invention is the first to utilize a single extractant and hydrogen-bonded molecular recognition mechanism to achieve highly selective separation of magnolol isomers. Furthermore, by integrating multi-stage extraction and variable-concentration back-extraction, the purity and recovery rate of magnolol and honokiol can both reach over 99%. The entire process operates under mild conditions, is energy-efficient and economical, and ensures the activity and stability of the product. Through concentration, complete recovery and recycling of the extractant and process water are achieved, realizing a closed-loop cycle that is environmentally friendly.