99 results about "Honokiol" patented technology

The invention relates to an antibacterial fabric and a preparation process thereof, and relates to the technical field of fabrics. The antibacterial fabric comprises a fabric body, the fabric body is formed by weaving polyester fibers, an antibacterial fiber membrane layer is arranged on the fabric body, and a preparation method of the antibacterial fiber membrane layer comprises the following steps that honokiol is added into a hexafluoroisopropanol solution and stirred to be uniform, then a polylactic acid-glycolic acid copolymer is added and stirred to be uniform, and the antibacterial fiber membrane layer is obtained. Preparing an antibacterial fiber membrane layer through electrostatic spinning equipment; the antibacterial fabric has the effect of improving the antibacterial property of the fabric.

The invention belongs to the technical field of biological medicine, and discloses application of magnolol as a polymyxin synergist in inhibition of salmonella. The application finds that the combination of magnolol and polymyxin has a good synergistic effect on salmonella in vitro and in vivo experiments. Compared with the traditional method of killing salmonella through combination of antibiotics, the method has the advantages that the magnolol and the polymyxin which are plant-derived synergistically kill bacteria, the generation of bacterial drug resistance is not easy to induce, and the magnolol has the characteristics of wide source, low price and good treatment effect; the method has good research and application significance for excavating antibiotic synergistic substitution and solving bacterial drug resistance.

The invention relates to the technical field of biological medicines, in particular to a preparation method of extracellular vesicles derived from myocardial cells derived from human induced pluripotent stem cells as well as a product and application of the extracellular vesicles. The method comprises the following steps: pretreating human induced pluripotent stem cell derived myocardial cells (hiPSCs-CMs) by using honokiol, and culturing the treated human induced pluripotent stem cell derived myocardial cells to collect extracellular vesicles (EVs) secreted by the human induced pluripotent stem cell derived myocardial cells. The extracellular vesicles secreted by the myocardial cells derived from the human induced pluripotent stem cells pretreated by honokiol are rich in functional mitochondria, show a better myocardial infarction treatment effect in animal experiments, and have huge clinical potential.

The invention provides a combined use of a hyaluronic acid-bilirubin conjugate and honokiol in preparation of a medicine for treating osteoarthritis. The invention provides a honokiol-loaded nanoparticle, which is characterized in that a hyaluronic acid-bilirubin conjugate and honokiol are used as raw materials to prepare a nanoparticle HKL-PNPs, and then the nanoparticle HKL-PNPs is modified by a mitochondrial targeting peptide to obtain the honokiol-loaded nanoparticle HKL-MPNPs. The invention also provides a bionic nanoparticle for treating bone joints. The bionic nanoparticle is prepared by wrapping the honokiol-loaded nanoparticle with an engineered cartilage cell membrane (ECM). According to the invention, cartilage cells with high expression of IL-1R2 are obtained through a gene editing method for the first time, and mitochondrial targeted nanoparticle cores loaded with Sirtuin-3 agonists are coated by cell membranes of the cells, so that the bionic nano preparation is obtained and is used for treating OA. The prepared bionic nano preparation not only can neutralize IL-1beta mediated inflammatory reaction, but also can recover Sirtuin-3 mediated mitochondrial function imbalance, so that the result of synergistic treatment of OA is achieved.

The invention belongs to the technical field of agricultural biology, and particularly discloses application of honokiol in preparation of a bactericide for preventing and treating fungal diseases of plants, and honokiol is derived from plants, is a green, environment-friendly and high-safety small molecule compound, is wide in antibacterial spectrum and long in lasting period, and can be applied to prevention and treatment of fungal diseases of plants. The bactericidal composition can be used for effectively preventing and treating plant diseases of peanuts, corns, wheat, Chinese chives, soybeans, peppers, tomatoes and the like, can be applied to industrial crops such as various grains, melons and fruits, vegetables and the like, is safe to non-target organisms, meets the requirements of green sustainable development, and has a wide application value.

The present invention relates to a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, a feed composition for improving brain cognitive function, and a method for preparing same and, specifically, to: a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredients, extracts of Atractylodes lancea, Eclipta prostrata, and Magnolia officinalis, and a method for preparing same; and a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredient(s), atractylodin, wedelolactone, and / or honokiol, and a method for preparing same.

The invention provides honokiol crystal form A, crystal form B, crystal form C and amorphous form and a preparation method thereof. The method comprises: dissolving honokiol in n-heptane, standing at room temperature overnight, and the precipitated crystal is the honokiol crystal form A; the honokiol crystal form A is cooled to room temperature after heating, and the obtained solid is the honokiol crystal form B; the honokiol crystal form A is heated to a molten state, and then placed at a quenching temperature, and the precipitated crystal is the honokiol crystal form C; the oily substance obtained by adding the honokiol crystal form A with a DMSO / H2O system anti-solvent is the honokiol amorphous form. The honokiol crystal form A, crystal form B and crystal form C of the invention have good solubility, good stability, low hygroscopicity, can be stored for a long time, have good repeatability, and are suitable for drug development; the honokiol amorphous form of the invention has good solubility and is suitable for the development of pharmaceutical preparations.

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

The present application relates to a kind of composition capable of relieving fatigue-related emotional fluctuation and anxiety and its application.The composition includes: and magnolol, ergothioneine, ginsenoside and plant extract;The plant source of the plant extract includes eucommia leaf and schisandra chinensis.The above components cooperate with each other, and have significant synergistic effect in relieving tension, anxious mood and anti-depression.

The invention relates to the technical field of anti-cancer drugs, and provides a traditional Chinese medicine multi-component nano drug delivery system as well as a preparation method and application thereof. According to the invention, honokiol (HN) is entrapped by adopting lipid nanoparticles formed by a berberine (BR)-disulfide bond-caprylic capric triglyceride compound, the surface of the lipid nanoparticles is coated with a gelatin layer, and quercetin (QE) is entrapped in the gelatin layer, so that simultaneous delivery of HN, BR and QE and programmed release outside and inside cells are realized. Furthermore, the surface of the gelatin layer is modified with PEG, so that the long circulation of the drug delivery system in blood is improved; furthermore, cRGD is connected to PEG, and the synergistic lung cancer resisting effect of HN, BR and QE is greatly improved through the targeting effect of cRGD. In conclusion, the drug delivery system provided by the invention can give full play to the effect of synergistically treating lung cancer by HN, QE and BR, and has a wide application prospect.

The invention relates to the technical field of biomedical materials, in particular to a COF heterojunction nanosphere with biomimetic mineralization and antibacterial functions and a preparation method and application thereof. The preparation method comprises the following steps: mixing a magnolol solution, a 1, 3, 5-tris (4-aminophenyl) benzene solution, a polyvinylpyrrolidone solution, a 2, 5-dimethoxybenzene-1, 4-dicarboxaldehyde solution and acetic acid, so as to obtain COFDMTP-coated Honokiol nanospheres; the preparation method comprises the following steps: mixing 4, 4 '-((2, 5-diformyl-1, 4-phenylene) bis (oxy)) dibutyric acid, COFDMTP (at) Honokiol nanospheres, acetonitrile and an acetic acid solution, and reacting to obtain the COFFPBA (at) Honokiol heterojunction nanospheres. The heterojunction nanosphere provided by the invention not only can promote the mineralization of acid-etched enamel, but also can effectively inhibit the growth of oral bacteria and reduce the occurrence of decayed teeth.

The present invention relates to a cosmetic composition for improving skin and a pharmaceutical composition for preventing or treating skin damage, each comprising honokiol and polyol. When dissolved in polyol, honokiol enhances anti-wrinkle, elasticity, moisturization, barrier improvement, anti-inflammatory, and antioxidant activities, and thus can be advantageously applied to the production of cosmetic compositions for skin improvement or pharmaceutical compositions for preventing or treating skin damage.

The invention discloses a method for determining four mangnolia officinalis extracts in import and export cosmetics, which is used for detecting magnolol, honokiol, magnoflorine and magnoliavine, and comprises the following steps: S1, uniformly mixing a cosmetic sample with a solvent; s2, after uniform mixing, carrying out vortex oscillation treatment on the sample; s3, after vortex oscillation treatment, carrying out ultrasonic extraction on the sample at room temperature to obtain an extracting solution; s4, mixing the extracting solution with an adsorbent to obtain a purified to-be-detected solution; and S5, filtering the to-be-detected liquid, and determining the to-be-detected liquid through LC-MS / MS to obtain a detection result. According to the present invention, the target object in the cosmetics with different matrix types can be effectively represented, the core functional components such as magnolol and honokiol in the cortex magnoliae officinalis extract can be detected, the qualitative and quantitative analysis can be further performed on the potential supervision risk substance, and the dual functions of quality evaluation and safety supervision can be provided for the cosmetics.

The invention discloses an isoxazoline hybridized neolignan compound as well as a preparation method and application of the isoxazoline hybridized neolignan compound. The neolignan compound disclosed by the invention is one of isoxazoline magnolol, isoxazoline honokiol, isoxazoline nitrated magnolol and isoxazoline nitrated honokiol derivatives, and has the following chemical general formula: # imgabs0. The neolignan compound disclosed by the invention takes one of magnolol, honokiol, nitrated magnolol or nitrated mangnolia officinalis as a raw material; the preparation method comprises the following steps: by taking triethylamine as alkali and dichloromethane as a solvent, carrying out 1, 3-dipolar cycloaddition reaction on a raw material and alpha-chlorooxime, and separating and purifying to obtain the isoxazoline hybridized neolignan compound. The compound disclosed by the invention has relatively good insecticidal activity on plutella xylostella Linnaeus and Mythimna separata Walker, can be used for preparing a novel efficient insecticide, and is applied to prevention and treatment on the plutella xylostella Linnaeus and the Mythimna separata Walker.

The invention discloses a nano composition of pterostilbene, a preparation method of the nano composition, and application of the pterostilbene in preparation of an anti-hair loss product. Comprising the following components in percentage by mass: 0.1-25% of pterostilbene, 0.1-30% of polyol ether, 0.1-8% of terpene essential oil, 0.5-30% of a flexible agent, 0.1-20% of phospholipid and / or phospholipid derivative, 0-2% of honokiol, 0-3% of cinnamic acid, 0-35% of an additive and the balance of water. The invention proves that the pterostilbene has an excellent anti-hair loss effect and has relatively strong 5 alpha-reductase inhibitory activity, and the nano composition containing the pterostilbene, honokiol and cinnamic acid can synergistically enhance the 5 alpha-reductase inhibitory and anti-hair loss effects of the pterostilbene, and meanwhile, the nano composition enhances the solubility and stability of the pterostilbene, so that the anti-hair loss effect of the pterostilbene is improved, and the anti-hair loss effect of the pterostilbene is improved. The application of the pterostilbene is expanded.

The invention discloses a preparation method and application of a ZnO-ZIF-8 composite material loaded with honokiol, belonging to the technical field of agricultural plant protection. The method comprises the following steps: (1) mixing 2-methylimidazole and N,N-dimethylformamide to obtain a preheating solution; preparing a zinc oxide suspension from nano zinc oxide; (2) preparing a mixed solution from honokiol; (3) preparing a sodium alginate solution from sodium alginate, and then heating the sodium alginate solution, the mixed solution, the preheating solution and the zinc oxide suspension for reaction for 2 hours, collecting the precipitate by centrifugation and drying to obtain a ZnO-ZIF-8 composite material loaded with honokiol. The composite material prepared by the invention solves the problems of low honokiol loading rate and poor control effect under acidic conditions, and the prepared composite material can reduce the harm to soil or animals and plants.

The present invention belongs to the field of pharmaceutical chemistry, and particularly relates to a method for preparing a honokiol derivative and an intermediate thereof. The preparation method comprises: reacting compound M2 with ethyltriphenylphosphonium bromide under alkaline conditions to prepare a compound of formula I; allylating the compound of formula I to prepare compound M3; demethylating compound M3 under acidic conditions to prepare compound M4; and rearranging compound M4 to prepare a compound of formula II. This method utilizes readily available, inexpensive raw materials, is low cost, has simple steps, mild reaction conditions, low purification requirements, high purity, high yield, is environmentally friendly, safe, and suitable for industrial production, thus possessing significant application value.

Provided are a honokiol liposome lyophilized agent and a preparation method therefor, belonging to the technical field of the preparation of liposome formulations. Provided is a honokiol liposome lyophilized agent. The active ingredient of the lyophilized agent is honokiol, and a protective agent povidone is contained. Further, the lyophilized agent is prepared from 1 part of honokiol, 2-8 parts of phospholipid, 0.3-2.2 parts of cholesterol, 0.1-1.5 parts of polyethylene glycol or phospholipid treated by polyethylene glycol, and 30-300 parts of a protective agent. The liposome lyophilized agent has low impurity content, better stability, and lower requirements on the storage environment.

The present invention relates to a honokiol derivative represented by the following formula I or formula II, a preparation method therefor, and use thereof. The compound according to the present invention can serve as a prodrug of honokiol, greatly improving the bioavailability of honokiol, overcoming the problem that honokiol monomer cannot be developed into a drug due to its low bioavailability in vivo, and making the clinical development of honokiol possible.

The invention belongs to the technical field of organic synthesis, and discloses a dialkylated cationic derivative based on honokiol mother nucleus as well as a preparation method and antibacterial application of the dialkylated cationic derivative. The preparation method comprises the following steps: mixing honokiol, potassium carbonate, dibromoalkane and acetone, and carrying out first reaction to obtain an intermediate product; and mixing the intermediate product, a compound R1H and acetonitrile, and carrying out a second reaction to obtain the honokiol mother nucleus-based dialkylated cationic derivative. A series of novel amphiphilic derivatives are designed and synthesized by reasonably modifying a natural product honokiol, and the novel amphiphilic derivatives show effective in-vitro antibacterial activity on gram-positive bacteria.

The invention belongs to the technical field of biopesticides, and particularly relates to a microbial biopesticide for preventing and treating wheat scab. The invention relates to a microbial biopesticide. The microbial biopesticide is prepared by binary compounding of ceriporia lacerata, physcion, L-alkannin or honokiol according to a certain mass ratio. According to the invention, the ceriporia lacerata GXMS1 is compounded with the existing bioactive bactericidal component physcion, L-alkannin or honokiol, and compared with the single use of the ceriporia lacerata GXMS1, the control effect on the wheat scab can be improved. The microbial biopesticide provided by the invention is environment-friendly, and compared with the use of chemical agents, the microbial biopesticide provided by the invention can reduce adverse effects such as drug resistance, environmental pollution and the like caused by chemical prevention and treatment, conforms to the ideas of green and sustainable development of agriculture, and can provide support for developing biopesticides for preventing and treating gibberellic disease.

The invention relates to an acne-removing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The acne-removing composition is prepared from the following components: amur corktree bark extract, herba houttuyniae extract, mango leaf extract, radix cynanchi atrati extract, licochalcone A, functional particles and hydroxyl pinacolone retinoate. According to the preparation method, phenolic hydroxyl groups of honokiol and carboxyl groups of ferulic acid are subjected to esterification reaction, so that the stability of honokiol modified ferulic acid is improved, then nicotinamide and xylose are used as wall materials to coat the honokiol modified ferulic acid, and the stability of the honokiol modified ferulic acid is further enhanced; the introduced Schiff base structure can effectively remove free radicals in the skin and reduce pigmentation.

The invention discloses a bacteriostatic liposome with lipase responsiveness, a preparation method and application thereof and a product, and belongs to the technical field of cosmetics. The invention aims to solve the technical problems of drug resistance, high skin irritation and the like of the existing acne treatment means. Meanwhile, antibacterial core materials such as totarol and the like have the problems of poor solubility, poor transdermal absorption, burst release stimulation and the like. According to the key point of the technical scheme, the bacteriostatic liposome with lipase responsiveness is provided, and a wall material of the bacteriostatic liposome comprises soybean phosphatidylcholine, hydrogenated phosphatidylcholine, cholesterol, PEG-7 olivate, glyceryl stearate and ceramide NP, the inner core material is prepared from at least one of totarol, paeonol, honokiol, capryloyl glycine, glabridin, ascorbyl tetraisopalmitate, tetrahydrocurcumin or pterostilbene. Through a specific preparation method, the release speed of the core material is regulated and controlled by utilizing the reaction of lipase and the wall material, the slow release and controlled release effects are achieved, and industrial production is easy.

The present application relates to a high-refractive material based on biomass magnolol and honokiol. Specifically, the high-refractive material of the present application can be obtained by photo-curing reaction of a photo-curable monomer and a plurality of mercaptans / mercaptanols under photo-initiation, wherein the photo-curable monomer is derived from a monomer containing an allyl functional group derived from biomass magnolol and honokiol. The high-refractive material provided by the present application has good optical performance, in particular, it not only has a high refractive index (1.67-1.71) but also has a relatively high Abbe number (35-24).

The application belongs to the technical field of disease prevention and treatment of aquaculture, and particularly relates to application of honokiol combined with sulfisoxazole sodium in preparation of a Vibrio parahaemolyticus inhibitor, characterized by that the mass ratio of honokiol to sulfisoxazole sodium in the composition is 1:0.5-2, the concentration of honokiol in the composition is 32-64 µg / mL, and the concentration of sulfisoxazole sodium in the composition is 32-128 µg / mL, and the application further provides a medicine for improving sensitivity of Vibrio parahaemolyticus to sulfisoxazole sodium and treating acute hepatopancreas necrosis disease of prawns, and the mass ratio of honokiol to sulfisoxazole sodium in the medicine is 1:0.125-0.5; the composition can significantly reverse drug resistance of Vibrio parahaemolyticus to SMM-Na, reduce the use amount of SMM-Na, and produce a rapid sterilization effect through combined action, and meanwhile, the composition exhibits excellent protection efficacy in prawn bodies.

The present disclosure relates to a pharmaceutical composition for treatment of muscle disease, comprising a Magnolia officinalis extract. The Magnolia officinalis extract contains various ingredients other than magnolol and honokiol, and inhibits cisplatin-induced weight loss, muscle mass reduction, grip strength reduction, and muscle fiber damage, and promotes the repair of damaged muscle fibers through macrophage polarization from M1 to M2 without interfering with an antitumor function of cisplatin, and thus can be effectively used for prevention and treatment of muscle disease, especially, anticancer drug-induced muscle disease.

The present invention belongs to the technical field of chemical medicine, and particularly relates to a mitochondrion-targeted honokiol derivative, a preparation method thereof and an application thereof. It is a compound represented by Formula I or Formula II, or a pharmaceutically acceptable salt of the compound represented by Formula I or Formula II, or a pharmaceutically acceptable ester of the compound represented by Formula I or Formula II, or a pharmaceutically acceptable solvate of the compound represented by Formula I or Formula II; #imgabs0# wherein, R1 is a straight-chain or branched-chain saturated alkyl group with 1 to 5 carbon atoms, R2 is a straight-chain or branched-chain saturated alkyl group with 1 to 5 carbon atoms, and n is an integer from 1 to 10. The mitochondrion-targeted honokiol derivative provided by the present invention not only has higher anti-tumor activity and cell selectivity, but also can improve the in vivo toxicity to the Caenorhabditis elegans model.

The application belongs to the technical field of content detection, and discloses a kind of HPLC detection methods for simultaneously determining the content of multiple components in semen Cannabis capsules.The detection method includes mixing reference solution, chrysophanol and methanol to obtain mixed reference solution.The reference solution includes physcion solution, magnolol solution, houpo chrysophanol solution, emodin solution, rhein solution, nobiletin solution, aloe emodin solution, hesperidin solution and paeoniflorin solution;The contents of semen Cannabis capsules are mixed with methanol, and the test solution is obtained after heating and refluxing;The mixed reference solution and test solution are respectively sucked and injected into high performance liquid chromatograph.The detection method can simultaneously determine the content of multiple index components, can comprehensively reflect the quality of the preparation, and the test method has excellent precision, repeatability, stability and high sample recovery rate.

This invention belongs to the field of pharmaceutical technology and relates to a preparation process of a modified Huoxiang Zhengqi compound. The preparation process is as follows: Pinellia ternata and Angelica dahurica are percolated; Pogostemon cablin, Perilla frutescens, Citrus reticulata peel, Magnolia officinalis, and Atractylodes macrocephala are extracted in groups for 2-5 hours, and the total volatile oil is collected. The residues of each group are decocted with water, and the decoctions of each group are collected; Poria cocos, Platycodon grandiflorus, Glycyrrhiza uralensis, Areca catechu peel, Ziziphus jujuba, and Zingiber officinale are decocted with water to obtain a decoction; the total volatile oil is added to an inclusion material, and inclusion is obtained using an ultrasonic-assisted method; the percolation and decoctions are combined, concentrated, and centrifuged to obtain a supernatant; a preservative is added to the supernatant and the inclusion material to obtain the final product. This invention extracts medicinal materials containing volatile oils in groups and uses a cyclodextrin inclusion complexation process, which not only improves the total extraction rate of volatile oils, but also increases the content of hesperidin, hydrated oxypenicillin, magnolol, honokiol, patchouli flavonol, and baicalein, while improving the taste and flavor of the flavored patchouli flavonoid compound.