The invention provides toothpaste. The toothpaste comprises, by weight percentage, 1.0-10.0% of grapefruit extract, 0-1.0% of pyridoxine hydrochloride, 12-55% of abrasive agent, 10-70% of moisturizer, 0.5-2.5% of binder, 1-3% of foaming agent, 0.1-0.5% of sweetening agent, 0.1-0.5% of preservatives, 0.6-3% of essence, 0-0.5% of auxiliaries and the balance water. The toothpaste has the advantages that the toothpaste can effectively relieve various symptoms of pregnant women during pregnancy, the toothpaste's relieving effective rate of the morning sickness of the pregnant women is more than 91%, the toothpaste's relieving effective rate of the dental caries of the pregnant women is more than 85%, the toothpaste's relieving effective rate of gingival inflammation is more than 79%, the toothpaste's relieving effective rate of periodontitis is more than 83%, and the toothpaste's relieving effective rate of oral ulcer is more than 80%.