Preparation method and applications of anti-allergy biologically active glass powder

A bioactive glass, active glass technology, applied in allergic diseases, organic active ingredients, medical preparations containing active ingredients, etc. Anti-allergic effect, inhibition of oral bacteria, effect of repairing damaged teeth

Active Publication Date: 2018-07-31
DONGGUAN HONGYUAN MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, in order to resist tooth sensitivity, tranexamic acid is usually used for hemostasis, but tranexamic acid needs to directly act on the bleeding point in the oral cavity, which can obtain better hemostatic effect and alleviate the problem of oral sensitivity. Tranexamic acid tablets, it is difficult to directly act on the bleeding point in the mout

Method used

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  • Preparation method and applications of anti-allergy biologically active glass powder
  • Preparation method and applications of anti-allergy biologically active glass powder
  • Preparation method and applications of anti-allergy biologically active glass powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A kind of preparation method of anti-allergic bioactive glass powder provided by the present embodiment, it comprises the following steps:

[0045] (1) the concentrated nitric acid of 6ml 69wt.% is dispersed in 250ml deionized water, stirs, obtains dilute nitric acid;

[0046] (2) Get 125g ethyl orthosilicate and dissolve in dilute nitric acid, stir and hydrolyze for 1.5 hours;

[0047] (3) 10g of triethyl phosphate was dissolved in the solution obtained in step (2), stirred and hydrolyzed for 0.8 hours;

[0048] (4) Get 62.5g calcium nitrate tetrahydrate and be dissolved in the solution gained in step (3), stir and hydrolyze for 15 minutes;

[0049] (5) Get 700g sodium nitrate, be dissolved in the solution gained in step (4), stir and hydrolyze for 30 minutes;

[0050](6) Place the solution obtained in step (5) at room temperature to age for 20 hours, the solution gradually forms a gel, and continue to age the gel at 60-70°C for 20 hours;

[0051] (7) drying the gel...

Embodiment 2

[0058] The preparation method of the anti-allergic bioactive glass powder provided in this embodiment comprises the following steps:

[0059] (1) disperse the concentrated nitric acid of 8ml 69wt.% in 250ml deionized water, stir, obtain dilute nitric acid;

[0060] (2) Get 160g ethyl orthosilicate and dissolve in dilute nitric acid, stir and hydrolyze for 0.5 hour;

[0061] (3) 14g of triethyl phosphate was dissolved in the solution obtained in step (2), stirred and hydrolyzed for 0.6 hour;

[0062] (4) Get 54g calcium nitrate tetrahydrate and be dissolved in the solution gained in step (3), stir and hydrolyze for 5 minutes;

[0063] (5) Get 300g sodium nitrate and 300g potassium nitrate, be dissolved in the solution gained in step (4), stir and hydrolyze for 20 minutes;

[0064] (5.1) Get 15g citric acid and be dissolved in the solution gained in step (5), stir and hydrolyze for 15 minutes;

[0065] (6) Place the solution obtained in step (5) at room temperature to age for...

Embodiment 3

[0073] The preparation method of the anti-allergic bioactive glass powder provided in this embodiment comprises the following steps:

[0074] (1) the concentrated nitric acid of 10ml 69wt.% is dispersed in 250ml deionized water, stirs, obtains dilute nitric acid;

[0075] (2) Get 195g ethyl orthosilicate and dissolve in dilute nitric acid, stir and hydrolyze for 2 hours;

[0076] (3) 18g of triethyl phosphate was dissolved in the solution obtained in step (2), stirred and hydrolyzed for 0.7 hours;

[0077] (4) Get 105.5g calcium nitrate tetrahydrate and be dissolved in the solution gained in step (3), stir and hydrolyze for 12 minutes;

[0078] (5) Get 500g sodium nitrate and 100g potassium nitrate, be dissolved in the solution gained in step (4), stir and hydrolyze for 5 minutes;

[0079] (6) Place the solution obtained in step (5) at room temperature to age for 24 hours, the solution gradually forms a gel, and continue to age the gel at 60-70°C for 24 hours;

[0080] (7) ...

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Abstract

The invention discloses a preparation method and applications of anti-allergy biologically active glass powder. The anti-allergy biologically active glass powder is prepared from concentrated nitric acid, ethyl orthosilicate, triethyl phosphate, calcium nitrate tetrahydrate, sodium nitrate, potassium nitrate, and a tranexamic acid aqueous solution via reaction. The invention also discloses applications of the anti-allergy biologically active glass powder. The anti-allergy biologically active glass powder can be used in oral cavity preparations. The anti-allergy biologically active glass powderis capable of preventing tooth sensitivity, repairing damaged teeth, and inhibiting oral cavity bacteria preferably, is especially suitable for targeting treatment of gingival bleeding. 3 months using of the anti-allergy biologically active glass powder is capable of reducing dental plaque index and sulcus bleeding index obviously; oral cavity preparations prepared from the anti-allergy biologically active glass powder is capable of inhibiting dental plaque and reliving gingival inflammation preferably, and is suitable for targeting precision therapy of patients with gingivitis.

Description

technical field [0001] The invention relates to the technical field of manufacturing bioactive glass powder, in particular to a preparation method and application of an anti-allergic bioactive glass powder. Background technique [0002] Biomaterials are a class of high-tech materials, mainly used in the diagnosis and repair of human tissues or organs. The first generation of biomaterials has no biological activity, such as medical metals, inert ceramics, etc., which are biologically inert materials; the second generation of biomaterials, such as bioactive ceramics, hydroxyapatite, etc., can provide tissue conduction for newborn tissues The ability, that is, tissue-conducting biomaterials, has biological activity; in the 1990s, the concept of third-generation biomaterials was proposed, which stimulated cell responses at the molecular level, and belonged to tissue-inducing biomaterials. This kind of material is bioactive and degradable, and at the same time, it has gene activ...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K31/195A61P1/02A61P31/04A61P7/04A61P37/08
CPCA61K31/195A61K47/02A61P1/02A61P7/04A61P31/04A61P37/08
Inventor 李祥永李雨丝
Owner DONGGUAN HONGYUAN MEDICINE TECH
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