19 results about "Aloe emodin" patented technology

The invention relates to a microbial single-cell gelation encapsulation method based on aloe gel and application, the method realizes single-cell gelation encapsulation through electrostatic interaction of sterile aloe gel and intestinal anaerobic bacteria (such as Agathobacter rectasis), and the method comprises the specific steps of aloe gel preparation, bacterial suspension culture and oscillation mixing to form a stable structure. The preparation method has the advantages that the acid resistance and biocompatibility of the natural aloe gel are utilized to replace a traditional synthetic material, so that the gastrointestinal tolerance of thalli is improved; meanwhile, the synergistic effect of aloe active ingredients (such as aloe-emodin) and intestinal bacterial metabolites (butyric acid) is combined, so that the anti-inflammatory and intestinal steady-state regulation and control effects are enhanced. Experiments show that the survival rate of the encapsulated bacteria in simulated gastric juice within 4 hours is larger than or equal to 90%, the intestinal colonization rate is effectively increased compared with naked bacteria, the inflammatory factor level of a colitis model mouse can be remarkably reduced, and a safe and efficient new strategy is provided for micro-ecological treatment of inflammatory bowel diseases.

The application belongs to the field of agricultural fungicide compound, discloses a composition containing new white folium altheae alkaloid derivative Z-24 and anthraquinone components (emodin, emodin methyl ether, chrysophanol, aloe emodin) in rhubarb and mixed concentration thereof. The application of the composition in preventing and treating plant diseases caused by rhizoctonia solani, sclerotinia sclerotiorum, fusarium graminearum, botrytis cinerea, pyricularia oryzae and phytophthora capsici is disclosed, and the mass percentage of new white folium altheae alkaloid derivative Z-24 and anthraquinone components is 1:500, 1:100, 1:50 or 1:25. The fungicidal composition disclosed in the application has the advantages of wide fungicidal spectrum, low toxicity, effective delay of drug resistance of plant pathogens and the like, and has the value of further research and development.

The present application relates to a kind of method for simultaneously identifying 78 components in traditional Chinese medicine aloe barbadensis miller, using HPLC-DAD-ESI-IT-TOF-MS n The present application detects traditional Chinese medicine aloe barbadensis miller through specific mass spectrometry conditions and specific gradient elution program, so that the present application can simultaneously identify 78 components. In addition, in addition to the index components such as aloe-emodin, aloin D and aloin A, the present application can also simultaneously identify 14 compounds with pharmacological activity, which can more comprehensively and completely reflect the quality of traditional Chinese medicine aloe barbadensis miller, and is of great significance for the quality control of traditional Chinese medicine aloe barbadensis miller. Especially nowadays, the quality of traditional Chinese medicine aloe barbadensis miller on the market is uneven, and simultaneously identifying multiple index components with pharmacological activity is more important for quality evaluation. At the same time, the method of the present application has good repeatability and stability.

The invention relates to an application of aloe-emodin. The invention provides an application of aloe-emodin in preparation of a PARP (poly-ADP-ribose polymerase) inhibitor. The aloe-emodin provided by the invention has relatively good inhibitory activity on PARP (Poly ADP-ribose Polymerase Chain Reaction).

This invention discloses a method for preparing selenium-cuprous oxide-lithium saponite composite nanozymes from plant-derived complexes and their antibacterial applications, belonging to the fields of nanomaterials technology and antibacterial agents. The method includes the following steps: using peeled lithium saponite as a carrier, and utilizing a plant-derived complex formed from quinoa husk extract, aloe-emodin, and ascorbic acid as a reducing agent and stabilizer, the selenium-cuprous oxide-lithium saponite composite nanozyme is synthesized. The resulting composite nanozyme has a core-shell structure, with lithium saponite nanosheets as a carrier and uniformly distributed selenium-cuprous oxide nanoparticles on the surface. It exhibits excellent peroxidase-mimicking activity, catalyzing the generation of a large number of reactive oxygen species and disrupting bacterial cell structure. It shows significant antibacterial effects against various drug-resistant bacteria, and possesses good biocompatibility and environmental friendliness, showing broad application prospects in antibacterial therapy, wound dressings, and biomedical engineering.

The application discloses a method for constructing a characteristic map of a traditional Chinese medicine and the characteristic map, wherein the method adopts an HPLC method to determine the content of an effective component, imperatorin, in Zhikang capsules, and constructs a high performance liquid chromatography characteristic map of the Zhikang capsules; 10 characteristic peaks are determined as the characteristic map, which are respectively from dragon's blood, rhubarb and Bai Zhi; the components from the dragon's blood are dracorhodin B (peak 2) and pterostilbene (peak 4); the components from the rhubarb are peak 1 (aloe-emodin), peak 3, peak 6 (emodin), peak 9 and peak 10; and the components from the Bai Zhi are imperatorin (peak 5), peak 7 and peak 8; the method covers polyphenols, anthraquinones and furanocoumarins and other main components, and constructs a quality evaluation system of the Zhikang capsules; the method has good specificity, precision, repeatability and solution stability, and can be used for standardizing the production of the Zhikang capsules and guaranteeing the uniformity and stability of the internal quality of products to provide comprehensive quality control.

The invention relates to an aloe-emodin piperazine derivative as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. The aloe-emodin piperazine derivative is obtained by taking aloe-emodin as a raw material, substituting 15-site alcoholic hydroxyl of the aloe-emodin with piperazine and then connecting the 15-site alcoholic hydroxyl with a natural compound with anti-tumor activity and a derivative of the natural compound by utilizing different connecting arms. In-vitro anti-tumor experiments of the aloe-emodin piperazine derivative show that the aloe-emodin piperazine derivative has good anti-tumor activity on human cervical cancer cells (HeLa), human liver cancer cells (HepG2), human lung cancer cells (A549) and human osteosarcoma cells (U2OS), is expected to be developed into drugs for treating cervical cancer, osteosarcoma, lung cancer or liver cancer and other cancers, and has wide clinical application prospects.

The application provides a 10A-grade antibacterial cloth and a preparation method thereof, and relates to the technical field of cloth preparation.The 10A-grade antibacterial cloth and the preparation method thereof comprise the following steps: adding aloe-emodin into distilled water, performing ultrasonic dispersion, and obtaining a stock solution a; drying and crushing fresh red clover, performing sieving, inoculating aseptobacter ferreus for fermentation, performing filtration, adding an extract of salvia officinalis in a mass ratio of 3-4:1 to the filtrate, and obtaining a stock solution b; adding the stock solution a into the stock solution b while mechanically stirring, performing vacuum degassing, forming a composite antibacterial solution, performing granulation, and obtaining antibacterial masterbatch; after pretreating terylene chips, the terylene chips and the antibacterial masterbatch are added into a screw injection molding machine, heated and melted to be spun, stretched, and wound, and fused antibacterial fibers are obtained; warp knitting is performed by using the fused antibacterial fibers as warp yarns and cotton yarns as weft yarns, and an antibacterial cloth is obtained.

The application belongs to the technical field of content detection, and discloses a kind of HPLC detection methods for simultaneously determining the content of multiple components in semen Cannabis capsules.The detection method includes mixing reference solution, chrysophanol and methanol to obtain mixed reference solution.The reference solution includes physcion solution, magnolol solution, houpo chrysophanol solution, emodin solution, rhein solution, nobiletin solution, aloe emodin solution, hesperidin solution and paeoniflorin solution;The contents of semen Cannabis capsules are mixed with methanol, and the test solution is obtained after heating and refluxing;The mixed reference solution and test solution are respectively sucked and injected into high performance liquid chromatograph.The detection method can simultaneously determine the content of multiple index components, can comprehensively reflect the quality of the preparation, and the test method has excellent precision, repeatability, stability and high sample recovery rate.

The invention belongs to the technical field of photocatalysis, and relates to a metal organic framework AE / Fe-MOF-PVDF photocatalytic membrane as well as a preparation method and application thereof. The invention relates to a metal organic framework AE / Fe-MOF-PVDF (Polyvinylidene Fluoride) photocatalytic membrane, which is formed by introducing AE (Aloe-emodin) into Fe-MOF to construct a heterojunction and immobilizing the heterojunction on a PVDF membrane. In the heterojunction, the mass ratio of AE to Fe is (0.5-2): 1. The metal organic framework AE / Fe-MOF-PVDF photocatalytic membrane prepared by the method has a self-cleaning effect, pollution of the PVDF membrane is avoided, the utilization rate of the membrane is improved, meanwhile, the separation efficiency of photon-generated carriers can be promoted, and the photocatalytic degradation efficiency of macromolecular substances in traditional Chinese medicine wastewater is improved.

The invention discloses a preparation method of an aloe-emodin regulated Hippo-YAP1 pathway medicine, and relates to the technical field of data encryption, and the preparation method comprises the following steps: S1, providing an aloe-emodin raw material with the purity not lower than 98.32%, the CAS number of the aloe-emodin raw material being 481-72-1, the molecular formula being C15H10O5, and the molecular weight being 270.24; s2, dissolving the aloe-emodin raw material provided in the step S1 into a proper solvent to prepare an aloe-emodin stock solution; the suitable solvent comprises DMSO, and the preparation concentration is not lower than 20.83 mg / mL (77.08 mM); s3, sub-packaging the aloe-emodin stock solution prepared in the step S2, and storing the aloe-emodin stock solution at-80 DEG C for a storage period of not more than 2 years; or storing at-20 DEG C, wherein the storage life is not more than 1 year. The cisplatin and the preparation method thereof show dual beneficial effects of bone protection and tumor sensitization in drug combination, that is, on the premise that the killing effect of cisplatin on osteosarcoma cells is not affected, the normal osteogenesis function is selectively protected, and the anti-tumor synergistic effect is enhanced.

The present application relates to the technical field of pharmaceutical preparation, and discloses a kind of quenching medicine composition for alcohol by regulating liver inflammation through NF-κB channel, including core active monomer consisting of quercetin, kaempferol and aloe emodin, HPMCAS-HF type skeleton network polymer, L-arginine, poloxamer 188, and by PEG 400 and deionized water composition transient mass transfer fluid, each raw material is made into amorphous powder by hot melt extrusion reaction through co-rotating twin-screw extruder.The processing temperature is reduced by the aid of transient mass transfer fluid plasticizing, and the degradation of active monomer by heat is avoided;The monomer is stabilized in amorphous form by polymer skeleton, and the local dissolution microenvironment is adjusted by L-arginine, which overcomes the defect of poor water solubility of natural monomer.The present application improves the dissolution and bioavailability of the drug, so that multiple components synergistically inhibit the NF-κB inflammatory pathway, and enhance the effect of quenching liver.

The application discloses a quality detection method of a Yishen Qingli Huoxue recipe, which comprises preparation of a test sample solution, preparation of a standard solution, preparation of a standard curve and content determination. The application screens an optimal test sample preparation method, a preparation method of a control sample and optimal chromatographic conditions and mass spectrometric analysis conditions through a large number of experiments, and establishes a content determination method of the Yishen Qingli Huoxue recipe, which can simultaneously determine the contents of 11 compounds with different structural types, such as resveratrol, rhein, formononetin, aloe-emodin, emodin, chlorogenic acid, polydatin, astilbin, hyperoside, calycosin-7-glucoside and beta-ecdysterone. The method is favorable for comprehensively monitoring the quality of the Yishen Qingli Huoxue recipe and guaranteeing clinical curative effects. Moreover, the method has the advantages of good stability, high accuracy, good repeatability and high precision.

This application discloses an intramolecular hydrogen bond-enhanced anthraquinone derivative, its synthesis method, and its application, relating to the field of electrochemical energy storage. The acetic acid-modified anthraquinone RH-DA or AE-DA is 2,2'-(3-carboxyl-1,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2,7-diyl)diacetic acid and 2,2'-(1,8-dihydroxy-3-(hydroxymethyl)-9,10-dioxo-9,10-dihydroanthracene-2,7-diyl)diacetic acid. Rhein or aloe-emodin is dissolved in NaOH, glyoxylic acid solution and sodium dithionite are added, and after stirring, sodium dithionite is added again. After stirring and cooling to room temperature, hydrogen peroxide solution and HCl solution are added, causing precipitation. After washing with HCl, the precipitate is dried in a vacuum drying oven to obtain a black-green solid RH-DA or a yellow-green solid AE-DA. Its application in alkaline aqueous organic flow batteries is also disclosed.

The application discloses a traditional Chinese medicine micro-capsule enteric-coated tablet for promoting intestinal mucosa repair and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine pharmacy, and comprises a micro-capsule tablet core and an enteric-coated layer coated on the outer surface of the micro-capsule tablet core, wherein the micro-capsule tablet core comprises microcapsules with white-bark tree gum liquid as a wall material and Chinese herbal medicine extract as a core material, the Chinese herbal medicine extract comprises water-soluble inclusion compounds prepared by extracting aloe emodin, Danshen, processed ginger, Sanqi and spina date seed and then being wrapped by beta-cyclodextrin, and active polysaccharide retentate prepared by extracting Herba Baphicacanthis, fried coix seed, white peony root, licorice, Fructus Mume, Astragalus and dendrobium by complex enzymolysis and then being separated by ultrafiltration, and the white-bark tree gum liquid is prepared by swelling white-bark tree in cold water and then being treated by high-pressure homogenization; the micro-capsule is adsorbed on an intestinal ulcer surface to form a physical isolation barrier, and the ultrafiltration detoxification and cyclodextrin wrapping process improves the utilization degree and safety of active ingredients at a target site.

The invention relates to the technical field of antibacterial materials, in particular to a method for enhancing photodynamic antibacterial activity of aloe-emodin, which comprises the following steps: S1, adding copolymer dry powder into ultrapure water, and stirring at room temperature to obtain a copolymer stock solution; s2, adding aloe-emodin into absolute ethyl alcohol, dissolving, adding ultrapure water, and performing ultrasonic treatment to obtain primary dispersion liquid of aloe-emodin nanocrystals; s3, placing the primary dispersion liquid in an ice bath, dropwise adding the copolymer stock solution while stirring, and purifying to obtain the aloe-emodin nanocrystal. The constructed aloe-emodin nanocrystal effectively solves the key bottlenecks of poor water solubility and poor light stability of aloe-emodin, and can significantly improve the photodynamic active oxygen yield of the aloe-emodin nanocrystal, so that the aloe-emodin nanocrystal has a relatively strong bactericidal effect on gram-negative bacteria.

This invention relates to the field of traditional Chinese medicine component analysis technology, specifically to the fingerprint spectrum of Juanxiao tablets and its establishment method. The method for establishing the fingerprint spectrum of Juanxiao tablets includes: using isoharonidin, isovitexin, rutin, hesperidin, lemon balm glycoside, aloe-emodin, nobiletin, and citrus reticulataein as reference standards, and Juanxiao tablets as the test sample; using HPLC to detect the reference standards and the test sample, and then comparing and analyzing them to determine the common characteristic peaks of Juanxiao tablets; wherein the HPLC conditions include: a C18 column, mobile phase A as a nitrile solvent, mobile phase B as a 0.05-0.15% phosphoric acid solution, and gradient elution. This method can effectively detect characteristic peaks, reduce the drying of impurity peaks, and the obtained fingerprint spectrum has high resolution and good peak shape. All characteristic peaks are baseline separated, enabling a more comprehensive and accurate evaluation of the quality of Juanxiao tablets.

The application relates to the fields of medicine and health care products, and discloses a natural small-molecule alcoholism-relieving and liver-protecting composition for inhibiting expression of liver inflammation factors, which is prepared from a core group, polyvinylpyrrolidone, polysorbate-80 and micro-powder silica gel, and is composed of quercetin, kaempferol and aloe-emodin. During preparation, the core group and the polyvinylpyrrolidone are dissolved to form a homogeneous dispersion liquid, the anti-solvent phase containing the micro-powder silica gel and the polysorbate-80 is synchronously pumped into a pipeline high-shear emulsifier and collides against each other, phase change precipitation occurs, ceramic membrane cross-flow filtration washing and vacuum drying in stages are carried out, and finally the finished product is obtained. Through the synergistic effect of polymer hydrogen bond and micro-powder silica gel steric hindrance, the natural molecules are fixed in a stable co-amorphous state, the water solubility and oral bioavailability of the insoluble polyphenols and anthraquinone components are improved, and crystallization aging of the composition during the storage period is effectively prevented.

The invention relates to a low-density micro-balloon loaded with aloe-emodin and a preparation method and application thereof.The low-density micro-balloon loaded with the aloe-emodin comprises a low-density micro-balloon carrier, an excipient, a filler and a functional component, the functional component is the aloe-emodin, the low-density micro-balloon carrier is Eudragit S 100, and the excipient is a filler. The excipient is hydroxypropyl methyl cellulose, and the low-density micro-balloon loaded with the aloe-emodin is prepared through an emulsion solvent diffusion method. Compared with the prior art, the prepared low-density micro-balloon loaded with the aloe-emodin can be widely distributed in the whole gastrointestinal tract, more lasting and more consistent aloe-emodin drug release is achieved, and H.pylori is effectively removed.