15 results about "Crataegus monogyna" patented technology

The invention discloses a culture optimization method of brevibacillus laterosporus and application of brevibacillus laterosporus in inhibiting pathogenic bacteria of hawthorn, an LB liquid culture medium is adopted in the culture process, and the culture medium comprises the following components: 10 g / L peptone, 15 g / L sucrose and 10 g / L yeast powder; the initial pH of fermentation is 7-8, the culture temperature is 30-35 DEG C, the rotating speed is 180-200rpm, the culture time is 24-36 hours, and the inoculum size of the brevibacillus laterosporus CB-528 bacterial liquid is 3-5vol%, and finally obtaining the fermented bacterial liquid through fermentation. The zymophyte liquid prepared on the basis of the method can be used for preparing biopesticides for preventing and treating Chinese yam diseases. The fermentation process disclosed by the invention is simple to control, easy to operate and obvious in effect, and the thallus yield and the spore rate can be greatly improved under the fermentation process. The fermentation culture solution disclosed by the invention has the characteristics of high activity, high viable organism content and high spore rate, and can prolong the preservation time of a subsequent preparation and improve the drug effect stability of the preparation.

The invention discloses a formula and a preparation method of a stomach-invigorating parasite-expelling tablet for livestock. The parasite expelling tablet is formed by compounding and tabletting parasite expelling core enteric particles A and stomach invigorating and relieving quick-release particles B. The particles A contain praziquantel and levamisole or salts thereof, and are coated with enteric materials, so that the parasite expelling activity is limited in gastric segment release and is quickly released in intestinal segment; the particles B contain a cortex meliae extract, a fructus quisqualis extract, pericarpium citri reticulatae, fried malt and fructus crataegi, are compounded with mucous membrane protection or adsorption stimulation components such as sodium alginate / pectin / montmorillonite and the like, and are subjected to post-treatment adsorption through essence, so that the taste covering stability is improved. The preparation method comprises the following steps: plant extraction, wet granulation in two ways, enteric coating of particles A, essence post-treatment of particles B, and compounding, lubricating and tabletting. According to the scheme, the insect expelling effect is guaranteed, gastrointestinal stimulation is reduced, the voluntary ingestion rate and administration compliance are improved, and the composition is suitable for dogs, cats and livestock to expel insects by oral administration.

The invention discloses an extraction method of hawthorn exosomes and application of the hawthorn exosomes in treatment of DSS-induced colitis, and belongs to the technical field of plant exosomes. The extraction method comprises the steps of raw material treatment, differential centrifugation, membrane filtration, ultracentrifugation enrichment, density gradient purification and desugaring refining, and the high-purity crataegus pinnatifida exosome with the capsule-shaped structure can be obtained. The hawthorn exosome intervenes DSS-induced colitis through preventive intragastric administration (25-50 mg / kg / d), the disease activity index (DAI) can be reduced to 2 or below, the expression quantity of colon tissue TNF-alpha is recovered to the normal level, the IL-1beta inhibition effect is superior to that of a hawthorn extract, and the curative effect is remarkably superior to that of plant exosomes such as rhizoma curcumae longae, tea leaves and black tea. The process is standardized, the curative effect is definite, and a new scheme is provided for colitis treatment.

This invention discloses a composition and its preparation method for treating human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN), belonging to the field of traditional Chinese medicine technology. The formula consists of 6-15 parts of American cockroach, 5-11 parts of hawthorn, 5-11 parts of chicory, 3-9 parts of *Scutellaria baicalensis*, 8-20 parts of *Sophora flavescens*, and 6-15 parts of *Cnidium monnieri*, and also contains 0.01-1 parts by weight of toad venom. The dosage form is one or more of the following: external gel, rinse, foam, suppository, and film preparation. It has high safety and is suitable for HPV infection and CIN changes, solving the problem of poor efficacy in existing treatments.

The application provides a blood-activating and stasis-removing medicinal composition containing fermented douchi and a preparation method thereof, belongs to the technical field of biological medicine, and the medicinal composition comprises fermented douchi, drynaria extract, extract of pereskia aculeata, tanshinone II A, notoginsenoside R1, ligustrazine, rhodioside, total flavones of hawthorn leaves and total flavones of mulberry leaves. The fermented douchi is prepared from soybeans and black beans through fermentation by bacillus subtilis and bacillus coagulans. The drynaria extract is prepared from drynaria powder through common enzymolysis by cellulase, chitinase and beta-glucanase, extraction by a two-phase solvent, and purification by a dextran gel column. The extract of pereskia aculeata is prepared from pereskia aculeata powder through common enzymolysis by pectinase, cellulase and xylanase, common enzymolysis by bromelain and subtilisin, and purification by a macroporous adsorption resin column. The medicinal components are prepared in a specific proportion to relieve blood stasis from two dimensions of "improving blood flow dynamics + preventing thrombus formation".

The present application provides a kind of shrimp breeding phagostimulant and its preparation method.The phagostimulant comprises the following components by weight: 10-30 parts of schisandra chinensis, 150-200 parts of hawthorn powder microcapsule, 1-10 parts of baking soda, and 0.1-1 part of phagostimulant aid.The phagostimulant prepared by the present application, when applied to the growth test of grass shrimp with feed, can increase the yield per mu of grass shrimp by 127.6%-159.2%, and the growth rate, feeding rate and survival rate are all significantly better than conventional aquaculture, and no stress, disease and water ecological imbalance of shrimp body are caused during the aquaculture process, which meets the non-polluting fishery drug standard, and the effect is stable and reliable when used in different aquaculture areas, with strong adaptability.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation, a pharmaceutical composition and application thereof. The traditional Chinese medicine composition consists of bulbus fritillariae cirrhosae, kelp, thunberg fritillary bulb, turmeric, endothelium corneum gigeriae galli, raw hawthorn and selfheal. According to the application, the bulbus fritillariae cirrhosae and the bulbus fritillariae thunbergii are compatible to synergistically exert the effects of reducing phlegm and resolving The endothelium corneum gigeriae galli and the raw hawthorn have the effect of removing food retention, the selfheal has the effect of clearing liver and removing stasis, and all the medicines are combined to achieve the effects of reducing phlegm, removing blood stasis, softening hard mass and eliminating diseases. Experiments show that the traditional Chinese medicine composition can significantly improve the liver function of Wilson disease model mice, reduce collagen deposition of liver tissues, down-regulate fibrosis markers and inhibit activation of hepatic stellate cells.

This invention relates to the field of biomedical technology, specifically to a topical composition for improving acne and its application. The topical composition is made from pharmaceutical raw materials including a first component, a second component, and a third component. The first component comprises 25-35 parts of *Ampelopsis japonica*, 25-35 parts of hawthorn, 25-35 parts of *Salvia miltiorrhiza*, 13-17 parts of gardenia, and 8-12 parts of *Bletilla striata*. The second component comprises 25-35 parts of mother-of-pearl, 13-17 parts of tribulus terrestris, and 8-12 parts of safflower. The third component comprises 13-17 parts of raw rhubarb, 8-12 parts of gallnut, 8-12 parts of turmeric, 3-7 parts of *Ganoderma lucidum*, and 3-7 parts of asparagus. This invention also provides a topical composition consisting of the first, second, or third component alone. The topical composition of this invention has dual effects of inhibiting *Propionibacterium acnes* and anti-inflammatory properties, and can be further prepared into cosmetics or pharmaceuticals for the prevention, relief, and treatment of various types of acne and the improvement of acne scars. Clinical trials have shown significant effects, high safety, and promising application prospects.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating pulmonary nodules and a preparation method of the traditional Chinese medicine composition. The active component is prepared from the following raw materials in parts by mass: 30 to 36 parts of rhizoma fagopyri dibotryis, 16 to 20 parts of herba hedyotidis diffusae, 12 to 14 parts of rhizoma arisaematis, 8 to 10 parts of bulbus fritillariae thunbergii, 6 to 9 parts of rhizoma corydalis, 6 to 7 parts of rhizoma polygonati, 1 to 2 parts of rhizoma dioscoreae, 4 to 5 parts of poria cocos, 3 to 4 parts of radix angelicae and 1 to 2 parts of liquorice root; in the preparation process, a synergistic accelerant is added, and the synergistic accelerant is prepared by mixing honeysuckle, burdock, hawthorn and seaweed according to a certain proportion and then performing enzymolysis; the combination of the four medicines can guide and improve the overall efficacy by optimizing the immune microenvironment, multi-target immune regulation and other ways, and ensures the pertinence and effectiveness of the traditional Chinese medicine composition for treating pulmonary nodules.

This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a traditional Chinese medicine composition for treating type 2 diabetes and its preparation method. The raw materials consist of Coptis chinensis, hawthorn, Polygonatum sibiricum, Salvia miltiorrhiza, Lycium barbarum, Atractylodes lancea, dried ginger, mulberry leaf, and silkworm excrement, with a mass ratio of 3:6:6:3:2:3:3:3:3. This traditional Chinese medicine composition can not only improve blood glucose indicators, but also adjust the internal environment of the body and improve the patient's metabolic level by exerting the functions of invigorating qi and nourishing yin, promoting blood circulation and removing blood stasis, thereby achieving the purpose of lowering and stabilizing blood glucose. It can treat both the symptoms and the root cause of glucose and lipid metabolism disorders.

The present application provides a kind of containing sanqi polysaccharide composition, preparation method and its application, belong to plant extraction technical field.The present application containing sanqi polysaccharide composition includes: composite polysaccharide extract, salvia miltiorrhiza extract, kudzu extract and red yeast powder.The present application is crushed after sanqi, angelica, rehmannia glutinosa, ginseng, platycodon grandiflorum and hawthorn is prepared composite polysaccharide extract by removing fat, water extraction, enzymolysis, alcohol precipitation, drying and other steps, salvia miltiorrhiza, kudzu and 70-80% ethanol are mixed to extract, and salvia miltiorrhiza and kudzu extract are dried;Composite polysaccharide extract, salvia miltiorrhiza and kudzu extract and red yeast powder are mixed to obtain sanqi polysaccharide composition.The composite polysaccharide extract prepared by the present application has high hypolipidemic activity, can significantly reduce the body weight and liver weight of hyperlipidemic rats, will not inhibit the normal feeding of hyperlipidemic rats, can improve the HDL-C level in serum, reduce the TC content, TG content and LDL-C content in serum.

The invention relates to the technical field of medicinal breeding of special insects, in particular to a method for improving digestion and absorption efficiency and antibacterial immune components of maggots, and the method comprises the following steps: preparing a fish-hawthorn-astragalus membranaceus fermented feed; continuous three generations of directional stress screening are carried out, offspring is used as next generation provenance, and a target population is obtained; the three continuous generations of directional stress screening are performed according to the following modes: first-generation screening: feeding larvae with fermented feed, and applying high-protein stress; the larvae are fed with fermented feed added with astragaloside, low-temperature stress is applied, and individuals with the immune globulin IMPI content larger than or equal to 600 mu g / g are screened; and third-generation screening: feeding the larvae with fermented feed, and applying high-protein and low-temperature composite stress. The fish-hawthorn-astragalus membranaceus fermented feed is prepared in combination with continuous three-generation directional stress screening, so that the effects of activating intestinal protease of maggots to improve the digestion efficiency, promoting immune cell differentiation to accumulate immune components, enhancing intestinal flora regulation and enhancing the digestion and immune synthesis capability are achieved.

The invention discloses a natural extract preparation for promoting rehabilitation after illness and a preparation method thereof, and relates to the technical field of physical rehabilitation, dandelion, clinacanthus nutans, paulownia flower and chrysanthemum have the effects of clearing away heat and toxic materials, diminishing swelling and dispersing blocks; the radix astragali, the herba houttuyniae and the fructus crataegi have the effects of tonifying spleen and middle warmer and replenishing qi and blood The liquorice and the sticktight have the effects of cooling blood and diminishing swelling; willow barks and pine needles have the effects of relieving pain and itching; turmeric has the effects of clearing and activating the channels and collaterals; the cacumen biotae has the effects of cooling blood and stopping bleeding; particularly, the traditional Chinese medicine composition has a good effect on rehabilitation of excessive blood loss after diseases, and can accelerate wound healing, promote blood circulation and accelerate human body recovery.

This invention discloses a blood-stasis-removing and conditioning granule for individuals with blood stasis constitution and its preparation method. The granule comprises 5-10 parts of Dioscorea opposita, 5-10 parts of Prunus persica kernel, 5-10 parts of Hawthorn, 5-15 parts of Pueraria lobata, 5-10 parts of Angelica sinensis, 3-8 parts of Sophora japonica flower bud, 3-8 parts of Glycyrrhiza uralensis, and 2-5 parts of Rosa rugosa. This blood-stasis-removing and conditioning granule can be used to regulate the condition of individuals with blood stasis constitution. Long-term use can effectively resolve symptoms caused by blood stasis constitution, such as dull complexion, pigmentation or purplish spots, dark tongue, dark tongue or petechiae, dark or thickened sublingual veins, and a choppy pulse. It can be taken long-term as a health supplement. This blood-stasis-removing and conditioning granule can also be made into dry tablets, beverages, etc. for consumption.

This invention discloses a sea buckthorn compound composition, sea buckthorn compound active ingredients, sea buckthorn compound preparations, their preparation methods, and applications. The sea buckthorn compound composition, by weight, comprises the following components: 20-26 parts sea buckthorn, 17-21 parts kelp, 9-11 parts chuanxiong rhizome, 9-11 parts astragalus root, 9-11 parts notoginseng, 7-9 parts earthworm, 7-9 parts scutellaria baicalensis, 7-9 parts cassia seed, 3-5 parts hawthorn, and 3-5 parts chrysanthemum. The sea buckthorn compound active ingredients and sea buckthorn compound preparations obtained from the sea buckthorn compound composition of this invention exhibit excellent stability and pharmacodynamic properties, can improve vascular condition or blood lipid levels, and are suitable for treating various diseases related to arterial plaque, dyslipidemia, vascular wall thickening, or vascular endothelial inflammation.