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4 results about "Cephalotaxus" patented technology
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Cephalotaxus, commonly called plum yew or cowtail pine, is a genus of conifers comprising 11 species, treated in either the Cephalotaxaceae, or in the Taxaceae when that family is considered in a broad sense. The genus is endemic to eastern Asia, though fossil evidence shows it had a wider Northern Hemisphere distribution in the past. The species are evergreen shrubs and small trees reaching 1.0–10 m (rarely to 20 m) tall.
Oxidase and application thereof
The invention belongs to the field of genetic engineering and synthetic biology, provides a novel oxidase from cephalotaxus plants, nucleotide for coding the oxidase, a recombinant vector containing the nucleotide and a host containing the vector, and further provides application of the oxidase in preparation of cephalotaxus diterpenoid compounds. The oxidase provided by the invention can efficiently catalyze C-17 site oxidation of cephalotaxene, and a new method is provided for obtaining a cephalotaxane diterpenoid compound by adopting a synthetic biological means.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Hydroxylase and application thereof
The invention belongs to the field of genetic engineering and synthetic biology, and particularly relates to novel hydroxylase from cephalotaxus plants, a nucleic acid molecule of the hydroxylase, an expression vector containing the nucleic acid molecule, a host cell containing the vector and application of the hydroxylase or the host cell in biosynthesis of cephalotaxus diterpenoid compounds. The hydroxylase provided by the invention can efficiently catalyze C-13 site hydroxylation of cephalotaxene, and a new method is provided for obtaining a cephalotaxane diterpenoid compound by adopting a synthetic biological means.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Composition for preventing or treating lung cancer, comprising a compound isolated from Cephalotaxus extract as an active ingredient
The present disclosure relates to a composition for preventing or treating lung cancer, comprising a compound isolated from a Cephalotaxus extract as an active ingredient. Isoharringtonine, which is the compound isolated from the Cephalotaxus extract according to the present disclosure, induces apoptosis and exhibits the effect of inhibiting the growth of non-small cell lung cancer cell lines, and thus can be useful in the prevention or treatment of lung cancer.In addition, the combined treatment of isoharringtonine and siNR4A1 enhances anticancer activity, and the combined treatment of isoharringtonine and cisplatin, which is a conventional anticancer drug, induces a high anticancer effect at a low concentration of cisplatin, thereby reducing side effects of anticancer treatment.
Owner:NATIONAL CANCER CENTER(JP) +1
Oxidase and application thereof in preparation of cephalotaxane diterpenoid compound
The invention belongs to the field of genetic engineering and synthetic biology, provides a novel oxidase from cephalotaxus plants, nucleotide for coding the oxidase, a carrier containing the nucleotide and a host containing the carrier, and further provides application of the oxidase in preparation of cephalotaxus diterpenoid compounds. The oxidase provided by the invention can be applied to efficient catalytic generation of cephalotaxane diterpenes of a C19 cycloheptatrienone structure type represented by cephalotaxus hainanensis lactone, and lays a solid foundation for efficient production of important active molecules such as cephalotaxus hainanensis lactone and the like through biosynthesis and synthetic biological means; and a prospect is developed for large-scale and commercialized application of the compound.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI