132results about How to "Reasonable prescription" patented technology

The invention discloses a wild grape cuttage seedling culturing method. The method comprises the steps of selection of a seedling culturing base, building of the seedling culturing base, cuttage, management and the like. A breakthrough improvement is carried out on a conventional cuttage method, cuttage strips are soaked in a culture solution before cuttage is carried out, in this way, the survival rate of grape seedlings cultivated by the method can be remarkably increased, root systems are flourishing, and the grape seedlings grow fast after being transplanted. The important basis is provided for planting wild grapes in a large-scale and industrialization mode.

The invention relates to a vitamin D calcium chewable tablet for calcium supplementation of children and a preparation method thereof. The chewable tablet consists of calcium carbonate, vitamin D3 powder, sorbitol, glucose, maltodextrin, citric acid, magnesium stearate, lemon essence and water. The preparation method comprises the following steps: (1) inspecting the necessary raw materials and additives, and separately sieving through a 100 meshes sieve for later use; (2) mixing; (3) preparing a soft material; (4) granulating and drying; (5) finishing the granules and mixing all together; and (6) measuring the moisture and a midbody content, tabletting and bottling. The vitamin D calcium chewable tablet provided by the invention can promote the absorption of calcium, can guarantee the utilization rate of calcium, is taken in a chewing way, has a fruit flavor and is convenient for oral administration of children. Since vitamin D3 is poor in stability and is easy to oxidize, vitamin D3 is added in the mixing procedure, to ensure the product stability.

The invention discloses a compound telmisartan amlodipine besylate medicinal composition. The composite is a tablet which is prepared by the following steps: preparing amlodipine besylate into amlodipine besylate solid dispersion by a solid-state dispersion technology; and preparing the amlodipine besylate solid dispersion and telmisartan into the composite. The tablet improves the dissolubility of primary medicine, promotes the medicament to be quickly disintegrated, prevents dissolution influence of meglumine to the amlodipine besylate, simultaneously improves the absorptivity in blood, and improves the bioavailability of the primary medicine. The tablet has excellent curative effect to hypertension symptoms.

The invention relates to a compound valsartan benzenesulfonic acid amlodipine medicament composition and a new preparation method thereof. The compound valsartan benzenesulfonic acid amlodipine medicament composition is in a capsule type and is prepared by adopting the preparation method of a solid dispersion technique so that the dissolution of a medicament and the adsorption of the medicament in gastrointestinal tracts can be obviously promoted. The preparation method overcomes the defects of poor dissolution outside benzenesulfonic acid amlodipine and low bioavailability, greatly improve the quality of a preparation product and can realize industrial production.

The invention relates to a pharmaceutical combination with repaglinide and metformin as active components and a preparation method thereof. The pharmaceutical combination comprises 0.1-10 weight portions of repaglinide and 100-1500 weight portions of metformin as active components and pharmaceutic adjuvants, wherein, the pharmaceutic adjuvants comprise filler, disintegrating agent, adhesive, flavoring agent, lubricant and swelling accessory, and the repaglinide is repaglinide crystal. The invention adopts the repaglinide crystal with small particle size, metformin and pharmaceutic adjuvants to prepare the pharmaceutical combination, so as to realize the purpose of simultaneous release. Since the particle size of the repaglinide used in the invention is small, the dissolvability is improved, so that the dissolution is improved and the bioavailability is increased.

The invention discloses a brand-new oral solid medicinal composition. The medicinal composition is an oral preparation prepared from hydrochlorothiazide, levamlodipine, valsartan and pharmaceutically acceptable auxiliaries, and the oral preparation comprises but is not limited to tablets or capsules. The composition comprises the following raw materials in parts by weight: 5-25 parts of the hydrochlorothiazide, 2.5-5 parts of the levamlodipine, 80-160 parts of the valsartan, 40-120 parts of microcrystalline cellulose, 30-90 parts of compressible starch, 5-25 parts of cross-linked sodium carboxymethylcellulose, 3-8 parts of silicon dioxide and 1-2 parts of stearic acid. The medicinal composition disclosed by the invention has the advantages of scientific and reasonable prescription, low auxiliary content and high bioavailability, and is a first choice of medicine for treating hypertension.

The invention provides a natural drug oral preparation for relieving or neutralizing effects of alcohol. The natural drug oral preparation comprises, by mass, 10-15% of curcumin, 15-25% of kudzu vine root extract flavonoids, 10-25% of Chinese magnoliavine fruit total lignins, 0.05-5% of VB6, 0.05-5% of VE, 0.05-5% of VC and the balance auxiliary materials. The natural drug oral preparation is processed to form common oral preparations such as particles, tablets and capsules. Curcumin, kudzu vine root total flavonoids and Chinese magnoliavine fruit total lignins are obtained through extraction and then macroporous resin separation purification. The natural drug oral preparation has active ingredient content of 30-80%. A product test proves that the natural drug oral preparation can obviously reduce malonaldehyde, triglyceride and glutathione content of mouse hepatic tissue, inhibit alcohol-caused small intestine permeability increasing, reduce a blood alcohol concentration and relieve discomfort after drinking and alcoholic liver injury.

The invention provides a Chinese medicine preparation capable of diminishing inflammation, relieving pains, resisting bacteria, expelling stone and benefiting gallbladder, a preparation method thereof and applications of the Chinese medicine preparation in preparing medicines for treating urinary system calculi, urinary tract infection, cholecystitis, gall-stone and prostatitis. According to the theory of Chinese medicines, through the experiment and screening for many years, the invention reselects raw drugs in the prescription, optimizes the preparation technology, greatly enhances the medicinal functions of promoting diuresis for stranguria and removing heat for detumescence, has unexpected obvious curative effect on treating urinary system diseases, and especially produces unexpected effects of resisting bacteria, resisting prostatitis, relieving pains and benefiting gallbladder which are not provided in the prior art. The Chinese medicine preparation of the invention exerts the traditional advantages of Chinese medicines, takes effect quickly, obviously improves the subjective symptom and the physical sign, and does not have obvious side effect.

The invention relates to a repaglinide/metformin combo tablet, particularly a pharmaceutical composition in the form of a tablet, which comprises the following components in parts by weight: 500 parts of metformin hydrochloride, 0.5-5 parts of repaglinide and 10-200 parts of medicinal auxiliary materials. The medicinal auxiliary materials include, but are not limited to filler, disintegrant, binding agent, alkali and lubricant. The invention also relates to a method for preparing the pharmaceutical composition. The pharmaceutical composition provided by the invention has favorable pharmaceutical properties.

The invention relates to an amoxicillin compound and a pharmaceutical composition of the amoxicillin compound and potassium clavulanate. The pharmaceutical composition is an oral sustained-release preparation. The amoxicillin compound is a crystalline compound which is provided with the following structural formula, wherein the characteristic peaks as shown in an X-ray powder diffraction pattern obtained by measuring through Cu-K alpha rays are displayed in 2 theta of 8.0 degrees, 12.1 degrees, 15.4 degrees, 17.0 degrees, 19.8 degrees, 21.6 degrees, 23.0 degrees, 24.3 degrees, 25.7 degrees, 27.4 degrees, 30.7 degrees and 33.5 degrees. The novel crystalline compound is improved in stability and dissolubility. The amoxicillin and clavulanate potassium prepared from the crystalline compound is higher in stability. The amoxicillin and clavulanate potassium oral sustained-release preparation prepared from the crystalline compound can be synchronously released, and is excellent in in-vitro dissolution and higher in bioavailability.

The invention discloses a novel oral solid medicinal composition. The novel oral solid medicinal composition is an oral preparation prepared from hydrochlorothiazide, levamlodipine besylate, candesartan cilexetil and pharmaceutically acceptable auxiliary materials. The novel oral solid medicinal composition can be processed into tablets, capsules and the like. Specifically, the novel oral solid medicinal composition comprises: be weight, 5 to 25 parts of hydrochlorothiazide, 2.5 to 5 parts of levamlodipine besylate, 4 to 20 parts of candesartan cilexetil, 30 to 60 parts of microcrystalline cellulose, 30 to 60 parts of compressible starch, 30 to 50 parts of crosslinked polyvinylpyrrolidone, 1 to 2 parts of silica and 0.5 to 2 parts of magnesium stearate. The novel oral solid medicinal composition has a scientific and reasonable formula, low auxiliary material content and high bioavailability. Therefore, the novel oral solid medicinal composition is a drug of first choice for the treatment of hypertension.

The invention discloses rupatadine fumarate tablets and a preparation method thereof, belonging to the technical field of medicine. The tablets are prepared by making granules from rupatadine fumarate as active ingredient, and pharmaceutical adjuvants including a filler, a binder and a disintegrant, adding a lubricant, and making into tablets. Through the screening of the type and use amount of the filler, disintegrant, binder and lubricant and the use of specific sieving mesh to sieve raw materials during a preparation process, the prepared tablets have stable properties, good content uniformity, good dissolution, small tablet weight difference and high stability, so as to ensure in vivo bioavailability and clinical curative effect.

The invention discloses an iloperidone pharmaceutical composition and a preparation method thereof. The invention is characterized in that 1000 iloperidone pharmaceutical composition tablets are prepared from the following components: 1-24g of iloperidone, lactose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, 5% povidone K30 and a proper amount of 70% ethanol solution. The invention also relates to the preparation method of the iloperidone pharmaceutical composition. The iloperidone tablet prepared by the prescription and preparation method provided by the invention has the advantages of good liquidity, good dissolution rate, small tablet weight variation, high bioavailability and good treatment effect.

The invention relates to a composition injection of glycerol and fructose and a preparation method thereof. The composition injection of the glycerol and the fructose comprises the following main ingredients: 25-40 parts of glycerol, 3-8 parts of fructose, 3-13 parts of maltitol and 80-120 parts of water for injection. The composition injection of glycerol and fructose is prepared according to the following steps: (1) liquid preparation: dissolving the main materials and auxiliary materials into proper amount of water for injection to prepare solution, respectively stirring evenly, mixing the prepared solution evenly by stirring, and using a pH regulator to regulate pH to be 4 to 5, wherein hydrochloric acid or sodium hydroxide is preferred as the pH regulator, and filtering to obtain filtrate; (2) sterilization: carrying out high-temperature sterilization on the filtrate in the step (1), and taking proper amount of active carbon for high-temperature sterilization; and (3) decolorization: adding the medical active carbon after high-temperature sterilization into the filtrate after high-temperature sterilization, decolorizing and filtering.

The invention discloses a fully-novel oral solid pharmaceutical composition. The pharmaceutical composition is an oral preparation prepared from hydrochlorothiazide, L-amlodipine, telmisartan and pharmaceutically acceptable auxiliary materials; and the oral preparation includes but is not limited to tablets or capsules. The composition is prepared from the following raw materials in parts by weight: 5-25 parts of hydrochlorothiazide, 2.5-5 parts of L-amlodipine, 20-80 parts of telmisartan, 0.1-0.5 part of sodium bicarbonate, 40-120 parts of microcrystalline cellulose, 20-60 parts of hydroxypropyl cellulose, 30-100 parts of lactose, 30-90 parts of compressible starch, 2-5 parts of low-substituted hydroxypropyl cellulose, 10-45 parts of crosslinked polyvinylpyrrolidone and 1-2 parts of magnesium stearate. The pharmaceutical composition disclosed by the invention has the advantages of reasonable and scientific prescription, low auxiliary material content and high bioavailability, and is a drug of first choice for treating hypertensive.

The present invention discloses a levetiracetam tablet and a preparation method thereof. The levetiracetam tablet is reasonable in formulation and stable in preparation process, achieves better auxiliary material selection effect, and is low in production cost.

The invention belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating migraine and a preparation method thereof. The traditional Chinese medicine composition is composed for the following bulk drugs: radix bupleuri, angelica dahurica, Chinese angelica, atractylodes macrocephala, poria cocos, ligusticum chuanxiong, rhizoma gastrodiae, radix paeoniae rubra, radix paeoniae alba, chrysanthemum, mint, salvia miltiorrhiza and fructus viticis. The traditional Chinese medicine composition is prepared into tablets, capsules or granula according to a traditional Chinese medicine preparation method. The traditional Chinese medicine composition is reasonable in prescription, substantial in curative effect, none in side effect and high in safety.

The invention discloses a Prulifloxacin composition. The composition comprises the following components: 130 to 135 parts of Prulifloxacin, 35 to 45 parts of lactose, 9 to 10 parts of hydroxypropyl cellulose, 1.5 to 2.5 parts of magnesium stearate and 15 to 20 parts of povidone K30. Quality and yield of the Prulifloxacin are greatly improved by adjusting parameters during synthesis, such as addition speed of reactants. The method for preparing the composition comprises the following steps of preparing solution of povidone K30 ethanol; uniformly mixing the Prulifloxacin with the hydroxypropyl cellulose, and crushing the mixture with mechanical crusher; screening, and screening crushed lactose; adding lactose into mixed powder of the Prulifloxacin and the hydroxypropyl cellulose, and uniformly mixing with a three-dimensional mixer; then adding the prepared solution of povidone K30; uniformly mixing, granulating, and straightening granules after drying; and adding the magnesium stearate into the prepared granules and uniformly mixing with the three-dimensional mixer. The composition prepared by the method has advantages of good quality, less disintegration time and high dissolution efficiency.

The invention provides an inflammation-diminishing paste for dental pulp. The inflammation-diminishing paste for the dental pulp is prepared from an active ingredient; the active ingredient is prepared from the following components in parts by weight: 10-40 parts of iodoform, 10-40 parts of metronidazole, 10-40 parts of ciprofloxacin and 5-20 parts of chitosan. The inflammation-diminishing paste for the dental pulp has the technical effects that 1, the inflammation-diminishing paste has better antibacterial and anti-inflammatory effects, is stable and lasting in efficacy and high in permeability, and is capable of promoting the recovery of normal physiological functions of the dental pulp, thus remarkably improving the success rate of vital pulp preservation of diseased teeth; 2, during clinical use, compared with the traditional root canal therapy, the inflammation-diminishing paste for the dental pulp is simple and convenient in operation by oral clinical doctors and short in treatment time; after the inflammation-diminishing paste for the dental pulp is used, the subsequent visit times of a patient are reduced, and the treatment efficiency of dental pulp diseases is greatly increased. Mechanical preparation does not need to be carried out, so that root canal wall tissues are prevented from being damaged for a second time, and the risk of fracture of teeth is reduced.

The invention discloses a compound telmisartan hydrochlorothiazide pharmaceutical composition, which is a tablet. For the tablet, hydrochlorothiazide and telmisartan are prepared into a coated tablet so as to make the telmisartan and the hydrochlorothiazide in the telmisartan hydrochlorothiazide pharmaceutical composition respectively released. The composition has a controlled release effect and improves the bioavailability. The employment of a coated tablet preparation process can make the two medicines effectively released successively. The pharmaceutical composition has a controlled release effect, maintains a long-term blood concentration, has a more stable blood pressure reduction effect, and reduces adverse reactions.

The invention belongs to the field of traditional Chinese medicine, and discloses an external preparation for treating acute eczema. The external preparation is composed of the following raw materials by weight: 10 to 20 grams of natural indigo, 10 to 20 grams of talcum powder, 8 to 12 grams of coptis, 8 to 12 grams of calcined gypsum, and 5 to 10 grams of borneol. The external preparation has the advantages of reasonable formula, user-friendliness, and prominent effect.

The invention discloses a brand-new oral solid pharmaceutical composition. The pharmaceutical composition is an oral preparation prepared from hydrochlorothiazide, l-amlodipine, olmesartan medoxomil and pharmaceutically acceptable auxiliary materials, and the oral preparation comprises but is not limited to tablets or capsules. The composition comprises the following raw materials in parts by weight: 5-25 parts of hydrochlorothiazide, 2.5-5 parts of l-amlodipine, 20-40 parts of olmesartan medoxomil, 40-120 parts of microcrystalline cellulose, 30-90 parts of pregelatinized starch, 15-40 parts of low-substituted hydroxypropyl cellulose, 10-45 parts of crosslinked polyvinylpyrrolidone, 3-8 parts of silica and 1-2 parts of magnesium stearate. The pharmaceutical composition disclosed by the invention has the advantages of scientific and reasonable prescription, low auxiliary material content and high bioavailability, and is a drug of first choice for treating hypertension.

The invention discloses a traditional Chinese medicine combination preparation for treating gout and a preparation method of the traditional Chinese medicine, and belongs to the technical field of traditional Chinese medicines. The effective constituents of the traditional Chinese medicine combination preparation comprise the following raw materials: chinaroot greenbrier, herba plantaginis, Chinese tulip bulb, celastrus aculeatus, laxflower pottsia roots, rhizoma polygonati, common jasminorange roots, equisetum sylvaticum, tube clematis roots or stems, folium daphnes odorae, clematis florida, cowberry leaves, ovate catalpa fruit, cortex fraxini, lycoris radiate and stevia rebaudiana. The traditional Chinese medicine combination preparation provided by the invention is reasonable in prescription, good in curative effect, convenient to use, good in absorbing effect, is free of adverse, toxic or side effects, has a good therapeutic effect on gout by clinical verifications, and is suitable for gout clinical treating and nursing popularization and application.

A Chinese medicine in the form of chewing tablet for treating cold and clearing heat is prepared from 11 Chinese-medicinal materials including schizonepeta ear, mint, ledebouriella root, bupleurum root, etc.

The invention discloses a Chinese medicinal health-care composition which has the effects of clearing heat, nourishing yin, promoting production of body fluid, quenching thirst, relieving summer-heat and removing dampness through diuresis and a preparation method thereof. The Chinese medicinal health-care composition is prepared from the following components in part by weight: 5 to 30 parts of fragrant solomonseal rhizome, 8 to 40 parts of corn, 8 to 40 parts of common lophatherum herb, 0.5 to 5 parts of lotus leaf, 20 to 200 parts of mesona chinensis benth, 5 to 30 parts of honeysuckle flower, 5 to 30 parts of chrysanthemum, 8 to 40 parts of grosvener siraitia and 5 to 30 liquoric root. The Chinese medicinal health-care composition has the effects of nourishing yin to reduce fire, refreshing, moistening, detoxicating and the like, has the advantages of excellent flavor and health-care effect, good effect and mouthfeel, capacity of being prepared into various formulations, unique and scientific prescription and simple production method, and is an ideal health-care product for clearing heat, nourishing yin, relieving summer-heat and removing dampness.