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Vitamin D calcium chewable tablet for calcium supplementation of children and preparation method thereof

A chewable tablet and calcium supplement technology, applied in the field of medicine, can solve the problems of difficulty in taking, low utilization rate, etc., and achieve the effects of simple process, low production cost and simple production process

Inactive Publication Date: 2014-06-11
ZHEJIANG JOLLY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the shortcomings of low calcium utilization rate and difficulty in taking some calcium supplement preparations on the market. The preparation we developed is added with vitamin D3 powder, which can promote calcium absorption and ensure calcium utilization rate. Chewing and taking, fruity taste is convenient for children oral

Method used

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  • Vitamin D calcium chewable tablet for calcium supplementation of children and preparation method thereof
  • Vitamin D calcium chewable tablet for calcium supplementation of children and preparation method thereof
  • Vitamin D calcium chewable tablet for calcium supplementation of children and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Mix by weight:

[0053] Calcium carbonate 55%

[0054] Vitamin D 3 Powder 0.08%

[0055] Sorbitol 12%

[0056] Glucose 12%

[0057] Maltodextrin 15%

[0058] Citrate 0.8%

[0059] Magnesium Stearate 1.8%

[0060] Lemon essence 1.2%

[0061] Purified water 70ml;

[0062] The required raw materials and auxiliary materials have passed the inspection and passed through a 100-mesh sieve for later use. Blend: Vitamin D 3 Powder and citric acid are mixed evenly, and are mixed by equal addition method. Preparation of soft materials: Weigh the prescribed amount of calcium carbonate, maltodextrin and glucose, put them in a high-efficiency wet granulator, and mix them evenly; add purified water as a wetting agent to prepare soft materials. Granulation and drying: use 18-mesh sieve to granulate, dry in an oven at 45°C-65°C, and control the moisture content at 2% to 4%. Grain granulation and blending: After drying, the granules are granulated with an 18-mesh sieve, and c...

Embodiment 2

[0064] Mix by weight:

[0065] Calcium Carbonate 60%

[0066] Vitamin D 3 Powder 0.1%

[0067] Sorbitol 10%

[0068] Glucose 15%

[0069] Maltodextrin 10%

[0070] Citrate 1.5%

[0071] Magnesium Stearate 1.2%

[0072] Lemon essence 1.5%

[0073] Purified water 90ml;

[0074] The required raw materials and auxiliary materials have passed the inspection and passed through a 100-mesh sieve for later use. Blend: Vitamin D 3 Powder and citric acid are mixed evenly, and are mixed by equal addition method. Preparation of soft materials: Weigh the prescribed amount of calcium carbonate, maltodextrin and glucose, put them in a high-efficiency wet granulator, and mix them evenly; add purified water as a wetting agent to prepare soft materials. Granulation and drying: use 18-mesh sieve to granulate, dry in an oven at 45°C-65°C, and control the moisture at 2%-4. Grain granulation and blending: After drying, the granules are granulated with an 18-mesh sieve, and citric acid and ...

Embodiment 3

[0076] Mix by weight:

[0077] Calcium Carbonate 65%

[0078] Vitamin D 3 Powder 0.12%

[0079] Sorbitol 12%

[0080] Glucose 10%

[0081] Maltodextrin 8%

[0082] Citrate 0.8%

[0083] Magnesium Stearate 2.0%

[0084] Lemon essence 0.5%

[0085] Purified water 80ml;

[0086] The required raw materials and auxiliary materials have passed the inspection and passed through a 100-mesh sieve for later use. Blend: Vitamin D 3 Powder and citric acid are mixed evenly, and are mixed by equal addition method. Preparation of soft materials: Weigh the prescribed amount of calcium carbonate, maltodextrin and glucose, put them in a high-efficiency wet granulator, and mix them evenly; add purified water as a wetting agent to prepare soft materials. Granulation and drying: use 18-mesh sieve to granulate, dry in an oven at 45°C-65°C, and control the moisture at 2%-4. Grain granulation and blending: After drying, the granules are granulated with an 18-mesh sieve, and citric acid an...

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Abstract

The invention relates to a vitamin D calcium chewable tablet for calcium supplementation of children and a preparation method thereof. The chewable tablet consists of calcium carbonate, vitamin D3 powder, sorbitol, glucose, maltodextrin, citric acid, magnesium stearate, lemon essence and water. The preparation method comprises the following steps: (1) inspecting the necessary raw materials and additives, and separately sieving through a 100 meshes sieve for later use; (2) mixing; (3) preparing a soft material; (4) granulating and drying; (5) finishing the granules and mixing all together; and (6) measuring the moisture and a midbody content, tabletting and bottling. The vitamin D calcium chewable tablet provided by the invention can promote the absorption of calcium, can guarantee the utilization rate of calcium, is taken in a chewing way, has a fruit flavor and is convenient for oral administration of children. Since vitamin D3 is poor in stability and is easy to oxidize, vitamin D3 is added in the mixing procedure, to ensure the product stability.

Description

technical field [0001] The invention belongs to the field of medicine. In particular, the invention relates to a prescription and a preparation method of vitamin D calcium chewable tablets for children. In particular, natural fruit flavors are added to the prescription, which has moderate taste and is convenient for children to take. Background technique [0002] Now the calcium supplements sold in the market are all health food. How to ensure the safety of children’s calcium supplements, the price of imported medicines is expensive. Under the full market research and analysis, we have carried out the research and development of children’s vitamin D calcium chewable tablets, and foreign countries The clinical and prescription of the company have been analyzed and studied in detail, and the prescription analysis has been carried out with reference to the production situation of domestic raw materials. The flavoring agent with fruit taste has been used and compared with the fl...

Claims

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Application Information

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IPC IPC(8): A61K33/10A61K9/20A61K47/26A61P3/02A61K31/593
Inventor 秦序锋彭晓国王开颖王丹凤
Owner ZHEJIANG JOLLY PHARMA
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