Common cold heat clearing chewing tablet and its preparation method

A technology for clearing away heat and chewing a cold, which is applied in the directions of anti-infective drugs, pharmaceutical formulations, and medical preparations containing active ingredients to achieve the effects of improving bioavailability, definite curative effect and better curative effect.

Active Publication Date: 2006-08-30
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chewable tablet not only retains the characteristics of ordinary tablets such as easy portability, stable properties, and simple preparation process, but also has the following advantages as a chewable tablet: no disintegration process is required, the drug dissolves quickly, absorbs quickly, and has high bioavailability; it is convenient to take, It does not need to be washed or taken with water, and is especially suitable for the elderly, children and patients who have difficulty swallowing; at the same time, the preparation of sugar-free preparations from chewable tablets is relatively mature, which can expand the patient population and is especially suitable for the majority of diabetic patients; and according to the database search, the current Chewable tablets of preparations are still blank in China

Method used

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  • Common cold heat clearing chewing tablet and its preparation method
  • Common cold heat clearing chewing tablet and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1: Nepeta 750g, Mint 225g, Fangfeng 375g, Bupleurum 375g, Perilla leaves 225g, Pueraria 375g, Bellflower 225g, Bitter almond 300g, Angelica dahurica 225g, Kudiding 750g, Reed rhizome 600g

[0067] For the above eleven flavors, mix Nepeta chinensis, mint, and perilla leaves, add 10 times the amount of water, soak for 2 hours, and steam distill for 6 hours to extract volatile oil. Beta-cyclodextrin inclusions (volatile oil-beta-cyclodextrin-water = 1:6:80, stirred at 60°C for 1 hour), refrigerated overnight, filtered, dried at low temperature (40°C), crushed into fine pink. Add 12 times the amount of water to decoct the dregs and the rest of Fangfeng and other eight flavors for two times, 1.5 hours each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, and concentrate to a thick paste with a relative density of 1.25-1.30 (60°C) , dried under reduced pressure, pulverized into fine powder, mixed with the fine powder of inclu...

Embodiment 2

[0068] Example 2: Nepeta 750g, Mint 225g, Fangfeng 375g, Bupleurum 375g, Perilla leaves 225g, Pueraria 375g, Bellflower 225g, Bitter almond 300g, Angelica dahurica 225g, Kudiding 750g, Reed rhizome 600g

[0069] For the above eleven flavors, mix Nepeta chinensis, mint, and perilla leaves, add 8 times the amount of water, soak for 4 hours, steam distill for 4 hours, extract volatile oil, collect the distilled aqueous solution in a separate container, and keep the medicinal residues; use the volatile oil Beta-cyclodextrin inclusions (volatile oil-beta-cyclodextrin-water = 2:7:90, stirred at 50°C for 1.5 hours), refrigerated overnight, filtered, dried at low temperature (30°C), and crushed into fine powder; add 10 times the amount of water to decoct the dregs and the rest of Fangfeng and other eight flavors, decoct twice for 3 hours each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, and concentrate to a relative density of 1.25-1.30 (60...

Embodiment 3

[0070] Example 3: Nepeta 750g, Mint 225g, Fangfeng 375g, Bupleurum 375g, Perilla leaves 225g, Pueraria 375g, Bellflower 225g, Bitter almond 300g, Angelica dahurica 225g, Kudiding 750g, Reed rhizome 600g

[0071] For the above eleven flavors, mix nepeta panicles, mint, and perilla leaves, add 8 times the amount of water, soak for 2 hours, steam distill for 6 hours, extract volatile oil, collect the distilled aqueous solution in another device, and keep the medicinal residues; Beta-cyclodextrin inclusions (volatile oil-beta-cyclodextrin-water=3:10:100, stirred at 40°C for 3 hours), refrigerated overnight, filtered, dried at low temperature (50°C), and crushed into fine powder; dregs and other Bawei, such as Fangfeng, add 12 times the amount of water and decoct twice, 3 hours each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, and concentrate to a relative density of 1.25-1.30 (60°C) The thick paste, dried, crushed into fine powder, mix...

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PUM

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Abstract

A Chinese medicine in the form of chewing tablet for treating cold and clearing heat is prepared from 11 Chinese-medicinal materials including schizonepeta ear, mint, ledebouriella root, bupleurum root, etc.

Description

technical field [0001] The invention relates to a Ganmao Qingre chewable tablet and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. technical background [0002] Influenza is a multiple disease, and the demand for cold medicine is extremely high in the market. According to industry estimates, half of my country's 1 billion population will get more than one cold every year, and each time the cost is calculated at 10 to 50 yuan, the market share of my country's cold medicine is about 5 billion yuan; an optimistic estimate is that the annual sales More than 10 billion yuan. However, China's cold medicine market is almost all occupied by well-known international brands from abroad, and the market share of domestic products is extremely small. However, the PPA incident and SARS in 2003 made people see the market space left by western medicine for traditional Chinese medicine, and many Chinese medicine companies saw huge business op...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/20A61P31/00A61P11/00
Inventor 张保献
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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