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Compound telmisartan hydrochlorothiazide pharmaceutical composition and preparation method thereof

A technology of telmisartan and hydrochlorothiazide, applied in the field of telmisartan hydrochlorothiazide pharmaceutical composition and its new preparation, can solve the problems of low dissolution rate of hydrochlorothiazide

Inactive Publication Date: 2013-01-02
庞晓斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Since the dissolution rate of hydrochlorothiazide caused by the interaction between drugs is very low, conventional methods such as crushing to improve drug solubility cannot play their due role

Method used

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  • Compound telmisartan hydrochlorothiazide pharmaceutical composition and preparation method thereof
  • Compound telmisartan hydrochlorothiazide pharmaceutical composition and preparation method thereof
  • Compound telmisartan hydrochlorothiazide pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] A compound telmisartan hydrochlorothiazide pharmaceutical composition, the described compound telmisartan hydrochlorothiazide pharmaceutical composition of every 1000, its formula consists of:

[0079] Inner Tablet Prescription

[0080]

[0081]

[0082] Outer Tablet Prescription

[0083]

[0084] Inner Tablet Coating Solution Prescription

[0085]

[0086] Preparation Process:

[0087] 1) Preparation of the inner layer tablet: After crushing hydrochlorothiazide through a 100-mesh sieve, place it in a rapid mixer with microcrystalline cellulose, crospovidone, and pregelatinized starch, and mix rapidly for 3-5 minutes, then add appropriate amount of water, Make soft material, pass through 20-mesh sieve, dry at 50±5℃, granulate with 20-mesh sieve, add sucrose fatty acid ester, and press into tablets.

[0088] 2) Inner layer tablet coating: Weigh the Eudragit L30D-55 of the prescription amount, add an equal volume of water dissolving the prescription amount...

Embodiment 2

[0091] A compound telmisartan hydrochlorothiazide pharmaceutical composition, the compound telmisartan hydrochlorothiazide pharmaceutical composition described in every 1000

[0092] compound, its formula consists of:

[0093] Inner Tablet Prescription

[0094]

[0095] Outer Tablet Prescription

[0096]

[0097] Inner Tablet Coating Solution Prescription

[0098]

[0099] Preparation Process:

[0100] 1) Preparation of the inner layer tablet: After crushing hydrochlorothiazide through a 100-mesh sieve, place it in a rapid mixer with microcrystalline cellulose, crospovidone, and pregelatinized starch, and mix rapidly for 3-5 minutes, then add appropriate amount of water, Make soft material, pass through 20-mesh sieve, dry at 50±5℃, granulate with 20-mesh sieve, add sucrose fatty acid ester, and press into tablets.

[0101] 2) Inner layer tablet coating: Weigh the Eudragit L30D-55 of the prescription amount, add an equal volume of water dissolving the prescription...

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PUM

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Abstract

The invention discloses a compound telmisartan hydrochlorothiazide pharmaceutical composition, which is a tablet. For the tablet, hydrochlorothiazide and telmisartan are prepared into a coated tablet so as to make the telmisartan and the hydrochlorothiazide in the telmisartan hydrochlorothiazide pharmaceutical composition respectively released. The composition has a controlled release effect and improves the bioavailability. The employment of a coated tablet preparation process can make the two medicines effectively released successively. The pharmaceutical composition has a controlled release effect, maintains a long-term blood concentration, has a more stable blood pressure reduction effect, and reduces adverse reactions.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a telmisartan hydrochlorothiazide pharmaceutical composition and a new preparation method thereof. Background technique [0002] Telmisartan is a new antihypertensive drug and a specific angiotensin II receptor (AT I type) antagonist. Compared with other antihypertensive drugs, telmisartan has the following characteristics: specificity of receptor action, significant antihypertensive effect, good diuretic effect, can improve myocardial stenosis, drug safety, and tolerance Good 1 time a day, easy to take. [0003] The chemical name is: 4-{[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazol-1-yl]methyl}biphenyl-2 -Carboxylic acid [0004] Molecular formula: C 33 h 30 N 4 o 2 ; [0005] Molecular weight: 514.62; [0006] Hydrochlorothiazide [0007] The chemical name is: 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61K31/4184A61K9/28A61P9/12
Inventor 张昊
Owner 庞晓斌
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