Compound valsartan benzenesulfonic acid amlodipine medicament composition and new preparation method thereof

A technology of valsartan amlodipine besylate capsule and amlodipine besylate solid, which is applied in the field of valsartan amlodipine besylate pharmaceutical composition and its new preparation, and can solve the problem of poor fluidity , slow dissolution of amlodipine besylate, high price, etc.

Active Publication Date: 2010-09-22
天津汉嘉医药科技有限公司
View PDF6 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] US6858228, US6485745, WO2005082329, EP1410797, WO9749394, WO2007022113 and other patents all adopt dry granulation process, all of which use expensive auxiliary materials, and the cost is high
[0008] Regardless of the rolling method or the dry method, it is easy to cause uneven particle size, which may lead to poor fluidity, large differences in tab

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound valsartan benzenesulfonic acid amlodipine medicament composition and new preparation method thereof
  • Compound valsartan benzenesulfonic acid amlodipine medicament composition and new preparation method thereof
  • Compound valsartan benzenesulfonic acid amlodipine medicament composition and new preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Valsartan 80g

[0078] Microcrystalline Cellulose 30g

[0079] Croscarmellose Sodium 10g

[0080] Appropriate amount of water

[0081] Amlodipine besylate solid dispersion 45.161g

[0082] Lactose 64.839g

[0083] Carboxymethyl Starch Sodium 10g

[0084] Appropriate amount of water

[0085] Magnesium Stearate 1g

[0086] Composition of amlodipine besylate solid dispersion

[0087] Amlodipine besylate 6.944g

[0088] Povidone K30 34.72g

[0089] Polyoxyethylene castor oil 3.497g

[0090] 1) Preparation of amlodipine besylate solid dispersion: Weigh amlodipine besylate, povidone K30 and polyoxyethylene castor oil respectively, add absolute ethanol, stir to dissolve, evaporate under reduced pressure to remove absolute ethanol , evacuated, dried overnight, ground through a 100-mesh sieve, and set aside.

[0091] 2) Preparation of amlodipine besylate granules: Weigh amlodipine besylate solid dispersion, lactose, sodium starch glycolate, mix well, adopt water-based...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a compound valsartan benzenesulfonic acid amlodipine medicament composition and a new preparation method thereof. The compound valsartan benzenesulfonic acid amlodipine medicament composition is in a capsule type and is prepared by adopting the preparation method of a solid dispersion technique so that the dissolution of a medicament and the adsorption of the medicament in gastrointestinal tracts can be obviously promoted. The preparation method overcomes the defects of poor dissolution outside benzenesulfonic acid amlodipine and low bioavailability, greatly improve the quality of a preparation product and can realize industrial production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a valsartan amlodipine besylate pharmaceutical composition and a new preparation method thereof. Background technique [0002] Valsartan / amlodipine besylate is a combination of calcium channel antagonist amlodipine besylate and angiotensin receptor inhibitor valsartan. Amlodipine besylate and valsartan are all leading varieties in their respective therapeutic fields, wherein, valsartan (trade name: substitute ) sales in 2006 exceeded 6 billion US dollars, while amlodipine besylate (trade name: Luohuo) whose patent expired in 2007 ), with a sales volume of 5 billion US dollars in 2006, which is in a period of growth in my country. [0003] Amlodipine valsartan besylate tablets are consistent with the recommendations of the current US treatment guidelines, that is, combined medication should be used for the initial treatment of suitable patients. Studies ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4422A61K31/41A61K9/48A61K47/32A61K47/34A61P9/12A61K47/44
Inventor 严洁黄欣
Owner 天津汉嘉医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap