Cerebroprotein hydrolysate preparation and designing method thereof

Abstract

The invention relates to a cerebroprotein hydrolysate preparation and a designing method thereof, belonging to the technical field of a pharmaceutical preparation. The method comprises the following steps: selection of dosage form: according to the repair rate of cerebroprotein hydrolysate to oxidative damage models in the stomach and intestines, selecting the dosage form; design of prescriptions: according to a star point design-response surface method, designing different prescriptions by taking preset pharmaceutical adjuncts as an influencing factor and an accumulative releasing rate as a response variable; experiments: preparing the cerebroprotein hydrolysate preparation according to the prescriptions, and respectively conducting releasing experiments; modeling: performing model fitting of the experiment results according to the star point design-response surface method, so as to obtain a fitted equation by taking the influencing factor as an independent variable and the accumulative releasing rate as a response variable; optimization of the prescriptions: according to the fitted equation, optimizing and screening the independent variable, so as to obtain the independent variable corresponding to the highest accumulative releasing rate, namely the optimal prescription. The method can be used for optimizing the pharmaceutical prescription, and has the scientific, stable and feasible advantages.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a cerebroprotein hydrolyzate preparation and a design method thereof. Background technique [0002] Brain protein hydrolyzate is extracted and separated from animal brain tissue. It is easy to cross the biofilm and pass through the blood-brain barrier. It promotes cell metabolism and increases brain activity in various ways. At the same time, it acts on the nerve center and nourishes nerve cells. Meta-repair provides amino acids and promotes synapse formation, thereby protecting nerve cells and improving nervous system dysfunction. [0003] In recent years, the domestic drug is mainly administered by injection, with less oral administration and low bioavailability. Therefore, how to deliver and preserve such drugs is the goal that pharmacy should persist in exploring. [0004] Gastric floating preparations are a type of preparations prepared based on the pri...

AI Technical Summary

Problems solved by technology

However, there are still many deficiencies in the current prescription screening of gastric floating preparations, for example, it needs to rely on the experience of researchers, or even if orthogonal tests can be used to screen prescriptions, the test accuracy is not enough, and the selected test values ​​are only Close to the optimal value, it is impossible to find the optimal point accurately, and the conditions are optimized based on experience, and the interaction between various factors cannot be sensitively examined, etc.

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