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Iloperidone pharmaceutical composition and preparation method thereof

A technology of iloperidone and composition, which is applied in the field of iloperidone pharmaceutical composition and its preparation, and can solve problems such as not giving further prompts

Inactive Publication Date: 2011-06-01
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] How to adjust the formulation and process adjustment of the dissolution rate of iloperidone to obtain a more excellent dissolution rate, how to improve its fluidity and loading difference through a suitable process method, and how to select suitable process conditions to make iloperidone medicine The composition has excellent long-term stability, and the prior art does not provide further hints. In view of this, the present invention is proposed

Method used

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  • Iloperidone pharmaceutical composition and preparation method thereof
  • Iloperidone pharmaceutical composition and preparation method thereof
  • Iloperidone pharmaceutical composition and preparation method thereof

Examples

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Embodiment 1

[0132] Tablet prescription composition, each 1000 tablets are composed as follows:

[0133] Iloperidone 1g

[0134] Lactose 40g

[0135] Microcrystalline Cellulose 30g

[0136] Croscarmellose Sodium 8g

[0137] Magnesium stearate 0.5g

[0138] 5% povidone K30 70% ethanol solution appropriate amount

[0139] Preparation Process

[0140] 1) Grinding the iloperidone until the average particle size is less than 80 μm.

[0141] 2) Pass lactose, microcrystalline cellulose, and croscarmellose sodium magnesium stearate through an 80-mesh sieve for subsequent use.

[0142] 3) According to the prescription quantity, the iloperidone, lactose, microcrystalline cellulose, croscarmellose sodium, and magnesium stearate of the prescription quantity were weighed after double-checking.

[0143] 4) Mix iloperidone and other excipients except magnesium stearate uniformly in equal increments.

[0144] 5) Use 5% povidone K3070% ethanol solution to make soft material, and granulate with 16-3...

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Abstract

The invention discloses an iloperidone pharmaceutical composition and a preparation method thereof. The invention is characterized in that 1000 iloperidone pharmaceutical composition tablets are prepared from the following components: 1-24g of iloperidone, lactose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, 5% povidone K30 and a proper amount of 70% ethanol solution. The invention also relates to the preparation method of the iloperidone pharmaceutical composition. The iloperidone tablet prepared by the prescription and preparation method provided by the invention has the advantages of good liquidity, good dissolution rate, small tablet weight variation, high bioavailability and good treatment effect.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing iloperidone as an active ingredient and a preparation method thereof. Background technique [0002] Iloperidone, the English name is iloperidone, the chemical name is 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl] Propoxy]-3-methoxyphenyl]ethanone, molecular formula C 24 h 27 FN 2 o 4 , the molecular weight is 426.48. Iloperidone is indicated for the treatment of schizophrenia in adults. Iloperidone is an atypical antipsychotic, namely a 5-HT2 / D2 dual antagonist. Iloperidone can not only effectively treat the positive symptoms of schizophrenia (hallucinations, delusions, and strange behaviors), while reducing the occurrence of EPS, but also improve the negative symptoms of schizophrenia (affective and language dullness, social avoidance, and lack of attention). [0003] US Patent No. 5,364,886 describe...

Claims

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Application Information

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IPC IPC(8): A61K31/454A61K47/26A61K47/38A61K47/12A61K47/32A61K9/20A61P25/18
Inventor 严洁黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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