Fully-novel oral solid pharmaceutical composition and preparation method thereof

Abstract

The invention discloses a fully-novel oral solid pharmaceutical composition. The pharmaceutical composition is an oral preparation prepared from hydrochlorothiazide, L-amlodipine, telmisartan and pharmaceutically acceptable auxiliary materials; and the oral preparation includes but is not limited to tablets or capsules. The composition is prepared from the following raw materials in parts by weight: 5-25 parts of hydrochlorothiazide, 2.5-5 parts of L-amlodipine, 20-80 parts of telmisartan, 0.1-0.5 part of sodium bicarbonate, 40-120 parts of microcrystalline cellulose, 20-60 parts of hydroxypropyl cellulose, 30-100 parts of lactose, 30-90 parts of compressible starch, 2-5 parts of low-substituted hydroxypropyl cellulose, 10-45 parts of crosslinked polyvinylpyrrolidone and 1-2 parts of magnesium stearate. The pharmaceutical composition disclosed by the invention has the advantages of reasonable and scientific prescription, low auxiliary material content and high bioavailability, and is a drug of first choice for treating hypertensive.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel oral solid pharmaceutical composition comprising hydrochlorothiazide, telmisartan and levamlodipine and a preparation method thereof. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. In 1991, my country conducted a sample survey of 940,000 people over the age of 15. Statistics show that the prevalence of hypertension in my country has reached 11.26%, which is 25% higher than that in the 10 years from 1979 to 1990. There are more than 130 million hypertensive patients in my country. . Moreover, this upward momentum continues. Statistics also show that the treatment rate of hypertension is 17.4% in urban areas and 5.4% in rural areas; the control rate (systolic blood pressure<140mmHg and diastolic blood pressure<90mmHg after treatment) is only 2.9%. From the above statistic...

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Problems solved by technology

However, no specific implementation is given in the above-mentioned application. Those skilled in the art know that for a certain preparation, especially a new type of compound preparation, different adjuvants and dosages seriously affect the curative effect of the drug. Therefore, although the above-mentioned application is proposed, it will The three together prepare the technical scheme of the compound preparation, but it does not give a prescription for any compound preparation, and it does not propose any improvement on the excipients. The enlightenment obtained by those skilled in the art is simply to contain the above three active ingredients Two or three tablets are made into one. Such excipients have a large content, which reduces the efficacy of the medicine and makes it difficult for patients to take the medicine.

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