154results about How to "Lower systolic blood pressure" patented technology

An implantable blood pressure regulator is provided. The blood pressure regulator includes at least one connection zone and an attenuation zone. The connection zone is suitable for connection to a body conduit, such as a blood vessel. The attenuation zone is movable from a first state to a second state in response to a physiological pressure spikes. The movement from the first state to the second state lowers a level of pressure or dampens a pressure spike in the body conduit.

This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder. The compounds may bind to and antagonize receptor α_2B, α_1B or α_2A. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption, or to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. The compounds may also be used to treat diseases or conditions that are expected to be responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular, renal disorders or type 2 diabetes is particularly described.

Methods of administering and pharmaceutical compositions of a biphenyl sulfonamide compound which is a dual angiotensin and endothelin receptor antagonist are disclosed for treating diseases.

The present invention relates to methods of treating subjects suffering from pre-hypertension or hypertension by administering to a subject in need of treatment thereof a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting compound or salt thereof.

The invention discloses functional nutritional blend oil and a preparation method thereof, and belongs to the field of healthy blend oil. The functional nutritional blend oil is formed by blending the following components in percentage by weight: 50 to 92 percent of rice oil serving as a main raw material, 8 to 50 percent of one or more other edible vegetable oils, 0.5 to 1.2 percent of octacosanol, and 0.6 to 1 percent of resveratrol. The other edible vegetable oils are one or more of safflower seed oil, corn oil, soybean oil, olive oil, linseed oil, sunflower seed oil and peanut oil. The invention solves the problems that the conventional edible oil is single in nutrient and unbalanced in content and lacks functional components, and provides the edible vegetable blend oil which is in accordance with an optimal proportion of multiple unsaturated fatty acids such as omega-6 (linoleic acid) and omega-3 (linolenic acid) recommended by Chinese Society of Nutrition and is functional and stable.

The invention discloses a brand-new oral solid medicinal composition. The medicinal composition is an oral preparation prepared from hydrochlorothiazide, levamlodipine, valsartan and pharmaceutically acceptable auxiliaries, and the oral preparation comprises but is not limited to tablets or capsules. The composition comprises the following raw materials in parts by weight: 5-25 parts of the hydrochlorothiazide, 2.5-5 parts of the levamlodipine, 80-160 parts of the valsartan, 40-120 parts of microcrystalline cellulose, 30-90 parts of compressible starch, 5-25 parts of cross-linked sodium carboxymethylcellulose, 3-8 parts of silicon dioxide and 1-2 parts of stearic acid. The medicinal composition disclosed by the invention has the advantages of scientific and reasonable prescription, low auxiliary content and high bioavailability, and is a first choice of medicine for treating hypertension.

The invention discloses nutrient food for a sub healthy group. The nutrient food comprises oat flour, isolated soybean protein, flaxseeds, broccoli, cherry tomatoes, okras, coconuts, pawpaw, mangoes, noni fruits, oat dietary fibers, fructose-oligosaccharide, spiral seaweeds, vine tea, green tea, plant comprehensive ferment, L-carnitine, taurine, octacosanol, vitamin B1, vitamin B2 and nicotinic acid. The nutrient food can solve the problem that an existing sub health conditioning health product is single in nutrient component and fuzzy in suitable people; total-nutrient vegetable food which is convenient to eat and good in mouthfeel is specially designed according to the factors of daily routine, a body condition and the like of the sub health conditioning health product suitable people, so that required nutrients of the suitable people can be quickly compensated in a balanced manner. The nutrient food is beneficial to guaranteeing the special nutrient needs of the people, so that the quality and the acceptability of the product are guaranteed, and the health condition of the target people is finally improved.

The invention provides a camellia nitidissima milk tea with the health care functions of blood pressure lowering, blood lipid lowering and blood sugar lowering. According to the technical scheme of the invention, the formula of the milk tea comprises, by weight: 20-40 parts of camellia nitidissima, 5-15 parts of tea leaves, 20-50 parts of skim milk powder, 5-15 parts of xylitol, 0.05-0.5 parts of potassium sorbate, and 200-400 parts of water. With fresh, sweet and mellow tastes, the camellia nitidissima milk tea of the invention has the health care functions of lowering blood pressure, blood lipid and blood sugar, and is suitable for patients with high blood pressure, high blood lipid and high blood sugar as well as for auxiliary health care of vast customers in daily food.

The invention relates to a benzothiazole derivative, a preparation method and an application thereof, wherein the benzothiazole derivative is 2-m-aniline benzothiazole-1H-pyrazole-3-formamide, and the structural formula of the benzothiazole derivative is shown in the description. The benzothiazole derivative disclosed by the invention can accelerate the growth of saccharomycetes, strengthen the metabolic activity of the saccharomycetes, obviously reduce the plasma triglyceride, the total cholesterol and the high-density lipoprotein of C57 BL/6J mice fed with high-fat feedstuff, reduce the systolic pressure and the diastolic pressure of model mice, reduce the fasting blood glucose of the model mice, improve the sugar tolerance of the mice, affect the expression of SIRT1 and relevant genes (FOXO1, P53, PPAB gamma and PGC-1 alpha), and obviously improve the sugar and fat metabolism of diabetic model mice. Therefore, the benzothiazole derivative can be applied to preparing medicines for preventing and treating diabetes mellitus and complications of the diabetes mellitus.

The invention discloses a novel oral solid medicinal composition. The novel oral solid medicinal composition is an oral preparation prepared from hydrochlorothiazide, levamlodipine besylate, candesartan cilexetil and pharmaceutically acceptable auxiliary materials. The novel oral solid medicinal composition can be processed into tablets, capsules and the like. Specifically, the novel oral solid medicinal composition comprises: be weight, 5 to 25 parts of hydrochlorothiazide, 2.5 to 5 parts of levamlodipine besylate, 4 to 20 parts of candesartan cilexetil, 30 to 60 parts of microcrystalline cellulose, 30 to 60 parts of compressible starch, 30 to 50 parts of crosslinked polyvinylpyrrolidone, 1 to 2 parts of silica and 0.5 to 2 parts of magnesium stearate. The novel oral solid medicinal composition has a scientific and reasonable formula, low auxiliary material content and high bioavailability. Therefore, the novel oral solid medicinal composition is a drug of first choice for the treatment of hypertension.

An anti-diabetic or anti-hypertensive fish protein hydrolysate is provided, in which the fish is of the genus Salmo or Oncorhynchus, and wherein the fish protein is hydrolysed by a metalloendopeptidase obtainable from Bacillus amyloliquefaciens. Methods of making and methods for using such fish protein hydrolysates are also provided.

The invention discloses a health care product for cleaning colon and promoting defecation, and eliminating toxin and beautifying skin and a preparation method of same. The health care product is mainly prepared from the following raw materials by the following steps: smashing cleaned and baked inflatedfruit senna seed, baked flower, and baked inflatedfruit senna stem leaf by an ultra-micro pulverizer into 360 to 450 meshes, then airing and sterilizing the obtained product to obtain inflatedfruit senna powder; and filling the inflatedfruit senna powder into capsules to prepare hard and soft capsules for eliminating toxin and beautifying skin. The Chinese herbal medicaments are organically combined, perform treatment based on the syndrome differentiation, are mutually supported, and have the effects of eliminating toxin and beautifying skin, lubricating bowel and promoting defecation, eliminating halitosis and clearing toxicants accumulated at gastrointestinal tracts, so as to achieve the purposes of cleaning colon and promoting defecation, and treating constipation. More importantly, the health care product is very gentle and can solve constipation without causing diarrhea. Meanwhile, the product is selected from natural raw materials which are free from pesticide residue pollution, and has no preservatives to achieve the effects of clearing heat and refreshing, cooling down and cleaning colon, repressing the liver and improving eyesight, resisting cancer and aging, and strengthening the immunity for a patient; and furthermore, the product has no toxin or side effect after being taken for a long time and improves the body immunity.

The invention discloses a Fumailing capsule for preventing and treating slow arrhythmia and a preparation method of the Fumailing capsule. The capsule is prepared from the following traditional Chinese medicinal materials: 8-12g of ephedra, 8-10g of aconite roots, 2-4g of asarum herb, 25-32g of prepared liquorice roots, 10-14g of radix ginseng, 10-12g of ramulus cinnamomi, 25-32g of prepared rhizome of rehmannia, 8-10g of bretschneider pear pericarp, 10-12g of carthamus tinctorius, 8-10g of fragrant solomonseal rhizome, 10-12g of fossil fragment, 10-14g of curcuma roots, 18-22g of astragalus mongholicus, 26-32g of salvia miltiorrhiza, 8-10g of ginger and 26-30g of Chinese dates. Fumailing particles prepared from the traditional Chinese medicinal materials such as the ephedra, the aconite roots and the asarum herb are used for preventing and treating the slow arrhythmia; the materials are easy to obtain; the preparation method is simple; and the Fumailing capsule has a significant treatment effect on the arrhythmia, takes effect quickly, is safe to use and has no toxic or side effects, and can improve a sinoatrial node function and prevent and treat sinoatrial node hypofunction caused by various reasons.

The invention discloses a gynura divaricata (L.) DC jelly, and provides a jelly with health functions of reducing blood pressure, blood fat and blood sugar and the like. The gynura divaricata (L.) DC jelly comprises the following components in percentage by weight: 10 to 30 percent of gynura divaricata (L.) DC extract, 8 to 20 percent of xylitol, 0.5 to 0.7 percent of agar, 0.15 percent of citric acid and the balance water, wherein the gynura divaricata (L.) DC extract is prepared from gynura divaricata (L.) DC by a Chinese medicine decocting method. The gynura divaricata (L.) DC jelly has effects of clearing heat and releasing toxin, has the health functions of reducing blood pressure, blood fat and blood sugar and the like, and is suitable for auxiliary health care of daily foods for patients suffering from high blood pressure, high blood fat, high blood sugar and the like.

The invention provides kelp micro powder lotus seed paste with health care function of lowering blood pressure, blood lipid and blood sugar. The lotus seed paste comprises the following components by weight percent: 40-70% of lotus seed micro powder, 10-15% of xylitol, 10-20% of vegetable oil, 10-20% of kelp micro powder, 0.5-2% of ginger juice and 0.5-2% of edible alcohol, wherein the lotus seedmicro powder and the kelp micro powder are made by an ultra-micro pulverizer and have grain size of 0.1-10mu m. The lotus seed paste has fresh, sweet and mellow taste, has the health care function oflowering blood pressure, blood lipid and blood sugar and is suitable to serve as an auxiliary health care product of the daily food of the patients with hypertension, hyperlipidemia, hyperglycemia and the like or vast consumers.

The invention discloses a fully-novel oral solid pharmaceutical composition. The pharmaceutical composition is an oral preparation prepared from hydrochlorothiazide, L-amlodipine, telmisartan and pharmaceutically acceptable auxiliary materials; and the oral preparation includes but is not limited to tablets or capsules. The composition is prepared from the following raw materials in parts by weight: 5-25 parts of hydrochlorothiazide, 2.5-5 parts of L-amlodipine, 20-80 parts of telmisartan, 0.1-0.5 part of sodium bicarbonate, 40-120 parts of microcrystalline cellulose, 20-60 parts of hydroxypropyl cellulose, 30-100 parts of lactose, 30-90 parts of compressible starch, 2-5 parts of low-substituted hydroxypropyl cellulose, 10-45 parts of crosslinked polyvinylpyrrolidone and 1-2 parts of magnesium stearate. The pharmaceutical composition disclosed by the invention has the advantages of reasonable and scientific prescription, low auxiliary material content and high bioavailability, and is a drug of first choice for treating hypertensive.

Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a reduction in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.

The invention discloses a compound traditional Chinese medicine for treating hypertension. The compound traditional Chinese medicine is prepared by the step of carrying out extraction separation on raw materials including uncaria rhynchophylla, ligusticum wallichii, angelica sinensis, rauvolfia verticillate and apocynum venetum with 0-75% ethanol and is prepared into a certain dosage form. The five drugs used together have the effects of calming liver wind and relieving dizziness, nourishing yin and invigorating pulse and are applied to patients suffering from yin deficiency and yang excess and venation stasis of hypertension symptoms. Pharmacodynamic studies show that the compound traditional Chinese medicine can obviously reduce the systolic pressure and the diastolic pressure of spontaneous hypertension and renal hypertension model animals and the antihypertensive effect is longlasting. Clinical research results show that the compound traditional Chinese medicine can effectively improve various traditional Chinese medicine symptoms of the patients suffering from yin deficiency and yang excess and venation stasis of hypertension and reduce the blood pressure of the patients without obvious adverse drug reaction. The compound traditional Chinese medicine can be prepared into a medically acceptable oral solid preparation such as a tablet, a capsule (a soft capsule or a hard capsule), granules and other dosage forms, is used for treating hypertension and is safe, effective and convenient to use.

The invention discloses a traditional Chinese medicine composition with the function of reducing blood pressure, as well as a preparation method thereof. The traditional Chinese medicine composition is prepared from perilla leaves, Apocynum venetum, rhizoma gastrodiae and uncaria according to a certain weight mixture ratio, and can be prepared to be any common orally taken medicament. The traditional Chinese medicine composition has the efficacy of reducing blood pressure and can be used for treating hypertension.

The invention discloses a brand-new oral solid pharmaceutical composition. The pharmaceutical composition is an oral preparation prepared from hydrochlorothiazide, l-amlodipine, olmesartan medoxomil and pharmaceutically acceptable auxiliary materials, and the oral preparation comprises but is not limited to tablets or capsules. The composition comprises the following raw materials in parts by weight: 5-25 parts of hydrochlorothiazide, 2.5-5 parts of l-amlodipine, 20-40 parts of olmesartan medoxomil, 40-120 parts of microcrystalline cellulose, 30-90 parts of pregelatinized starch, 15-40 parts of low-substituted hydroxypropyl cellulose, 10-45 parts of crosslinked polyvinylpyrrolidone, 3-8 parts of silica and 1-2 parts of magnesium stearate. The pharmaceutical composition disclosed by the invention has the advantages of scientific and reasonable prescription, low auxiliary material content and high bioavailability, and is a drug of first choice for treating hypertension.