97results about How to "Lower diastolic blood pressure" patented technology

This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and / or a neuronal disorder. The compounds may bind to and antagonize receptor α2B, α1B or α2A. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and / or (ii) promote renal blood flow and / or (iii) decrease or inhibit sodium reabsorption, or to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. The compounds may also be used to treat diseases or conditions that are expected to be responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular, renal disorders or type 2 diabetes is particularly described.

The invention provides a drug for rapidly treating hypertension. The drug is prepared from the following Chinese medicine materials: mother-of-pearl, chrysanthemum, herba lophatheri, ramuli umcariae cum uncis, mistletoe, rhizoma ligustici wallichii, folia mori, fructus viticis, dutchmanspipe root, magnet, notoginseng, radices cyathulae, herba leonuri, cortex eucommiae, rhizoma coptidis, clerodendron trichotomum thunb, selfheal, rhizoma gastrodiae, radices paeoniae alba, kendir, caulis polygoni multiflori, indian bread with hostwood, scutellaria, burdock root, semen cassiae torae, lotus leaf, flos sophorae and stigmata maydis. The drug uses traditional Chinese herbal medicines as raw materials and is prepared through a scientific formula and repeated validation of clinical test and meets the theory of traditional Chinese medicine; and the drug has the advantages that the drug has no toxicity and side effect, can stabilize blood pressure and effectively reduce diastolic pressure. The drug has good treatment effect on headache, dizziness, insomnia, tinnitus, finger numbness, ankylosis and other symptoms; therefore, the drug has good social benefits when widely popularized.

Methods of administering and pharmaceutical compositions of a biphenyl sulfonamide compound which is a dual angiotensin and endothelin receptor antagonist are disclosed for treating diseases.

Methods of administering and pharmaceutical compositions of a biphenyl sulfonamide compound which is a dual angiotensin and endothelin receptor antagonist are disclosed for treating diseases.

This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and / or a neuronal disorder. The compounds may bind to and antagonize receptor α2B, α1B orα2A. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and / or (ii) promote renal blood flow and / or (iii) decrease or inhibit sodium reabsorption, or to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. The compounds may also be used to treat diseases or conditions that are expected to be responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular, renal disorders or type 2 diabetes is particularly described.

The present invention relates to the use of betaine in functional products, such as pharmaceutical products, functional food products, food supplements, natural products and the like. In particular, the present invention relates to the use of betaine for the manufacture of functional products having blood pressure lowering effects, and to methods for lowering blood pressure.

The invention relates to a method for preparing an angiotensin converting enzyme (ACE) inhibitory peptide from sea cucumber. The method comprises the following steps of: de-salting and softening raw materials including fresh sea cucumber, or dry sea cucumber, or soaked sea cucumber, or high-pressure sea cucumber; after preparing slurry, adding water into the slurry; heating the slurry to kill microorganisms; after cooling the slurry, adding composite proteolytic enzyme or flavor proteolytic enzyme into the slurry to perform enzymolysis; killing enzymes; after cooling, centrifuging the product to remove undissolved substances; filtering the supernatant fluid in a pipe; filtering the filtrate with a 3,000 Dalton organic membrane to trap and classify; and performing nano filtration and drying on the trapped liquid which is less than 3,000 Dalton in mass to obtain the ACE inhibitory peptide. A zymolytic technical scheme is optimized; and due to the separation and extraction technology of pipe filtration, ultrafiltration and nano filtration, the extraction efficiency is high, and the pressure-reducing effect of the obtained ACE inhibitory peptide is good. The method is reasonable in process, simple and convenient in operation and high in operability; and industrial production is easy to realize.

A Chinese medicine for treating hypertension is prepared from 12-15 Chinese-medicinal materials including Dragon's bone, oyster shell, sea-ear shell, yam, etc.

The invention discloses a health care product for cleaning colon and promoting defecation, and eliminating toxin and beautifying skin and a preparation method of same. The health care product is mainly prepared from the following raw materials by the following steps: smashing cleaned and baked inflatedfruit senna seed, baked flower, and baked inflatedfruit senna stem leaf by an ultra-micro pulverizer into 360 to 450 meshes, then airing and sterilizing the obtained product to obtain inflatedfruit senna powder; and filling the inflatedfruit senna powder into capsules to prepare hard and soft capsules for eliminating toxin and beautifying skin. The Chinese herbal medicaments are organically combined, perform treatment based on the syndrome differentiation, are mutually supported, and have the effects of eliminating toxin and beautifying skin, lubricating bowel and promoting defecation, eliminating halitosis and clearing toxicants accumulated at gastrointestinal tracts, so as to achieve the purposes of cleaning colon and promoting defecation, and treating constipation. More importantly, the health care product is very gentle and can solve constipation without causing diarrhea. Meanwhile, the product is selected from natural raw materials which are free from pesticide residue pollution, and has no preservatives to achieve the effects of clearing heat and refreshing, cooling down and cleaning colon, repressing the liver and improving eyesight, resisting cancer and aging, and strengthening the immunity for a patient; and furthermore, the product has no toxin or side effect after being taken for a long time and improves the body immunity.

The invention discloses a Chinese medicinal composition for preventing and treating diabetes and a preparation method thereof. The Chinese medicinal composition consists of the following components in parts by weight: 10-20 parts of vervain, 1-2 parts of typhonium giganteum, 10-20 parts of barley root, 10-20 parts of coptis root, 10-20 parts of black fungus, 10-20 parts of white fungus, 10-20 parts of sticky rice, 10-20 parts of barley rice, 10-20 parts of buckwheat, 5-50 parts of honey and 50-100 parts of vinegar. Natural animal and plant medicinal materials are taken as raw material sources, and diabetics syndrome and nephrotic syndrome are treated by using the comprehensive function of various Chinese medicinal components. As proved by acute toxicity test and long-term toxicity test, the Chinese medicinal composition is nontoxic to human body and good in medicinal effect and has the effects of improving the hypercoagulable state, improving blood fat, reducing blood sugar, dissolving thrombi, dredging microcirculation and improving the immunity of organisms.

The invention discloses a Fumailing capsule for preventing and treating slow arrhythmia and a preparation method of the Fumailing capsule. The capsule is prepared from the following traditional Chinese medicinal materials: 8-12g of ephedra, 8-10g of aconite roots, 2-4g of asarum herb, 25-32g of prepared liquorice roots, 10-14g of radix ginseng, 10-12g of ramulus cinnamomi, 25-32g of prepared rhizome of rehmannia, 8-10g of bretschneider pear pericarp, 10-12g of carthamus tinctorius, 8-10g of fragrant solomonseal rhizome, 10-12g of fossil fragment, 10-14g of curcuma roots, 18-22g of astragalus mongholicus, 26-32g of salvia miltiorrhiza, 8-10g of ginger and 26-30g of Chinese dates. Fumailing particles prepared from the traditional Chinese medicinal materials such as the ephedra, the aconite roots and the asarum herb are used for preventing and treating the slow arrhythmia; the materials are easy to obtain; the preparation method is simple; and the Fumailing capsule has a significant treatment effect on the arrhythmia, takes effect quickly, is safe to use and has no toxic or side effects, and can improve a sinoatrial node function and prevent and treat sinoatrial node hypofunction caused by various reasons.

The invention discloses a compound traditional Chinese medicine for treating hypertension. The compound traditional Chinese medicine is prepared by the step of carrying out extraction separation on raw materials including uncaria rhynchophylla, ligusticum wallichii, angelica sinensis, rauvolfia verticillate and apocynum venetum with 0-75% ethanol and is prepared into a certain dosage form. The five drugs used together have the effects of calming liver wind and relieving dizziness, nourishing yin and invigorating pulse and are applied to patients suffering from yin deficiency and yang excess and venation stasis of hypertension symptoms. Pharmacodynamic studies show that the compound traditional Chinese medicine can obviously reduce the systolic pressure and the diastolic pressure of spontaneous hypertension and renal hypertension model animals and the antihypertensive effect is longlasting. Clinical research results show that the compound traditional Chinese medicine can effectively improve various traditional Chinese medicine symptoms of the patients suffering from yin deficiency and yang excess and venation stasis of hypertension and reduce the blood pressure of the patients without obvious adverse drug reaction. The compound traditional Chinese medicine can be prepared into a medically acceptable oral solid preparation such as a tablet, a capsule (a soft capsule or a hard capsule), granules and other dosage forms, is used for treating hypertension and is safe, effective and convenient to use.

The invention discloses a traditional Chinese medicine composition with the function of reducing blood pressure, as well as a preparation method thereof. The traditional Chinese medicine composition is prepared from perilla leaves, Apocynum venetum, rhizoma gastrodiae and uncaria according to a certain weight mixture ratio, and can be prepared to be any common orally taken medicament. The traditional Chinese medicine composition has the efficacy of reducing blood pressure and can be used for treating hypertension.

The invention belongs to the technical field of medicine and particularly relates to traditional Chinese medicine for treating liver and kidney yin deficiency and qi and blood deficiency type hypertension. The traditional Chinese medicine for treating liver and kidney yin deficiency and qi and blood deficiency type hypertension is prepared from, by weight, 11-19 parts of Chinese wolfberry fruits, 11-19 parts of eclipta, 11-19 parts of mulberries, 6-14 parts of black sesame, 11-19 parts of prepared rehmannia roots, 11-19 parts of astragalus membranaceus, 11-19 parts of rhizoma atractylodis macrocephalae, 11-19 parts of codonopsis pilosula, 11-19 parts of angelica sinensis, 11-19 parts of radix paeoniae alba, 11-19 parts of concha haliotidis, 6-14 parts of tribulus terrestris, 6-14 parts of apocynum venetum, 6-14 parts of gastrodia elata, 6-14 parts of uncaria, 5-13 parts of periostracum cicada, 5-13 parts of folium mori, 5-13 parts of chrysanthemums, 11-19 parts of tuber fleeceflower stems, 6-14 parts of cortex albiziae, 6-14 parts of wild jujube seeds, 4-8 parts of fructus evodiae and 4-8 parts of liquorice. The traditional Chinese medicine for treating liver and kidney yin deficiency and qi and blood deficiency type hypertension can obviously reduce systolic pressure, diastolic pressure and mean arterial pressure of patients while western medicine reduces pressure basically, obviously avoid the clinical symptoms of patients like headache, dizziness, insomnia, tinnitus and annoyance and irritability, and improve the quality of life of patients.

The invention discloses a method for preparing functional oligomerization xylitol, which belongs to the technical field. The preparation method comprises that common oligomerization xylose is taken as a raw material; and under the action of a catalyst, by a hydrogenation reaction, the functional oligomerization xylitol is prepared. The method has the advantages of improving product physical-chemical property and guarantee period of the oligomerization xylose, modifying strengthened physiological function of a product structure functional group, and effectively improving poor conditions of the prior material oligomerization xylose, wherein the process equipment and technical line are relatively mature, and easy to operate; moreover, on the basis of keeping basic physiological properties of the prior oligomerization xylose, the prepared functional oligomerization xylitol has higher sugariness and more pure sweetness, and tastes soft, and the liquid product is transparent.

The invention discloses a furocoumarin compound, and a preparation method and medical application thereof. The furocoumarin compound is a novel compound having vasodilating activity; and the compoundis obtained by structurally modifying and optimizing the natural product xanthotoxin to improve its physical and chemical properties, pharmacological activity and drug-forming properties. The preparation method for the furocoumarin compound provided by the invention has the advantages that raw materials are widely available, reaction conditions are mild, reaction process is simple to operate and reagents used therein are cheap and easily available. The prepared novel furocoumarin compound has effect similar to the effect of xanthotoxin; the study results of isolated vascular ring tension indicate that the relaxation effect of the novel furocoumarin compound on the aortic vessels of rat is stronger than the relaxation effect of xanthotoxin and the positive control drug nifedipine; the cytotoxicity of the novel furocoumarin compound on normal liver cells L02 in vitro is significantly lower than the cytotoxicity of nifedipine; and the results of in-vivo antihypertensive studies show thatthe antihypertensive effect of the novel furocoumarin compound is stronger than the antihypertensive effect of xanthotoxin and nifedipine, so the novel furocoumarin compound can be applied to the preparation of antihypertensive drugs.

The present invention relates to a Chinese medicine with the functions of clearing the liver, drawing fire, calming liver and extinguishing wind for curing essential hypertension. It is made up by using 7 Chinese medicinal materials of prunella spike, uncaria stem and thorn, earthworm, fetid cassia seed, scutellaria root, chinaberry root bark and lotus embryo through a certain preparation process, and can be made into the Chinese medicine capsule or table preparation.

The invention provides a weight-losing product. The weight-losing product is characterized in that the weight-losing product is a beverage and contains conjugated linoleic acid, hydroxyl citric acid, white granulated sugar, citric acid, sodium citrate, vitamin C, a sweetening agent and pure water. The weight-losing product has good weight-losing effects and small side effects, and has a very wide market prospect.

The coptis chinensis health drink is prepared by the following methods: washing and airing coptis chinensis, liquorice and hawthorn and then preparing the components into powder; mixing the powdered coptis chinensis, liquorice and hawthorn according to the proportion of 1-3:3-6:4-7; adding water and stirring the mixture to prepare mixed solution; heating the fully stirred solution to boiling point; purifying the mixed solution and filtering residues in the mixed solution; and packaging the filter liquor to obtain the coptis chinensis health drink after collecting and purifying the filter liquor;Wherein when water is added to the powdered mixture of coptis chinensis, liquorice and hawthorn, quality and volume ratio of coptis chinensis to water is 1-2:2-30g / ml.In the invention, with the medical principle of liquorice, bitter taste inherently defined in the bias of the coptis chinensis is fundamentally eliminated and no additional sugar is needed, so that the drink can be provided with natural sweet taste; in addition, the drink has the functions of clearing heat and detoxicating, eliminating dampness and reducing pathogenic fire, relieving summer heat, preventing diarrhea and dysentery, tonifying spleen and tonifying qi, eliminating phlegm relieving coughs, relieving pain fast, helping digest food and reducing phlegm, promoting the circulation of qi and removing blood stagnation and helping digest backup of greasy meat.

The invention discloses a pure Chinese medicine preparation for treating hypertension, which is prepared by the following basic medicines by weight: 20-40 parts of Ligusticum chuanxiong Hort, 20-40 parts of the root of red-rooted salvia, 5-15 parts of Polygonum multiflorum, 20-40 parts of Angelica sinensis, 5-15 parts of red flower, 20-40 parts of devilpepper, 20-40 parts of the root of bidentate achyranthes, 10-30 parts of Radix Ophiopogonis and 10-30 parts of Schisandra chinensis. The pure Chinese medicine preparation is used for treating hypertension, treats symptoms and source of disease simultaneously, uses drug interactions and mutual supplementation of the medicines, and has the advantages of reducing blood pressure and stabilizing blood pressure, improving blood viscosity and microcirculation flow, improving lipid metabolism of blood vessel walls, resisting artherosclerosis, improving blood flow of brain and heart, reducing rate of cerebral apoplexy and heart accidents and reducing heart death rate and disability rate. Proved by clinical experiments, effective rate of the pure Chinese medicine preparation is 93.6%. According to pharmacology experiments, the pure Chinese medicine preparation has the functions of reducing blood pressure and lipid and improving elasticity of blood vessel walls.

The invention relates to an antihypertensive pharmaceutical composition as well as a preparation method and application thereof, and belongs to the technical field of antihypertensive drugs. The pharmaceutical composition disclosed by the invention is prepared from isorhynchophylline and sinapine thiocyanate. The pharmaceutical composition is low in price, easy to obtain, definite in curative effect, low in toxic and side effect and capable of preventing and treating hypertension in a multi-target mode.

The invention relates to a medicine for treating hypertension. The medicine consists of the following total 11 medicine components: 10g of gastrodia elata, 10g of chrysanthemum, 10g of radix paeoniae alba, 10g of oyster, 10g of uncaria, 10g of motherwort, 15g of cassia occidentalis, 6g of scorpio, 10g of ligusticum wallichii, 12g of rehmannia root and 10g of radix bupleuri, wherein a grinding surface is prepared into a pill by virtue of a water method. The medicine especially has a significant effect on treating headache, palpitation and insomnia, dysphoria and irritability, weakness and inertia, tinnitus or front heaviness, high blood pressure or instability caused by hypertension represented as liver heat and yang hyperactivity, liver depression of the fire, oxygen activity and hyperactivity of liver and yang; in the prescription, the scorpio functions as activating meridians to stop pain; the semen cassiae is capable of relaxing the bowls to eliminate heat; the rehmannia root is capable of nourishing internal organs. The prescription can be used for achieving a clinical treatment effective rate of 100%, relieving diseases on that day and curing the diseases within a treatment course, namely seven days, without relapse, and the prescription is stable and reliable. The prescription achieves a treatment effect of treating both symptoms and root causes; moreover, raw materials can be purchased easily; the prescription is low in cost and simple in production process, and is an ideal medicine for treating hypertension.

The invention relates to a traditional Chinese medicine composition for controlling hypertension and protecting hypertension target organ against damage, and the traditional Chinese medicine composition is prepared from the following raw material medicines: rhizoma chuanxiong, bupleurum, coptis root, notopterygium, radix saposhnikoviae, prunella spike, cyathula root, polygonatum, concha haliotidis, fried radix scutellariae and herba taxilli. The invention also provides the application of the traditional Chinese medicine composition. The advantages of the traditional Chinese medicine composition are that: the traditional Chinese medicine composition can significantly improve blood pressure indexes of pre hypertension patients, significantly reduces systolic pressure and diastolic pressure level of spontaneously hypertensive rats (SHR), and more important, has significant protective effect against target organ damage in heart, brain and kidney. The traditional Chinese medicine composition used in hypertension early intervention can not only delay the process of hypertension, more important, has the protective effect against target organ damage in hypertension, can be clinically and widely popularized, delays target organ damage, and improves the life quality of the patients.

The present invention relates to one kind of medicine composition for treating hypertension, and features that the medicine composition is prepared with medicine materials including gastrodia tuber, sealwort, fried eucommia bark, cassia obtusifolia, madder, white puncture vine, oriental water plantain, water melon seed and atenolol in certain weight proportion. Compared with singly Western medicine, the medicine composition of the present invention has the advantages of stable blood pressure lowering, effective lowering of the diastolic pressure and effect of lowering systolic pressure singly.

The invention belongs to the technical field of medicine and particularly relates to traditional Chinese medicine for treating liver and kidney yin deficiency and blood-stasis orifice blocking type hypertension. The traditional Chinese medicine for treating liver and kidney yin deficiency and blood-stasis orifice blocking type hypertension is prepared from, by weight, 11-19 parts of Chinese wolfberry fruits, 11-19 parts of eclipta, 11-19 parts of mulberries, 6-14 parts of black sesame, 11-19 parts of prepared rehmannia roots, 11-19 parts of concha haliotidis, 6-14 parts of tribulus terrestris, 6-14 parts of apocynum venetum, 6-14 parts of gastrodia elata, 6-14 parts of uncaria, 6-14 parts of common peony roots, 6-14 parts of roots of red-rooted salvia, 6-14 parts of ligusticum wallichii, 6-14 parts of peach kernels, 6-14 parts of safflower carthamus, 5-13 parts of periostracum cicada, 5-13 parts of folium mori, 5-13 parts of chrysanthemums, 11-19 parts of tuber fleeceflower stems, 6-14 parts of cortex albiziae, 6-14 parts of wild jujube seeds, 4-8 parts of fructus evodiae and 4-8 parts of liquorice. The traditional Chinese medicine for treating liver and kidney yin deficiency and blood-stasis orifice blocking type hypertension can obviously reduce systolic pressure, diastolic pressure and mean arterial pressure of patients while western medicine reduces pressure basically, obviously avoid the clinical symptoms of patients like headache, dizziness, insomnia, tinnitus and annoyance and irritability, and improve the quality of life of patients.

The invention discloses a Chinese medicinal preparation for treating and preventing hypertension, and the Chinese medicinal preparation comprises the following components in parts by weight: 0.5 to 5 parts of red-rooted salvia root, 0.3 to 3 parts of cowherb seed, 0.3 to 3 parts of Chinese angelica, and 0.2 to 3 parts of uncaria rhynchophylla. The Chinese medicinal preparation provided by the invention is scientific and reasonable, accords with traditional Chinese medicine theory, has exact drug effect in treating and preventing hypertension by approval of modern pharmacology and toxicology tests, does not have remarkable toxic or side effect, and is safe in clinical administration. Furthermore, ethanol extraction and water extraction processes are respectively adopted in the preparation method of the Chinese medicinal preparation according to physicochemical properties of effective components of each drug material, so that the content of the effective components can be guaranteed, impurities can be reduced, the dose can be reduced, and batch production can be facilitated due to low production cost.

The invention discloses a pure traditional Chinese medicine composition for controlling hypertension. Aiming at pathogenesis of primary hypertension, a pure traditional Chinese medicine formula is used, the pure traditional Chinese medicine composition is different from the previous mode that traditional Chinese medicines are matched with western medicines for adjuvant therapy, and meanwhile, rawmaterials extracted from simple food are selected so that the pure traditional Chinese medicine composition can be suitable for any crowd; and the active ingredients in the medicinal materials generate a synergistic effect to mutually enhance and improve the functions of circulation of vertebral artery and brain blood, peripheral blood and stomach blood, relieve cerebral and peripheral vasospasm,promote diuresis, reduce blood pressure and reduce diastolic pressure, so that the effect of treating primary hypertension is achieved.

The invention discloses potassium-enriched small wheat peptide with a blood pressure lowering effect and a preparation method thereof, and belongs to the field of biotechnology. The potassium-enriched small wheat peptide is characterized by being prepared from wheat protein as a starting material through chelating enzymolysis, performing ultrafiltration, resin column purification, concentrated under reduced pressure, and spray drying. The wheat protein can be used as a main raw material, the other raw materials and auxiliary materials are added, and according to the conventional preparation method, a series of corresponding preparations are prepared. A synchronous method of enzymolysis and enrichment, adopted by the invention, has the characteristics of high enrichment efficiency and high element organizing efficiency; the potassium-enriched small wheat peptide can significantly lower high blood pressure.

Provided herein are pharmaceutical compositions that are useful for the treatment of hypertension comprising an angiotensin II receptor blocker, a diuretic, and a calcium channel blocker.

The invention provides a weight reducing product. The weight reducing product is characterized by being blend oil which contains conjugated linoleic acid, hydroxyl citric acid and one or two kinds of edible oil selected from sesame oil, olive oil, soybean oil and sunflower seed oil. The weight reducing product is good in weight reducing effect and little in side effect, and has a very broad market prospect.