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Chinese medicine for curing primary hypertension and its preparation method

A technology of essential hypertension and drugs, which is applied in the direction of drug combinations, pharmaceutical formulas, cardiovascular system diseases, etc., can solve the needs of patients who cannot meet the needs of treatment, patients are prone to drug resistance to multiple drugs, contraindications and There are many side effects and other problems, and the effect of reducing plasma renin activity and angiotensin II level, dilating renal artery, and increasing renal artery blood flow is achieved.

Inactive Publication Date: 2006-11-08
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these drugs have many contraindications and side effects, and patients are prone to drug resistance to multiple drugs, among which orthostatic hypotension is a common clinical side effect
In recent years, more drugs for the treatment of hypertension by traditional Chinese medicine have been developed and developed, but few have significant curative effects, and with the sharp increase in the number of patients with hypertension, they are far from meeting the needs of patients for treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Take 1100 g of Prunella vulgaris, add 6 times the amount of 90% ethanol to reflux extraction for 3 times, each time for 1.5 hours, combine the ethanol extracts, filter, recover ethanol, and dry under reduced pressure to obtain the Prunella vulgaris extract;

[0022] (2) Take 1250g of Uncaria chinensis, 450g of bitter wood, and 400g of lotus seed heart, grind them into coarse powder, add 9 times the amount of 80% ethanol, heat and reflux to extract twice, the first time is 2.5 hours, the second time is 1.5 hours, combined alcohol extraction Liquid, filtered, recovered ethanol and concentrated to a relative density of 1.10-1.15 (50°C), adjusted to pH 2-3 with dilute hydrochloric acid, allowed to stand, filtered, adjusted to neutral acid water, added ethanol to make the alcohol content reach 75 %, let it stand, filter, recover ethanol from the alcohol solution under reduced pressure and concentrate to a relative density of 1.30-1.35 (60°C), dry under reduced pressure to...

Embodiment 2

[0027] (1) Take 1200 g of Prunella vulgaris, add 10 times the amount of 80% ethanol to reflux extraction for 3 times, each time for 2 hours, combine the ethanol extracts, filter, recover ethanol, and dry under reduced pressure to obtain the Prunella vulgaris extract;

[0028] (2) Take 1350g of Uncaria chinensis, 500g of bitter wood, and 500g of lotus seed heart, grind them into coarse powder, add 8 times the amount of 90% ethanol, heat and reflux extraction for 3 times, the first time is 2 hours, and the second and third times are 1.5 hours , combine the alcohol extracts, filter, recover the ethanol and concentrate to a relative density of 1.10-1.15 (50°C), adjust the pH to 2-3 with dilute hydrochloric acid, let it stand, filter, adjust the acid water to neutral, add ethanol to make the containing The alcohol content reaches 80%, let it stand, filter, the alcohol solution is decompressed to recover ethanol and concentrated to a relative density of 130-1.35 (60°C), and dried und...

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Abstract

The present invention relates to a Chinese medicine with the functions of clearing the liver, drawing fire, calming liver and extinguishing wind for curing essential hypertension. It is made up by using 7 Chinese medicinal materials of prunella spike, uncaria stem and thorn, earthworm, fetid cassia seed, scutellaria root, chinaberry root bark and lotus embryo through a certain preparation process, and can be made into the Chinese medicine capsule or table preparation.

Description

technical field [0001] The invention relates to a medicine for treating essential hypertension, in particular to a Chinese patent medicine prepared from Chinese herbal medicine, and also relates to a preparation method of the medicine. Background technique [0002] Hypertension is a systemic disease of unknown cause, mainly manifested by elevated systemic arterial pressure. The main clinical manifestations are headache, dizziness, palpitation, insomnia, and fatigue. Patients in the advanced stage may show various clinical symptoms due to varying degrees of damage to organs such as the heart, brain, and kidneys. Its prevalence increases with age. [0003] In 1991, 950,356 adults over the age of 15 were surveyed in the sample survey of hypertension in China, including 274 sampled populations in 30 provinces, municipalities and autonomous regions (excluding Hong Kong and Macao). The prevalence of hypertension was found to be 11.29%, of which 5.14% were diagnosed with hyperte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/536A61K36/74A61K35/64A61K36/482A61K36/539A61K36/185A61K36/62A61P9/12A61K35/62
Inventor 张晴龙
Owner 张晴龙
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