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Chinese medicinal preparation for treating and preventing hypertension and preparation method thereof

A traditional Chinese medicine preparation and high blood pressure technology, which is applied in the field of medicine, can solve the problems of short duration of action, elevated blood potassium, azotemia, etc., and achieve the effects of low drug toxicity, improvement of dizziness symptoms, and reduction of arterial diastolic pressure Effect

Active Publication Date: 2013-04-17
苏州华测生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] The first generation of ACEI is represented by captopril, and its shortcoming is that the duration of action is short, and it is easy to cause elevated blood potassium and skin rashes; the second generation is represented by enalapril, which is prone to azotemia; the current third generation The research on the generation ACEI is very active, represented by ramipril, as well as trandolapril, lisinopril, benazepril and fosinopril, etc.

Method used

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  • Chinese medicinal preparation for treating and preventing hypertension and preparation method thereof
  • Chinese medicinal preparation for treating and preventing hypertension and preparation method thereof
  • Chinese medicinal preparation for treating and preventing hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Take 600 grams of Salvia miltiorrhiza, 300 grams of Wang Buliuxing, and 300 grams of angelica, add water to decoct twice, the first time 10 times the amount of water for 2 hours, the second time 8 times the amount of water for 1.5 hours, filter, combine the filtrate, Load the sample on AB-8 macroporous resin, elute with 1 times the column volume of water, discard the eluent, and elute with 4 times the column volume of 75% ethanol, recover the ethanol from the eluate, concentrate to the relative density at 50°C For 1.2, get Danshen, Wang Buliuxing and Angelica extract;

[0071] Get 240 grams of Uncaria, add 0.7 times the amount of 10% sodium bicarbonate and mix well, let it stand for 14 hours, and extract it with ethanol with a concentration of 75% (V / V), recycle the ethanol from the extract, and concentrate to a relative density of 50 ° C. For 1.15, get Uncaria extract;

[0072] Combine salvia miltiorrhiza, wangbuliuxing, angelica extract and Uncaria extract, add 32g o...

Embodiment 2

[0074] Take 900 grams of Salvia miltiorrhiza, 300 grams of Wang Buliuxing, 300 grams of Angelica sinensis, and 300 grams of Uncaria uncaria, and use 70% ethanol to reflux extract twice, the first time is 8 times the amount, 3 hours, the second time is 6 times the amount, After 2 hours, filter, combine the filtrates, recover ethanol until there is no alcohol smell, and obtain an alcohol extract; load the sample on AB-8 macroporous resin, elute with 1.5 times the column volume of water, and discard the eluent; Volume and concentration of 70% ethanol for elution, ethanol is recovered from the eluent, and the relative density is 1.30 when concentrated to 50°C, to obtain Danshen, Wangbuliuxing, Angelica and Uncaria extracts;

[0075] Add 120 g of starch, mix well, dry at 70°C until the water content is lower than 5%, pass through a No. 7 sieve, and pack into capsules to obtain 2000 capsules.

Embodiment 3

[0077] Take 300 grams of Salvia miltiorrhiza, 200 grams of Wang Buliuxing, 300 grams of Angelica sinensis, 200 grams of Uncaria uncariae, add 75% ethanol to reflux and extract twice, the first time is 8 times the amount, 3 hours, the second time is 6 times the amount, After 2 hours, filter, combine the filtrates, recover ethanol until there is no alcohol smell, and continue to concentrate until the relative density is 1.31 at 50°C to obtain the extracts of Danshen, Wangbuliuxing, Angelica and Uncaria;

[0078] Add 90 g of dextrin, mix well, granulate with a 24-mesh sieve, and dry at 70°C until the water content is lower than 5%, to obtain 120 g of granules.

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Abstract

The invention discloses a Chinese medicinal preparation for treating and preventing hypertension, and the Chinese medicinal preparation comprises the following components in parts by weight: 0.5 to 5 parts of red-rooted salvia root, 0.3 to 3 parts of cowherb seed, 0.3 to 3 parts of Chinese angelica, and 0.2 to 3 parts of uncaria rhynchophylla. The Chinese medicinal preparation provided by the invention is scientific and reasonable, accords with traditional Chinese medicine theory, has exact drug effect in treating and preventing hypertension by approval of modern pharmacology and toxicology tests, does not have remarkable toxic or side effect, and is safe in clinical administration. Furthermore, ethanol extraction and water extraction processes are respectively adopted in the preparation method of the Chinese medicinal preparation according to physicochemical properties of effective components of each drug material, so that the content of the effective components can be guaranteed, impurities can be reduced, the dose can be reduced, and batch production can be facilitated due to low production cost.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a traditional Chinese medicine preparation for treating and preventing hypertension. Background technique [0002] In recent years, with the continuous improvement of the living standards of the Chinese people and the growth of the elderly population, hypertension is becoming a common disease with a very high prevalence rate and has entered our lives. At present, there is no effective way to cure hypertension in the world. Once the disease is diagnosed, it will be accompanied by lifelong and cause many other related diseases. According to the World Health Organization (WHO) statistics on the death of various diseases in the world, the proportion of the death toll of cardiovascular and cerebrovascular diseases represented by hypertension will increase from 28.8% in 1997 to 36.0% in 2002, a high Blood pressure is seriously endangering human health. Therefore, the characteristics of "one-t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P9/12
Inventor 夏玉叶袁宁生闵旸
Owner 苏州华测生物技术有限公司
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