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Compound traditional Chinese medicine for treating hypertension

A compound traditional Chinese medicine, high blood pressure technology, applied in the field of medicine, can solve problems to be improved, etc.

Pending Publication Date: 2014-10-08
谭元生 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent ZL201010125992.2 authorized by the inventor of the present application also discloses a traditional Chinese medicine composition for treating hypertension, but the effect of the traditional Chinese medicine composition on nourishing yin, softening the liver and relieving wind, promoting blood circulation, dredging the meridian and stopping dizziness, and long-lasting drug effect is still not enough. Room for improvement

Method used

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  • Compound traditional Chinese medicine for treating hypertension
  • Compound traditional Chinese medicine for treating hypertension
  • Compound traditional Chinese medicine for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 2 parts of Uncaria, 1 part of Chuanxiong, and 1 part of Angelica, add water to decoct twice, first add 8 times the amount of water to soak for 30 minutes, decoct for 2 hours, and second time add 6 times the amount of water to decoct for 1.5 hours, Filtrate, combine the filtrates for later use, concentrate to a relative density of 1.30 (measured at 60° C.), dry and pulverize, add an appropriate amount of excipients, mix, granulate, sieve, and dry to obtain a pharmaceutical composition preparation in the form of granules.

Embodiment 2

[0016] The tablet form of embodiment 2 pharmaceutical composition of the present invention

[0017] Take 1.5 parts of Uncaria, 1 part of Chuanxiong, 1 part of Angelica, and 2 parts of Apocynum, add 75% ethanol to extract twice, add 6 times the amount for the first time to soak for 30 minutes, extract for 2 hours, and add 4 times the amount for the second time to extract After 1 hour, filter and combine the filtrates. After recovering ethanol, combine with the water-extracted filtrates, concentrate to a relative density of 1.30 (measured at 60°C), dry and pulverize, add an appropriate amount of auxiliary materials, mix well, and granulate. Tablet pressing, drying, promptly prepares the pharmaceutical composition preparation of tablet dosage form.

Embodiment 3

[0018] The capsule dosage form of embodiment 3 pharmaceutical compositions of the present invention

[0019] Take 0.5 parts of Uncaria, 1 part of Chuanxiong, 1 part of Angelica, 2 parts of Rauwolfia, and 3 parts of Apocynum, add 60% ethanol to extract twice, add 6 times the amount for the first time and soak for 30 minutes, extract for 2 hours, the second Add 4 times the amount to extract for 1 hour, filter, combine the filtrate, recover ethanol, combine with the water extraction filtrate, concentrate to a relative density of 1.30 (measured at 60°C), dry and pulverize, add an appropriate amount of auxiliary materials, mix well, and granulate. The prepared granules are packed into capsule shells to make capsules, that is, the pharmaceutical composition preparations in the form of capsules are made.

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PUM

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Abstract

The invention discloses a compound traditional Chinese medicine for treating hypertension. The compound traditional Chinese medicine is prepared by the step of carrying out extraction separation on raw materials including uncaria rhynchophylla, ligusticum wallichii, angelica sinensis, rauvolfia verticillate and apocynum venetum with 0-75% ethanol and is prepared into a certain dosage form. The five drugs used together have the effects of calming liver wind and relieving dizziness, nourishing yin and invigorating pulse and are applied to patients suffering from yin deficiency and yang excess and venation stasis of hypertension symptoms. Pharmacodynamic studies show that the compound traditional Chinese medicine can obviously reduce the systolic pressure and the diastolic pressure of spontaneous hypertension and renal hypertension model animals and the antihypertensive effect is longlasting. Clinical research results show that the compound traditional Chinese medicine can effectively improve various traditional Chinese medicine symptoms of the patients suffering from yin deficiency and yang excess and venation stasis of hypertension and reduce the blood pressure of the patients without obvious adverse drug reaction. The compound traditional Chinese medicine can be prepared into a medically acceptable oral solid preparation such as a tablet, a capsule (a soft capsule or a hard capsule), granules and other dosage forms, is used for treating hypertension and is safe, effective and convenient to use.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a compound traditional Chinese medicine for treating hypertension. Background technique [0002] Hypertension is a clinical syndrome characterized by elevated systemic arterial systolic blood pressure (SBP) and / or diastolic blood pressure (DBP). Its high disability rate and death rate have brought serious material and spiritual damage to social families. In my country, the prevalence rate of people over 15 years old is as high as 11.2%, and that of people over 60 years old is 43.7%. characteristics of medication. [0003] At present, the six major types of drugs used in the treatment of hypertension by western medicine are still the main antihypertensive drugs in clinical application. Most western medicines have certain side effects, such as propranolol and other beta-receptor blocking drugs, which cannot be taken by people with asthma, and if these drugs are taken in excess, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P9/12
Inventor 谭元生王宇红
Owner 谭元生
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