The invention discloses a therapeutic cold ointment for changing 'three signs positive' into negative of hepatitis B by food therapy and improving the immunity. The cold ointment of the invention is prepared by the medicinal materials of radix astragali, Gynostemma pentaphylla, radix paeoniae rubra, red sage root, lithospermum, Barbat Skullcap, Oldenlandia diffusa, Chinese Siphonostegia Herb, radix bupleuri, rhizoma pinelliae preparatum, toosendan fruit, herba epimedii, Polygonum cuspidatum, fresh common crapemyrtle root, hawthorn, radix aucklandiae, licorice root, fresh bonito stick, and Guiling jelly, etc. The cold ointment of the invention has the advantages and effects of rich raw materials, sealed decoction and steaming of cream, easy preparation of cold cream, convenient therapeutic taking, strong directing force and guiding force, good curative effect, no toxic and side effects, 100 percent of total effective rate in the clinical treatment of the hepatitis B with 'three signs positive' and fills the gap of the subject field of changing 'three signs positive' into negative of hepatitis B by food therapy, which is an innovative progress of the study of clinical therapeutic medicinal culture to human liver diseases at present.