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Polypeptide with uric acid-lowering effect, composition, compound preparation, preparation method and application

A composite preparation, a technology for lowering uric acid, which is applied in the field of biomedicine to achieve a good effect of lowering uric acid

Active Publication Date: 2021-11-23
中食都庆(山东)生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of effective ingredients for lowering uric acid obtained from natural raw materials of animals and plants

Method used

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  • Polypeptide with uric acid-lowering effect, composition, compound preparation, preparation method and application
  • Polypeptide with uric acid-lowering effect, composition, compound preparation, preparation method and application
  • Polypeptide with uric acid-lowering effect, composition, compound preparation, preparation method and application

Examples

Experimental program
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Effect test

preparation example Construction

[0041] The present invention also provides the preparation method of the bonito collagen peptide described in the above scheme, comprising the following steps:

[0042] 1) Mix bonito flakes with water, and keep warm at 50-55°C for 0.5-1.5 hours to obtain the mixture;

[0043] 2) After adjusting the pH value of the mixture to 6.5-7.5, mix it with papain, and enzymolyze it at 58-62°C for 2.5-3.5 hours to obtain an enzymolysis solution; the mass parts of skipjack meat is 100 parts In total, the mass parts of the papain are 2.5 to 3.5 parts;

[0044] 3) adjusting the pH value of the enzymolysis solution to 4.8-5.2, and inactivating the enzyme at 105-115° C. for 3-8 minutes to obtain an enzyme-inactivating solution;

[0045] 4) Mix the enzyme inactivating solution with activated carbon, heat it at 55-60°C for 0.5-1.5 hours, filter it through a 30000Da ceramic membrane and a 1Kd organic membrane in turn, collect the filtrate, and freeze-dry the filtrate to obtain bonito collagen pe...

Embodiment 1

[0059] The preparation method of embodiment 1 skipjack protein peptide

[0060] 1. Take the frozen skipjack out of the freezer, wash it 3 times with deionized water and soak it to defrost. Grind the bonito flakes using a meat grinder to obtain minced bonito flakes.

[0061] 2. Weigh 100 kg of the bonito flakes obtained in step 1, add 200 kg of deionized water and stir the solution evenly, heat up to 55° C., and keep it warm for 1 hour to obtain bonito flakes.

[0062] 3. Adjust the pH of the skipjack minced meat in step 2 to 7 with 1M NaOH, and raise the temperature to 60° C., add 3% papain (3 kg), and perform enzymatic hydrolysis for 3 hours to obtain an enzymatic hydrolysis solution.

[0063] 4. Adjust the pH value of the enzymolysis solution in step 3 to 5 with 1M HCl, raise the temperature to 110°C, and keep it for 5 minutes. , to inactivate the enzyme to obtain an inactivated enzyme solution.

[0064] 5. Cool down the enzyme-inactivating solution in step 4 to 55°C, add...

Embodiment 2

[0085] Example 2 A composite preparation prepared based on the bonito collagen peptide prepared in Example 1 (bonito collagen peptide compound)

[0086] The quality of each raw material is as follows: bonito collagen peptide 84kg, kudzu root powder 5kg, chrysanthemum powder 5kg, coix seed powder 3kg, galangal powder 3kg.

[0087] Preparation method (flow chart sees Figure 4 ) consists of the following steps:

[0088] 1) According to the order of bonito peptide, kudzu root powder, chrysanthemum powder, coix seed powder, and galangal powder, add the raw materials into the mixer and mix them thoroughly; pack them into bags to obtain the product, 8g per package.

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Abstract

The present invention provides polypeptides, compositions, compound preparations, preparation methods and applications with the effect of lowering uric acid, and belongs to the field of biomedicine technology. The polypeptides include the first polypeptide and / or the second polypeptide; the first polypeptide The amino acid sequence of the second polypeptide is shown in SEQ ID NO.1; the amino acid sequence of the second polypeptide is shown in SEQ ID NO.2. The invention provides a bonito collagen peptide; the bonito collagen peptide includes anserine, carnosine, a first polypeptide and a second polypeptide. The present invention also provides a composite preparation; the composite preparation includes bonito collagen peptide, kudzu root powder, chrysanthemum powder, coix seed powder and galangal powder. The polypeptide, composition and compound preparation of the present invention are derived from natural raw materials of animals and plants, and can effectively reduce uric acid.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to polypeptides, compositions, compound preparations, preparation methods and applications with uric acid-lowering effects. Background technique [0002] Uric acid is the main metabolite of birds and reptiles. It is slightly soluble in water and easily forms crystals. The product in normal human urine is mainly urea, with a small amount of uric acid. Under normal circumstances, there are about 1200mg of uric acid in the body, about 600mg is newly produced every day, and 600mg is excreted at the same time, which is in a balanced state. However, if there is too much uric acid in the body to excrete or the uric acid excretion mechanism degrades, the body will retain too much uric acid. When the blood uric acid concentration is greater than 7mg / DL, the body fluids will become acidic and affect the normal function of human cells. If left alone for a long time, it will cause gout. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06C07D233/64C12P21/06C07K1/34A23L33/18A23L33/00A61K38/08A61P19/06A61K36/9062A61K31/4172
CPCA23V2002/00A61K31/4172A61K36/287A61K36/488A61K36/8994A61K36/9062A61K38/00A23L33/00A23L33/18A61P19/06C07D233/64C07K1/34C07K7/06C12P21/06A23V2200/30A23V2250/55A61K2300/00
Inventor 张九勋张学军田明展张西平魏玮裴中立
Owner 中食都庆(山东)生物技术有限公司
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