Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polypeptide, composition and compound preparation with uric acid lowering effect, preparation method and application

A compound preparation and uric acid-lowering technology, applied in the field of biomedicine, to achieve a good effect of lowering uric acid

Active Publication Date: 2020-09-25
中食都庆(山东)生物技术有限公司
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of effective ingredients for lowering uric acid obtained from natural raw materials of animals and plants

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polypeptide, composition and compound preparation with uric acid lowering effect, preparation method and application
  • Polypeptide, composition and compound preparation with uric acid lowering effect, preparation method and application
  • Polypeptide, composition and compound preparation with uric acid lowering effect, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0041] The present invention also provides the preparation method of the bonito collagen peptide described in the above scheme, comprising the following steps:

[0042] 1) Mix bonito flakes with water, and keep warm at 50-55°C for 0.5-1.5 hours to obtain the mixture;

[0043] 2) After adjusting the pH value of the mixture to 6.5-7.5, mix it with papain, and enzymolyze it at 58-62°C for 2.5-3.5 hours to obtain an enzymatic solution; the mass parts of skipjack meat are 100 parts In total, the mass parts of the papain are 2.5 to 3.5 parts;

[0044] 3) adjusting the pH value of the enzymolysis solution to 4.8-5.2, and inactivating the enzyme at 105-115° C. for 3-8 minutes to obtain an enzyme-inactivating solution;

[0045] 4) Mix the enzyme-inactivating solution with activated carbon, heat it at 55-60°C for 0.5-1.5 hours, filter it through a 30000Da ceramic membrane and a 1Kd organic membrane in turn, collect the filtrate, and freeze-dry the filtrate to obtain bonito collagen pep...

Embodiment 1

[0059] The preparation method of embodiment 1 skipjack protein peptide

[0060] 1. Take the frozen skipjack out of the freezer, wash it 3 times with deionized water and soak it to defrost. Grind the bonito flakes using a meat grinder to obtain minced bonito flakes.

[0061] 2. Weigh 100 kg of the bonito flakes obtained in step 1, add 200 kg of deionized water and stir the solution evenly, heat up to 55° C., and keep it warm for 1 hour to obtain bonito flakes.

[0062] 3. Adjust the pH of the skipjack minced meat in step 2 to 7 with 1M NaOH, and raise the temperature to 60° C., add 3% papain (3 kg), and perform enzymatic hydrolysis for 3 hours to obtain an enzymatic hydrolysis solution.

[0063] 4. Adjust the pH value of the enzymolysis solution in step 3 to 5 with 1M HCl, raise the temperature to 110°C, and keep it for 5 minutes. , to inactivate the enzyme to obtain an inactivated enzyme solution.

[0064] 5. Cool down the enzyme-inactivating solution in step 4 to 55°C, add...

Embodiment 2

[0085] Example 2 A composite preparation prepared based on the bonito collagen peptide prepared in Example 1 (bonito collagen peptide compound)

[0086] The quality of each raw material is as follows: bonito collagen peptide 84kg, kudzu root powder 5kg, chrysanthemum powder 5kg, coix seed powder 3kg, galangal powder 3kg.

[0087] Preparation method (flow chart sees Figure 4 ) consists of the following steps:

[0088] 1) According to the order of bonito peptide, kudzu root powder, chrysanthemum powder, coix seed powder, and galangal powder, add the raw materials into the mixer and mix them thoroughly; pack them into bags to obtain the product, 8g per package.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a polypeptide, a composition and a compound preparation with uric acid lowering effect, a preparation method and application, and belongs to the technical field of biomedicine.The polypeptide comprises a first polypeptide and / or a second polypeptide; the amino acid sequence of the first polypeptide is shown in SEQ ID NO. 1; and the amino acid sequence of the second polypeptide is shown in SEQ ID NO.1. The invention provides a bonito collagen peptide; and the bonito collagen peptide comprises anserine, carnosine, the first polypeptide and the second polypeptide. The present invention also provides a compound preparation; and the compound preparation comprises bonito collagen peptide, kudzu root powder, chrysanthemum powder, coix seed powder and galangal powder. The polypeptide, composition and compound preparation of the invention are derived from natural raw materials of animals and plants, and uric acid can be effectively reduced.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to polypeptides, compositions, compound preparations, preparation methods and applications with uric acid-lowering effects. Background technique [0002] Uric acid is the main metabolite of birds and reptiles. It is slightly soluble in water and easily forms crystals. The product in normal human urine is mainly urea, with a small amount of uric acid. Under normal circumstances, there are about 1200mg of uric acid in the body, about 600mg is newly produced every day, and 600mg is excreted at the same time, which is in a balanced state. However, if there is too much uric acid in the body to excrete or the uric acid excretion mechanism degrades, the body will retain too much uric acid. When the blood uric acid concentration is greater than 7mg / DL, the body fluids will become acidic and affect the normal function of human cells. If left alone for a long time, it will cause gout. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C07D233/64C12P21/06C07K1/34A23L33/18A23L33/00A61K38/08A61P19/06A61K36/9062A61K31/4172
CPCA23V2002/00A61K31/4172A61K36/287A61K36/488A61K36/8994A61K36/9062A61K38/00A23L33/00A23L33/18A61P19/06C07D233/64C07K1/34C07K7/06C12P21/06A23V2200/30A23V2250/55A61K2300/00
Inventor 张九勋张学军田明展张西平魏玮裴中立
Owner 中食都庆(山东)生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com