44 results about "Potassium oxonate" patented technology

The invention provides a method for refining high-purity potassium oxonate. The method is characterized by comprising the following steps: adding an potassium oxonate crude product into water; adding alkali into the water until the crude product is completely dissolved; adding a polar solvent into the solution; adjusting the pH of the solution to neutrality by acid; filtering and separating out crystal; and drying the crystal so as to obtain the high-purity potassium oxonate. The method has the advantages of simple operation, mild reaction condition, high yield, pure product and the like, andhas yield over 90 percent, purity over 99.95 percent (detected by HPLC), and a single impurity peak reduced from 0.5 percent to below 0.05 percent.

A strain of Lactobacillus plantarum UA149 and its application belong to the field of functional food microorganisms. A strain of Lactobacillus plantarum (L. plantarum) UA149 of the present invention has been preserved in the China Center for Type Culture Collection on November 29, 2018, with the preservation number CCTCC NO: M2018842. The bacterial strain can be used in the preparation of products with uric acid-lowering function or anti-gout function. The invention takes the lactic acid bacteria isolated and identified from the surface of succulent leaves as the research object, and a new strain of the lactic acid bacteria is screened out through a large number of experiments. Hyperuricemia model rats were established by using potassium oxonate combined with fructose water, and intragastric administration of Lactobacillus plantarum UA149 strain for 14 days could significantly reduce blood uric acid levels; during gout attacks, neutrophil-mediated inflammation could be reduced. The release of sex factor thromboxane and leukotrienes prevents the influx of neutrophils into the joints and reduces redness, pain, heat and other symptoms.

The present invention relates to a method for constructing a mouse model of acute hyperuricemia, which comprises the following steps: giving the test mice a diet containing hairtail fish every day to carry out a modeling test for 7 to 8 days; at the end of the modeling test For two days, hypoxanthine and potassium oxonate were administered each day. Its beneficial effect is that the construction method of the mouse model of acute hyperuricemia of the present invention, due to the combination of hypoxanthine, potassium oxonate and hairtail as a modeling agent, compared with the prior art, it can be achieved by The synergistic effect of multiple mechanism modeling agents prepares a model similar to the pathogenesis of human hyperuricemia, thereby reducing the time for modeling.

The invention relates to a traditional Chinese medicine composition for gout, comprising 10-35 parts of Alisma, 5-20 parts of Plantaginaceae, 5-20 parts of Angelica dahurica, 5-20 parts of Chonglou, 2-10 parts of Ephedra, and menthol 0.01‑1 part, borneol 0.05‑4 part, licorice 1‑10 part. The traditional Chinese medicine composition has a better uric acid-lowering effect on the zebrafish hyperuricemia model induced by potassium oxonate combined with xanthine.

The invention provides the application of 3-acetylaminocoumarin in the preparation of medicine for treating or preventing hyperuricemia, and also provides the application of 3-acetamidocoumarin in the preparation of medicine for treating or preventing kidney damage. The present invention induces hyperuricemia in mice by potassium oxonate and hypoxanthine, and 5-100 mg / kg / d of 3-acetamidocoumarin is orally administered, wherein the blood uric acid level of the mice in the model group is significantly increased, and the kidney The damage was significant; the blood uric acid level of mice in the administration group decreased significantly, and the kidney protection effect was remarkable.