The invention relates to a capsule preparation containing tegafur, Jimeisita and Potassium Oxonate and a preparation method thereof, which is characterized in that the capsule preparation contains tegafu micropill, Jimeisita micropill and Potassium Oxonate micropill, wherein, the micropill is prepared from active drug ingredient, thinner, bond and surface active agent. The micropill is prepared with the extruding-rolling method, the centrifugal-fluidifying method, the pan coating pill floating method and the like, and then, other minor ingredients are added; finally, the capsule is filled. The capsule prepared with the preparation method can be steadily and quickly released in bodies, thus the drug stability is improved. The capsule has high dissolution rate and biological availability, and reduces adverse reaction of medicine.