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Application of Radix Polygoni Multiflori Benzophenone in the Preparation of Uric Acid-lowering Drugs

A technology of benzophenone and Baishouwu, which is applied in the field of medicine, can solve problems such as abnormal liver function, rapid or irregular heartbeat, etc., and achieve a good effect of reducing uric acid and blood uric acid level

Active Publication Date: 2022-04-08
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the traditional treatment drugs allopurinol and benzbromarone, febuxostat is more effective in lowering uric acid, but it often causes adverse liver function abnormalities, diarrhea, rash, chest pain, syncope or dizziness, rapid or irregular heartbeat, speech Adverse side effects such as difficulty, sudden blurred vision, or headaches such as cardiovascular disease, heart attack, stroke, and heart-related death have been reported

Method used

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  • Application of Radix Polygoni Multiflori Benzophenone in the Preparation of Uric Acid-lowering Drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Effects of Radix Polygoni Multiflori Benzophenone on Blood Uric Acid Levels in Hyperuricemia Mice Induced by Potassium Oxonate

[0019] Test animals: male KM mice (purchased from Beijing Huafukang Biotechnology Co., Ltd., animal license number: SCXK (Beijing) 2019-0008), 18-22g.

[0020] Operation steps: the mice were divided into random groups, 10 in each group, respectively normal group, model group, each administration group and positive control group (the positive control drug was febuxostat 1.0 mg / kg, each administration group was divided into 10 mL / kg volume intragastric administration of the test drug benzophenone of Radix Polygoni Multiflori 5 times, twice a day with an interval of 8h, wherein the doses of benzophenone of Radix Polygonum multiflorum were 4mg / kg, 8mg / kg and 16mg / kg respectively; positive The treatment of the control group is the same as that of the administration group, except that the drug given is a positive control drug. 1h after the last adm...

Embodiment 2

[0028] Effect of benzophenone of Radix Polygoni Multiflori on blood uric acid level in uric acid-induced hyperuricemia mice

[0029] Test animals: male KM mice (purchased from Beijing Huafukang Biotechnology Co., Ltd., animal license number: SCXK (Beijing) 2019-0008), 18-22g.

[0030] Operation steps: mice were randomly divided into groups, 10 in each group, respectively normal group, model group, each administration group and positive control group (the positive control drug was 25.0 mg / kg benzbromarone), and each administration group was divided into 10mL / kg volume intragastric administration of the test drug benzophenone of Radix Polygoni Multiflori 5 times, twice a day with an interval of 8h, wherein the doses of benzophenone of Radix Polygonum multiflorum were 4mg / kg, 8mg / kg and 16mg / kg respectively; The treatment of the positive control group was the same as that of the treatment group, except that the drug given was benzbromarone. 0.5h after the last administration of ...

Embodiment 3

[0037] Preliminary Toxicity and Safety Evaluation of Radix Polygonum Benzophenone

[0038] Select 40 healthy ICR mice, half male and half female, weighing 18-22 g, and fast for about 12 hours before administration. The benzophenone of Radix Polygoni Multiflori is prepared into a suspension with 0.5% CMC-Na, and the maximum concentration, The maximum volume of 30mL / kg body weight was administered by intragastric administration, and the intragastric administration was administered once at 9:00 a.m., which was 3.0g / kg / d. After administration, continuous observation was carried out for 14 days, and the animal poisoning and death conditions were recorded. The test results are shown in Table 3 and Table 4.

[0039] Table 3 Effects of Radix Polygoni Multiflori Benzophenone Orally Administered on Body Weight of Mice on Day 0, 7, and 14 (n=10, x±s)

[0040]

[0041]

[0042] Table 4 Coefficients of organ organs (heart, kidney, spleen, liver) of mice (n=10, x±s) 14 days after int...

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Abstract

The invention provides the application of Radix Polygonum benzophenone in the preparation of uric acid-lowering medicine, which belongs to the technical field of medicine. The test results showed that Baishouwu benzophenone could significantly reduce the blood uric acid level in mice with hyperuricemia induced by potassium p-oxonate, and its potency was stronger than that of the positive drug febuxostat 1mg / kg dose group, the difference was significant. Statistically significant; at the same time, the 8.0mg / kg and 16.0mg / kg dose groups of Radix Polygonum benzophenone can significantly reduce the blood uric acid level of mice with uric acid-induced hyperuricemia, and there is a certain dose-dependence, Compared with the positive drug, its potency is stronger than that of the positive drug benzbromarone 25mg / kg dose group, and the difference is statistically significant. The application of the Radix Polygoni Multiflori benzophenone provided in the present invention in the preparation of uric acid-lowering medicines has achieved good uric acid-lowering effects and is safe and has no sequelae.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Radix Polygonum benzophenone in the preparation of uric acid-lowering medicine. Background technique [0002] Gout is a heterogeneous disease characterized by hyperuricemia (HUA) caused by metabolic disorders of purine substances and / or decreased uric acid excretion. HUA is not only the biochemical basis of gout, but also an independent risk factor for metabolic syndrome, diabetes, hypertension, myocardial infarction, stroke, cardiovascular disease, coronary heart disease, all-cause death, metabolic disease, and chronic kidney disease. The prevalence of HUA is also on the rise worldwide, becoming a worldwide public health problem that seriously threatens human health. [0003] At present, the representative drug that inhibits uric acid synthesis is allopurinol, and the representative drug that promotes uric acid excretion is benzbromarone. Patients will ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61P19/06
CPCA61K31/122A61P19/06
Inventor 黄烈军郝小江李玲牛艳芬高丽辉杨娟苑春茂顾玮金军蹇军友胡占兴
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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