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Traditional Chinese medicine compound for treating gout

A technology of traditional Chinese medicine and compound prescription is applied in the field of good curative effect of treating gout, and the field of traditional Chinese medicine compound prescription can solve the problems of staying, lack of systematicness, inaccurate evaluation of anti-gout drugs, etc., and achieve the effects of low cost, lowering blood uric acid level and obvious effect.

Active Publication Date: 2017-02-22
YANGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many deficiencies in the treatment of gout by traditional Chinese medicine: the role of traditional Chinese medicine is multi-target, so the comprehensive regulation of traditional Chinese medicine on the multi-level and multi-faceted influencing factors of gouty arthritis needs further research; current studies mostly use exogenous uric acid The model for simulating local joint symptoms caused by sodium crystals (MSU) is different from human gouty arthritis caused by metabolic disorders, so the evaluation of the effect and mechanism of anti-gout drugs is not yet accurate[2]; It is difficult for the active ingredients of traditional Chinese medicine with curative effects to enter the stage of clinical trials of traditional Chinese medicine, and most of them only stay in the stage of exploration of drug efficacy and animal experiments. However, there are many problems in how these basic research results can be truly transformed into the stage of clinical application. components, lack of systematization in basic research[3]

Method used

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  • Traditional Chinese medicine compound for treating gout
  • Traditional Chinese medicine compound for treating gout
  • Traditional Chinese medicine compound for treating gout

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Experimental program
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Embodiment Construction

[0029] 1. Medicines needed

[0030] Colchicine (positive control drug) (specification: 0.5mg, manufacturer: Xishuangbanna Banna Pharmaceutical Co., Ltd., production batch number: 150208)

[0031] Normal saline (NS) (specification: 250ml, manufacturer: Sichuan Kelun Pharmaceutical Co., Ltd.)

[0032] Sodium urate crystal (MSU) (specification: 15mg, manufacturer: sigma, item number: U2875)

[0033] Adenine (Specification: 25g, Manufacturer: sigma, Item No.: A8626)

[0034] Oxonic acid potassium salt (specification: 25g, manufacturer: sigma, item number: 156124)

[0035] Sodium carboxymethyl cellulose (specification: 100g, manufacturer: sigma, item number: 419273)

[0036] Customized high-yeast feed (specification: 2kg, manufacturer: Jiangsu Synergy Pharmaceutical Bioengineering Co., Ltd., mass fraction 0.1) traditional Chinese medicine:

[0037] Smilax Smilax (Specification: 1kg, manufacturer: Anhui Huilong Traditional Chinese Medicine Pieces Co., Ltd., production batch number...

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine compound for treating gout. The compound comprises the following components in parts by weight: 1 part of glabrous greenbrier rhizome, 1 part of winged euonymus twig, 1 part of Coix Semen Coicis and 1 part of Paniculate Swallowwort Root. The traditional Chinese medicine compound achieves an obvious treatment effect for hyperuricemia and acute gouty arthritis, and has no severe toxic or side effect. Statistics of clinical use results and animal experiment research show that the traditional Chinese medicine compound can obviously relieve pain caused by hyperuricemia and gouty arthritis, can obviously reduce the blood uric acid levels of patients and rats, and has no obvious toxic or side effect. The traditional Chinese medicine compound has the advantages of favorable effect, low price, low side effect and the like, and meets the most simple three basic requirements of patients for a medicine for idealized gout treatment, i.e. for obviously relieving pain of the patients, reducing the side effect on the patients caused by medicine taking and lightening the medicine taking economic burden of the patients.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound prescription for treating special diseases, especially good curative effect for treating gout, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Gout is a crystal-associated arthropathy caused by deposition of monosodium urate, which is directly related to hyperuricemia caused by disturbance of purine metabolism or decreased uric acid excretion. Gout is a group of clinical syndromes characterized by long-term purine metabolism disorder and / or decreased uric acid excretion and tissue damage caused by increased blood uric acid. Hyperuricemia is the most important biochemical basis of gout. Gout includes acute gouty arthritis and chronic tophi disease, which may be complicated by kidney disease. In severe cases, joint damage and renal function damage may occur, often accompanied by hyperlipidemia, hypertension, diabetes, arteriosclerosis and co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K36/90A61P19/06
Inventor 刘延庆钱亚云王海波史有阳金凤冯俊倪腾洋
Owner YANGZHOU UNIV
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