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Pharmaceutical composition for treating acute gout and its extraction method

A kind of acute gout, composition technology, applied in the field of traditional Chinese medicine, can solve the problem of not showing anti-inflammatory, analgesic effect and the like

Active Publication Date: 2008-07-09
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

200410034933), has significant efficacy in reducing high uric acid, but does not show efficacy in anti-inflammatory and analgesic effects

Method used

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  • Pharmaceutical composition for treating acute gout and its extraction method
  • Pharmaceutical composition for treating acute gout and its extraction method
  • Pharmaceutical composition for treating acute gout and its extraction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1. The pharmaceutical composition for the treatment of acute gout

[0025] The active ingredients from the raw materials Phellodendron Phellodendron, Atractylodes atractylodes, Achyranthes bidentata, coix seed, Smilax cocos, Lonicera vine extracts are prepared according to the following proportions:

[0026] 1 part of alkaloid, 1 part of volatile oil, 5 parts of saponin, 1 part of organic acid, 1 part of flavonoid, 5 parts of aqueous sugar.

Embodiment 2

[0027] Embodiment 2. The pharmaceutical composition for the treatment of acute gout

[0028] The active ingredients are prepared from the extracts of Phellodendron Phellodendron, Atractylodes atractylodes, Achyranthes bidentata, Coix Seed, Smilax Smilax and Lonicerae vine extracts according to the following proportions:

[0029] 2 parts of alkaloids, 2 parts of volatile oil, 6 parts of saponins, 2 parts of organic acids, 2 parts of flavonoids, 4 parts of aqueous sugars.

Embodiment 3

[0030] Embodiment 3. The extraction method of the pharmaceutical composition for the treatment of acute gout, its extraction steps are as follows:

[0031] 1. Phellodendron Phellodendri Extract (I):

[0032] Get 4 parts of Cortex Phellodendri and extract 4 times with 10 times the amount of 95% ethanol, the extract reclaims ethanol, and use 10% H 2 SO 4 Adjust the pH to 2, let stand and centrifuge, discard the precipitate to obtain the supernatant, adjust the pH to 7 with 10% NaOH, put it on a macroporous resin column (HPD100), wash with water until colorless, elute with 50% ethanol, collect the eluate, and recover the ethanol. Get Phellodendron Phellodendri Extract (I), containing 100% alkaloids and 15% saponins;

[0033] 2. Volatile oil extract (II): Take 3 parts of Atractylodes atractylodes and 2 parts of coix seed and extract them with steam distillation for 5 hours to obtain volatile oil extract (II), which contains 100% volatile oil.

[0034] 3. Other extracts (III): ...

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Abstract

The invention discloses a pharmaceutical composition for treating acute gout and its extraction method, wherein the composition composes active constituents extracted from the following medicinal materials, corktree bark, atractylodes rhizome, achyranthes and cyathula root, coix seed, poria cocos, and honey-suckle stem, alkaloids, volatile oil, saponin, organic acid, flavone and carbohydrate by a finite proportion.

Description

1. Technical field: [0001] The invention relates to the field of traditional Chinese medicine, in particular to a composition of medicinal extracts for treating acute gout and an extraction method thereof. 2. Background technology [0002] Gout is a clinical syndrome caused by long-term disturbance of purine metabolism or decreased excretion of uric acid. It is characterized by hyperuricemia, recurrent attacks of characteristic acute arthritis, tophi deposition, and tophi chronic arthritis. In terms of Western medicine treatment, two goals to be achieved in the treatment of gout are proposed: timely control of the acute attack of gouty arthritis; long-term treatment of hyperuricemia, prevention of urate deposition and acute recurrence of gout, and promotion of tophi absorption. However, the three drugs selected by Western medicine in the acute attack stage: colchicine, non-steroidal anti-inflammatory drugs and adrenal cortex hormones, although the anti-inflammatory and anal...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K36/896A61K36/756A61K36/355A61K36/284A61K36/21A61P19/06
Inventor 尹莲史欣德徐立
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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