The invention provides homogeneous florfenicol particles and a preparation method thereof. The homogeneous florfenicol particles comprises, in percentage by weight, 2%-50% a florfenicol raw material and 50%-98% of an auxiliary material, wherein the auxiliary material is selected from one or more of hydrogenated castor oil, hydrogenated soybean oil, stearic acid, solid lipid wax and solid-state polyethylene glycol. Firstly, the auxiliary material is heated and melted at the temperature of 70 DEG C-90 DEG C and then uniformly stirred, the florfenicol raw material and the melted auxiliary material are mixed, sheared and uniformly stirred, a mixed solution is obtained, sprayed, condensed and granulated, and the homogeneous florfenicol particles are obtained. According to the homogeneous florfenicol particles and the preparation method, a main chemical in the homogeneous florfenicol particles is uniformly distributed, the homogeneous florfenicol particles have smooth surfaces, the flowability and the dispersibility of the particles are improved, the particles are easily mixed during use, and the problems about uniformity and wall adhering of florfenicol preparaitons as well as chemical residues, animal poisoning and the like due to non-uniform mixing during use are solved.