Homogeneous florfenicol particles and preparation method thereof

Abstract

The invention provides homogeneous florfenicol particles and a preparation method thereof. The homogeneous florfenicol particles comprises, in percentage by weight, 2%-50% a florfenicol raw material and 50%-98% of an auxiliary material, wherein the auxiliary material is selected from one or more of hydrogenated castor oil, hydrogenated soybean oil, stearic acid, solid lipid wax and solid-state polyethylene glycol. Firstly, the auxiliary material is heated and melted at the temperature of 70 DEG C-90 DEG C and then uniformly stirred, the florfenicol raw material and the melted auxiliary material are mixed, sheared and uniformly stirred, a mixed solution is obtained, sprayed, condensed and granulated, and the homogeneous florfenicol particles are obtained. According to the homogeneous florfenicol particles and the preparation method, a main chemical in the homogeneous florfenicol particles is uniformly distributed, the homogeneous florfenicol particles have smooth surfaces, the flowability and the dispersibility of the particles are improved, the particles are easily mixed during use, and the problems about uniformity and wall adhering of florfenicol preparaitons as well as chemical residues, animal poisoning and the like due to non-uniform mixing during use are solved.

Description

technical field [0001] The invention belongs to the technical field of florfenicol pharmacy, and in particular relates to a florfenicol homogeneous granule and a preparation method thereof. Background technique [0002] With the high intensification of animal husbandry, a large number of antibacterial drugs are used to prevent and control diseases, resulting in the residue of antibacterial drugs in animal food, which poses a serious threat to people's health. Pollution during feed processing or transportation (such as feed crushing, mixing equipment not cleaned and contaminated) is also a major factor causing animal food drug residues. At the same time, uneven drug content or uneven drug mixing leads to overdose or even poisoning of some animals from time to time. Therefore, when farms use antibiotic products, they always spend a lot of time mixing and cleaning mixers, troughs, etc., especially when using powdered antibiotic preparations. [0003] Florfenicol (Florfenicol)...

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of the uniformity of the existing florfenicol preparations, the present invention proposes a florfenicol homogeneous granule, the homogeneous granule is combined with the florfenicol raw material through screening of auxiliary materials, so that the main drug is evenly distributed and the surface is smooth , easy to mix, improve the fluidity and dispersibility of the granules, and solve the problems of florfenicol sticking to the wall and uneven mixing, drug residues, animal poisoning, etc.

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