32 results about "Control diseases" patented technology

Provided herein are compounds of Formula (I): (I), or a pharmaceutically acceptable salt or composition thereof, which are useful in the treatment or management of diseases or disorders mediated by AAK1 activity, muscle diseases and disorders, and other conditions.

The application discloses a primer, a probe composition for nontuberculous mycobacteria typing and application thereof, and provides a PCR primer and a probe for rapid detection and typing of 13 common NTM in clinic based on genome big data for carrying out pan-genomics analysis, and the specific genes of the common NTM in clinic are screened by using a pan-genomics method, and then typing primers and probes are designed based on the genes, so that the problems of insufficient accuracy and specificity in NTM typing are solved; the various NTM specific sequences screened guarantee the accuracy and specificity; the high sensitivity of the PCR method and the specificity of the sequences guarantee that various interference substances in the clinical samples can be avoided, and the clinical samples can be directly analyzed; the PCR detection is low in cost and low in equipment requirement, and can be carried out in primary hospitals, thereby providing an efficient and economical solution for the precise diagnosis of nontuberculous mycobacteria, the control of disease prevalence and the large-scale disease screening.

The invention provides an unmanned aerial vehicle prevention and control method and system for disease and insect pest monitoring, and relates to the technical field of path planning, and the method comprises the steps: controlling an unmanned aerial vehicle to fly along an initial inspection path; determining disease and pest occurrence points, and determining a disease and pest occurrence point set according to the disease and pest occurrence points; determining a plurality of risk areas; determining a target hovering entry point based on each risk area; the current position and environment information of the unmanned aerial vehicle are obtained, a three-dimensional discrete grid field is constructed based on the target hovering entry point and the current position and environment information of the unmanned aerial vehicle, and the three-dimensional discrete grid field comprises a plurality of grid units and corresponding grid risk values; and in the three-dimensional discrete grid field, generating a plurality of candidate tracks based on an RRT algorithm, and determining a transition track based on a target hovering entry point and a grid risk value in combination with wind field analysis. The selection of the target hovering entry point effectively avoids the problem of unstable flight caused by local airflow disturbance in the approaching and hovering process of the unmanned aerial vehicle.

This invention provides methods to determine the stage in the natural time course of immune response in a subject. It describes method to control immune response by targeting regulatory mechanisms differentially operating in lymphocytes at different stages in the natural time course of immune response. One kind of such regulatory mechanism is the mechanisms of energy metabolism that control intracellular pH (pHi), which in turn control cell death and proliferation. This invention also describes a combinatorial approach to lowering pHi of neoplastic cells to induce their death using compositions of combinations of regulators of energy metabolism. Finally, this invention provides methods to treat skin or mucosa infections or neoplasia by topical application of pH modifier(s) that lower pH.

The invention belongs to the technical field of biological medicine, and discloses application of JAM3 protein in preparation of a medicine for inhibiting formation of a neutrophil extracellular trapping net. JAM3 is an I-type single transmembrane protein containing 310 amino acids, and belongs to an immunoglobulin superfamily. Researches show that the JAM3 protein remarkably inhibits excessive formation of a sepsis neutrophile granulocyte extracellular trapping net by regulating and controlling an activation path of neutrophile granulocytes, and meanwhile prevents blood platelets from being excessively captured, so that formation of microthrombus in the liver and damage to organs are avoided, disease progression is effectively controlled, and recovery of peripheral blood cells and organisms is promoted.

This disclosure provides microbial consortia to target Colletotrichum or Botrytis species that target flowers, such as those of blueberries, to control diseases caused by these phytopathogenic species. Methods of delivery of the consortia to plants, including pre-blossom and post-blossom stages.

The application provides a disease and pest control method for Dendrobium cultivation, comprising: obtaining a UAV aerial image, identifying a suspected disease and pest area based on the UAV aerial image, and sending the position of the suspected disease and pest area to a background system; obtaining environmental parameters, analyzing the influence weight of the environmental parameters on diseases and pests, and performing disease and pest risk prediction to obtain a risk prediction result; starting a control measure when the risk value exceeds a warning threshold according to the risk prediction result, adjusting the environment through a sunshade and a ventilation device, collecting a plant image to identify a disease spot coverage rate, and adjusting a control frequency according to the coverage rate.

The present application relates to a kind of fungicidal composition containing prothioconazole and mefenoxam in the use for preventing and treating peanut diseases;The pesticide composition at least includes active ingredient A prothioconazole and active ingredient B mefenoxam, the mass ratio of the active ingredient A prothioconazole and active ingredient B is 1:50-50:1.The fungicidal composition of the present application can be used for preventing and treating various diseases on peanut, has good control effect, can prolong the effective period of pesticide, reduce the frequency of use, effectively reduce the use amount of active ingredient and use cost, delay the generation and development of resistance, and is environment-friendly.

The invention discloses a compound microorganism for preventing and treating chestnut fruit rot and application of the compound microorganism. The compound microorganism is composed of trichoderma atroviride, bacillus siamensis and bacillus velezensis, and is constructed by directionally screening strains with broad-spectrum inhibition effect on seven core pathogenic bacteria from Chinese chestnut fruit endophytes and verifying compatibility. The method has the advantages that the compound flora synergistically prevents and controls diseases through direct antagonism and induction of plant system resistance, and the defensive enzyme activity and the content of total polyphenol and total flavone of Chinese chestnuts are remarkably improved; according to the compound microorganism, the indoor control effect reaches 90% (the morbidity is reduced), the diseased fruit rates of Chinese chestnut fruits treated in a chestnut garden are reduced by 60% and 42.86% respectively after the Chinese chestnut fruits are stored for 30 days and 120 days, the effectiveness and the stability are obviously higher than those of a single strain, the compound microorganism can be introduced in the flowering period or sprayed in the storage period, use is convenient and flexible, and an efficient and stable biocontrol strategy is provided for green prevention and control of the Chinese chestnut fruit rot.

According to one embodiment of the present invention, the smart livestock housing system capable of active disease prediction and control based on data-driven intelligent spraying and air conditioning technology is specifically a technology designed to prevent predictable diseases and actively control quarantine systems within farms to prevent animal infectious diseases and ultimately improve farm productivity. The smart livestock housing system may comprise: a housing for raising animals; a plurality of opening / closing ports formed on one side and another side of the housing, respectively, to control inflow of outside air into the interior; a breeding space installed inside the housing and formed to bound the space where animals are raised in all directions; at least one filter formed in one area constituting the breeding space; and an injector located between the opening / closing ports and the filter, operating to remove viruses by spraying disinfectant into outside air entering from the opening / closing ports.

The application discloses a strain of Pseudomonas extremorientalis LJ-6 and application of the strain in preventing and controlling mulberry diseases. The Pseudomonas extremorientalis in the application is preserved in the Guangdong Microbial Culture Collection Center on June 18, 2024, and the preservation number is GDMCC NO: 64766. The Pseudomonas extremorientalis LJ-6 has good antagonistic effects on bacterial pathogenic bacteria such as Caulobacter segnis, Pantoea ananatis, Klebsiella michiganensis and Enterobacter cloacae, and fungal pathogenic bacteria such as Fusarium oxysporum, Curvularia lunata and Guignardia bidwellii. The Pseudomonas extremorientalis LJ-6 has good prevention and control effects on plant diseases caused by the above pathogenic bacteria invading plants, such as mulberry bacterial wilt, mulberry bacterial blight, mulberry leaf spot and mulberry anthracnose. Therefore, the Pseudomonas extremorientalis LJ-6 has good application prospect and value in preventing and controlling plant diseases such as mulberry and preparing disease prevention and control preparation products.

The invention belongs to the technical field of gene engineering, and discloses a disease-resistant gene NbSTOMR and application thereof in improving the disease resistance of plants and preventing and controlling diseases, the sequence of a protein coded by the gene is shown as SEQ ID NO.2, and the nucleotide sequence of the coded protein is shown as SEQ ID NO.1. Molecular genetic experiments show that after the NbSTOMR gene is knocked out from tobacco, cell death and reactive oxygen generation induced by the pathogen-related molecular mode STOM are remarkably weakened, and the NbSTOMR is considered to be a mode recognition receptor for recognizing the pathogen-related molecular mode STOM. Importantly, the disease resistance of a tobacco knockout body (nbstomr) of the NbSTOMR gene to sclerotinia sclerotiorum is remarkably weakened, and the disease resistance of the Bensi tobacco to sclerotinia sclerotiorum is remarkably enhanced by expressing the gene. Therefore, the NbSTOMR provided by the invention is a disease-resistant related mode recognition receptor in the tobacco, can improve the disease resistance of the tobacco to sclerotinia sclerotiorum, and can be applied to disease-resistant breeding of the tobacco.

The invention discloses a crop growth state-based intelligent pest and disease damage prediction, prevention and control method, which comprises the following steps of: acquiring multi-source observation data related to a crop growth state and a crop growth environment in a crop growth process, and preprocessing the data to obtain multi-source heterogeneous data of crops; inputting the multi-source heterogeneous data into a pest and disease damage prediction model to predict the occurrence probability of the pest and disease damage in the current growth state and the growth environment, outputting a pest and disease damage prediction result according with the current crop growth state, and performing prevention and control analysis on the pest and disease damage prediction result through a pest and disease damage prevention expert knowledge base. And generating corresponding prevention and control decisions, sending the decisions to corresponding management personnel terminals for disease and pest prevention and control early warning, monitoring disease and pest prevention and control effects of the prevention and control decisions, feeding back the disease and pest prevention and control effects to the disease and pest prediction model for model optimization, and adaptively updating the disease and pest prediction model. The effects of improving the yield and quality of crops and effectively preventing and controlling diseases and pests in the whole growth period of the crops are achieved.

A composition suitable for control of diseases caused by phytopathogens comprising (A) a compound of formula (I) wherein R1 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C3 alkoxyC1-C3 alkyl, C3-C5 cycloalkyl, C2-C4 alkenyl, C2-C4 alkynyl; R2 is hydrogen, C1-C3 alkyl, C1-C3 alkoxy or C3-C5 cycloalkyl; R3 is C1-C6 alkyl; R4 is hydrogen or fluoro and A is 1,4-phenyl or 2,5-thienyl; and (B) at least one compound selected from compounds known for their fungicidal activity; and a method of controlling diseases on useful plants, especially rust diseases on soybeans or cereals.

The application discloses a kind of for preventing and treating chestnut fruit rot disease complex microorganism and its application.The application complex microorganism is composed of Trichoderma atroviride and Bacillus siamensis, Bacillus velezensis, by from chestnut fruit endophyte directional screening to seven kinds of core pathogenic bacteria have broad-spectrum inhibitory effect strain, is constructed after compatibility verification.It is superior in that: complex microbial population is synergistically controlled disease by direct antagonism and induced plant system resistance, significantly improves chestnut defense enzyme activity and total polyphenol, total flavone content;Indoor control efficiency reaches 90% (reduces the incidence), chestnut fruit in chestnut orchard treatment is reduced 60% and 42.86% respectively in 30 days and 120 days, effective and stability are obviously stronger than single strain, and the application complex microorganism can be introduced by flowering period or sprayed in storage period, and is convenient and flexible, provides efficient, stable biocontrol strategy for chestnut fruit rot green control.

The present invention relates to directly fed microorganisms for controlling diseases caused by a species of the genus Fusobacterium or Arcanobacterium in an animal. More specifically, the present invention relates to isolated Bacillus strains 86, 300, 101, 235, 177 and 102, as well as strains having all identifying characteristics of these strains, their use for comprising the above use.

The application discloses a root cutter for preventing and controlling disease infection by using medicine in a sugarcane harvesting process, which comprises a medicine tank, an electric control proportional valve, a flowmeter, a slip ring stator pipeline, a slip ring rotor pipeline, a cutter head, a root cutter, a slip ring stator, a root cutter transmission shaft, a slip ring rotor and a control unit. One end of the slip ring stator pipeline is connected with a pump on the medicine tank in communication through the flowmeter and the electric control proportional valve; the other end of the slip ring stator pipeline is connected with a channel I of the slip ring stator; one end of a channel II of the slip ring rotor is connected with an annular groove of the slip ring stator in communication, and the other end is connected with one end of the slip ring rotor pipeline in communication; the other end of the slip ring rotor pipeline is connected with a channel III of the root cutter in communication after penetrating through the cutter head. The root cutter is designed to make the medicine water act on the sugarcane roots in the sugarcane harvesting process, so that the pathogenic bacteria in the incisions of the sugarcane roots are killed or prevented, and the risk of healthy sugarcane roots being infected by the pathogenic bacteria is effectively reduced.

The invention relates to the technical field of plant genetic engineering, in particular to a GhCKA1 protein and application thereof in regulating and controlling the disease resistance of cotton verticillium wilt. The invention provides a gene casein kinase GhCKA1 related to disease resistance of cotton verticillium wilt. According to the invention, the effect of the GhCKA1 gene in regulating and controlling the disease resistance of the cotton verticillium wilt is defined for the first time, and a new target gene is provided for preventing and controlling the cotton infected by the verticillium wilt. The GhCKA1 gene disclosed by the invention can be used for preventing and treating cotton verticillium wilt, and particularly can be used for genetic improvement or molecular breeding of cotton verticillium wilt resistance, such as cultivation of new varieties of cotton with verticillium wilt resistance. A new way is provided for cultivation of cotton verticillium wilt resistant plants, and theoretical guidance and genetic resources are provided for improvement of cotton disease resistance through molecular design breeding or genetic engineering.

The invention relates to a compound of formula (I), a composition comprising the compound of formula (I) and a use of the compound of formula (I) as an antimicrobial agent. The invention also relates to a compound of formula (I) for use in treating a bacterial disease or infection in a subject, a method for treating a plant to control a disease, and a method for producing a compound of formula (I).

This utility model discloses a chili pepper pest and disease control device, relating to the field of pest and disease control technology. The device includes a support block, a support frame mounted on top of the support block, and photovoltaic power generation equipment mounted around and on top of the support frame. The bottom of the support block is mounted on the output end of a first electric actuator. Two adjustment components are mounted on both sides of the support block. Each adjustment component includes a support frame mounted on both sides of the support block, and a second electric actuator is installed inside the support frame. An insertion frame is mounted on the output end of the second electric actuator. This utility model adjusts the position of the support block using the adjustment components, and a third electric actuator drives a brush to move up and down against the inside of the electric grid, facilitating cleaning of the grid. Fallen pests are collected in a collection box, avoiding the problem of pest carcasses accumulating on the grid surface and reducing the insect-attracting effect.

The present invention relates to novel fungicidal compositions, to their use in agriculture or horticulture for controlling diseases caused by phytopathogens, especially phytopathogenic fungi, and to methods of controlling diseases on useful plants.

The invention relates to a DRG disease group target cost management method and system based on value chain optimization, and belongs to the technical field of medical management information. The method comprises the following steps: based on charge item attributes of disease diagnosis grouping cost, decomposing a contract research organization into different value activity responsibility subjects through a responsibility center cost tracking method, and generating cost data of a disease diagnosis group; establishing a dynamic cost analysis model according to the cost data of the disease diagnosis group, optimizing the charge item attributes of the disease diagnosis group cost through a target cost accounting method, and establishing an optimization target map of the activity cost; performing internal value engineering analysis on the responsibility center or the value activity which does not reach the target cost based on the optimization target map, identifying cost composition characteristics of the responsibility center or the value activity, and generating a target cost interval; and analyzing the target cost interval, establishing a disease diagnosis disease group cost management strategy through a disease category shunting algorithm, and controlling the target cost of a disease diagnosis disease group.

A composition suitable for control of diseases caused by phytopathogens comprising (A) a compound of formula (I) wherein R1 is hydrogen or halogen; R2 and R3 are either independently of each other hydrogen or C1-C3alkyl or they form together with the carbon atom to which they are attached a C3-C5cycloalkyl ring: R4, R5, R6 and R6 are independently of each other hydrogen, halogen or C1-C3alkoxy; and X is O or NH; and (B) at least one compound selected from compounds known for their fungicidal activity; and a method of controlling diseases on useful plants, especially rust diseases on soybeans or cereals.

Disclosed in the present invention is a use of a 2-cyano-3-aminoacrylate compound in control of fungal diseases caused by Pestalotiopsis-like fungi. The compound exhibits generally ultrahigh ex-vivo antifungal activity against Pestalotiopsis-like fungi, including Pestalotiopsis, Neopestalotiopsis, and Pseudopestalotiopsis. Phenamacril exhibits a median effective concentration (EC50) ranging from 0.1455 to 0.6025 μg / mL, a mean value of 0.2800 μg / mL and a standard deviation of 0.095 μg / mL against 56 strains of Pestalotiopsis-like pathogenic fungi isolated from Camellia sinensis, Prunus persica, and Vitis vinifera. The Phenamacril suspension formulation spray treatment scheme for Camellia sinensis provided by the present invention can significantly increase tea yield, and provide a basis for controlling diseases caused by Pestalotiopsis, Neopestalotiopsis, and Pseudopestalotiopsis pathogens in tea plantations as well as for monitoring fungicide resistance.

This invention relates to a strain of *Bacillus sicca* capable of producing volatile broad-spectrum antibacterial substances and its applications, belonging to the field of biological control technology. To address the shortcomings of chemical control of tomato gray mold, this invention provides a strain of *Bacillus sicca* and its applications. This strain, isolated from honeysuckle, produces IAA (inhibitory acetic acid), antimicrobial peptides, and volatile organic compounds. The volatile organic compounds produced by this strain exhibit broad-spectrum antibacterial activity, achieving a 100% inhibition rate against *Botrytis cinerea*, *Fusarium oxysporum*, *Fusarium graminearum*, and *Cucumis mellitus* var. *cubiclesii*. Furthermore, this strain demonstrates excellent control efficacy against tomato gray mold caused by *Botrytis cinerea* and can be used for the control of gray mold in tomato plants and for fruit preservation. Compared to traditional control measures, the *Bacillus sicca* strain provided by this invention offers advantages such as high efficiency, broad-spectrum disease resistance, easy spread and transmission, wide coverage, and low likelihood of developing drug resistance, making it a promising candidate for controlling diseases in greenhouse fruits and vegetables.

The invention provides application of thymine or probiotics over-expressing pyrimidine nucleoside phosphorylase from clostridium papyrosolvens to preparation of drugs for regulating and controlling diseases related to glucose and lipid metabolism disorder, and belongs to the technical field of biological drugs. The invention discloses application of probiotics of pyrimidine nucleoside phosphorylase derived from thymine or over-expression clostridium papyrosolvens in preparation of drugs for regulating and controlling diseases related to glucose and lipid metabolism disorder. Glycolipid metabolism disorder caused by high-fat diet induction can be remarkably improved through thymine treatment. The thymine provided by the invention can be used for preparing food or medicines for preventing or treating metabolic diseases, and has a very wide application prospect.

The application discloses application of UFC1 as a biomarker in preparation of reagents for diagnosing and / or treating prostatic hyperplasia. In the technical scheme, the cell experiment result shows that UFC1 can significantly inhibit the proliferation ability of WPMY-1 and BPH-1 cells, and can effectively promote the apoptosis of the cells. The finding reveals the core driving role of UFC1 in BPH progress, that is, maintaining the imbalance between the proliferation and apoptosis of prostate cells, and promoting the tissue hyperplasia. The mechanism indicates the precise intervention direction of the targeted treatment: if the activity or expression of UFC1 can be specifically inhibited, the abnormal proliferation of prostate cells can be blocked from the source, the normal apoptosis program of the cells can be restored, and the proliferation progress can be reversed by realizing the "two-way regulation". Compared with the existing alpha receptor blockers which can only relieve the obstruction symptoms, and the 5 alpha-reductase inhibitors which need long-term medication and can cause sexual dysfunction, the treatment strategy of targeting UFC1 directly attacks the biological nature of the hyperplastic cells, and is expected to more effectively control the disease progress.

The invention discloses a chronic obstructive pulmonary disease marker LSM2 and application thereof in disease screening, and belongs to the technical field of disease screening and diagnosis. The invention finds that the LSM2 protein is related to the occurrence of the chronic obstructive pulmonary disease, so that the LSM2 protein can be used as a biomarker for screening the chronic obstructive pulmonary disease. On the basis, the invention provides the kit, the kit accurately judges the early-stage chronic obstructive pulmonary disease by detecting LSM2 protein expression or Lsm2 gene expression quantity in lung tissues of a subject, early discovery and early treatment are realized, and the kit has important significance in controlling disease symptoms and relieving disease progression and clinical outcome.

The invention discloses radix scutellariae endophytic fungi and application thereof. The bacterial strain is separated from root tissues of healthy scutellaria baicalensis plants, is classified and named as Fusarium oxysporum, is preserved in the China General Microbiological Culture Collection Center (CGMCC), and has the preservation number of CGMCC NO.41912. The invention further discloses a preparation method of the bacterial strain. The fermentation liquor of the strain is used for treating scutellaria baicalensis seedlings, so that the root rot caused by rhizoctonia solani can be effectively prevented and treated, and meanwhile, the root development of the seedlings and the growth of overground parts are remarkably promoted. The endophytic fungus shows good application potential in the aspects of promoting the growth of scutellaria baicalensis and enhancing the disease resistance.