265 results about "Time course" patented technology

Embodiments of the present invention include methods and systems for predicting the likelihood of topics appearing in a set of data such as text. A number of latent variable methods are used to convert the data into a set of topics, topic values and topic profiles. A number of time-course methods are used to model how topic values change given previous topic profiles, or to find historical times with similar topic values and then projecting the topic profile forward from that historical time to predict the likelihood of the topics appearing. Embodiments include utilizing focus topics, such as valence topics, and data representing financial measures to predict the likelihood of topics. Methods and systems for modeling data and predicting the likelihood of topics over other dimensions are also contemplated.

A method and system that provides for minute-to-minute EBC pH monitoring (or for other EBC characteristic monitoring) of a subject that greatly assists in determining the time-course of airway pH changes (or other characteristic changes) in evolving disease processes, and may assist in determining the predictive ability of these tests, as well as determining response to therapy.

A hemodialysis treatment apparatus includes a circulating blood volume variation rate detecting device, a vital sign detecting device and a display. The circulating blood volume variation rate detecting device detects a circulating blood volume variation rate of a patient in a time-course of a hemodialysis treatment. The vital sign detecting device detects a vital sign value of the patient in the time-course of the hemodialysis treatment. The display has a screen and displays both the circulating blood volume variation rate and the vital sign value on the screen along a time scale. The hemodialysis treatment apparatus dialyzes and ultrafiltrates extracorporeally circulating blood of the patient to perform the hemodialysis treatment.

The invention discloses an unmanned plane autonomous flight cloud control system. The system comprises a ground control station, a cloud server, an unmanned plane device and an aerial photography device. Real-time autonomous flight of an unmanned plane involves establishment of a course planning control analysis module based on real-time information, the ground control station carries out preliminary automatic planning of a course by use of flight coordinate scope information, in case of low-attitude flight, aerial photography data acquisition is carried out on landform space information by use of the aerial photography device, the information is transmitted to the cloud server by use of a 4G network through the ground control station, three-dimensional real-time visualization space modeling of aerial photography data is carried out by use of a cloud processing technology, through combination with a DEM and space topology relation, real-time course correction is carried out on an unmanned plane task flight preliminary course, flight control signals are returned to an autopilot, and thus autonomous flight of the unmanned plane is realized.

The invention is directed to one-tube nested nucleic acid amplification methods, as well as compositions for performing these methods, which employ one or more outer primers containing one or more exo-sample nucleotides and inner primers. Nested amplification reactions are performed in these methods in the presence of an agent that degrades the exo-sample-nucleotide-containing primers in time course fashion during the PCR cycles.

A method for intracellular metabolic flux analysis comprising (a) culturing cells in a medium not containing any isotope-labeled substrate to a target phase of the metabolic flux analysis, (b) adding an isotope-labeled substrate to the medium, and continuing culture and collecting samples from the medium in time course, (c) measuring isotope distribution in an intracellular metabolite contained in the samples collected in time course, (d) performing a regression analysis for measured data and calculating an isotope distribution ratio in a steady state, and (e) analyzing a metabolic flux of the cultured cells by using the calculated isotope distribution ratio.

The invention belongs to the technical field of navigation and provides an integrated navigation and positioning system and method for a submarine oil and gas pipe detection robot. The integrated navigation and positioning system mainly comprises a differential GPS system, an ultra-short baseline positioning system (USBL), a strapdown inertial navigation system (SINS), a Doppler log (DVL) and thelike. The differential GPS system accurately positions geographic position coordinates of a surface vessel; the ultra-short baseline positioning system determines a three-dimensional vector position of the underwater unmanned aerial vehicle relative to the water surface unmanned ship; the strapdown inertial navigation system detects the real-time course and attitude of the underwater unmanned vehicle; and the Doppler log detects the absolute running speed of the underwater unmanned vehicle. The SINS and the DVL are combined to realize short-time high-precision positioning of the underwater unmanned vehicle, and the differential GPS and the USBL are combined to realize absolute positioning of the underwater unmanned vehicle; the long-endurance and long-voyage high-precision positioning of the underwater unmanned vehicle is realized, and the accurate position information is provided. The invention further provides a combined positioning method of various navigation instruments, and a solution is provided for underwater high-precision combined navigation.

[Problems] The present invention provides pharmaceutical composition which is effective for the prophylaxis or treatment of pathology showing involvement of uric acid (hyperuricemia, gouty tophus, acute gout arthritis, chronic gout arthritis, gouty kidney, urolithiasis, renal function disorder, coronary arterial disease, ischemic heart disease and the like) and the like, and is superior in the time-course stability and dissolution property (disintegration property).

[Solving Means] The pharmaceutical composition of the present invention is a pharmaceutical composition comprising a nitrogen-containing fused ring compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable additives, wherein the nitrogen-containing fused ring compound or a pharmaceutically acceptable salt thereof is not in contact with a basic additive:

wherein each symbol is as described in the specification.

In-vivo optical molecular imaging methods for producing an image of an animal are described. A time series of image data sets of an optical contrast substance in the animal is acquired using an optical detector Each image data set is obtained at a selected time and has the same plurality of pixels, with each pixel having an associated value. The image data sets are analyzed to identify a plurality of distinctive time courses, and respective pixel sets are determined from the plurality of pixels which correspond to each of the time courses. In one embodiment, each pixel set is associated with an identified anatomical or other structure, and an anatomical image map of the animal can be generated which includes one or more of the anatomical structures.

An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and the control signal for delivery of insulin and a counter-regulatory agent such as glucagon is based solely on online glucose concentration measurements. The MPC signal is synthesized by optimizing an augmented objective function that minimizes local insulin accumulation in the subcutaneous depot and control signal aggressiveness, while simultaneously regulating glucose concentration to a preset reference set point. The mathematical formulation governing the subcutaneous accumulation of administered insulin is derived based on nominal temporal values pertaining to the pharmacokinetics (time-course of activity) of insulin in human, in terms of its absorption rate, peak absorption time, and overall time of action. The MPC algorithm is also formulated to provide control action with an integral effect, and in essence minimizes overall drug consumption. When employed as a modulator in an automated integrated glucose-control system for type 1 diabetes, the control algorithm provides the system with self-learning capability that enables it to operate under unrestricted activity of the subject.

A method and apparatus to detect anomalies in the conductors of leads attached to implantable medical devices based on the dynamical electrical changes these anomalies cause. In one embodiment, impedance is measured for weak input signals of different applied frequencies, and a conductor anomaly is detected based on differences in impedance measured at different frequencies. In another embodiment, a transient input signal is applied to the conductor, and an anomaly is identified based on parameters related to the time course of the voltage or current response, which is altered by anomaly-related changes in capacitance and inductance, even if resistance is unchanged. The method may be implemented in the implantable medical device or in a programmer used for testing leads.

The invention belongs to the field of metal processing preparation, and in particular, relates to a method for high-throughput preparation of multi-component gradient metal materials for multi-component alloy tubes, rods, sectional materials and other long materials with continuous gradient distribution of chemical components in the length direction. The device comprises a powder flow velocity on-line regulating system, a rotary feeding system, a heating system, a heat preservation system, a motor drive system, a blank forming system and a control system. By adopting the technical scheme, the device has the advantages of simple structure, convenient use and easy control; the device achieves preparation of high-throughput preparation of the multi-component gradient metal materials through controlling of molten metal components and a continuous casting process, shortens the time course of the materials in composition design, melting, performance preparation and application preparation, reduces the metallurgical energy consumption of multi-furnace smelting of the alloys, reduces development costs, and improves the preparation quality and efficiency of the new metal gradient materials.

The invention relates to a contact network key position dynamic offset detection method and a device thereof. A detection identification is arranged on objects at the key position of the contact network to be detected such as contact line of the section, carrier cable, dropper and upright of the detected contact network, an online CCD detection device is arranged on the upright of the contact network, a CCD camera acquires video image of the contact network, the detected displacement and quantity of motion are stored and amplitude, angle of twist and corresponding time course curve are drawn, and the online CCD detection device transmits the data to an upper machine room data center by virtue of a wireless communication module. The method and device of the invention are non contact and self-calibration, practicability is strong, and synchronous monitoring is carried out, so as to obtain data and image; amplitude, frequency, angle of twist and corresponding time course curve are recorded in real time and are used for analyzing influence of the stability of the contact network in high wind environment or under the action of other factors, and travelling is guided according to the real-time deviation state of the contact network.

An inhalation device comprising a control and an air pump connected to the control, the air pump being controlled by the control such that it supplies an inhalation flow, or inhalation volume or both according to a predetermined time course to a nebulizer connected to the air pump.

This invention relates to localized magnetic resonance spectroscopy (MRS) and to magnetic resonance spectroscopic imaging (MRSI) of the proton NMR signal, specifically to a magnetic resonance spectroscopy (MRS) method to measure a single volume of interest and to a magnetic resonance spectroscopic imaging method with at least one spectral dimension and up to three spatial dimensions. MRS and MRSI are sensitive to movement of the object to be imaged and to frequency drifts during the scan that may arise from scanner instability, field drift, respiration, and shim coil heating due to gradient switching. Inter-scan and intra-scan movement leads to line broadening and changes in spectral pattern secondary to changes in partial volume effects in localized MRS. In MRSI movement leads to ghosting artifacts across the entire spectroscopic image. For both MRS an MRSI movement changes the magnetic field inhomogeneity, which requires dynamic reshimming. Frequency drifts in MRS and MRSI degrade water suppression, prevent coherent signal averaging over the time course of the scan and interfere with gradient encoding, thus leading to a loss in localization. It is desirable to measure object movement and frequency drift and to correct object motion and frequency drift without interfering with the MRS and MRSI data acquisition.

A stray-light tolerant LIDAR measurement system. The system comprises an interferometer assembly having a continuous-wave laser source, a photodetection arrangement and optical components. The laser source comprises a laser-light-generating component, a downstream optical phase modulator and a control unit connected to the modulator to deliver a control signal corresponding to a pseudo-noise signal defined by a predetermined phase function. The interferometer assembly comprises an evaluation unit which is coupled to the interferometric photodetector assembly to detect the detector signals of same and to determine the presence and/or movement of particles and/or objects from the detector signals wherein, in the case of two wavelengths emitted from the laser light generating components, the detector signals are detected separately in two wavelength regions, and the phase function has a predetermined step-like time course and the evaluation unit scans the detector signals in synchrony with the timing of the steps of the phase function.

A graphical user interface and method allows a user to interactively select an arterial input function. An anatomical image and time-course data corresponding to a selected region of interest are displayed simultaneously. The time-course data is displayed as an array of graphs, annotated with best-fit curves and parameters derived from fitting the time-course data. The region displayed in the graphs may be updated by panning and zooming with a mouse in the image. Time-course data corresponding to a graph is selected for use in deriving an arterial input function. The arterial input function is used to calculate maps of hemodynamic parameters.

An engine oil deterioration detection apparatus includes a sensing capacitor CS formed of paired electrodes dipped into engine oil whose deterioration is to be detected, the engine oil deterioration detection apparatus detecting deterioration of the engine oil on the basis of a change in electrostatic capacitance of the sensing capacitor CS. A measurement signal generation circuit generates a measurement signal to be supplied to the sensing capacitor CS. A detection signal output circuit outputs a detection signal on the basis of a response wave signal produced from the sensing capacitor CS in response to supply of the measurement signal thereto, the detection signal reflecting the electrostatic capacitance of the sensing capacitor CS. A temperature compensation mechanism is provided to compensate for a level change of the detection signal stemming from a temperature characteristic and/or a time-course deterioration of the detection signal output circuit.

In a vibrating microtome (1), a knife (6) is caused to vibrate during a sectioning operation in a direction parallel to a section plane and substantially parallel to the knife's edge, during which a transverse offset can occur as a consequence of a potentially present inclination of the cutting edge with respect to the section plane. A measuring device (3) for measuring the transverse offset comprises a light barrier (9) into which the cutting edge is placeable so as to partially cover the light of the light barrier. The vibrating microtome (1) generates, from the motion of the knife, a control application signal (pklo, pkhi) that describes the time course of the vibration of the knife (6), and the electronic measurement system of the measuring device (3) measures the coverage of the light barrier as a consequence of the vibration of the knife as an oscillating signal (tpm), and determines the transverse offset from the signal values at points in time that are defined by the control application signal.