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32 results about "Exhaled breath condensate" patented technology

Exhaled breath condensate (EBC) is the exhalate from breath, that has been condensed, typically via cooling using a collection device (commonly to 4 °C or subzero temperatures using a refrigerating device). EBC reflects changes in the respiratory fluid that lines the airways and is an inexpensive, non-invasive tool that has potential for scientific research. Despite its promises, it has not been proven for screening or diagnosing diseases of the lung and other conditions, yet. It has long been appreciated that the exhaled breath is saturated by water vapour (e.g. by wind musical instrument players), but using it for studies of the lung was probably first described in the Russian scientific literature.

Condensate glucose analyzer

The present invention provides systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments of the invention, electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and / or concentration of glucose.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Exhaled Breath Condensate Collection and Assay System and Method

InactiveUS20080214947A1Easy to determineDetermining the predictive ability of these testsRespiratory organ evaluationSensorsTime courseAssay
A method and system that provides for minute-to-minute EBC pH monitoring (or for other EBC characteristic monitoring) of a subject that greatly assists in determining the time-course of airway pH changes (or other characteristic changes) in evolving disease processes, and may assist in determining the predictive ability of these tests, as well as determining response to therapy.
Owner:UNIV OF VIRGINIA

High frequency airway oscillation for exhaled air diagnostics

The present invention relates to noninvasive methods for obtaining exhaled breath condensate (EBC) samples from the airways and lungs of a subject for use in diagnosing various conditions and diseases associated with biomarkers present in EBC, including diagnosis of lung cancer. The methods of the subject invention include generating and / or applying an oscillating airflow to a subject during inhalation and / or exhalation to induce increased concentration of biomarkers in EBC; collecting EBC from exhaled breath; and analyzing the collected EBC for biomarkers associated with disorders and / or diseases.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Exhaled breath condensate biometric marker measurement apparatus and method

The present invention includes an apparatus and a method for testing exhaled breath condensate for at least one biometric marker, including a substrate for collecting exhaled breath condensate, the substrate capable of being brought to a temperature below a dew point of vapor in exhaled breath, a collector for retaining the substrate and for receiving a biometric marker reagent. The invention may further include receiving exhaled breath in a collector, the collector comprising a substrate, the substrate being at a temperature below a dew point of vapor in exhaled breath, collecting the exhaled breath condensate on the substrate, and bringing a biometric marker reagent in contact with the substrate.
Owner:VYAIRE MEDICAL 207 INC

Condensate Glucose Analyzer

Systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments, electrochemical- or coulometnc-based sensing technologies are used to analyze EBC for the presence and / or concentration of glucose. Based on the detected glucose m EBC, the subject invention provides systems and methods for non-invasive, accurate assessment of blood glucose levels.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Integrated analysis device for simultaneously detecting ebcs and vocs in human exhaled breath

The present invention discloses an integrated analysis device for simultaneously detecting exhaled breath condensates (EBCs) and volatile organic compounds (VOCs) in human exhaled breath. The device comprises a module for sampling, separating and enriching a detected object, an EBCs detection module and a combined VOCs detection module. The module for sampling, separating and enriching a detected object is connected with the EBCs detection module via a syringe pump for sample injection. The module for sampling, separating and enriching a detected object is connected with the combined VOCs detection module by a capillary separation column. In the present invention, it is achieved that EBCs and VOCs in human exhaled breath are simultaneously sampled, separated and condensed; the heavy metal ions, cell factors, etc. in the collected EBCs are detected with a light addressable potentiometric sensor (LAPS); the condensed VOCs can be quantitatively detected by the combined VOCs detection module with a high sensitivity; and a heating rod and a platinum resistor can be conveniently replaced because a separated outlet heating piece is designed in the combined VOCs detection module.
Owner:ZHEJIANG UNIV

Collecting device of exhaled breath condensate (EBC)

InactiveCN101238980ASolve the automatic separationAddressing the effects of entry into refrigeration zonesWithdrawing sample devicesDiagnostic recording/measuringOxidative stressEngineering
The invention relates to a EBC detection as a detection technique completely without wound, with important use value for airway inflammation. A fourway gaspath solves the automatic separation of entrance of expired air, exit of expired air, inspired air and spit residue. The upbending design and 'claw type' of the exit pipeline of the expired air can solve the effect of spit residue from the expired air on refrigeration area. A singlechip system detects the expired air amount and the condensing temperature is set to quantify the collection of the condensate of expired air, so as to quantitatively evaluate change and degree of states such as oxidation stress, inflammation and the like in airway of a variety of respiratory disease.
Owner:JILIN UNIV

Breath Condensate Sampler And Detector And Breath/breath Condensate Sampler And Detector

The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate / breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.
Owner:NANOMIX

Human Exhaled Aerosol Droplet Biomarker System and Method

A system and method for detecting a biomarker in exhaled breath condensate nanodroplets comprises noninvasively collecting exhaled breath condensate nanodroplets of a subject, and analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction to detect one or more target biomarkers.
Owner:UNIV OF MARYLAND

Human Exhaled Aerosol Droplet Biomarker System and Method

A system and method for detecting a biomarker in exhaled breath condensate nanodroplets comprises noninvasively collecting exhaled breath condensate nanodroplets of a subject, and analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction to detect one or more target biomarkers.
Owner:UNIV OF MARYLAND

Exhaled breath condensate biometric marker measurement apparatus and method

The present invention includes an apparatus and a method for testing exhaled breath condensate for at least one biometric marker, including a substrate for collecting exhaled breath condensate, the substrate capable of being brought to a temperature below a dew point of vapor in exhaled breath, a collector for retaining the substrate and for receiving a biometric marker reagent. The invention may further include receiving exhaled breath in a collector, the collector comprising a substrate, the substrate being at a temperature below a dew point of vapor in exhaled breath, collecting the exhaled breath condensate on the substrate, and bringing a biometric marker reagent in contact with the substrate.
Owner:VYAIRE MEDICAL 207 INC

Integrated analysis device for simultaneously detecting EBCs and VOCs in human exhaled breath

The present embodiments disclose a device including a module for sampling, separating and enriching a detected object, an exhaled breath condensates (EBCs) detection module and a combined volatile organic compounds (VOCs) detection module. The sampling module is connected with the EBCs detection module via a syringe pump for sample injection and is connected with the combined VOCs detection module by a capillary separation column. EBCs and VOCs in human exhaled breath are simultaneously sampled, separated and condensed; the heavy metal ions, cell factors, etc. in the collected EBCs are detected with a light addressable potentiometric sensor (LAPS); the condensed VOCs can be quantitatively detected by the combined VOCs detection module with a high sensitivity; and a heating rod and a platinum resistor can be conveniently replaced because a separated outlet heating piece is designed in the combined VOCs detection module.
Owner:ZHEJIANG UNIV

Exhaled breath condensate collector

The invention discloses an exhaled breath condensate collector. The collector comprises a refrigeration system and a condensate collecting system; the refrigeration system comprises a temperature control box and a condensation tube sleeve, and the outer wall of the condensation tube sleeve is provided with an evaporator; the condensate collecting system comprises a breath inlet nozzle, an inhalation and exhalation four-way control valve, a condensation tube and a collecting cup, the inhalation and exhalation four-way control valve comprises a breath inlet nozzle connector, an inhalation inlet,an exhalation outlet and a condensation tube connector, and the collecting cup sleeves the bottom of an outer tube of a condensation tube; during use, the condensation tube sleeve sleeves the outer wall of the condensation tube and the collecting cup. The exhaled breath condensate collector is convenient to mount and dismount, the refrigeration system and the condensate collecting system are structurally independent, a patient is subjected to exhaled breath condensate detection without sitting up, and the collector is friendly to users.
Owner:PEKING UNIV FIRST HOSPITAL +1

Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia

A device for collecting exhaled breath condensate from a subject. The device comprises a plunger assembly and a stopper. The stopper is connected to the plunger disk of the plunger assembly by a plurality of support pins and is configured for sealing engagement. The device is utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate.
Owner:CHARLOTTE MECKLENBURG HOSPITAL AUTHORITY

Application of ezrin in preparing asthma diagnostic reagent

The invention discloses application of ezrin in preparing an asthma diagnostic reagent. From exhaled breath condensate (EBC)and serum (serum) of a healthy person and an asthma patient, it is found that the ezrin level of the healthy person can be remarkably differentiated from that of the asthama patient. The EBC and the ezrin level in the serum of the asthma patient are remarkably declined, and the EBC and the ezrin level in the serum have positive correlations with a lung function and have negative correlations with IL-13 and a periosteum peotein level in the serum, therefore, by monitoring the ezrin level in the human body serum (serum) or the exhaled breath condensate (EBC), diagnosis of the asthma can be conducted, treatment of the asthma is assisted, and prognosis of the asthma is evaluated. According to the application of the ezrin in preparing the asthma diagnostic reagent, guiding functions can be achieved in aspects of prediction, diagnosis and evaluation of a bronchial asthma disease through a simpler and more convenient method, and air passage barrier function changing conditions of the asthma patient can be more sensitively reflected. Based on the function of a biomarker of the ezrin, a more reliable and more sensitive kit can be hopefully prepared, asthma controlling conditions can be directly reflected, and treatment and prognosis evaluating of the asthma are guided.
Owner:JIANGSU PROVINCE HOSPITAL

Method of directly and simultaneously detecting nitrate and nitrite in exhaled breath condensate

The invention provides a method of directly and simultaneously detecting nitrate and nitrite in an exhaled breath condensate. Based on thermal desorption ion mobility spectrometry, phosphoric acid isadded to the collected exhaled breath condensate for acidification and is then dropped on a thermal desorption carrier for thermal desorption detection, and as nitric acid, nitrous acid and a substrate have different desorption time and different mobility, simultaneous quick detection on nitrate and nitrite in a complex biological sample is realized.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Disposable wearable sensor for continuous monitoring of breath biochemistry

An electrochemical method and an electrochemical sensor for breath analysis of single or multiple analytes using a porous, preferably flexible and disposable supporting material is provided, a salt is incorporated, and which can be wetted in contact with the exhaled breath condensate. The electrochemical method acting simultaneously as sampling method, as an electrolyte and as a support for the electrode structures. In some embodiments the salt may be hygroscopic, such that the porous substrate stays wet. To ensure that the obtained signal originates from the analyte, the electrochemical sensor preferably exhibits a differential electrode design, including a sensing (analyte-sensitive) and a blank (analyte-insensitive) electrode in order to isolate and remove the background signals.
Owner:ALBERT LUDWIGS UNIV FREIBURG +1

Quantification Of Inflammatory Molecules In Exhaled Breath Condensate Using Differential Pulse Voltammetry On Reduced Graphene Oxide Sensor

A device for detecting a biomarker for inflammation in a respiratory system includes a sample collection and / or holding area to receive an exhaled breath condensate (EBC) sample obtained from a respiratory system; an electrode system coupled to the sample collection area, the electrode system including reduced graphene oxide (rGO); and circuitry coupled to the electrode system. The circuitry is configured to apply a voltage to the EBC sample in the sample collection area via the electrode system and to measure a current via the electrode system in response to the voltage applied, in order to determine a concentration of nitrite in the EBC sample based on the current measured. The concentration of nitrite is a biomarker for inflammation in the respiratory system.
Owner:RUTGERS THE STATE UNIV

Exhaled breath condensate collector

An exhaled breath condensate collection device (10) is described. The device includes a condensation chamber (12) having an inlet and an outlet and arranged such that breath exhaled from the lungs of a user flows through the condensation chamber from the inlet to the outlet; at least one cooling element (16); and a frame (18) supporting the condensation chamber and the at least one cooling element. The frame (18) is movable between a first configuration in which the at least one cooling element is operable to cool the condensation chamber so as to promote the formation of breath condensate in the condensation chamber, and a second configuration in which the cooling element is displaced from the condensation chamber so as to encourage condensate to flow into a collection region in fluid communication with the condensation chamber. To be accompanied by FIG. 5.
Owner:MADDISON PROD DESIGN +1

Portable sampler for exhaled breath condensate and sampling method

PendingCN112890871AAcquisition is non-invasive and fastAvoid discomfortSurgeryVaccination/ovulation diagnosticsDiseaseHuman body
The invention discloses a portable sampler for exhaled breath condensate and a sampling method. A semiconductor chilling plate is utilized to provide a low-temperature condensing environment, and a sterile disposable suction tube and a 50ml centrifugal tube are utilized to collect the exhaled breath condensate of a human body. The sampler is simple in structure and portable in volume; the sampling method is simple in operation; except for an external power supply, the portable sampler does not need other consumable items and auxiliary equipment which are difficult to carry, such as a refrigerant; the exhaled breath condensate of the human body, which is enough for analyzing the disease infection condition, can be noninvasively and quickly collected; meanwhile, the discomfort and cross infection of a testee and the cross contamination of a sample can be avoided to the greatest extent; and the portable sampler is suitable for large-scale sampling detection diagnosis and epidemiological investigation of people infected by respiratory pathogens.
Owner:PEKING UNIV

Biomarkers for pulmonary embolism in exhaled breath condensate

A method is provided for determining pulmonary embolism and / or increased risk thereof in a human being, comprising collecting a sample of exhalation air from said human being and determining the presence or absence in said exhaled air of one or more biomarkers associated with pulmonary embolism. Additionally, a kit that comprises the means for detecting at least one biomarker associated with pulmonary embolism or risk thereof is provided.
Owner:REGION NORDJYLLAND AALBORG UNIV HOSPITAL +2

Apparatus and method for determination of banned substances

The present invention relates to roadside analyzer for determination of illegal drugs abuse, including, but not limiting to detection of explosives, toxic industrial chemicals and other banned or regulated compounds, biomarkers and phytochemicals in a sample in situ in at least one human body fluid sample, specifically in oral fluid (saliva), but not limiting to other clinical samples of interest (urine, blood, exhaled breath, exhaled breath condensate, etc.) It consists of automatic processor for preparing samples suitable for analysis. Analysis part of the instrument implements three technologies, namely solid phase extraction prior to analysis, capillary electrophoresis for separation of analytes from the sample matrix and impedance (contactless conductivity) or fluorescence or both impedance (contactless conductivity) and fluorescence for detection of analytes of interest.
Owner:TALLINN UNIVERSITY OF TECHNOLOGY

Method for detecting antigens or antibodies to the antigens using EBC and EBC collection device

An exhaled breath condensate (EBC) collection device comprising two adjacent parts foldable together and apart from each other, a condensation zone to condense exhaled breath from a subject, the condensation zone being a third part provided between the two adjacent parts and connectable to cooling means arranged in each of the two parts being in cooling relationship with the condensation zone. There is also provided a method for detecting antigens or antibodies to the antigens, the method comprising collecting EBC from a subject using the EBC collection device, performing immunochromatographic testing (ICT) of the collected exhaled breath condensate, and interpreting the immunochromatographic testing results as follows: if the immunochromatographic testing results are positive, the antigens or antibodies to the antigens are detected, or if the immunochromatographic testing results are negative, the antigens or antibodies to the antigens are not detected.
Owner:COLLINS T QUE +1

Dermcidin-derived peptides for lung cancer diagnostics

Methods for diagnosis of non-small cell lung cancers by detection of endogenous peptides in exhaled breath condensate (EBC) are provided. Diagnostic peptides derived from dermcidin (DC) are provided. A specific dermcidin-derived peptide E-R11, having the sequence ENAGEDPGLAR (SEQ ID NO:2), is provided. E-R11 peptide levels in EBC, as measured by mass spectrometry (MS), are highly diagnostic of non-small cell lung cancers. A method for inhibiting growth of lung cancer cells by inhibiting DCD expression by RNA interference also is provided.
Owner:ACAD SINIC

Application of ezrin in the preparation of asthma diagnostic reagents

The invention discloses application of ezrin in preparing an asthma diagnostic reagent. From exhaled breath condensate (EBC)and serum (serum) of a healthy person and an asthma patient, it is found that the ezrin level of the healthy person can be remarkably differentiated from that of the asthama patient. The EBC and the ezrin level in the serum of the asthma patient are remarkably declined, and the EBC and the ezrin level in the serum have positive correlations with a lung function and have negative correlations with IL-13 and a periosteum peotein level in the serum, therefore, by monitoring the ezrin level in the human body serum (serum) or the exhaled breath condensate (EBC), diagnosis of the asthma can be conducted, treatment of the asthma is assisted, and prognosis of the asthma is evaluated. According to the application of the ezrin in preparing the asthma diagnostic reagent, guiding functions can be achieved in aspects of prediction, diagnosis and evaluation of a bronchial asthma disease through a simpler and more convenient method, and air passage barrier function changing conditions of the asthma patient can be more sensitively reflected. Based on the function of a biomarker of the ezrin, a more reliable and more sensitive kit can be hopefully prepared, asthma controlling conditions can be directly reflected, and treatment and prognosis evaluating of the asthma are guided.
Owner:JIANGSU PROVINCE HOSPITAL

Exhaled breath condensate collector

An exhaled breath condensate collection device (10) is described. The device includes a condensation chamber (12) having an inlet and an outlet and arranged such that breath exhaled from the lungs of a user flows through the condensation chamber from the inlet to the outlet; at least one cooling element (16); and a frame (18) supporting the condensation chamber and the at least one cooling element. The frame (18) is movable between a first configuration in which the at least one cooling element is operable to cool the condensation chamber so as to promote the formation of breath condensate in the condensation chamber, and a second configuration in which the cooling element is displaced from the condensation chamber so as to encourage condensate to flow into a collection region in fluid communication with the condensation chamber. To be accompanied by FIG. 5.
Owner:MADDISON PROD DESIGN +1

Breath Condensate Samplers and Detectors and Breath/Breath Condensate Samplers and Detectors

The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate / breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.
Owner:NANOMIX INC
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