The invention discloses application of ezrin in preparing an
asthma diagnostic reagent. From
exhaled breath condensate (EBC)and serum (serum) of a healthy person and an
asthma patient, it is found that the ezrin level of the healthy person can be remarkably differentiated from that of the asthama patient. The EBC and the ezrin level in the serum of the
asthma patient are remarkably declined, and the EBC and the ezrin level in the serum have positive correlations with a
lung function and have negative correlations with IL-13 and a
periosteum peotein level in the serum, therefore, by monitoring the ezrin level in the
human body serum (serum) or the
exhaled breath condensate (EBC), diagnosis of the asthma can be conducted, treatment of the asthma is assisted, and prognosis of the asthma is evaluated. According to the application of the ezrin in preparing the asthma
diagnostic reagent, guiding functions can be achieved in aspects of prediction, diagnosis and evaluation of a bronchial asthma
disease through a simpler and more convenient method, and air passage
barrier function changing conditions of the asthma patient can be more sensitively reflected. Based on the function of a biomarker of the ezrin, a more reliable and more sensitive kit can be hopefully prepared, asthma controlling conditions can be directly reflected, and treatment and prognosis evaluating of the asthma are guided.