Application of ezrin in the preparation of asthma diagnostic reagents

Abstract

The invention discloses application of ezrin in preparing an asthma diagnostic reagent. From exhaled breath condensate (EBC)and serum (serum) of a healthy person and an asthma patient, it is found that the ezrin level of the healthy person can be remarkably differentiated from that of the asthama patient. The EBC and the ezrin level in the serum of the asthma patient are remarkably declined, and the EBC and the ezrin level in the serum have positive correlations with a lung function and have negative correlations with IL-13 and a periosteum peotein level in the serum, therefore, by monitoring the ezrin level in the human body serum (serum) or the exhaled breath condensate (EBC), diagnosis of the asthma can be conducted, treatment of the asthma is assisted, and prognosis of the asthma is evaluated. According to the application of the ezrin in preparing the asthma diagnostic reagent, guiding functions can be achieved in aspects of prediction, diagnosis and evaluation of a bronchial asthma disease through a simpler and more convenient method, and air passage barrier function changing conditions of the asthma patient can be more sensitively reflected. Based on the function of a biomarker of the ezrin, a more reliable and more sensitive kit can be hopefully prepared, asthma controlling conditions can be directly reflected, and treatment and prognosis evaluating of the asthma are guided.

Description

technical field [0001] The invention belongs to the field of detection reagents, in particular to the application of a protein in the preparation of asthma diagnostic reagents. Background technique [0002] Bronchial asthma (bronchial asthma), referred to as asthma, refers to the chronic inflammation of the airway involving a variety of cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, airway epithelial cells, etc.) and cell components disease. Asthma is one of the most common chronic diseases in the world. It can widely affect all age groups. The prevalence of asthma in various countries ranges from 1% to 18%. In my country, it is about 0.5% to 5%, and it shows an increasing trend year by year. has become a major burden in global health management. The mortality rate of asthma is 1.6-36.7 / 100,000, mostly due to long-term poor control of asthma and untimely treatment of acute attacks, and most of these are preventable and controllable. The diagnosis of as...

AI Technical Summary

Problems solved by technology

At present, there are many clinical studies on the single or combined use of plasma biomarkers as a means of disease diagnosis, but there is a lack of systematic and in-depth exploration of plasma markers for airway diseases such as asthma

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