Breath Condensate Sampler And Detector And Breath/breath Condensate Sampler And Detector

A technology of exhaled breath condensate and condenser, which is applied in the field of breath condensate sampler and detector and breath/breath condensate sampler and detector, which can solve the problems of physical difficulty and time-consuming of patients

Inactive Publication Date: 2012-11-28
NANOMIX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The process is time-consuming and physically difficult for the patient

Method used

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  • Breath Condensate Sampler And Detector And Breath/breath Condensate Sampler And Detector
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  • Breath Condensate Sampler And Detector And Breath/breath Condensate Sampler And Detector

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Embodiment Construction

[0014] In the following description, numerous details are set forth in order to provide a thorough understanding of the present invention. The present invention may be practiced without some or all of these details. In other instances, well known process operations have not been described in order not to unnecessarily obscure the present invention. While the invention will be described in conjunction with specific embodiments, it will be understood that they are not intended to limit the invention to the described embodiments. References herein to physical vapor deposition, chemical vapor deposition, and atomic layer deposition are intended to cover many variations of these processes, including those aided by plasma, vacuum or low pressure processes, atmospheric pressure processes, and the like.

[0015] introduction

[0016] Exhaled breath condensate (EBC) contains a variety of components, including small molecules, proteins, and DNA. By measuring the presence or amount of...

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Abstract

The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate / breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims the benefit under 35 USC § 119(e) of the following U.S. Provisional Application, which is hereby incorporated by reference in its entirety: U.S. Provisional No. 61 / 169,655 filed April 15, 2009 patent application. technical field Background technique [0003] Exhaled breath condensate (EBC) contains a variety of components, including small molecules, proteins, and DNA. By measuring the presence or amount of these components in the patient's exhaled breath condensate, diagnostic and other information can be provided, including pH, the presence of various proteins including anti-inflammatory or pro-inflammatory cytokines, and the like. However, to date, breath condensate samplers have required the patient to exhale into the sampling tube for an extended period of time, such as ten minutes, in order to collect the necessary number of samples. The process is time-consuming and physically difficult ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/00
CPCG01N33/497G01N2001/2282A61B5/097A61B5/0803A61B5/14539B82Y30/00A61B5/082
Inventor 布拉德利・N・约翰逊干乍恩・乔希张英兰雷・拉特凯
Owner NANOMIX
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