Diagnosis of tuberculosis and other diseases using exhaled breath

a technology of exhalation and diagnosis, applied in the field of diagnosis of tuberculosis and other diseases, can solve the problems of significant reduction of disease burden, inadequate rate of incidence decline, and inability to accurately diagnose the diseas

a technology of exhalation and diagnosis, applied in the field of diagnosis of tuberculosis and other diseases, can solve the problems of significant reduction of disease burden, inadequate rate of incidence decline, and inability to accurately diagnose the diseas

US20220322963A1Pending Publication Date: 2022-10-13ZETEO TECH INC
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  • Diagnosis of tuberculosis and other diseases using exhaled breath
  • Diagnosis of tuberculosis and other diseases using exhaled breath
  • Diagnosis of tuberculosis and other diseases using exhaled breath

Examples

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Embodiment Construction

[0036]Particular aspects of the invention are described below in considerable detail for the purpose for illustrating the compositions, and principles, and operations of the disclosed methods and systems. However, various modifications may be made, and the scope of the invention is not limited to the exemplary aspects described.

[0037]An exemplary diagnosis system 100 based on exhaled breath analysis (“EBA”) may comprise an EBA sample collection subsystem 101, and an analysis subsystem system 102 (FIGS. 1-3). These two subsystems are described in detail below.

[0038]EBA Sample Collection Subsystem 101

[0039]Subsystem 101 may comprise sample extraction component 104 which may be in the form of at least one of a shroud, and a loose-fitting cone shaped device. A tight-fitting suitable mask suitable for receiving an individual's face or that may be removably attached using straps and the like to the face / head of a patient / individual 105 may also be used, but is not preferred because it is ...

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Abstract

Disclosed are methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates using various diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates for tuberculosis diagnosis using mass spectrometry, including MALDI-MS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.

Description

RELATED APPLICATIONS[0001]This application is related to and claims the benefit of U.S. Provisional Application 62 / 891,954, filed Aug. 26, 2019, and entitled “Diagnosis of Tuberculosis and Other Diseases Using Exhaled Breath,” and U.S. Provisional Application 63 / 069,120, filed Aug. 23, 2020, and entitled “Diagnosis of Tuberculosis and Other Diseases Using Exhaled Breath,” which are both hereby incorporated by reference in their entirety.FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT[0002]None.FIELD[0003]This disclosure relates to methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates using various diagnostic tools to enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. More particularly, but not by way of limitation, the present disclosure relates to methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates for tuberculosis diagnosis using mass spectromtery...

Claims

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Application Information

Patent Timeline
13 Oct 2022
Publication
US20220322963A1
IPC
A61B5/08; A61B5/091; A61B5/097; G01N30/72
CPC
A61B5/082; A61B5/091; A61B5/097; G01N30/7206; A61B10/0045; A61B5/0836; A61B5/0833; G01N33/497
Inventors
BRYDEN, WAYNE A.; CALL, CHARLES J.