43 results about "Chronic gout" patented technology

Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and / or treatment of hyperuricemia and chronic gout.

The invention discloses a traditional Chinese medicine Tongfengling used for treating chronic gouty arthritis. Chronic gout is in 'pyretic arthralgia' scope of the traditional Chinese medicine. Pathogeneses of gout mainly lie in that healthy atmosphere of human body is insufficient, yin-yang disharmony is caused, damp and hot phlegm stagnation pathological products are gathered in vivo, main and collateral channels are blocked, and pain is caused by stagnation. Aiming at solving the problems, traditional Chinese medicines which have the effects of warming the kidney and tonifying spleen, clearing heat and promoting diuresis, activating blood and removing stasis as well as detoxifying and stopping pain, comprising spicate clerodendranthus herb, yam rhizome, golden cypress, kerr treebine root and stem, hopleaf ampelopsis root-bark, delavay violet root, tree peony bark, heartleaf saussurea root, glabrous greenbrier rhizome, mulberry twig, radix stephaniae tetrandrae, large-leaved gentian, allium macrostemon, sword bean and liquorice, are selected in the invention and are prepared into decoction by a drug manufacturing room of the hospital (described in the specification); and the clinical test shows that the total effective rate reaches up to 95.9% and is obviously better than that of a control group, and especially toxic and side effects are less and clinical popularization and application are deserved compared with the control group.

The invention discloses a probenecid slow-release tablet and a preparation method thereof. The components and parts by weight of the slow-release tablet include: 40-50 parts of probenecid, 30-35 parts of sodium bicarbonate, and 20-35 parts of blank pellet cores. 25 parts, 3-5 parts of slow-release material, 0.3-0.6 parts of plasticizer, 0.1-0.3 parts of porogen, 10-15 parts of filler, 0.5-1.0 parts of lubricant, 15-20 parts of disintegrant, package Clothing materials 2 to 5 parts. The preparation method of the sustained-release tablet comprises: preparation of raw materials, preparation of pill-containing cores, preparation of sustained-release pellets, tabletting and coating. Sodium bicarbonate is added to the formulation of the sustained-release tablet. When treating chronic gout, it only needs to be taken with a large amount of water to prevent urate from forming urinary stones in the urinary tract. Moreover, sodium bicarbonate can neutralize excessive gastric acid, and when increasing the effect of penicillins, it has the effect of invigorating the stomach and antacid. Taking it 1-2 times a day increases the patient's compliance.

The invention discloses a traditional Chinese medicine for treating gout. The traditional Chinese medicine is prepared from the following raw materials according to a weight ratio: 10-20 of pueraria, 20-40 of gynostemma, 10-20 of ligustrum lucidum, 30-50 of cordyceps, 15-25 of cinnamon, 30-50 of papaya, 10-20 of angelica, 15-25 of anemarrhena, 5-15 of safflower, 20-40 of white peony root, 3-10 ofplantago, 5-10 of radix semiaquilegiae, 15-25 of desmodium, 10-20 of gardenia, 5-10 of orienavine, 5-15 of radix isatidis, 10-20 of silkworm excrement, 5-10 of trachelospermum jasminoides, 5-18 of caulis spatholobi, 10-20 of salvia miltiorrhiza, 5-15 of prepared rehmannia root, 10-20 of clematis chinensis and 10-20 of trogopterus dung. The traditional Chinese medicine for treating gout disclosed by the invention contains carefully selected traditional Chinese medicines which are matched scientifically, has the effects of promoting blood circulating and removing obstruction in channels, expelling wind and removing dampness, eliminating swelling and alleviating paint, clearing away heat and toxic materials, warming channels and eliminating stasis and the like, and has better treatment effect on acute and chronic gout as well as gouty arthritis.

The invention provides application of a Chinese medicine composition to the preparation of medicine for treating chronic gout. The Chinese medicine composition is prepared by polygonum cuspidatum, semen plantaginis, caulis piperis futokadsurae, pyrola, radix curcuma, caulis spatholobi, rhizoma dioscoreae and semen cuscutae through water extraction. The Chinese medicine composition has the advantages that the polygonum cuspidatum and the semen plantaginis having the effect of clearing heat and promoting diuresis are used as the monarch drugs, the caulis piperis futokadsurae and the pyrola having the effect of dispelling wind and removing meridian obstruction are used as the ministerial drugs, the radix curcuma and the caulis spatholobi having the effect of promoting blood circulation to arrest pain and the rhizoma dioscoreae and the semen cuscutae having effects of tonifying qi and the spleen and nourishing the liver and the kidney are also used, and the Chinese medicine composition has an evident curative effect on the gout and hyperuricemia and is low in toxic and side effect and suitable for being taken by a patient for a long time.

The invention relates to application of a stilbene derivative and pharmaceutically acceptable salts thereof to preparation of medicines or health-care products for preventing and / or treating hyperuricemia, and acute gout, chronic gout, gouty arthritis, gout attack, uric acid nephrolithiasis and gouty nephropathy caused by the hyperuricemia. The stilbene derivative is used as an active component for preparing the medicines for treating the hyperuricemia, can reduce the concentration of uric acid in blood, has a significant effect on treatment of the hyperuricemia, does not have toxic or side effects and has good safety.