43 results about "Chronic gout" patented technology

[Problems] The present invention provides pharmaceutical composition which is effective for the prophylaxis or treatment of pathology showing involvement of uric acid (hyperuricemia, gouty tophus, acute gout arthritis, chronic gout arthritis, gouty kidney, urolithiasis, renal function disorder, coronary arterial disease, ischemic heart disease and the like) and the like, and is superior in the time-course stability and dissolution property (disintegration property).

[Solving Means] The pharmaceutical composition of the present invention is a pharmaceutical composition comprising a nitrogen-containing fused ring compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable additives, wherein the nitrogen-containing fused ring compound or a pharmaceutically acceptable salt thereof is not in contact with a basic additive:

wherein each symbol is as described in the specification.

The invention relates to application of a stilbene derivative and pharmaceutically acceptable salts thereof to preparation of medicines or health-care products for preventing and/or treating hyperuricemia, and acute gout, chronic gout, gouty arthritis, gout attack, uric acid nephrolithiasis and gouty nephropathy caused by the hyperuricemia. The stilbene derivative is used as an active component for preparing the medicines for treating the hyperuricemia, can reduce the concentration of uric acid in blood, has a significant effect on treatment of the hyperuricemia, does not have toxic or side effects and has good safety.

The invention discloses a polyethylene glycol (PEG) dog-source urate oxidase analogue, wherein the dog-source urate oxidase analogue is natural dog-source urate oxidase and chimeric protein and mutant protein containing part of dog-source and human-source urate oxidase amino acid sequences, the average molecular weight of polyethylene glycol is about 1kDa-40kDa, and each urate oxidase monomer is coupled with 2-15 polyethylene glycol molecules in average. According to the method for preparing mammal-source urate oxidase subjected to covalent modification by the polyethylene glycol, the enzyme activity retention rate is higher than 85.0%, and the purification is higher than 95.0%. According to the method, the dog-source urate oxidase analogue subjected to covalent modification by the polyethylene glycol and drug compositions thereof can be used for preventing and/or treating acute hyperuricemia caused by hematologic tumor chemotherapy and hyperuricemia and chronic gout caused by metabolic disorders.

The invention discloses a traditional Chinese medicine for treating gout. The traditional Chinese medicine is prepared from the following raw materials according to a weight ratio: 10-20 of pueraria, 20-40 of gynostemma, 10-20 of ligustrum lucidum, 30-50 of cordyceps, 15-25 of cinnamon, 30-50 of papaya, 10-20 of angelica, 15-25 of anemarrhena, 5-15 of safflower, 20-40 of white peony root, 3-10 ofplantago, 5-10 of radix semiaquilegiae, 15-25 of desmodium, 10-20 of gardenia, 5-10 of orienavine, 5-15 of radix isatidis, 10-20 of silkworm excrement, 5-10 of trachelospermum jasminoides, 5-18 of caulis spatholobi, 10-20 of salvia miltiorrhiza, 5-15 of prepared rehmannia root, 10-20 of clematis chinensis and 10-20 of trogopterus dung. The traditional Chinese medicine for treating gout disclosed by the invention contains carefully selected traditional Chinese medicines which are matched scientifically, has the effects of promoting blood circulating and removing obstruction in channels, expelling wind and removing dampness, eliminating swelling and alleviating paint, clearing away heat and toxic materials, warming channels and eliminating stasis and the like, and has better treatment effect on acute and chronic gout as well as gouty arthritis.

The present invention provides a new application of Fraxinus general counmarin and aesculetin as the extractives of Chinese medicine material cortex Fraxini. The said two has obvious effects of stopping pain, resisting inflammation and reducing blood uric acid. They has obvious curative effect on acute and chronic gout and no obvious toxic side-effect. The present invention also provides a simple preparation process of Fraxinus general coumarin, and that is a Fraxinus general coumarin concentrating and purifying process.

The invention discloses novel medicinal application of coreopsis tinctoria, and particularly relates to application of coreopsis tinctoria extract to preparing medicines for treating hyperuricemia. The novel medicinal application has the advantages that effects of treating the hyperuricemia can be realized by the coreopsis tinctoria extract, the concentration of uric acid in blood can be effectively reduced, and excellent curative effects can be realized for metabolic diseases such as acute gout, chronic gout, gouty arthritis, gout flare, uric acid renal lithiasis and gouty nephropathy which are relevant to the hyperuricemia.

The invention discloses a compound oral Chinese patent medicament for treating gout, which consists of the following raw materials in percentage by weight based on crude medicaments: 5 to 20 percent of phellodendron, 5 to 20 percent of root of common peony, 5 to 30 percent of sevenlobed yam rhizome, 5 to 30 percent of desmodium, 3 to 10 percent of mastic, 3 to 10 percent of myrrh, 5 to 25 percent of suberect spatholobus stem, 5 to 20 percent of rhizoma atractylodis, 5 to 28 percent of oriental waterplantain rhizome, 5 to 20 percent of medicinal cyathula root, and 5 to 20 percent of root of largeleaf gentian. The invention discloses a preparation method for the medicament, and the formulations of the medicament are tablets, capsules, granules, oral liquid, dropping pills, and other common formulations. The compound oral Chinese patent medicament is used for treating acute and chronic gout, gouty arthritis, gouty stone, and gouty nephrotic syndrome, is a new medicament with obvious curative effects and safe administration for clinical treatment, and has significant application value.

The invention discloses a probenecid sustained-release tablet and a preparation method. The probenecid sustained-release tablet is composed of, by weight, 40-50 parts of probenecid, 30-35 parts of sodium bicarbonate, 20-25 parts of core pellet, 3-5 parts of sustained-release material, 0.3-0.6 part of plasticizer, 0.1-0.3 part of porogen, 10-15 parts of filler, 0.5-1.0 of lubricating agent, 15-20 parts of disintegrant and 2-5 parts of coating material. The preparation method includes the steps of material preparation, preparation of pellet containing core, preparation of sustained-release pellets, tabletting and coating. Sodium bicarbonate is added in the formula, so that urate can be prevented from forming urinary stone in the urinary tract by taking the probenecid sustained-release tablet with a lot of water for treating chronic gout. Sodium bicarbonate can neutralize excessive gastric acid and has stomach-invigorating and antiacid effect when improving effect of penicillins. The probenecid sustained-release tablet is taken 1-2 times a day, so that compliance of patients is increased.

The invention is a medicine for curing arthrolithiasis and the preparing method thereof, characterized by that it is prepared of White Paeony Root, Fenbixian, Mulberry Twig, Herba Siegesbeckiae, Coix Seed, Glabrous Greenbrier Rhizome, Medicinal Cyathula Root, Clematis Root, and Membranous Milkvetch Root in certain proportion and able to be made into any oral form. It has functions of clearing heat and discharging corruption, tonifying spleen and promoting diuresis, and dispelling the wind and removing rheumatism and is used for curing diseases caused by damp, heat, accumulation and mass, especially pains in limbs, muscles and veins, red and swelling, fever and pains of joint, and inconvenient bending and extending. The curative effect study verifies that it can reduce the uric acid content of the blood serum of an animal with high- uric acid content blood disease, improve rheological indexes of the blood, and treat gouty arthritis and common inflammation and has good pain-stopping function and very curative effect on acute and chronic grouts, where the clinical effective rate is up to 91.36%.

The invention discloses application of a matching medicament to the preparation of medicaments for treating chronic gout with gouty tophus. The medicament consists of concentrated kidney tonifying and rheumatism eliminating pills and gout granules. The matching medicament has a reasonable formula and a good treatment effect.

The invention discloses a traditional Chinese medicine preparation for treating chronic gout. The traditional Chinese medicine preparation respectively comprises the following components in parts by weight: 20-30 parts of liquorice, 15-20 parts of medicinal cyathula root, 20-30 parts of prepared rehmannia root, 5-10 parts of schizophragma root, 10-15 parts of radix aconiti agrestis, 3-12 parts of root of red-rooted salvia, 10-12 parts of pericarpium citri reticulatae and 5-10 parts of lysimachia christinae hance. The traditional Chinese medicine preparation has the effects of dispelling wind and activating blood, and activating meridians to stop pain by the medicinal value and the effects of the components in the traditional Chinese medicine preparation, especially has a better curative effect on chronic gout, and is free of toxic and side effects on a sufferer, low in cost and small in risk.

The invention belongs to the field of health drink processing and provides a taxus chinensis chronic gout-dispelling nectar. The taxus chinensis chronic gout-dispelling nectar is obtained by extracting the processed taxus chinensis branches and roots, rhodiola rosea, catalpa speciosa and lucid ganoderma through an extraction process to prepare taxus chinensis chronic gout-dispelling nectar stock solution; then soaking and fermenting wolfberry, longan and litchi in high-purity rice wine through a fermentation process, and distilling to obtain the distilled wine; finally uniformly mixing the extracted taxus chinensis chronic gout-dispelling nectar stock solution with the distilled wine in a ratio of 1: (10 to 30), and then sterilizing, disinfecting and filling. The taxus chinensis chronic gout-dispelling nectar has the effect of dispelling chronic gout, and is capable of effectively treating the symptoms of cold-dampness, spur pain, scapulohumeral periarthritis, stomach cold, hand and foot cold, and the like.

The invention discloses a liquid for treating ostalgia, which comprises the following components: safflower carthamus, spatholobus stem, Chinese angelica, angelica sylvestris, levisticum, Thunbergia grandiflora, tree peony bark, cortex acanthopanacis, pseudo-ginseng, pyrite, Cudrania cochinchinensis, Zanthoxylum nitidum, fructus liquidambaris and rice wine. The invention also discloses a preparation method of the liquid for treating ostalgia, which is prepared by placing the safflower carthamus, spatholobus stem, Chinese angelica, angelica sylvestris, levisticum, Thunbergia grandiflora, tree peony bark, cortex acanthopanacis, pseudo-ginseng, pyrite, Cudrania cochinchinensis, Zanthoxylum nitidum and fructus liquidambaris in rice wine. The liquid for treating ostalgia is used for treating cervical vertebra, thoracic vertebra, lumbar vertebra, scapulohumeral periarthritis, rheumatoid disease edema pain, ankylosing spondylitis, hemiplegia hemiplegia, aches in the limbs, hyperosteogeny, acute and chronic gout, sciatica, muscle edema pain and traumatic injury.

The invention relates to a health product with an effect of alleviating and treating gout. The health product is prepared from the following raw materials in percentage by weight: 20-30% of female carrot, 50-60% of green papaya, 10-20% of konjac and 5-20% of horseradish tree leaves. The preparation method comprises the following steps: extracting and removing oxalic acid from the components in an extraction manner, performing low-temperature freeze drying, grinding the remained components into fine particles, thereby obtaining the product, wherein the main ingredients are not damaged. The health product disclosed by the invention has the effects of alkalinizing blood, dissolving uric acid crystals and repairing metabolism of liver and kidney for patients suffering from chronic gout crystals, so that the patients can restore to the health level; the health product can achieve the effects of rapidly eliminating red and swollen and heat pain and clearing away uric acid crystal salt for patients with acute gouty attack; and the health product disclosed by the invention can repair the renal function, so that the gout is difficult to reoccur, and benefits are brought to vast gout patients.

The invention provides a traditional Chinese medicinal preparation for treating chronic gout and a method for preparing the traditional Chinese medicinal preparation for treating the chronic gout. The traditional Chinese medicinal preparation is prepared from rhizoma polygoni cuspidati, semen plantaginis, caulis piperis kadsurae, herba pyrolae, rhizoma curcumae longae, caulis spatholobi, rhizoma dioscoreae and semen cuscutae through a water extraction method, wherein the rhizoma polygoni cuspidati and the semen plantaginis are used for clearing heat and promoting diuresis and are used as monarch drugs; the caulis piperis kadsurae and the herba pyrolae are used for dispelling wind and smoothing collaterals and are used as ministerial drugs; the traditional Chinese medicinal preparation for treating the chronic gout is supplemented by the rhizoma curcumae longae and the caulis spatholobi which are used for activating blood circulation and relieving a pain and is supplemented by the rhizoma dioscoreae and the semen cuscutae which are used for benefiting qi, strengthening the spleen and nourishing liver and kidney; the traditional Chinese medicinal preparation has obvious curative effects of resisting the gout and resisting hyperuricemia, moreover, is few in toxic and side effects, and is suitable for a patient to take for a long term.

The invention relates to a traditional Chinese medicine composition for treating gout, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition comprises the following components in parts by weight: 15-30 parts of longhairy antenoron herb, 15-25 parts of plantain, 5-20 parts of rhizoma atractylodis, 5-15 parts of phellodendron amurense, 10-15 parts of rhizoma anemarrhenae, 5-10 parts of radix pseudostellariae, 5-15 parts of rhizoma atractylodis macrocephalae, 3-10 parts of radix cyathulae, 5-8 parts of cassia twig and 3-8 parts of honey-fried licorice root. All the components of the traditional Chinese medicine composition are jointly ground into fine powder, and the fine powder is subpackaged for brewing and drinking; the traditional Chinese medicine composition has the effects of dispelling wind to activate collaterals and activating blood circulation to relieve pain; through the adoption of the traditional Chinese medicine composition, the pain caused by gout can be relieved, and the soreness caused by swelling of cervical vertebra and lumbar vertebra can be treated; especially, chronic gout can be treated radically.

The invention discloses a traditional Chinese medicinal composition having functions of strengthening tendons and warming bones, dispelling wind and eliminating dampness, removing stagnation and alleviating pain. The traditional Chinese medicinal composition consists of the following components in parts by weight: 30-60 parts of mashed potato, 15-35 parts of Chibing powder (mixed powder of semen phaseoli and borneol), 2-14 parts of Xinma powder (mixed powder of herba asari and herba ephedrae) and 12-32 parts of Baijiu. The traditional Chinese medicinal composition is elaborately prepared from a few of medicines which enhance each other in effects of strengthening tendons and warming bones, dispelling wind and eliminating dampness, cooling blood and removing swelling, tonifying qi and promoting blood circulation, removing stagnation and alleviating pain, so that an obvious synergistic effect is shown and side effects of the medicines are further reduced. In addition, the traditional Chinese medicinal composition provided by the invention, which is externally applied, directly acts on focuses; and the traditional Chinese medicinal composition is rapid to take effects, long in action duration and obvious in curative effect on treating such diseases as various soft tissue contusion, acute and chronic gout and the like.