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Prepn and application in preparing medicine of Fraxinus general coumarin

A technology of total coumarin and Qinpi, applied in the field of preparation of Qinpi total coumarin, can solve the problems of different, difficult to control the quality of Chinese patent medicines, difficult to determine effective components and the like

Inactive Publication Date: 2005-01-26
CHENGDU DIKANG PHARMA INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently used traditional Chinese medicines are mainly compound prescriptions, and no single Chinese medicine extract has been reported as a preparation for the treatment of gout. Due to the complexity of traditional Chinese medicine and compound prescriptions, it is difficult to determine the active ingredients. Therefore, it is difficult to accurately evaluate the clinical efficacy. The content of traditional Chinese medicine ingredients varies from place to place and batches, making it difficult to control the quality of Chinese patent medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Take 100 kg of Qinpi, cut into granules, add water to extract three times, concentrate the water extract into an extract, add 3.5 times the amount of ethanol, ethanol precipitation, filter, recover the solvent from the ethanol solution and concentrate it into an extract with a specific gravity of 1.1, and then place it in Refrigerate at 8° C. for 10 hours, filter, collect the precipitate, and dry to obtain 2.15 kg of total coumarins from fenugreek.

Embodiment 2

[0103] Take Qinpi 100kg, cut into granules, add water to extract three times, concentrate the water extract into an extract, add 5 times the amount of ethanol, ethanol precipitation, filter, recover the solvent from the ethanol solution and concentrate it into an extract with a specific gravity of 1.2, and then place it in Refrigerate at 12° C. for 12 hours, filter, collect the precipitate, and dry to obtain 2.22 kg of total coumarins from fenugreek.

Embodiment 3

[0105] 2kg of the total coumarin of the obtained fenugreek obtained in embodiment one or embodiment two, or other methods known to those skilled in the art, such as making extractum with alcohol extraction and alcohol precipitation method or alcohol extraction method and then concentrating with macroporous resin adsorption method to obtain The total coumarin of phoenix bark, according to the method of conventional preparation, is added the appropriate excipient, makes the 200 mg / capsule of the chin bark total coumarin capsule.

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PUM

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Abstract

The present invention provides a new application of Fraxinus general counmarin and aesculetin as the extractives of Chinese medicine material cortex Fraxini. The said two has obvious effects of stopping pain, resisting inflammation and reducing blood uric acid. They has obvious curative effect on acute and chronic gout and no obvious toxic side-effect. The present invention also provides a simple preparation process of Fraxinus general coumarin, and that is a Fraxinus general coumarin concentrating and purifying process.

Description

Technical field: [0001] The invention relates to a preparation method and application of a quince extract, in particular to a preparation method of quince total coumarin and its use in the field of pharmacy. Background technique: [0002] Gout is a disease caused by purine metabolism disorder or decreased uric acid excretion, which leads to continuous increase of blood uric acid as the basic cause and causes various lesions. It belongs to metabolic rheumatism. This disease belongs to the categories of TCM arthralgia, gout, and calendrical joints. It refers to the symptoms of external pathogens blocking the meridians, stagnation of Qi and blood, and joint and muscle pain, numbness, heaviness, and difficulty in flexion and extension caused by liver and kidney deficiency. Hyperuricemia is the basis of gout, and it is a different stage of the same disease as gout, and it is the pre-state of gout. The clinical features of gout are hyperuricemia, recurrent episodes of acute and c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61K36/00A61P19/06C07D311/08
CPCC07D311/08A61K36/63A61K31/37A61P19/06
Inventor 杨安东赵军宁
Owner CHENGDU DIKANG PHARMA INST
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