Probenecid sustained-release tablet and preparation method thereof

A probenecid and sustained-release tablet technology, applied in the field of medicine, can solve the problems of inconvenience in taking, reduced efficacy, poor patient compliance, etc., and achieves the effects of fast drug application, simple formula, and increased compliance

Active Publication Date: 2017-10-13
李超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is relatively inconvenient to take, and the patient's compliance is poor, and forgetting to take it will reduce the curative effect, especially in the treatment of chronic gout, if you forget to take sodium bicarbonate urate, it is easy to form urinary stones in the urinary tract

Method used

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  • Probenecid sustained-release tablet and preparation method thereof
  • Probenecid sustained-release tablet and preparation method thereof
  • Probenecid sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 45 parts of probenecid, 32 parts of sodium bicarbonate, 23 parts of sucrose pills, 4 parts of ethyl cellulose, and 0.4 part of castor oil , 0.2 parts of hypromellose, 12 parts of compressible starch, 0.8 parts of magnesium stearate, 17 parts of dry starch, and 3 parts of hydroxypropyl methylcellulose.

[0034] A preparation method of probenecid sustained-release tablets, the specific steps comprising:

[0035] 1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;

[0036] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve probenecid with 95% alcohol to prep...

Embodiment 2

[0042] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 40 parts of probenecid, 30 parts of sodium bicarbonate, 20 parts of microcrystalline cellulose pellets, 3 parts of polyethylene glycol, glycerin 0.3 parts of ester, 0.1 parts of polyacrylic resin, 10 parts of microcrystalline cellulose, 0.5 parts of micropowder silica gel, 15 parts of dry starch, and 2 parts of hydroxypropyl cellulose.

[0043] A preparation method of probenecid sustained-release tablets, the specific steps comprising:

[0044]1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;

[0045] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve p...

Embodiment 3

[0051] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 50 parts of probenecid, 35 parts of sodium bicarbonate, 35 parts of starch pellets, 5 parts of polyethylene, 0.6 part of succinate, 0.3 parts of polyethylene glycol, 15 parts of microcrystalline cellulose, 1.0 parts of talcum powder, 30 parts of sodium carboxymethyl starch, and 5 parts of hydroxypropyl cellulose.

[0052] A preparation method of probenecid sustained-release tablets, the specific steps comprising:

[0053] 1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;

[0054] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve probenecid with 98% alc...

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Abstract

The invention discloses a probenecid slow-release tablet and a preparation method thereof. The components and parts by weight of the slow-release tablet include: 40-50 parts of probenecid, 30-35 parts of sodium bicarbonate, and 20-35 parts of blank pellet cores. 25 parts, 3-5 parts of slow-release material, 0.3-0.6 parts of plasticizer, 0.1-0.3 parts of porogen, 10-15 parts of filler, 0.5-1.0 parts of lubricant, 15-20 parts of disintegrant, package Clothing materials 2 to 5 parts. The preparation method of the sustained-release tablet comprises: preparation of raw materials, preparation of pill-containing cores, preparation of sustained-release pellets, tabletting and coating. Sodium bicarbonate is added to the formulation of the sustained-release tablet. When treating chronic gout, it only needs to be taken with a large amount of water to prevent urate from forming urinary stones in the urinary tract. Moreover, sodium bicarbonate can neutralize excessive gastric acid, and when increasing the effect of penicillins, it has the effect of invigorating the stomach and antacid. Taking it 1-2 times a day increases the patient's compliance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a probenecid sustained-release tablet and a preparation method thereof. Background technique [0002] Hyperuricemia (HUA) refers to hyperuricemia when the blood uric acid level on an empty stomach exceeds 420 μmol / L for men and 360 μmol / L for women on two different days in a normal purine diet. Uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. According to reports on the prevalence of hyperuricemia in various places in recent years, there are currently about 120 million hyperuricemia patients in my country, accounting for about 10% of the total population. trend. [0003] Probenecid is a white crystalline powder, odorless, slightly bitter taste, soluble in acetone, slightly soluble in ethanol or chloroform, almost insoluble in water, soluble in dilute sodium hydroxide solution, almost insoluble in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61K33/00A61K9/22A61P19/06A61P13/04A61K31/43
Inventor 夏征梅
Owner 李超
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