Probenecid sustained-release tablet and preparation method thereof
A probenecid and sustained-release tablet technology, applied in the field of medicine, can solve the problems of inconvenience in taking, reduced efficacy, poor patient compliance, etc., and achieves the effects of fast drug application, simple formula, and increased compliance
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Embodiment 1
[0033] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 45 parts of probenecid, 32 parts of sodium bicarbonate, 23 parts of sucrose pills, 4 parts of ethyl cellulose, and 0.4 part of castor oil , 0.2 parts of hypromellose, 12 parts of compressible starch, 0.8 parts of magnesium stearate, 17 parts of dry starch, and 3 parts of hydroxypropyl methylcellulose.
[0034] A preparation method of probenecid sustained-release tablets, the specific steps comprising:
[0035] 1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;
[0036] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve probenecid with 95% alcohol to prep...
Embodiment 2
[0042] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 40 parts of probenecid, 30 parts of sodium bicarbonate, 20 parts of microcrystalline cellulose pellets, 3 parts of polyethylene glycol, glycerin 0.3 parts of ester, 0.1 parts of polyacrylic resin, 10 parts of microcrystalline cellulose, 0.5 parts of micropowder silica gel, 15 parts of dry starch, and 2 parts of hydroxypropyl cellulose.
[0043] A preparation method of probenecid sustained-release tablets, the specific steps comprising:
[0044]1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;
[0045] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve p...
Embodiment 3
[0051] A probenecid sustained-release tablet, the components and parts by weight of the sustained-release tablet include: 50 parts of probenecid, 35 parts of sodium bicarbonate, 35 parts of starch pellets, 5 parts of polyethylene, 0.6 part of succinate, 0.3 parts of polyethylene glycol, 15 parts of microcrystalline cellulose, 1.0 parts of talcum powder, 30 parts of sodium carboxymethyl starch, and 5 parts of hydroxypropyl cellulose.
[0052] A preparation method of probenecid sustained-release tablets, the specific steps comprising:
[0053] 1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release tablet, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, and fillers, lubricants, and disintegrants are pulverized through a 80-mesh sieve;
[0054] 2) Preparation of the drug-containing pellet core: adopt the drug-applying process at the bottom of the fluidized bed, dissolve probenecid with 98% alc...
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