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Probenecid slow release capsule and preparation method thereof

A technology of sustained-release capsules and probenecid, applied in the field of medicine, can solve the problems of inconvenience in taking, poor patient compliance, reduced efficacy and the like, and achieve the effects of fast drug application, increased compliance and simple formula

Inactive Publication Date: 2015-08-26
QINGDAO HAIZHIXING BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is relatively inconvenient to take, and the patient's compliance is poor, and forgetting to take it will reduce the curative effect, especially in the treatment of chronic gout, if you forget to take sodium bicarbonate urate, it is easy to form urinary stones in the urinary tract

Method used

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  • Probenecid slow release capsule and preparation method thereof
  • Probenecid slow release capsule and preparation method thereof
  • Probenecid slow release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A probenecid slow-release capsule, the components and parts by weight of the slow-release capsule include:

[0033] 45 parts of probenecid, 32 parts of sodium bicarbonate, 45 parts of sucrose pills, 4 parts of ethyl cellulose, 0.8 parts of castor oil, 0.2 parts of hypromellose, 4 parts of talc, 4 parts of microcrystalline cellulose, hydroxy 5 parts of propyl methylcellulose.

[0034] A preparation method of probenecid sustained-release capsules, the specific steps comprising:

[0035] 1) Prepare materials: prepare materials according to the components and parts by weight of a probenecid sustained-release capsule, wherein sodium bicarbonate and talcum powder are respectively pulverized through a 100-mesh sieve;

[0036] 2) preparation of probenecid drug-containing pellets: adopting the spraying process at the bottom of the fluidized bed, dissolving probenecid in alcohol with a mass concentration of 95% to prepare a saturated solution of probenecid, obtaining drug-contai...

Embodiment 2

[0043] A probenecid slow-release capsule, the components and parts by weight of the slow-release capsule include:

[0044] 40 parts of probenecid, 30 parts of sodium bicarbonate, 40 parts of microcrystalline cellulose pellets, 3 parts of polyacrylic acid resin, 0.5 parts of glyceride, 0.1 part of polyethylene glycol, 3 parts of talcum powder, 3 parts of microcrystalline cellulose, hydroxyl 3 parts of propyl cellulose.

[0045] A preparation method of probenecid sustained-release capsules, the specific steps comprising:

[0046] 1) Prepare materials: prepare materials according to the components and parts by weight of a probenecid sustained-release capsule, wherein sodium bicarbonate and talcum powder are respectively pulverized through a 100-mesh sieve;

[0047] 2) preparation of probenecid drug-containing pellets: adopting the spraying process at the bottom of the fluidized bed, dissolving probenecid in alcohol with a mass concentration of 100% to prepare a saturated solutio...

Embodiment 3

[0054] A probenecid slow-release capsule, the components and parts by weight of the slow-release capsule include:

[0055] 50 parts of probenecid, 35 parts of sodium bicarbonate, 50 parts of starch pellets, 5 parts of polyethylene, 1.0 parts of succinate, 0.3 parts of polyethylene glycol, 5 parts of talc, 5 parts of microcrystalline cellulose, hydroxypropyl 6 parts of methylcellulose.

[0056] A preparation method of probenecid sustained-release capsules, the specific steps comprising:

[0057] 1) Material preparation: prepare materials according to the components and parts by weight of a probenecid sustained-release capsule, wherein sodium bicarbonate is pulverized through a 100-mesh sieve, wherein sodium bicarbonate and talcum powder are pulverized through a 100-mesh sieve respectively;

[0058] 2) Preparation of probenecid drug-containing pellets: adopting the spraying process at the bottom of the fluidized bed, dissolving probenecid in alcohol with a mass concentration of...

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Abstract

The invention discloses a probenecid slow release capsule and a preparation method. The slow release capsule comprises the following ingredients in parts by weight: 5-8 parts of cefalexin, 5-8 parts of probenecid and 20-25 parts of medicinal auxiliary material. The preparation method of the slow release capsule comprises the steps of material preparation, preparation of cefalexin medicated pellets, preparation of probenecid medicated pellets, preparation of slow release pellets, and capsule loading. Cefalexin and probenecid are organically combined into the slow release capsule; the usage of active ingredients is saved; the usage of the medicinal auxiliary material is reduced to the greatest extent; the influence of reduction of blood concentration of cefalexin on the curative effect due to forget of taking probenecid is avoided; and the patient compliance is good. A preparation technology has high stability, the production efficiency is improved, and the whole technology does not adopt a toxic organic reagent and is green, environment-friendly and good in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a probenecid slow-release capsule and a preparation method thereof. Background technique [0002] Hyperuricemia (HUA) refers to hyperuricemia when the blood uric acid level on an empty stomach exceeds 420 μmol / L for men and 360 μmol / L for women on two different days in a normal purine diet. Uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. According to reports on the prevalence of hyperuricemia in various places in recent years, there are currently about 120 million hyperuricemia patients in my country, accounting for about 10% of the total population. trend. [0003] Probenecid is a white crystalline powder, odorless, slightly bitter taste, soluble in acetone, slightly soluble in ethanol or chloroform, almost insoluble in water, soluble in dilute sodium hydroxide solution, almost insoluble in dilu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K33/00A61P19/06A61P13/04A61K31/195
Inventor 夏征梅
Owner QINGDAO HAIZHIXING BIOLOGICAL SCI & TECH
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