102 results about "Antacid" patented technology

A pharmaceutical composition comprising: (a) meloxicam or a pharmaceutically acceptable salt thereof; and (b) one or more additional pharmaceutically active compounds selected from antacids, sedatives, and central nervous system stimulants, and the use of such composition of an inflammatory disease, symptoms of an inflammatory disease, including various symptoms thereof, and/or headache, toothache, ache after tooth extraction, sore throat, otalgia, arthralgia, neuralgia, lumbago, myalgia, muscle stiffness of shoulder, pain of contusion, pain of fracture, pain of sprain, menstrual pain, traumatic pain, chill, exothermic reaction and/or cold and various symptoms of cold such as sore throat, chill, pyrexia, headache, arthralgia and muscle pain.

The invention relates to an acid-free OCA (optical clear adhesive), an adhesive belt and a fabrication method of the acid-free OCA and the adhesive belt. The OCA comprises the following components in parts by weight: 100 parts of acrylate adhesive, 0.1-4.5 parts of soluble organometallic complex, 0.1-25.0 parts alkalescent antacid, 0.01-0.3 part of epoxy curing agent, and 0.01-0.5 part of antioxidant. Compared with the prior art and compared with the liquid OCA, the thickness of the prepared OCA is easy to control, the prepared OCA does not cause pollution easily and is convenient to operate when serving as a pressure sensitive adhesive; the adhesive belt has the advantages that the adhesive belt is excellent in adhesive following performance, and an edge does not raise easily. The adhesive belt is simple in production process, low in production cost and excellent in performance.

The invention relates to a preparation method of a blueberry wine. The preparation method comprises the following steps of cleaning blueberry fruits, and then, smashing the blueberry fruits to form blueberry slurry; adding pectinase into the blueberry slurry to carry out enzymolysis, carrying out enzyme deactivation, cooling to the room temperature to obtain cooled blueberry slurry, adding alcohol and an active dry yeast for a wine to ferment, and when the sugar content is measured to be up to 1 BoX, ending the fermentation to obtain a raw blueberry wine; and adding an antacid into the raw blueberry wine, filtering, blending the raw wine by using the alcohol to ensure that the alcohol strength is up to 9-12 degrees, and then, filtering to obtain the blueberry wine. According to the method disclosed by the invention, insoluble substances such as pectin substances, cellulosics and polysaccharides in the raw wine are effectively dissolved by using a pectinase enzymolysis agent, so that fruit juice is clarified within short time; and the blueberry wine with stable chemical property is brewed by using processes such as fermenting by using an active dry yeast for a wine, ageing and filtering, and the brewing period is shortened from more than three years consumed by using the traditional method to three to five months, so that the working period is shortened, the utilization ratio of equipment is increased, and the labor cost is reduced.

Chewable tablets and particulate food and pharmaceutical products are disclosed which are made from agglomerates comprising an alcohol sugar such as mannitol and a high intensity sweetener such as Aspartame from which agglomerate tablets may be directly compressed, and processes for making the agglomerates and tablets. The tablets or particulate product containing the agglomerate may contain active ingredients blended with the agglomerate or as part of the agglomerate structure. Tablets and particulate products according to the invention can contain active ingredients such as pharmaceuticals (e.g., antacids, analgesics, cough medicine, drugs, etc.) breath sweeteners, vitamins and dietary supplements, to name a few. The high intensity sweetener containing agglomerates can also be used to make solid food mix type products such as sugar free ice tea mixes.

The present invention provides a controlled release solid preparation superior in the stability of an active ingredient, which can exhibit pharmacological effects steadily and rapidly after administration, and shows a sustained pharmacological effect for a prolonged period of time: a controlled release solid preparation containing (1) an antacid, (2) an immediate-release part containing a compound unstable to acid and a basic substance, and (3) a sustained-release part containing a compound unstable to acid and a pH-independent material in combination.

The present invention deals with a multiparticulate tablet, which disintegrates in the mouth containing: i) a proton pump inhibiting agent, in particular of the benzimidazole type, in the form of enteric coated microgranules, which enteric coated granules are overcoated with at least one barrier coating, such as for instance a methacrylic copolymer-based protective film; ii) at least one antacid in the form of granules, for instance based on CaCO3 and/or Mg(OH)2 and/or Al(OH)3; and, iii) a mixture of excipients comprising at least one disintegrating agent, one diluent agent, a lubricant, and optionally a swelling agent, a permeabilising agent, sweeteners, flavourings and colours. Furthermore, the present invention is directed to processes for the manufacture of the tablet and its use in the treatment of gastrointestinal disorders.

The invention aims to provide a montmorillonite loaded calcium hydroxide antacid which uses montmorillonite loaded calcium hydroxide as the antacid on the basis of acid activation of montmorillonite loaded calcium hydroxide, and solves the conventional problem caused by direct contact of active components of the antacid and the gastric mucosa, wherein the montmorillonite has a gastric mucosa protection function simultaneously. The montmorillonite loaded calcium hydroxide antacid is characterized in that the antacid takes medicinal montmorillonite as the raw material, the montmorillonite is taken as a carrier after acid activation, loaded calcium hydroxide serves as an active ingredient, fatty acid is adopted for surface modification, the carrier of the obtained antacid is stable and insoluble, calcium hydroxide serving as the active ingredient can be continuously and firmly loaded on the carrier, the alkaline intensity is weakened, excessive taking of the antacid cannot cause too high gastric pH, and further, the carrier improves the dispersibility of calcium hydroxide serving as the active ingredient and forms a protective barrier, so that mucosa stimulation is avoided.

A method of making coated chewing gum products comprises the steps of providing chewing gum cores; providing a first coating syrup comprising a bulk sweetener; providing an aldehyde flavor; providing a second coating syrup separate from the first coating syrup and comprising a dipeptide sweetener; and applying the first and second coating syrups to the cores and drying the syrups to produce a coating on the cores. Calcium carbonate or another antacid may be incorporated in the coating by being mixed into the first coating syrup or applied as a dry charge.

The present invention provides a method for preparing 4-fluoro-1,3-dioxolane-2-one with reduced halide content at high yield. The preparation of 4-fluoro-1,3-dioxolane-2-one is characterized in that the preparation comprises: the process (A) of fluorizating 4-chloro-1,3-dioxolane-2-one by fluridizer in organic solvent; the process (B) of distilling reaction form solution 4-chloro-1,3-dioxolane-2-one; and the process (C) of treating by antacid.

Pharmaceutical formulations in the form of a powder for suspension comprising at least one proton pump inhibitor in micronized form; at least one antacid; and at lest one suspending agents are provided herein. Also provided herein are methods for making and using pharmaceutical formulations comprising at least one proton pump inhibitor and at least one antacid.

The present invention relates to synergistic compositions for protection against oxidative damage, consisting essentially of antacids in conjunction with antioxidants. The invention further relates to method for preventing oxidative damage using the compositions of the invention.

An organoleptically acceptable antacid lozenge including at least one antacid present in the form of micronized particles having a particle size of less than about 10 microns. The lozenge is a solid oral composition capable of dissolving slowly in the mouth for long lasting administration of an antacid at a sustained or slow release rate. The lozenge is non-gritty, smooth textured, and does not irritate the oral mucosa.

The present invention provides a controlled release solid preparation superior in the stability of an active ingredient, which can exhibit pharmacological effects steadily and rapidly after administration, and shows a sustained pharmacological effect for a prolonged period of time: a controlled release solid preparation containing a combination of (1) an antacid, (2) an immediate-release part containing a compound unstable to acid and a basic substance, and (3) a sustained-release part containing a compound unstable to acid and a basic substance, and having a film that dissolves at pH 6.5 or above.

A process for producing granular calcium carbonate for use as dietary supplements and/or antacids, which easily reconstitutes, upon mixing with a liquid or liquid-containing food prior to ingestion, into an ultra-fine calcium carbonate powder having improved non-gritty "mouthfeel". The process involves aggregating an ultra-fine calcium carbonate powder, having an average particle size of no more than 25 microns, into granular calcium carbonate particles. Methods for administering 100% of the adult RDA for calcium in a single dose, and for treating upper gastrointestinal tract disorders, using the granular calcium carbonate produced by the process of the present invention are also disclosed.

An antacid and laxative tablet comprising magnesium oxide particles as an effective component, wherein

• (i) the magnesium oxide particles contained in the tablet have an average secondary particle diameter measured by a laser diffraction scattering method of 0.5 to 10 μm,
• (ii) the content of magnesium oxide particles in the tablet is 88 wt % or more,
• (iii) the tablet does not become blackish and has substantially no tableting spot, and
• (iv) the disintegration time is 10 sec or less.

The antacid and laxative tablet of the present invention has a high content of magnesium oxide particles, a short disintegration time, does not become blackish, has no tablet trouble and no tableting spot and is suitably administered orally.

The invention provides an esomeprazole pharmaceutical composition with stronger acid resistance and a preparation thereof. The esomeprazole pharmaceutical composition comprises esomeprazole, one or more antacids and common pharmaceutical adjuvants, wherein the esomeprazole comprises esomeprazole salt, particularly esomeprazole magnesium salt and esomeprazole lithium salt; and the antacids comprise sodium bicarbonate, sodium carbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, aluminum carbonate, magnesium carbonate, magnesium hydroxide, magnesium oxide, aluminium hydroxide, magnesium aluminum carbonate and the like. The preparation of the esomeprazole pharmaceutical composition is prepared by adding the antacids via interior addition and exterior addition; and in an optimized preparation method, the weight ratio of the antacids in the interior addition and the exterior addition is 2: 3, so that the antacids play double efficacies, the dosage of acid neutralization agent is reduced and the acid resisting effect is better.

The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof. The invention also provides a method of treating a gastrointestinal malady by co-administering a ghrelin mimetic with a laxative, a H₂ receptor antagonist, a serotonin receptor agonist, pure or mixed, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.

The invention discloses a new preparation method for an aspirin-containing compound preparation, which is characterized in that: the aspirin-containing compound preparation is an internal and external multi-layer preparation consists of aspirin, and aluminum glycinate and heavy magnesium carbonate which are alkaline medicines; and an insulation layer is formed between the internal and externally-applied medicines to prevent the aspirin from contacting the alkaline medicines directly. The aluminum glycinate can neutralize gastric acid, relieve gastric acid increase, pain in upper abdomen and other clinic symptoms and has effects of astringing and stopping bleeding; and the heavy magnesium carbonate is an antiacid medicine and can reduce the adverse irritation of aspirin to the stomach, obviously reduce rate of gastric mucosal erosion and ulcer, thereby protecting the stomach.

The invention relates to a rapid-release compound omeprazole tablet and a preparation method thereof; the tablet contains effective amounts of omeprazole, sodium bicarbonate and magnesium hydroxide, and selectively contains or does not contain one or more than one pharmaceutically accepted auxiliary material; the tablet is characterized in that the tablet contains a proton pump inhibitor of omeprazole, contains antacids of sodium bicarbonate and magnesium hydroxide which can neutralize gastric acid and change the pH environment in gastric juice, and also contains one or more than one of pharmaceutical auxiliary materials of hydroxy propyl cellulose, cross-linked sodium carboxymethyl cellulose, and sodium stearyl fumaryl. The tablet of the invention can effectively prevent degradation of omeprazole caused by acidic substances in gastric juice, and unexpectedly reach the purpose of rapid disintegration of the drug.

The invention provides a dronedarone hydrochloride pharmaceutical composition which is suitable for the sublingual administration, can quickly run, and can greatly improve the bioavailability and the curative effect. The pharmaceutical composition consists of 5-65 parts of dronedarone hydrochloride, 1-10 parts of a disintegrating agent, 10-80 parts of filler, 0.5-3 parts of antacid, 0-5 parts of corrigent, 1-10 parts of an adhesive and 0.3-2 parts of a lubricating agent. The invention further provides a preparation method suitable for the industrial production. The dronedarone hydrochloride pharmaceutical composition provided by the invention is directly absorbed by the sublingual mucosa, and the first-pass effect of oral medicaments can be avoided, and the gastrointestinal digestion, acidolysis and the like can be avoided, so that the bioavailability can be greatly improved. The epithelium of the sublingual mucosa is not cornified, so that the dronedarone hydrochloride pharmaceutical composition is large in superficial area, and high in infiltration capacity. The medicament can be quickly absorbed after being administrated, so that the dronedarone hydrochloride pharmaceutical composition is quick to run, and convenient to use; and compared with the other administrated preparations, the dronedarone hydrochloride pharmaceutical composition is convenient to administrate, and good in patient compliance.

The present invention relates to a novel method for preparing a water-insoluble metal hydroxide, and a use thereof. The water-insoluble metal hydroxide of the present invention is conveniently and efficiently prepared s through the high-temperature heat treatment step two times and the washing step, and thus contains a small amount of an alkali metal and has a high crystallinity and a phase purity. The water-insoluble metal hydroxide of the present invention or metal oxide therefrom exhibits an absorption wavelength at a low wavelength range (for example, 490 nm or less) and a light emitting wavelength at a high wavelength range (for example, from 500 nm or more to less than 1,100 nm). Accordingly, the water-insoluble metal hydroxide of the present invention may be efficiently used in various applications such as a fire retardant, an antacid, an adsorbent and so forth, and may also be doped with another metal ion to be utilized as a raw material for fabricating a catalyst, a fluorescent material, an electrode material, a secondary battery material and the like.

A combination of an antacid, alginate, and a histamine H₂-receptor antagonist, and methods of using the same for providing fast and lasting relief of symptoms of episodic heartburn are provided.