66 results about "Drug test" patented technology

The invention provides a risk detection method and system for adverse events of a drug clinical test. The method comprises the following steps: constructing a clinical biological model according to a body health state, body parameters and a historical examination report of a subject; recording the trial information accepted by the subject, and generating a trial database; according to the physiological monitoring equipment and the health monitoring system, body function parameters and biological indexes of the subject after drug testing are monitored in real time, and drug testing data are obtained; screening and optimizing the drug test data based on a genetic algorithm to obtain drug test reaction characteristics; determining a risk score according to the reagent database and the reagent reaction characteristics; and dividing different risk levels according to the risk scores, and carrying out risk early warning according to the risk levels. According to the method, through screening of the drug reaction characteristics and calculation of the risk score, the monitoring efficiency of adverse events is improved, the data analysis capability is enhanced, and the scientificity and accuracy of the result are ensured.

The invention relates to the technical field of drug clinical trials, in particular to a drug clinical trial design auxiliary system based on a generative pre-training model, and the system comprises a knowledge fusion module, a real-time updating module, a clinical trial generation module and a clinical trial optimization module. According to the method, key drug data and biomarkers are integrated, a test design process is automated and optimized, and potential relevance among data is analyzed through a graph attention network, so that the analysis capability of a complex clinical data structure is enhanced, the quality and application efficiency of input data are ensured, the scientificity and adaptability of a test scheme are promoted, and the method is suitable for large-scale popularization and application. According to the method, the test related data and the parameter adjusting function are automatically updated, so that the design can reflect the latest achievement of drug research and development in time, the real-time performance and accuracy of the test design are improved, through the automatically generated test parameter design, human intervention is reduced, the error rate is reduced, and the overall efficiency of the test design process is improved.

The invention discloses a high-throughput drug screening and organoid culture device, and aims to overcome the defects that conventional drug testing in a laboratory mainly depends on a porous plate, operation is generally complex, cell culture and drug stimulation lack dynamic perfusion, and cross contamination is prone to occurring. The system comprises a drug concentration generation module and an organoid culture module, the drug concentration generation module comprises a plurality of drug concentration generation units, and the organoid culture module comprises a plurality of organoid culture units corresponding to the drug concentration generation units. A medicine inlet, a culture medium solution inlet and a plurality of liquid outlets are formed in the medicine concentration generation unit; the organoid culture unit comprises a plurality of groups of organoid culture chambers corresponding to the liquid outlets, and the organoid culture chambers in the same group are communicated with one another. The high-throughput drug screening and organoid culture device is convenient to operate, whole-course dynamic culture of organoid culture and drug stimulation can be achieved, and cross contamination is not prone to occurring.

A drug testing platform for simulating a lung environment includes a microfluidic chip and a stretching device. The microfluidic chip defines a microfluidic channel structure. The microfluidic channel structure includes a test unit, a cell shunt unit and a drug shunt unit. The stretching device is configured to stretch and contract the test unit in a manner of a reciprocal motion, thereby making degree of deformation of a plurality of test area of the test unit to be same during the reciprocal motion. The drug testing platform for simulating the lung environment according to the present disclosure may configure an environment that simulates a breathing motion of a human lung, and obtain multiple results within a single test.

The utility model discloses an organoid chip device convenient for drug testing, which relates to the technical field of biomedical engineering and comprises a shell, a mounting bracket, a quick assembly and a culture assembly, the mounting bracket is fixedly arranged at the top of the shell, and an external hose is arranged on the inner surface of the mounting bracket; and the quick mounting assembly is fixedly arranged on the inner surface of the shell and is used for quickly mounting and butting the mounting bracket and the external hose. The knob is manually screwed to drive the threaded sleeve to rotate, and the threaded sleeve extends to the inner surface of the fixed seat through the top of the mounting bracket. The outer surface of the threaded sleeve is in threaded connection with the inner surface of the fixing base and moves downwards during rotation. The inserting rod is inserted into the inner surface of the locking support, the threaded sleeve moves downwards to extrude the top slope of the locking support, and the locking support gets close to lock the inserting rod. The device can quickly fasten the knob and the mounting bracket, facilitates the installation of an external hose and the introduction of medicines, is simple and convenient to operate, and provides convenience for operators.

The utility model relates to the technical field of plastic spoons, in particular to a medical medicine test sampling plastic spoon which comprises a storage sleeve and a pen clip, a telescopic assembly is arranged at the bottom end of the storage sleeve and comprises a telescopic rod and a fixing bolt, and a spoon body is arranged at the bottom end of the telescopic rod; an antifouling sleeve is arranged at the bottom of the storage sleeve corresponding to the periphery of the telescopic rod, a first thread is arranged at the bottom end of the storage sleeve at the periphery of the telescopic rod, and a second thread is arranged at the top of the inner wall of the antifouling sleeve corresponding to the first thread; the anti-fouling sleeve is conveniently disassembled and assembled at the bottom of the storage sleeve through the first thread and the anti-fouling sleeve encloses and covers the spoon body at the bottom of the telescopic rod on the inner side of the storage sleeve, so that the problem that the spoon body is in a completely open state when not in use and is easy to pollute is solved, and the cleanliness during use is ensured.

The utility model discloses an automatic balancing device for a centrifuge, and relates to the technical field of experimental instruments, including a storage component arranged on the top of the fixed base, the storage component including a storage box, a power pump and a medicine tank, a balancing component arranged on the top of the storage box, the balancing component including a protective box, a control component arranged on the top of the protective box, and the control component including a controller, a display screen and an adjustment key. The medicine tank of the utility model can store experimental medicines, and the medicine tank can properly store and protect the medicines to prevent the medicines from being contaminated by air substances, the power pump can extract the medicines through the connecting pipe, which is convenient for the transportation of the medicines and improves the convenience of the medicine transportation, the display screen can display the balancing data, which is convenient for the staff to check the records, and the adjustment key is convenient for the staff to adjust the dosage of the medicines, and a certain amount of medicines can be accurately injected into the medicine test tube.

The application discloses a kind of for drug test research room subject sign dynamic monitoring system, it is related to the field of drug test, solve the problem that drug test research room subject sign dynamic monitoring monitoring effect is poor, including data acquisition module: a plurality of physiological indexes are set to the physiological index monitoring of subject for characteristic test drug, obtain physiological index acquisition data, sign analysis module: according to physiological index acquisition data, sign index analysis is carried out to characteristic drug subject, according to the type division of subject is carried out to analysis result, obtains subject type division data, symptom analysis module: the typical symptom coincidence degree analysis is carried out to normal subject, according to analysis result, obtain typical symptom similarity coefficient, monitoring feedback module: according to subject type division data and typical symptom similarity coefficient, monitoring result feedback is carried out to characteristic drug subject, the accuracy and pertinence of subject sign dynamic monitoring process can be improved by the application.

The present invention discloses a clinical trial drug access management method and system based on a smart medicine cabinet, the method comprising: establishing a drug access database; in the drug storage stage, analyzing the historical drug access data to determine the predicted number of door openings in a first preset time interval; judging whether the predicted number of door openings is less than the preset door opening threshold; if so, performing constant temperature control on the inside of the smart medicine cabinet based on the recommended temperature; if not, determining the first temperature and the second temperature by drawing a first temperature change curve; determining the first temperature interval based on the first temperature and the second temperature, and performing temperature control on the inside of the smart medicine cabinet based on the first temperature interval; in the drug access stage, controlling the air outlet device to perform auxiliary temperature control, and giving an early warning reminder based on the access duration; when the access is completed, resetting the first preset time interval based on the access completion time. The present invention reduces the problems of over-temperature failure of clinical trial drugs by regulating the internal temperature of the medicine cabinet.

The invention relates to the technical field of medicine analysis, in particular to a method for detecting the content of N-nitroso-demethylated olopatadine in an olopatadine hydrochloride raw material medicine. The analysis method comprises the following steps: preparing a blank solution, a system applicability solution and an olopatadine hydrochloride bulk drug test solution; sequentially injecting the blank solution, the system applicability solution and the olopatadine hydrochloride raw material medicine test solution, injecting into a high performance liquid chromatography-tandem mass spectrometer, and detecting the content of N-nitroso-demethylated olopatadine according to an external standard method; the invention discloses a method for detecting the content of N-nitroso-demethylated olopatadine in an olopatadine hydrochloride bulk drug, which has the advantages of high sensitivity, simplicity, rapidness, strong specificity, good accuracy, high precision, good stability and good linear relationship, and can be used for detecting the content of N-nitroso-demethylated olopatadine in the olopatadine hydrochloride bulk drug.

The invention discloses a dynamic monitoring system for physical signs of subjects in a drug test research laboratory, relates to the field of drug tests, and solves the problem of poor dynamic monitoring effect of the physical signs of the subjects in the drug test research laboratory. Comprising a data acquisition module for setting a plurality of physiological indexes for characteristic test drugs to perform physiological index monitoring on subjects to obtain physiological index acquisition data, and a physical sign analysis module for performing physical sign index analysis on the characteristic drug subjects according to the physiological index acquisition data, performing type division on the subjects according to an analysis result, and determining the types of the subjects according to the types of the subjects. The system comprises a subject classification module for classifying subjects to obtain subject type classification data, a symptom analysis module for performing typical symptom coincidence degree analysis on subjects with normal signs and obtaining typical symptom similarity coefficients according to analysis results, and a monitoring feedback module for performing monitoring result feedback on characteristic medicine subjects according to the subject type classification data and the typical symptom similarity coefficients. According to the invention, the accuracy and pertinence of the dynamic monitoring process of the physical signs of the subject can be improved.

The present invention relates to a method for producing an in vitro model of a human neurological disease. Furthermore, the invention relates to the in vitro model produced according to the method disclosed herein. The invention also relates to the use of the in vitro model in drug testing. In addition, the invention relates to methods for testing the efficacy of drugs in preventing, delaying, and alleviating a human neurological disease.

The application discloses a kind of blood vessel microfluidic device and method suitable for glycolipid drug test, the device constructs three-dimensional biomimetic microvessel chip using induced pluripotent stem cells, and integrates multiple sensors;Through integrated environmental control module, programmed blood flow loading and drug exposure are realized.Intelligent analysis system includes multimodal intelligent observation module, based on microscope imaging and artificial intelligence speed measurement technology, three-dimensional flow field is inverted;Microcirculation digital twin module reconstructs blood vessels based on medical imaging and constructs calibratable hemodynamic model, for simulation and prediction;And wet-dry interaction module, through two-way interface, realizes "experiment-simulation" closed loop, injects entity data into digital twin to calibrate, and converts the prediction instruction of digital twin into chip control command to drive verification experiment.The system realizes complete technical chain from biomimetic model construction, intelligent observation, digital twin simulation to active experiment optimization.

The application discloses a kind of matching method, device and computer equipment of clinical drug test patient, it is related to computer technical field, can solve the technical problem of the matching of clinical drug test patient at present, workload is big, efficiency is relatively low, and it is prone to cause error accumulation and information loss. Among them, the method comprises: obtaining patient information of test patient and medicine test entry condition information, patient information includes first numerical information and medical information, medicine test entry condition information includes second numerical information and description information;First numerical information and second numerical information are numerically matched, and first matching result is obtained;Medical information and description information are preprocessed, and the embedded matching of medical information and description information after preprocessing is carried out, and second matching result is obtained;According to first matching result and second matching result, the final matching result of test patient and medicine test is generated.

The utility model discloses a medicine stability test box, relates to the technical field of medicine test boxes, and aims to solve the problems that a humidifying mechanism in the test box converts liquid into gas through electric heating to increase the humidity in air, but the humid environment is an ideal condition for breeding microorganisms such as bacteria and molds, and the humidity in the air is increased. The problems that in the prior art, bacteria can rapidly breed in a high-humidity environment, especially in a water tank inside a humidifier, the bacteria and other microorganisms may form biological membranes, normal operation of the humidifier is affected, the humidifying performance of the humidifier is reduced, and the humidity adjustment of the drug stability test box is unstable are solved. A humidifying mechanism is arranged in the middle of the interior of the equipment cavity and comprises a liquid adding pipe, a liquid adding pipe valve, a liquid discharging pipe, a liquid discharging pipe valve, a humidifying pipe, a humidifying pipe valve, a cleaning driving motor frame, a cleaning driving motor, a cleaning lead screw, a sliding block, a cleaning brush and a fixing frame.

A portable, self-contained drug test kit for testing for the presence or absence of a drug has a housing having a hollow portion with a liquid solvent accessible from outside to enable introduction of a test solute therein. A lateral flow test strip is in user-selective fluid communication with the liquid solvent in the hollow portion. The lateral flow test strip is selectively moveable from a first position in which the lateral flow test strip is not in fluid communication with the liquid solvent in the hollow portion to a second position in which it is in fluid communication with the liquid solvent. When the lateral flow test strip is moved into the second position and the test solute is introduced into the hollow portion, the liquid solvent mixes with the test solute to form a test solution and thereby activate the lateral flow test strip.

The utility model discloses a solvent filter press for a medicine test, and relates to the technical field related to the medicine test. The filter comprises a base, a filter pressing head, a funnel, a sealing cover and a filter cartridge, a beaker is placed above the base, the filter cartridge is arranged above the beaker, a filter frame is fixed in the filter cartridge, a filter membrane is fixed in the filter frame, the upper end of the filter cartridge is screwed in the sealing cover, the funnel is located above the sealing cover, a second filter bag is placed in an inner cavity of the funnel, and the filter pressing head is arranged above the funnel. The filter pressing head is sleeved with a first filter bag, and a pressing plate is fixed to the top of the filter pressing head; a pressurizing pipe is fixed to the periphery of the filter cylinder in a penetrating mode, a piston is movably inserted into the pressurizing pipe, and a push rod is fixed to the end, away from the filter cylinder, of the piston. The filter cartridge, the sealing cover, the filter membrane, the funnel, the filter bag I, the filter bag II, the filter pressing head, the base and the beaker are arranged, so that the problem that solvents with different solid contents cannot be subjected to filter pressing treatment is solved; and the whole structure of the filter press is not very large, so that the test space is occupied.

The present disclosure relates to a container for in vitro drug testing. The container includes a reservoir having a wall made of a gel composition. The reservoir has an opening and is configured to receive a pharmaceutical formulation through the opening. The gel composition is selected to mimic one or more properties of tissue.

The invention relates to a microfluidic single cell culture plate based on AI image recognition and a global positioning method. A micropore array is arranged in the culture plate, a unique code is formed according to an asymmetric micropore pattern in a micropore positioning area, a global positioning method identifies the positioning pattern through a microscope bright field image, rapid and accurate positioning of micropores is realized in combination with an AI algorithm, dynamic tracking of cell positions in multi-time-point sampling is supported, and the positioning accuracy is improved. Drug testing of different drug use sequences is achieved, the problems of low micropore positioning efficiency and long-term occupation under a traditional microscope are solved, and cell-level drug effect data are provided for drug screening (targeted therapy / drug combination) and personalized medical treatment.

This invention discloses an automated injection device for batch mouse drug testing, comprising a base, an experimental box, a rotary mouse trapping and fixing mechanism, an injection mechanism, and an observation box. A support frame is mounted on the base, the experimental box is positioned above the support frame, and the observation box is located on the base. The rotary mouse trapping and fixing mechanism is located on the base, with its head and tail connected to the experimental box and observation box, respectively. The injection mechanism is located on the base and on one side of the rotary mouse trapping and fixing mechanism. This invention belongs to the technical field of mouse drug injection equipment, specifically providing an automated injection device for batch mouse drug testing that automatically traps and self-fixes mice individually for convenient tail vein injection, and automatically transfers the mice into the observation box after injection.

The present invention relates to devices, systems, and methods for cutting tissues. In some embodiments, the devices, systems, and methods of the invention relate to cutting tissues into fragments that find use in tissue culture and drug testing applications.

The disclosure provides in some aspects test kits useful for testing a sample of a substance for the presence of one or more chemical compounds, for example for drug checking, such as testing a drug sample for an adulterant or a contaminant. The disclosure provides in some further aspects single use test kits for drug checking, including test kits structured as an integrated single unit, and which may comprise multiple separable pouches, including where one pouch serves as a fluid reservoir for dissolving a test sample in a solvent for testing, such as dissolving a drug sample in water. The disclosure provides in yet further aspects methods of using the disclosed test kits, such as for drug checking. The disclosed integrated single use drug test kits are portable, user-friendly, cost-effective, efficient, reliable, and accurate, and have such other advantages and improvements over prior art test kits as are illustrated herein.

The utility model relates to a hair drug detection kit which comprises a kit body, an extension plate and a drawing component, the kit body comprises an upper kit plate, a middle kit plate and a lower kit plate which are sequentially arranged from top to bottom, the upper kit plate, the middle kit plate and the lower kit plate are connected into a whole through connecting parts arranged on the two sides of the upper kit plate, the middle kit plate and the lower kit plate, and the front and the back of the kit body are through. A first containing cavity is formed between the upper box plate and the middle box plate, a second containing cavity is formed between the middle box plate and the lower box plate, and a baffle fixedly connected with the middle box plate and the upper box plate is arranged at the front end of the first containing cavity. The extension plate is arranged in the first containing cavity and slides in the first containing cavity, supporting plate grooves are formed in the bottoms of the two sides of the rear end of the extension plate, and supporting plates rotationally connected with the extension plate are arranged in the supporting plate grooves. And the drawing assembly stretches across the space between the first containing cavity and the second containing cavity and is used for drawing the extension plate. The utility model has the advantages that the designed drawing assembly can realize the automatic drawing of each device in the box body, and is beneficial to use and support.

The invention belongs to the field of AD (Alzheimer's disease) drug tests by rats, and particularly relates to a method for screening AD rat models and a method for evaluating recovery conditions of AD rats after medication, and the screening method comprises the following steps: carrying out sweet water and spicy water drinking tests on known normal healthy rats and AD rats to be tested; if the water drinking times of the AD rats to be detected in the S area are obviously reduced relative to normal healthy rats and the water drinking times of the AD rats to be detected in the C area are obviously increased, the AD rats to be detected are AD rats, and the method for evaluating the recovery condition comprises the following steps: carrying out a sweet water and spicy water drinking test on the AD rats continuously taking medicines for several days, and if the water drinking times of the AD rats in the S area are gradually increased along with the increase of the date, judging that the AD rats to be detected are AD rats. If the water drinking frequency in the area C is gradually reduced, it is indicated that the AD rats recover after medication, the method can simply, rapidly and painlessly screen out the qualified AD rats, the recovery condition of the AD rats after medication can be evaluated by adopting a low-cost method, and the research and development cost and time of AD specific medicine are effectively reduced.

The present invention relates to a method for the preparation of an in vitro model for a human neurological disorder. Moreover, the invention relates to the in vitro model, produced according to the inventive method disclosed herein. In addition, the invention relates to the use of the in vitro model of the invention in drug testing. In addition, the invention relates to methods for testing the efficacy of drugs in the prevention, delay and amelioration of a human neurological disorder.

This invention discloses a model data standardization processing method and system for drug testing, relating to the field of biomedical technology. The method involves collecting cell culture plate numbers, drug concentrations, culture times, and absorbance readings; sorting concentrations and matching absorbance to form experimental sequence values; filtering for consistency in well readings within the same plate to eliminate deviations; normalizing absorbance ratios and generating response coefficients through difference; correcting for deviations in the mean values ​​of different batches to form correction coefficients; and superimposing the correction coefficients and mapping them to the concentrations to rearrange and output standardized drug efficacy data. This invention's model data standardization processing method and system for drug testing synchronizes the cell culture plate numbers and time scales in the original experimental records and performs gradient sorting of drug concentrations, enabling data under different time and dosage conditions to form a sequentially constrained sequence structure, enhancing the correspondence between experimental data in the time and dosage dimensions.

An automated system for anticancer drug sensitivity testing, according to an embodiment of the present invention, may comprise: a chopper configured to mince patient tissue; a cell dissociation device configured to apply a cell dissociation enzyme to the patient tissue minced by the chopper; a centrifuge configured to centrifuge cells to which the cell dissociation enzyme has been applied by the cell dissociation device; a liquid handler configured to mix the centrifuged cells with extracellular matrix to thereby generate a mixed sample and to inject the mixed sample into a nozzle tip; a spotter configured to dispense the mixed sample onto a pillar by using the nozzle tip; an automatic incubator configured to culture the mixed sample to generate cell organoids; a scanner configured to generate an image by scanning the cell organoids at high speed; and a multi-joint robot configured to move at least one of the patient tissue, the cells, and the mixed sample between at least some of the chopper, the cell dissociation device, the centrifuge, the liquid handler, the spotter, the automatic incubator, and the scanner. Thus, the entire process of cell extraction from tissue isolated from a patient to organoid culture, drug testing, and scanning can be performed fully automatically.

The present invention relates to a drug efficacy evaluation method based on the dynamic mechanical properties of single cells. A single cell is regarded as a linear time-invariant system, with mechanical stimulation as the virtual input of the system, and the continuous-time mechanical properties of the cell under the action of a drug as the output of the system. The dynamic mechanical properties of the cell are characterized according to the identified eigenvalues of the single-cell system matrix. Based on the characterization of cells with and without drug additions in the space, as well as the state of the cells during drug administration, drug efficacy evaluation based on the single-cell scale can be achieved. The present invention can characterize cells with and without drug additions in the space, as well as the state of the cells during drug addition, and establish the relationship between cell mechanical properties and cell state. In addition, compared with traditional methods, the drug testing cycle is greatly shortened, and drug efficacy evaluation based on the single-cell scale can be achieved. Therefore, it has important potential applications in the field of drug sensitivity testing based on the single-cell scale in clinical practice.

The present disclosure relates to a container for in vitro drug testing. The container comprises a receptacle having a wall made of a gel composition. The receptacle has an opening and is configured to receive a drug formulation through the opening. The gel composition is selected to simulate one or more properties of tissue.

The sulfonamide drug detection reagent strip comprises a shell and reagent strips, a detection chamber is formed in the upper portion of the shell, an upper cover covers an opening in the top of the detection chamber in a pluggable mode, a detection disc is rotatably connected to the interior of the detection chamber, and a plurality of reagent strips are pasted to the surface of the detection disc; the interior of the detection chamber is rotatably connected with one end of an adjusting rod through a bearing, the other end of the adjusting rod penetrates through the top wall of the shell, extends to the exterior of the shell and forms a screwing part, and the adjusting rod is in transmission connection with the detection disc through a transmission belt; a first sliding groove and a second sliding groove are formed in the side wall of the lower portion of the shell, a first box chamber is rotationally connected into the first sliding groove, and a second box chamber is slidably connected into the second sliding groove. According to the utility model, the rotatable detection disc is arranged, so that the detection disc can be controlled to select a required reagent strip according to a sample, multiple experiments can be quickly carried out, multiple detection results can appear at the same time, and the convenience and the detection speed are improved.