23 results about "Drug test" patented technology

A drug testing platform for simulating a lung environment includes a microfluidic chip and a stretching device. The microfluidic chip defines a microfluidic channel structure. The microfluidic channel structure includes a test unit, a cell shunt unit and a drug shunt unit. The stretching device is configured to stretch and contract the test unit in a manner of a reciprocal motion, thereby making degree of deformation of a plurality of test area of the test unit to be same during the reciprocal motion. The drug testing platform for simulating the lung environment according to the present disclosure may configure an environment that simulates a breathing motion of a human lung, and obtain multiple results within a single test.

The application discloses a kind of for drug test research room subject sign dynamic monitoring system, it is related to the field of drug test, solve the problem that drug test research room subject sign dynamic monitoring monitoring effect is poor, including data acquisition module: a plurality of physiological indexes are set to the physiological index monitoring of subject for characteristic test drug, obtain physiological index acquisition data, sign analysis module: according to physiological index acquisition data, sign index analysis is carried out to characteristic drug subject, according to the type division of subject is carried out to analysis result, obtains subject type division data, symptom analysis module: the typical symptom coincidence degree analysis is carried out to normal subject, according to analysis result, obtain typical symptom similarity coefficient, monitoring feedback module: according to subject type division data and typical symptom similarity coefficient, monitoring result feedback is carried out to characteristic drug subject, the accuracy and pertinence of subject sign dynamic monitoring process can be improved by the application.

The present invention relates to a method for producing an in vitro model of a human neurological disease. Furthermore, the invention relates to the in vitro model produced according to the method disclosed herein. The invention also relates to the use of the in vitro model in drug testing. In addition, the invention relates to methods for testing the efficacy of drugs in preventing, delaying, and alleviating a human neurological disease.

The application discloses a kind of blood vessel microfluidic device and method suitable for glycolipid drug test, the device constructs three-dimensional biomimetic microvessel chip using induced pluripotent stem cells, and integrates multiple sensors;Through integrated environmental control module, programmed blood flow loading and drug exposure are realized.Intelligent analysis system includes multimodal intelligent observation module, based on microscope imaging and artificial intelligence speed measurement technology, three-dimensional flow field is inverted;Microcirculation digital twin module reconstructs blood vessels based on medical imaging and constructs calibratable hemodynamic model, for simulation and prediction;And wet-dry interaction module, through two-way interface, realizes "experiment-simulation" closed loop, injects entity data into digital twin to calibrate, and converts the prediction instruction of digital twin into chip control command to drive verification experiment.The system realizes complete technical chain from biomimetic model construction, intelligent observation, digital twin simulation to active experiment optimization.

The application discloses a kind of matching method, device and computer equipment of clinical drug test patient, it is related to computer technical field, can solve the technical problem of the matching of clinical drug test patient at present, workload is big, efficiency is relatively low, and it is prone to cause error accumulation and information loss. Among them, the method comprises: obtaining patient information of test patient and medicine test entry condition information, patient information includes first numerical information and medical information, medicine test entry condition information includes second numerical information and description information;First numerical information and second numerical information are numerically matched, and first matching result is obtained;Medical information and description information are preprocessed, and the embedded matching of medical information and description information after preprocessing is carried out, and second matching result is obtained;According to first matching result and second matching result, the final matching result of test patient and medicine test is generated.

The present invention relates to devices, systems, and methods for cutting tissues. In some embodiments, the devices, systems, and methods of the invention relate to cutting tissues into fragments that find use in tissue culture and drug testing applications.

The utility model relates to a hair drug detection kit which comprises a kit body, an extension plate and a drawing component, the kit body comprises an upper kit plate, a middle kit plate and a lower kit plate which are sequentially arranged from top to bottom, the upper kit plate, the middle kit plate and the lower kit plate are connected into a whole through connecting parts arranged on the two sides of the upper kit plate, the middle kit plate and the lower kit plate, and the front and the back of the kit body are through. A first containing cavity is formed between the upper box plate and the middle box plate, a second containing cavity is formed between the middle box plate and the lower box plate, and a baffle fixedly connected with the middle box plate and the upper box plate is arranged at the front end of the first containing cavity. The extension plate is arranged in the first containing cavity and slides in the first containing cavity, supporting plate grooves are formed in the bottoms of the two sides of the rear end of the extension plate, and supporting plates rotationally connected with the extension plate are arranged in the supporting plate grooves. And the drawing assembly stretches across the space between the first containing cavity and the second containing cavity and is used for drawing the extension plate. The utility model has the advantages that the designed drawing assembly can realize the automatic drawing of each device in the box body, and is beneficial to use and support.

The present invention relates to a method for the preparation of an in vitro model for a human neurological disorder. Moreover, the invention relates to the in vitro model, produced according to the inventive method disclosed herein. In addition, the invention relates to the use of the in vitro model of the invention in drug testing. In addition, the invention relates to methods for testing the efficacy of drugs in the prevention, delay and amelioration of a human neurological disorder.

This invention discloses a model data standardization processing method and system for drug testing, relating to the field of biomedical technology. The method involves collecting cell culture plate numbers, drug concentrations, culture times, and absorbance readings; sorting concentrations and matching absorbance to form experimental sequence values; filtering for consistency in well readings within the same plate to eliminate deviations; normalizing absorbance ratios and generating response coefficients through difference; correcting for deviations in the mean values ​​of different batches to form correction coefficients; and superimposing the correction coefficients and mapping them to the concentrations to rearrange and output standardized drug efficacy data. This invention's model data standardization processing method and system for drug testing synchronizes the cell culture plate numbers and time scales in the original experimental records and performs gradient sorting of drug concentrations, enabling data under different time and dosage conditions to form a sequentially constrained sequence structure, enhancing the correspondence between experimental data in the time and dosage dimensions.

The present disclosure relates to a container for in vitro drug testing. The container comprises a receptacle having a wall made of a gel composition. The receptacle has an opening and is configured to receive a drug formulation through the opening. The gel composition is selected to simulate one or more properties of tissue.

A biomaterial testing device 100 is provided, comprising a substrate 102 on which at least one chamber unit 104 is defined, and a support member 106 for supporting a biomaterial received in at least one chamber unit. One of the substrate and the support member is molded on the other of the substrate and the support member. A method 10 for manufacturing such a biomaterial testing device is also provided. Furthermore, a method and use of the device for testing a biomaterial is provided, for example, in drug testing where the biomaterial is exposed to a drug to be tested.

The present application belongs to the field of AD drug test using rats, and particularly relates to a method for screening AD rat model and a method for evaluating recovery of AD rats after taking drugs, the screening method comprising the following steps: conducting sugar water and hot water drinking test on known normal healthy rats and AD rats to be tested; if the AD rats to be tested significantly decrease water drinking times in S area compared with normal healthy rats, and significantly increase water drinking times in C area, the AD rats to be tested are AD rats, the method for evaluating recovery comprises the following steps: conducting sugar water and hot water drinking test on AD rats continuously taking drugs for several days, if the AD rats gradually increase water drinking times in S area with increasing days, and gradually decrease water drinking times in C area, it is indicated that the AD rats recover after taking drugs, the method of the present application can simply, quickly and painlessly screen qualified AD rats, and can evaluate recovery of AD rats after taking drugs by using a low-cost method, thereby effectively reducing development cost and time of AD specific drugs.

The utility model discloses a temperature-control cold closet for a clinical drug test, which comprises a closet body, and a transverse partition plate and a vertical partition plate are fixedly connected with an inner cavity of the closet body; a medicine outlet is formed in the box door, a left sliding door and a right sliding door are slidably connected in the medicine outlet, a left connecting plate is fixedly arranged on the left sliding door, and a right connecting plate is fixedly arranged on the right sliding door; the medicine discharging assembly comprises an L-shaped plate, an air cylinder, a containing plate, a push plate and a connecting rod. The air cylinder is fixed to the side wall of the L-shaped plate; a sliding block is fixedly arranged on the bottom surface of the placing plate; the push plate is fixedly connected to the bottom surface of the sliding block and is fixedly connected with the air cylinder; a connecting column is fixedly arranged on the bottom surface of the placing plate; the other end of the connecting rod is rotationally connected with the left connecting plate and the right connecting plate. Loss caused by medicine deterioration due to temperature difference change during medicine taking is avoided, and medicine damage caused by cold air leakage due to the fact that the box door is not tightly closed is avoided.

The utility model discloses a work box for transferring medicine in a clinical medicine test, relates to the field of medical tool boxes, and mainly aims to solve the problem that an integrated medicine and consumable transferring tool which is integrated, efficient, safe and easy to manage is lacked at present. A first storage groove is formed in the top of a box body, and a telescopic goods shelf is installed in the first storage groove. A second storage groove is formed in the upper portion of the side wall of the box body, and a multifunctional treatment plate is inserted into the second storage groove. A third storage groove is formed in the side wall, below the second storage groove, of the box body, and a medicine storage drawer is inserted into the third storage groove. And fourth storage grooves communicating with the third storage groove are formed in the positions, on the two sides of the third storage groove, of the side wall of the box body correspondingly, and refrigeration drawers are inserted into the fourth storage grooves. The device is high in integration level, safe and convenient to use and easy to manage medicines and consumables.

A drug screening platform for tumor microenvironment simulation includes a tumor microenvironment simulating chip, a drug testing chip, and a permeable thin film disposed between the tumor microenvironment simulating chip and the drug testing chip. The tumor microenvironment simulating chip includes a microenvironment building unit which is used for conducting a chemical reaction to generate an acid gas, an alkaline gas and / or an oxygen concentration for simulating the tumor microenvironment. The drug testing chip includes a testing unit which is used for allowing interaction of a therapeutic drug with a cell-containing hydrogel. An orthographic projection of the testing unit falls on the microenvironment building unit. The permeable thin film is used for diffusing the acid gas, the alkaline gas and / or the oxygen concentration generated by the microenvironment building unit to the testing unit.

1. Name of the designed product: multi-copy drug detection card. 2. Use of the designed product: for drug detection. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The invention discloses a method for determining allylamine in a sevelamer carbonate medicine. The method comprises the following steps: (1) preparing a sevelamer carbonate drug test solution and an allylamine reference solution; (2) respectively carrying out derivatization treatment on the test solution and the reference solution, and during derivatization treatment, adjusting the pH value of a derivatization system by using a buffer solution with the pH value of 8.4-10.8; and (3) determining the derivatization system by using a high performance liquid chromatography. The sevelamer carbonate drug is alkaline, so that the pH value of a test product reaction system is high, the pH value is greatly different from the pH value of a reference product reaction system, the analysis result is unstable, the pH values of a test product derivative system and a reference product derivative system are adjusted to tend to be consistent by adding a buffer solution, so that the influence of the pH value difference on the analysis result is reduced, and the accuracy of the analysis result is improved. The accuracy, repeatability and stability of analysis are improved, the requirements and standards of pharmacopeia on the analysis method are better met, and quality control and safe production of sevelamer carbonate drugs are facilitated.

A drug screening platform for simulating a tumor microenvironment comprises a wafer for tumor microenvironment simulation, a wafer for drug testing and a permeable film arranged between the wafer for tumor microenvironment simulation and the wafer for drug testing. The wafer for simulating the tumor microenvironment comprises a microenvironment establishing unit, wherein the microenvironment establishing unit is used for chemical reaction to generate acid gas, alkaline gas and / or oxygen concentration for simulating the tumor microenvironment. The wafer for the drug test comprises a test unit for interaction between a therapeutic drug and a cell hydrogel, and the orthographic projection of the test unit falls on the microenvironment establishing unit. According to the invention, the tumor microenvironment is simulated through the wafer for tumor microenvironment simulation, so that the therapeutic drug and the cell hydrogel interact in the simulated tumor microenvironment to obtain an accurate test result.

The utility model discloses an automatic medicine centrifugal separation all-in-one machine which comprises a machine body, a centrifugal bin is arranged in the machine body, a driving shaft is arranged in the centrifugal bin, an upper rotating disc and a lower rotating disc are arranged on the surface of the driving shaft, and the upper rotating disc and the lower rotating disc are fixedly connected with the driving shaft. And placing holes are formed in the upper rotating disc and the lower rotating disc and correspond to each other. The driving box is arranged on the side face of the machine body, the driver is arranged on the surface of the driving box, the first driving wheel is arranged at the power output end of the driver, the first driven wheel is arranged on the surface of the driving shaft, the first driving chain is arranged between the first driving wheel and the first driven wheel, and the driver drives the first driving wheel to rotate. The first driven wheel and the driving shaft are driven by the first driving chain to rotate, so that the upper rotating disc and the lower rotating disc rotate, solid-liquid separation of suspension liquid in the medicine test tube is realized under the action of centrifugal force, and subsequent detection is facilitated.

The present application relates to a kind of siglitin metformin sustained-release tablets combined drug effect detection method in the field of pharmaceutical testing, in the application, by introducing intelligent terminal and monitoring terminal, real-time observation is realized using mechanical vision technology in the experiment process, the observation pressure of experimental personnel is reduced, the labor cost of experimental detection is greatly reduced, the detection efficiency is improved, at the same time, the identity of experimental personnel is identified using intelligent terminal, all experimental operations are bound with its experimental personnel, it is convenient to subsequent summary when experiment is summarized, the traceability work is carried out, the standardization of experimental detection is improved, at the same time, protection unit is set for monitoring terminal, when experimental organism touches trigger lever, a part of stored stimulating smell in slow-release unit is released, the expelling effect is strengthened, and experimental organism is formed to expel domestication, so that experimental organism forms the habit of keeping away from monitoring terminal.

A biological material testing apparatus (100) is provided that includes a substrate (102) having at least one chamber unit (104) defined therein, and a support member (106) for supporting a biological material contained in the at least one chamber unit. One of the substrate and the support member is molded on the other of the substrate and the support member. A method (10) for manufacturing such a biological material testing device is also provided. Uses and methods are also provided in which the device is used to test a biological material, for example in a drug test in which the biological material is exposed to a drug to be tested.

A lung environment-imitating drug testing platform comprises a microfluid wafer and a stretching device. The microfluidic chip defines a micro-channel structure, and the micro-channel structure comprises a test area unit, a cell sub-channel unit and a drug sub-channel unit. The stretching device comprises a clamping structure and a moving unit. The clamping structure is provided with a fixed part, a movable part spaced from the fixed part, and a groove part formed between the fixed part and the movable part; and the fixed part and the movable part are matched with each other to clamp two opposite ends of the microfluidic wafer and enable the orthographic projection of the test area unit of the microfluidic wafer to completely coincide with the groove part. According to the drug test platform simulating the lung environment, the environment simulating the respiratory movement of the human lung can be constructed, and multiple test results can be obtained through one-time test.

The invention belongs to the technical field of organ chips, and discloses an organ chip capable of realizing parallel precise time-sequence drug delivery and application of the organ chip. The organ chip comprises an organ chip main body, a perfusion culture main channel is arranged in the organ chip main body, a plurality of medicine preloading cavities are arranged beside the organ chip main body, and the organ chip main body and the medicine preloading cavities are communicated through a micro-fence structure; and the medicine preloading chamber is provided with micropores and is sealed by a manual or automatic sealing element. Based on the principle of airlock effect, through the synergistic effect of the micro-fence structure, the sealing piece and the negative pressure environment, stable pre-storage and controllable release of the medicine are achieved. The application method comprises the steps of drug preloading, cell culture and drug administration triggering in sequence. The airlock can be removed by sequentially removing or simultaneously removing the sealing element, so that the medicine is accurately guided into the main channel in a controllable laminar flow state, and parallel and high-flux medicine testing is realized. According to the scheme, a passive flow control mechanism is used for replacing complex external equipment, and the system has the remarkable advantages of being simple in structure, convenient to operate, accurate in control and low in cost.