43 results about "Drug test" patented technology

A drug testing platform for simulating a lung environment includes a microfluidic chip and a stretching device. The microfluidic chip defines a microfluidic channel structure. The microfluidic channel structure includes a test unit, a cell shunt unit and a drug shunt unit. The stretching device is configured to stretch and contract the test unit in a manner of a reciprocal motion, thereby making degree of deformation of a plurality of test area of the test unit to be same during the reciprocal motion. The drug testing platform for simulating the lung environment according to the present disclosure may configure an environment that simulates a breathing motion of a human lung, and obtain multiple results within a single test.

The application discloses a kind of for drug test research room subject sign dynamic monitoring system, it is related to the field of drug test, solve the problem that drug test research room subject sign dynamic monitoring monitoring effect is poor, including data acquisition module: a plurality of physiological indexes are set to the physiological index monitoring of subject for characteristic test drug, obtain physiological index acquisition data, sign analysis module: according to physiological index acquisition data, sign index analysis is carried out to characteristic drug subject, according to the type division of subject is carried out to analysis result, obtains subject type division data, symptom analysis module: the typical symptom coincidence degree analysis is carried out to normal subject, according to analysis result, obtain typical symptom similarity coefficient, monitoring feedback module: according to subject type division data and typical symptom similarity coefficient, monitoring result feedback is carried out to characteristic drug subject, the accuracy and pertinence of subject sign dynamic monitoring process can be improved by the application.

The invention discloses a dynamic monitoring system for physical signs of subjects in a drug test research laboratory, relates to the field of drug tests, and solves the problem of poor dynamic monitoring effect of the physical signs of the subjects in the drug test research laboratory. Comprising a data acquisition module for setting a plurality of physiological indexes for characteristic test drugs to perform physiological index monitoring on subjects to obtain physiological index acquisition data, and a physical sign analysis module for performing physical sign index analysis on the characteristic drug subjects according to the physiological index acquisition data, performing type division on the subjects according to an analysis result, and determining the types of the subjects according to the types of the subjects. The system comprises a subject classification module for classifying subjects to obtain subject type classification data, a symptom analysis module for performing typical symptom coincidence degree analysis on subjects with normal signs and obtaining typical symptom similarity coefficients according to analysis results, and a monitoring feedback module for performing monitoring result feedback on characteristic medicine subjects according to the subject type classification data and the typical symptom similarity coefficients. According to the invention, the accuracy and pertinence of the dynamic monitoring process of the physical signs of the subject can be improved.

The present invention relates to a method for producing an in vitro model of a human neurological disease. Furthermore, the invention relates to the in vitro model produced according to the method disclosed herein. The invention also relates to the use of the in vitro model in drug testing. In addition, the invention relates to methods for testing the efficacy of drugs in preventing, delaying, and alleviating a human neurological disease.

The application discloses a kind of blood vessel microfluidic device and method suitable for glycolipid drug test, the device constructs three-dimensional biomimetic microvessel chip using induced pluripotent stem cells, and integrates multiple sensors;Through integrated environmental control module, programmed blood flow loading and drug exposure are realized.Intelligent analysis system includes multimodal intelligent observation module, based on microscope imaging and artificial intelligence speed measurement technology, three-dimensional flow field is inverted;Microcirculation digital twin module reconstructs blood vessels based on medical imaging and constructs calibratable hemodynamic model, for simulation and prediction;And wet-dry interaction module, through two-way interface, realizes "experiment-simulation" closed loop, injects entity data into digital twin to calibrate, and converts the prediction instruction of digital twin into chip control command to drive verification experiment.The system realizes complete technical chain from biomimetic model construction, intelligent observation, digital twin simulation to active experiment optimization.

The application discloses a kind of matching method, device and computer equipment of clinical drug test patient, it is related to computer technical field, can solve the technical problem of the matching of clinical drug test patient at present, workload is big, efficiency is relatively low, and it is prone to cause error accumulation and information loss. Among them, the method comprises: obtaining patient information of test patient and medicine test entry condition information, patient information includes first numerical information and medical information, medicine test entry condition information includes second numerical information and description information;First numerical information and second numerical information are numerically matched, and first matching result is obtained;Medical information and description information are preprocessed, and the embedded matching of medical information and description information after preprocessing is carried out, and second matching result is obtained;According to first matching result and second matching result, the final matching result of test patient and medicine test is generated.

The utility model discloses a medicine stability test box, relates to the technical field of medicine test boxes, and aims to solve the problems that a humidifying mechanism in the test box converts liquid into gas through electric heating to increase the humidity in air, but the humid environment is an ideal condition for breeding microorganisms such as bacteria and molds, and the humidity in the air is increased. The problems that in the prior art, bacteria can rapidly breed in a high-humidity environment, especially in a water tank inside a humidifier, the bacteria and other microorganisms may form biological membranes, normal operation of the humidifier is affected, the humidifying performance of the humidifier is reduced, and the humidity adjustment of the drug stability test box is unstable are solved. A humidifying mechanism is arranged in the middle of the interior of the equipment cavity and comprises a liquid adding pipe, a liquid adding pipe valve, a liquid discharging pipe, a liquid discharging pipe valve, a humidifying pipe, a humidifying pipe valve, a cleaning driving motor frame, a cleaning driving motor, a cleaning lead screw, a sliding block, a cleaning brush and a fixing frame.

The present disclosure relates to a container for in vitro drug testing. The container includes a reservoir having a wall made of a gel composition. The reservoir has an opening and is configured to receive a pharmaceutical formulation through the opening. The gel composition is selected to mimic one or more properties of tissue.

The invention relates to a microfluidic single cell culture plate based on AI image recognition and a global positioning method. A micropore array is arranged in the culture plate, a unique code is formed according to an asymmetric micropore pattern in a micropore positioning area, a global positioning method identifies the positioning pattern through a microscope bright field image, rapid and accurate positioning of micropores is realized in combination with an AI algorithm, dynamic tracking of cell positions in multi-time-point sampling is supported, and the positioning accuracy is improved. Drug testing of different drug use sequences is achieved, the problems of low micropore positioning efficiency and long-term occupation under a traditional microscope are solved, and cell-level drug effect data are provided for drug screening (targeted therapy / drug combination) and personalized medical treatment.

This invention discloses an automated injection device for batch mouse drug testing, comprising a base, an experimental box, a rotary mouse trapping and fixing mechanism, an injection mechanism, and an observation box. A support frame is mounted on the base, the experimental box is positioned above the support frame, and the observation box is located on the base. The rotary mouse trapping and fixing mechanism is located on the base, with its head and tail connected to the experimental box and observation box, respectively. The injection mechanism is located on the base and on one side of the rotary mouse trapping and fixing mechanism. This invention belongs to the technical field of mouse drug injection equipment, specifically providing an automated injection device for batch mouse drug testing that automatically traps and self-fixes mice individually for convenient tail vein injection, and automatically transfers the mice into the observation box after injection.

The present invention relates to devices, systems, and methods for cutting tissues. In some embodiments, the devices, systems, and methods of the invention relate to cutting tissues into fragments that find use in tissue culture and drug testing applications.

The utility model relates to a hair drug detection kit which comprises a kit body, an extension plate and a drawing component, the kit body comprises an upper kit plate, a middle kit plate and a lower kit plate which are sequentially arranged from top to bottom, the upper kit plate, the middle kit plate and the lower kit plate are connected into a whole through connecting parts arranged on the two sides of the upper kit plate, the middle kit plate and the lower kit plate, and the front and the back of the kit body are through. A first containing cavity is formed between the upper box plate and the middle box plate, a second containing cavity is formed between the middle box plate and the lower box plate, and a baffle fixedly connected with the middle box plate and the upper box plate is arranged at the front end of the first containing cavity. The extension plate is arranged in the first containing cavity and slides in the first containing cavity, supporting plate grooves are formed in the bottoms of the two sides of the rear end of the extension plate, and supporting plates rotationally connected with the extension plate are arranged in the supporting plate grooves. And the drawing assembly stretches across the space between the first containing cavity and the second containing cavity and is used for drawing the extension plate. The utility model has the advantages that the designed drawing assembly can realize the automatic drawing of each device in the box body, and is beneficial to use and support.

The present invention relates to a method for the preparation of an in vitro model for a human neurological disorder. Moreover, the invention relates to the in vitro model, produced according to the inventive method disclosed herein. In addition, the invention relates to the use of the in vitro model of the invention in drug testing. In addition, the invention relates to methods for testing the efficacy of drugs in the prevention, delay and amelioration of a human neurological disorder.

This invention discloses a model data standardization processing method and system for drug testing, relating to the field of biomedical technology. The method involves collecting cell culture plate numbers, drug concentrations, culture times, and absorbance readings; sorting concentrations and matching absorbance to form experimental sequence values; filtering for consistency in well readings within the same plate to eliminate deviations; normalizing absorbance ratios and generating response coefficients through difference; correcting for deviations in the mean values ​​of different batches to form correction coefficients; and superimposing the correction coefficients and mapping them to the concentrations to rearrange and output standardized drug efficacy data. This invention's model data standardization processing method and system for drug testing synchronizes the cell culture plate numbers and time scales in the original experimental records and performs gradient sorting of drug concentrations, enabling data under different time and dosage conditions to form a sequentially constrained sequence structure, enhancing the correspondence between experimental data in the time and dosage dimensions.

An automated system for anticancer drug sensitivity testing, according to an embodiment of the present invention, may comprise: a chopper configured to mince patient tissue; a cell dissociation device configured to apply a cell dissociation enzyme to the patient tissue minced by the chopper; a centrifuge configured to centrifuge cells to which the cell dissociation enzyme has been applied by the cell dissociation device; a liquid handler configured to mix the centrifuged cells with extracellular matrix to thereby generate a mixed sample and to inject the mixed sample into a nozzle tip; a spotter configured to dispense the mixed sample onto a pillar by using the nozzle tip; an automatic incubator configured to culture the mixed sample to generate cell organoids; a scanner configured to generate an image by scanning the cell organoids at high speed; and a multi-joint robot configured to move at least one of the patient tissue, the cells, and the mixed sample between at least some of the chopper, the cell dissociation device, the centrifuge, the liquid handler, the spotter, the automatic incubator, and the scanner. Thus, the entire process of cell extraction from tissue isolated from a patient to organoid culture, drug testing, and scanning can be performed fully automatically.

The present invention relates to a drug efficacy evaluation method based on the dynamic mechanical properties of single cells. A single cell is regarded as a linear time-invariant system, with mechanical stimulation as the virtual input of the system, and the continuous-time mechanical properties of the cell under the action of a drug as the output of the system. The dynamic mechanical properties of the cell are characterized according to the identified eigenvalues of the single-cell system matrix. Based on the characterization of cells with and without drug additions in the space, as well as the state of the cells during drug administration, drug efficacy evaluation based on the single-cell scale can be achieved. The present invention can characterize cells with and without drug additions in the space, as well as the state of the cells during drug addition, and establish the relationship between cell mechanical properties and cell state. In addition, compared with traditional methods, the drug testing cycle is greatly shortened, and drug efficacy evaluation based on the single-cell scale can be achieved. Therefore, it has important potential applications in the field of drug sensitivity testing based on the single-cell scale in clinical practice.

The present disclosure relates to a container for in vitro drug testing. The container comprises a receptacle having a wall made of a gel composition. The receptacle has an opening and is configured to receive a drug formulation through the opening. The gel composition is selected to simulate one or more properties of tissue.

A biomaterial testing device 100 is provided, comprising a substrate 102 on which at least one chamber unit 104 is defined, and a support member 106 for supporting a biomaterial received in at least one chamber unit. One of the substrate and the support member is molded on the other of the substrate and the support member. A method 10 for manufacturing such a biomaterial testing device is also provided. Furthermore, a method and use of the device for testing a biomaterial is provided, for example, in drug testing where the biomaterial is exposed to a drug to be tested.

The present invention belongs to the field of clinical testing technology, and in particular to a medical clinical testing oscillation reaction device. In view of the problem that the existing oscillation reaction device has only one oscillation mode, the single oscillation mode cannot meet the use requirements of different drug tests, and it is inconvenient to fix test oscillation test tubes of different sizes, the following scheme is proposed, which includes: a power distribution base, the bottom of the power distribution base is provided with four feet, the outer side of the power distribution base is provided with heat dissipation holes, and the top of the power distribution base is provided with an oscillation bin. The present invention adopts an inflatable method to fix the test oscillation test tube, which can adapt to test oscillation test tubes of different sizes. Not only can the test oscillation test tube be oscillated left and right, but also rotationally oscillated, or both can be oscillated at the same time. Different drug oscillation modes can meet the use requirements of clinical tests of different drugs, and the test oscillation test tube fixing plate can be easily disassembled and cleaned.

The invention provides a hair drug kit and a detection method, and belongs to the technical field of hair drug detection. The kit body is provided with three parallel detection areas; the detection area comprises a sample inlet, a reaction chamber and a waste liquid collection cavity. The method comprises the following steps: sample collection, sample treatment, detection operation and result judgment. The kit has the characteristics of high sensitivity, high specificity, simplicity in operation, multiple functions and the like.

A computer system is provided for determining the relative effectiveness of anti-cancer drugs. The interface has selectable options, including an option to manage drug testing parameters, and enables user selection of desired drug testing parameters in relation to a virtual well plate associated with a physical well plate of a spectrophotometer. The computer system causes the spectrophotometer to start a drug test, wherein the physical well plate includes at least one test well containing viable cancer cells; and at least one drug candidate in a predetermined concentration; and at least one control well containing the viable cancer cells alone. The system records the optical density of the well at a predetermined wavelength at selected time intervals for a selected duration of time, and stores the optical density and time measurements in the database. An activity value is calculated from the optical density and time measurements, and a correlation is displayed between the activity value and the drug candidate's ability to induce apoptosis in the cancer cells.

The invention relates to the field of clinical information, in particular to a test follow-up visit dynamic scheduling method and system based on a rule engine, and the method comprises the steps: obtaining basic data of clinical test participants, generating information containers of the participants, and configuring the rule engine for the information containers; obtaining test related data of the participants, predicting clinical symptom changes, performing decision judgment on the clinical symptom changes and questionnaire replies of the participants by using a rule engine, and generating a follow-up schedule; and according to the implementation result of the follow-up schedule, updating the information container and reconfiguring the rule engine, so as to adjust the follow-up schedule according to the clinical symptom change and the questionnaire reply predicted next time, and dynamically update and set the follow-up schedule. According to the method, the follow-up schedule is adaptively changed according to the change conditions of the body, the body feeling and the drug effect of the participant in the drug test period, it is guaranteed that the participant obtains follow-up docking matched with the actual test condition in each follow-up process, and the effectiveness and the quality of the follow-up schedule are improved.

The present application belongs to the field of AD drug test using rats, and particularly relates to a method for screening AD rat model and a method for evaluating recovery of AD rats after taking drugs, the screening method comprising the following steps: conducting sugar water and hot water drinking test on known normal healthy rats and AD rats to be tested; if the AD rats to be tested significantly decrease water drinking times in S area compared with normal healthy rats, and significantly increase water drinking times in C area, the AD rats to be tested are AD rats, the method for evaluating recovery comprises the following steps: conducting sugar water and hot water drinking test on AD rats continuously taking drugs for several days, if the AD rats gradually increase water drinking times in S area with increasing days, and gradually decrease water drinking times in C area, it is indicated that the AD rats recover after taking drugs, the method of the present application can simply, quickly and painlessly screen qualified AD rats, and can evaluate recovery of AD rats after taking drugs by using a low-cost method, thereby effectively reducing development cost and time of AD specific drugs.

The present disclosure relates to a container for in vitro drug testing. The container includes a receptacle having a wall made from a gel composition. The receptacle has an opening and is configured to receive a drug formulation therethrough.

The invention belongs to the technical field of tissue engineering skin and drug testing, and particularly relates to a regenerated skin drug testing method which comprises the following steps: firstly, collecting in-vitro human skin samples of different genders, ages and anatomical areas to establish a sample library, then selecting the samples according to test requirements, and dividing the samples into test samples and culture samples; a culture sample is used for 3D printing of regenerated skin, and through comparison of IVRT / IVPT test data of a test sample and a regenerated skin sample and multi-round optimization of a printing strategy, regenerated skin with the skin type close to that of in-vitro skin is finally manufactured in batches and used for tests of multiple drug application strategies. By optimizing the 3D printing strategy, the 3D printing regenerated skin manufactured in batches can reflect gender, age and anatomical area information more accurately, the use amount requirements of various drug application strategies are met, test errors are reduced, and challenges caused by the large use amount of the in-vitro skin are reduced.

The utility model discloses a temperature-control cold closet for a clinical drug test, which comprises a closet body, and a transverse partition plate and a vertical partition plate are fixedly connected with an inner cavity of the closet body; a medicine outlet is formed in the box door, a left sliding door and a right sliding door are slidably connected in the medicine outlet, a left connecting plate is fixedly arranged on the left sliding door, and a right connecting plate is fixedly arranged on the right sliding door; the medicine discharging assembly comprises an L-shaped plate, an air cylinder, a containing plate, a push plate and a connecting rod. The air cylinder is fixed to the side wall of the L-shaped plate; a sliding block is fixedly arranged on the bottom surface of the placing plate; the push plate is fixedly connected to the bottom surface of the sliding block and is fixedly connected with the air cylinder; a connecting column is fixedly arranged on the bottom surface of the placing plate; the other end of the connecting rod is rotationally connected with the left connecting plate and the right connecting plate. Loss caused by medicine deterioration due to temperature difference change during medicine taking is avoided, and medicine damage caused by cold air leakage due to the fact that the box door is not tightly closed is avoided.

The utility model discloses a rapid detection device for a bacterial drug sensitivity test, and mainly relates to the technical field of bacterial drug sensitivity detection. Comprising a drug sensitivity detection body, a control panel is arranged on the surface of the drug sensitivity detection body, a detection frame is slidably connected to the inner wall of the drug sensitivity detection body, a plurality of detection test tubes are arranged on the upper surface of the detection frame, and adjusting devices are arranged at the positions, corresponding to the detection test tubes, of the upper surface of the detection frame. The adjusting device comprises a plurality of connecting grooves, the connecting grooves are evenly formed in the surface of the detection frame, a bearing frame is inserted into the inner walls of the connecting grooves, and a plurality of embedding holes are formed in the inner wall of the bearing frame. The movable test tube rack has the beneficial effects that the problems that a large number of bacterial drug test tubes need to be placed in detection equipment during drug sensitivity experiment detection, and a common detection movable rack is relatively poor in clamping stability on the detection test tubes, so that the test tubes are easy to fall off and are collided and damaged at the same time are solved.

Systems and methods are provided for streamlining the mandatory drug testing process for commercial drivers. The system includes a central database on a secure networked server provided in communications with several user applications. Drivers and / or their employers can register on the system, with registration data stored on a server database. Drug testing sites can also register with the system. The system can alert drivers to schedule testing through a driver application on a smartphone or tablet. The driver can schedule a test with a registered testing site and select a convenient site based on GPS data provided by their app to the system. Test results can be provided to appropriate government agencies, the driver, and the driver's employer. The driver app can be configured to schedule any required treatment with registered counselors, and counselors can report status of treatment to the driver, employer, and appropriate agencies.

The utility model discloses a work box for transferring medicine in a clinical medicine test, relates to the field of medical tool boxes, and mainly aims to solve the problem that an integrated medicine and consumable transferring tool which is integrated, efficient, safe and easy to manage is lacked at present. A first storage groove is formed in the top of a box body, and a telescopic goods shelf is installed in the first storage groove. A second storage groove is formed in the upper portion of the side wall of the box body, and a multifunctional treatment plate is inserted into the second storage groove. A third storage groove is formed in the side wall, below the second storage groove, of the box body, and a medicine storage drawer is inserted into the third storage groove. And fourth storage grooves communicating with the third storage groove are formed in the positions, on the two sides of the third storage groove, of the side wall of the box body correspondingly, and refrigeration drawers are inserted into the fourth storage grooves. The device is high in integration level, safe and convenient to use and easy to manage medicines and consumables.

A drug screening platform for tumor microenvironment simulation includes a tumor microenvironment simulating chip, a drug testing chip, and a permeable thin film disposed between the tumor microenvironment simulating chip and the drug testing chip. The tumor microenvironment simulating chip includes a microenvironment building unit which is used for conducting a chemical reaction to generate an acid gas, an alkaline gas and / or an oxygen concentration for simulating the tumor microenvironment. The drug testing chip includes a testing unit which is used for allowing interaction of a therapeutic drug with a cell-containing hydrogel. An orthographic projection of the testing unit falls on the microenvironment building unit. The permeable thin film is used for diffusing the acid gas, the alkaline gas and / or the oxygen concentration generated by the microenvironment building unit to the testing unit.