32 results about "Drug test" patented technology

A drug testing platform for simulating a lung environment includes a microfluidic chip and a stretching device. The microfluidic chip defines a microfluidic channel structure. The microfluidic channel structure includes a test unit, a cell shunt unit and a drug shunt unit. The stretching device is configured to stretch and contract the test unit in a manner of a reciprocal motion, thereby making degree of deformation of a plurality of test area of the test unit to be same during the reciprocal motion. The drug testing platform for simulating the lung environment according to the present disclosure may configure an environment that simulates a breathing motion of a human lung, and obtain multiple results within a single test.

The application discloses a kind of for drug test research room subject sign dynamic monitoring system, it is related to the field of drug test, solve the problem that drug test research room subject sign dynamic monitoring monitoring effect is poor, including data acquisition module: a plurality of physiological indexes are set to the physiological index monitoring of subject for characteristic test drug, obtain physiological index acquisition data, sign analysis module: according to physiological index acquisition data, sign index analysis is carried out to characteristic drug subject, according to the type division of subject is carried out to analysis result, obtains subject type division data, symptom analysis module: the typical symptom coincidence degree analysis is carried out to normal subject, according to analysis result, obtain typical symptom similarity coefficient, monitoring feedback module: according to subject type division data and typical symptom similarity coefficient, monitoring result feedback is carried out to characteristic drug subject, the accuracy and pertinence of subject sign dynamic monitoring process can be improved by the application.

The present invention relates to a method for producing an in vitro model of a human neurological disease. Furthermore, the invention relates to the in vitro model produced according to the method disclosed herein. The invention also relates to the use of the in vitro model in drug testing. In addition, the invention relates to methods for testing the efficacy of drugs in preventing, delaying, and alleviating a human neurological disease.

The application discloses a kind of blood vessel microfluidic device and method suitable for glycolipid drug test, the device constructs three-dimensional biomimetic microvessel chip using induced pluripotent stem cells, and integrates multiple sensors;Through integrated environmental control module, programmed blood flow loading and drug exposure are realized.Intelligent analysis system includes multimodal intelligent observation module, based on microscope imaging and artificial intelligence speed measurement technology, three-dimensional flow field is inverted;Microcirculation digital twin module reconstructs blood vessels based on medical imaging and constructs calibratable hemodynamic model, for simulation and prediction;And wet-dry interaction module, through two-way interface, realizes "experiment-simulation" closed loop, injects entity data into digital twin to calibrate, and converts the prediction instruction of digital twin into chip control command to drive verification experiment.The system realizes complete technical chain from biomimetic model construction, intelligent observation, digital twin simulation to active experiment optimization.

The application discloses a kind of matching method, device and computer equipment of clinical drug test patient, it is related to computer technical field, can solve the technical problem of the matching of clinical drug test patient at present, workload is big, efficiency is relatively low, and it is prone to cause error accumulation and information loss. Among them, the method comprises: obtaining patient information of test patient and medicine test entry condition information, patient information includes first numerical information and medical information, medicine test entry condition information includes second numerical information and description information;First numerical information and second numerical information are numerically matched, and first matching result is obtained;Medical information and description information are preprocessed, and the embedded matching of medical information and description information after preprocessing is carried out, and second matching result is obtained;According to first matching result and second matching result, the final matching result of test patient and medicine test is generated.

The invention relates to a microfluidic single cell culture plate based on AI image recognition and a global positioning method. A micropore array is arranged in the culture plate, a unique code is formed according to an asymmetric micropore pattern in a micropore positioning area, a global positioning method identifies the positioning pattern through a microscope bright field image, rapid and accurate positioning of micropores is realized in combination with an AI algorithm, dynamic tracking of cell positions in multi-time-point sampling is supported, and the positioning accuracy is improved. Drug testing of different drug use sequences is achieved, the problems of low micropore positioning efficiency and long-term occupation under a traditional microscope are solved, and cell-level drug effect data are provided for drug screening (targeted therapy / drug combination) and personalized medical treatment.

This invention discloses an automated injection device for batch mouse drug testing, comprising a base, an experimental box, a rotary mouse trapping and fixing mechanism, an injection mechanism, and an observation box. A support frame is mounted on the base, the experimental box is positioned above the support frame, and the observation box is located on the base. The rotary mouse trapping and fixing mechanism is located on the base, with its head and tail connected to the experimental box and observation box, respectively. The injection mechanism is located on the base and on one side of the rotary mouse trapping and fixing mechanism. This invention belongs to the technical field of mouse drug injection equipment, specifically providing an automated injection device for batch mouse drug testing that automatically traps and self-fixes mice individually for convenient tail vein injection, and automatically transfers the mice into the observation box after injection.

The present invention relates to devices, systems, and methods for cutting tissues. In some embodiments, the devices, systems, and methods of the invention relate to cutting tissues into fragments that find use in tissue culture and drug testing applications.

The utility model relates to a hair drug detection kit which comprises a kit body, an extension plate and a drawing component, the kit body comprises an upper kit plate, a middle kit plate and a lower kit plate which are sequentially arranged from top to bottom, the upper kit plate, the middle kit plate and the lower kit plate are connected into a whole through connecting parts arranged on the two sides of the upper kit plate, the middle kit plate and the lower kit plate, and the front and the back of the kit body are through. A first containing cavity is formed between the upper box plate and the middle box plate, a second containing cavity is formed between the middle box plate and the lower box plate, and a baffle fixedly connected with the middle box plate and the upper box plate is arranged at the front end of the first containing cavity. The extension plate is arranged in the first containing cavity and slides in the first containing cavity, supporting plate grooves are formed in the bottoms of the two sides of the rear end of the extension plate, and supporting plates rotationally connected with the extension plate are arranged in the supporting plate grooves. And the drawing assembly stretches across the space between the first containing cavity and the second containing cavity and is used for drawing the extension plate. The utility model has the advantages that the designed drawing assembly can realize the automatic drawing of each device in the box body, and is beneficial to use and support.

The present invention relates to a method for the preparation of an in vitro model for a human neurological disorder. Moreover, the invention relates to the in vitro model, produced according to the inventive method disclosed herein. In addition, the invention relates to the use of the in vitro model of the invention in drug testing. In addition, the invention relates to methods for testing the efficacy of drugs in the prevention, delay and amelioration of a human neurological disorder.

This invention discloses a model data standardization processing method and system for drug testing, relating to the field of biomedical technology. The method involves collecting cell culture plate numbers, drug concentrations, culture times, and absorbance readings; sorting concentrations and matching absorbance to form experimental sequence values; filtering for consistency in well readings within the same plate to eliminate deviations; normalizing absorbance ratios and generating response coefficients through difference; correcting for deviations in the mean values ​​of different batches to form correction coefficients; and superimposing the correction coefficients and mapping them to the concentrations to rearrange and output standardized drug efficacy data. This invention's model data standardization processing method and system for drug testing synchronizes the cell culture plate numbers and time scales in the original experimental records and performs gradient sorting of drug concentrations, enabling data under different time and dosage conditions to form a sequentially constrained sequence structure, enhancing the correspondence between experimental data in the time and dosage dimensions.

An automated system for anticancer drug sensitivity testing, according to an embodiment of the present invention, may comprise: a chopper configured to mince patient tissue; a cell dissociation device configured to apply a cell dissociation enzyme to the patient tissue minced by the chopper; a centrifuge configured to centrifuge cells to which the cell dissociation enzyme has been applied by the cell dissociation device; a liquid handler configured to mix the centrifuged cells with extracellular matrix to thereby generate a mixed sample and to inject the mixed sample into a nozzle tip; a spotter configured to dispense the mixed sample onto a pillar by using the nozzle tip; an automatic incubator configured to culture the mixed sample to generate cell organoids; a scanner configured to generate an image by scanning the cell organoids at high speed; and a multi-joint robot configured to move at least one of the patient tissue, the cells, and the mixed sample between at least some of the chopper, the cell dissociation device, the centrifuge, the liquid handler, the spotter, the automatic incubator, and the scanner. Thus, the entire process of cell extraction from tissue isolated from a patient to organoid culture, drug testing, and scanning can be performed fully automatically.

The present disclosure relates to a container for in vitro drug testing. The container comprises a receptacle having a wall made of a gel composition. The receptacle has an opening and is configured to receive a drug formulation through the opening. The gel composition is selected to simulate one or more properties of tissue.

A biomaterial testing device 100 is provided, comprising a substrate 102 on which at least one chamber unit 104 is defined, and a support member 106 for supporting a biomaterial received in at least one chamber unit. One of the substrate and the support member is molded on the other of the substrate and the support member. A method 10 for manufacturing such a biomaterial testing device is also provided. Furthermore, a method and use of the device for testing a biomaterial is provided, for example, in drug testing where the biomaterial is exposed to a drug to be tested.

The present application belongs to the field of AD drug test using rats, and particularly relates to a method for screening AD rat model and a method for evaluating recovery of AD rats after taking drugs, the screening method comprising the following steps: conducting sugar water and hot water drinking test on known normal healthy rats and AD rats to be tested; if the AD rats to be tested significantly decrease water drinking times in S area compared with normal healthy rats, and significantly increase water drinking times in C area, the AD rats to be tested are AD rats, the method for evaluating recovery comprises the following steps: conducting sugar water and hot water drinking test on AD rats continuously taking drugs for several days, if the AD rats gradually increase water drinking times in S area with increasing days, and gradually decrease water drinking times in C area, it is indicated that the AD rats recover after taking drugs, the method of the present application can simply, quickly and painlessly screen qualified AD rats, and can evaluate recovery of AD rats after taking drugs by using a low-cost method, thereby effectively reducing development cost and time of AD specific drugs.

The present disclosure relates to a container for in vitro drug testing. The container includes a receptacle having a wall made from a gel composition. The receptacle has an opening and is configured to receive a drug formulation therethrough.

The invention belongs to the technical field of tissue engineering skin and drug testing, and particularly relates to a regenerated skin drug testing method which comprises the following steps: firstly, collecting in-vitro human skin samples of different genders, ages and anatomical areas to establish a sample library, then selecting the samples according to test requirements, and dividing the samples into test samples and culture samples; a culture sample is used for 3D printing of regenerated skin, and through comparison of IVRT / IVPT test data of a test sample and a regenerated skin sample and multi-round optimization of a printing strategy, regenerated skin with the skin type close to that of in-vitro skin is finally manufactured in batches and used for tests of multiple drug application strategies. By optimizing the 3D printing strategy, the 3D printing regenerated skin manufactured in batches can reflect gender, age and anatomical area information more accurately, the use amount requirements of various drug application strategies are met, test errors are reduced, and challenges caused by the large use amount of the in-vitro skin are reduced.

The utility model discloses a temperature-control cold closet for a clinical drug test, which comprises a closet body, and a transverse partition plate and a vertical partition plate are fixedly connected with an inner cavity of the closet body; a medicine outlet is formed in the box door, a left sliding door and a right sliding door are slidably connected in the medicine outlet, a left connecting plate is fixedly arranged on the left sliding door, and a right connecting plate is fixedly arranged on the right sliding door; the medicine discharging assembly comprises an L-shaped plate, an air cylinder, a containing plate, a push plate and a connecting rod. The air cylinder is fixed to the side wall of the L-shaped plate; a sliding block is fixedly arranged on the bottom surface of the placing plate; the push plate is fixedly connected to the bottom surface of the sliding block and is fixedly connected with the air cylinder; a connecting column is fixedly arranged on the bottom surface of the placing plate; the other end of the connecting rod is rotationally connected with the left connecting plate and the right connecting plate. Loss caused by medicine deterioration due to temperature difference change during medicine taking is avoided, and medicine damage caused by cold air leakage due to the fact that the box door is not tightly closed is avoided.

Systems and methods are provided for streamlining the mandatory drug testing process for commercial drivers. The system includes a central database on a secure networked server provided in communications with several user applications. Drivers and / or their employers can register on the system, with registration data stored on a server database. Drug testing sites can also register with the system. The system can alert drivers to schedule testing through a driver application on a smartphone or tablet. The driver can schedule a test with a registered testing site and select a convenient site based on GPS data provided by their app to the system. Test results can be provided to appropriate government agencies, the driver, and the driver's employer. The driver app can be configured to schedule any required treatment with registered counselors, and counselors can report status of treatment to the driver, employer, and appropriate agencies.

The utility model discloses a work box for transferring medicine in a clinical medicine test, relates to the field of medical tool boxes, and mainly aims to solve the problem that an integrated medicine and consumable transferring tool which is integrated, efficient, safe and easy to manage is lacked at present. A first storage groove is formed in the top of a box body, and a telescopic goods shelf is installed in the first storage groove. A second storage groove is formed in the upper portion of the side wall of the box body, and a multifunctional treatment plate is inserted into the second storage groove. A third storage groove is formed in the side wall, below the second storage groove, of the box body, and a medicine storage drawer is inserted into the third storage groove. And fourth storage grooves communicating with the third storage groove are formed in the positions, on the two sides of the third storage groove, of the side wall of the box body correspondingly, and refrigeration drawers are inserted into the fourth storage grooves. The device is high in integration level, safe and convenient to use and easy to manage medicines and consumables.

A drug screening platform for tumor microenvironment simulation includes a tumor microenvironment simulating chip, a drug testing chip, and a permeable thin film disposed between the tumor microenvironment simulating chip and the drug testing chip. The tumor microenvironment simulating chip includes a microenvironment building unit which is used for conducting a chemical reaction to generate an acid gas, an alkaline gas and / or an oxygen concentration for simulating the tumor microenvironment. The drug testing chip includes a testing unit which is used for allowing interaction of a therapeutic drug with a cell-containing hydrogel. An orthographic projection of the testing unit falls on the microenvironment building unit. The permeable thin film is used for diffusing the acid gas, the alkaline gas and / or the oxygen concentration generated by the microenvironment building unit to the testing unit.

1. Name of the designed product: multi-copy drug detection card. 2. Use of the designed product: for drug detection. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The invention discloses a method for determining allylamine in a sevelamer carbonate medicine. The method comprises the following steps: (1) preparing a sevelamer carbonate drug test solution and an allylamine reference solution; (2) respectively carrying out derivatization treatment on the test solution and the reference solution, and during derivatization treatment, adjusting the pH value of a derivatization system by using a buffer solution with the pH value of 8.4-10.8; and (3) determining the derivatization system by using a high performance liquid chromatography. The sevelamer carbonate drug is alkaline, so that the pH value of a test product reaction system is high, the pH value is greatly different from the pH value of a reference product reaction system, the analysis result is unstable, the pH values of a test product derivative system and a reference product derivative system are adjusted to tend to be consistent by adding a buffer solution, so that the influence of the pH value difference on the analysis result is reduced, and the accuracy of the analysis result is improved. The accuracy, repeatability and stability of analysis are improved, the requirements and standards of pharmacopeia on the analysis method are better met, and quality control and safe production of sevelamer carbonate drugs are facilitated.

A drug screening platform for simulating a tumor microenvironment comprises a wafer for tumor microenvironment simulation, a wafer for drug testing and a permeable film arranged between the wafer for tumor microenvironment simulation and the wafer for drug testing. The wafer for simulating the tumor microenvironment comprises a microenvironment establishing unit, wherein the microenvironment establishing unit is used for chemical reaction to generate acid gas, alkaline gas and / or oxygen concentration for simulating the tumor microenvironment. The wafer for the drug test comprises a test unit for interaction between a therapeutic drug and a cell hydrogel, and the orthographic projection of the test unit falls on the microenvironment establishing unit. According to the invention, the tumor microenvironment is simulated through the wafer for tumor microenvironment simulation, so that the therapeutic drug and the cell hydrogel interact in the simulated tumor microenvironment to obtain an accurate test result.

The utility model discloses an automatic medicine centrifugal separation all-in-one machine which comprises a machine body, a centrifugal bin is arranged in the machine body, a driving shaft is arranged in the centrifugal bin, an upper rotating disc and a lower rotating disc are arranged on the surface of the driving shaft, and the upper rotating disc and the lower rotating disc are fixedly connected with the driving shaft. And placing holes are formed in the upper rotating disc and the lower rotating disc and correspond to each other. The driving box is arranged on the side face of the machine body, the driver is arranged on the surface of the driving box, the first driving wheel is arranged at the power output end of the driver, the first driven wheel is arranged on the surface of the driving shaft, the first driving chain is arranged between the first driving wheel and the first driven wheel, and the driver drives the first driving wheel to rotate. The first driven wheel and the driving shaft are driven by the first driving chain to rotate, so that the upper rotating disc and the lower rotating disc rotate, solid-liquid separation of suspension liquid in the medicine test tube is realized under the action of centrifugal force, and subsequent detection is facilitated.

The present application relates to a kind of siglitin metformin sustained-release tablets combined drug effect detection method in the field of pharmaceutical testing, in the application, by introducing intelligent terminal and monitoring terminal, real-time observation is realized using mechanical vision technology in the experiment process, the observation pressure of experimental personnel is reduced, the labor cost of experimental detection is greatly reduced, the detection efficiency is improved, at the same time, the identity of experimental personnel is identified using intelligent terminal, all experimental operations are bound with its experimental personnel, it is convenient to subsequent summary when experiment is summarized, the traceability work is carried out, the standardization of experimental detection is improved, at the same time, protection unit is set for monitoring terminal, when experimental organism touches trigger lever, a part of stored stimulating smell in slow-release unit is released, the expelling effect is strengthened, and experimental organism is formed to expel domestication, so that experimental organism forms the habit of keeping away from monitoring terminal.

A portable, self-contained drug test kit for testing for the presence or absence of a drug has a housing having a hollow portion with a liquid solvent accessible from outside to enable introduction of a test solute therein. A lateral flow test strip is in user-selective fluid communication with the liquid solvent in the hollow portion. The lateral flow test strip is selectively moveable from a first position in which the lateral flow test strip is not in fluid communication with the liquid solvent in the hollow portion to a second position in which it is in fluid communication with the liquid solvent. When the lateral flow test strip is moved into the second position and the test solute is introduced into the hollow portion, the liquid solvent mixes with the test solute to form a test solution and thereby activate the lateral flow test strip.

A biological material testing apparatus (100) is provided that includes a substrate (102) having at least one chamber unit (104) defined therein, and a support member (106) for supporting a biological material contained in the at least one chamber unit. One of the substrate and the support member is molded on the other of the substrate and the support member. A method (10) for manufacturing such a biological material testing device is also provided. Uses and methods are also provided in which the device is used to test a biological material, for example in a drug test in which the biological material is exposed to a drug to be tested.

The invention provides a drug coding method and device based on fluorescein dye types and fluorescence intensity, a medium and a program product. The method comprises the following steps: pre-selecting a plurality of fluorescein dyes with high discrimination; adjusting the dye concentration of the single fluorescein dye so as to determine the number of types which can be coded by the single fluorescein dye based on the fluorescence intensity difference under different dye concentrations; and calculating the combined coding capacity of the drug test according to the number of types capable of being coded of all the preselected fluorescein dyes. According to the invention, through combined use of multiple fluorescent dyes, a combined fluorescence code based on fluorescence types and intensity is constructed, and the combined fluorescence code is used for coding drugs, so that the screening flux is further improved, and the method can be used in a high-flux drug screening technology.

A lung environment-imitating drug testing platform comprises a microfluid wafer and a stretching device. The microfluidic chip defines a micro-channel structure, and the micro-channel structure comprises a test area unit, a cell sub-channel unit and a drug sub-channel unit. The stretching device comprises a clamping structure and a moving unit. The clamping structure is provided with a fixed part, a movable part spaced from the fixed part, and a groove part formed between the fixed part and the movable part; and the fixed part and the movable part are matched with each other to clamp two opposite ends of the microfluidic wafer and enable the orthographic projection of the test area unit of the microfluidic wafer to completely coincide with the groove part. According to the drug test platform simulating the lung environment, the environment simulating the respiratory movement of the human lung can be constructed, and multiple test results can be obtained through one-time test.