5 results about "Ilaprazole" patented technology

The present invention relates to an oral immediate-release formulation comprising ilaprazole with improved stability as an active ingredient and a method for preparing same, wherein the present invention relates to an oral immediate-release formulation and a method for preparing same, the oral immediate-release formulation comprising ilaprazole and a stabilizer in an inner core portion thereof and an antacid in an outer layer portion thereof, in which the oral immediate-release formulation has improved compounding stability by suppressing contact between the inner core portion and the outer layer portion through coating on the inner core portion, has excellent stability by minimizing the amount of related substances generated, and has a fast drug effect (the time to reach maximum blood concentration (Tmax) ranges from 0.3 hours to 0.8 hours) and excellent stability, through the rapid antacid effect of the antacid.

The invention discloses an ilaprazole sodium freeze-dried preparation as well as a preparation method and application thereof. The invention provides an ilaprazole sodium freeze-dried preparation which comprises the following components: ilaprazole sodium, an excipient, cycleanine tetraacetic acid and a pH (Potential of Hydrogen) regulator, and does not contain ethylenediamine tetraacetic acid. The ilaprazole sodium freeze-dried preparation is good in stability, lower in impurity content, good in solubility, safer, simple to prepare and suitable for industrial production.

The application provides a preparation method of crystalline form B of ilaprazole. The application provides a preparation method of crystalline form B of ilaprazole, which comprises the following steps: mixing a solution or slurry of ilaprazole raw materials and a good solvent with an anti-solvent, and crystallizing to obtain the crystalline form B of ilaprazole. The preparation method of the application has the advantages of good stability, high yield, good purity, low solvent residue, compliance with the standard of raw materials, and suitability for industrial production.

The application discloses a preparation method of ilaprazole, and belongs to the field of drug synthesis. The ilaprazole is synthesized from 5-(1H-pyrrol-1-yl)-2-mercaptobenzimidazole and 3-methyl-4-methoxy-2-chloromethylpyridine hydrochloride through two-step reaction. The preparation method is mild in process condition, good in quality, high in yield, and suitable for large-scale production.

The present invention relates to a pharmaceutical combination preparation comprising ilaprazole, an antacid, and an alkalizing agent and, more specifically, to a pharmaceutical combination preparation and a method for preparing same, wherein decomposition of ilaprazole in the stomach is prevented without enteric coating to improve stability, thereby increasing bioavailability, and the quality and productivity of pharmaceutical products are improved due to uncomplicated manufacturing processes and excellent storage stability of the preparation.