Ilaprazole sodium crystal form and preparation method thereof

A technology of ilaprazole sodium and its crystal form, which is applied in the field of ilaprazole sodium new crystal form and its preparation, and can solve the problems of no ilaprazole sodium crystal form, limited clinical application, gastric acid secretion rebound, etc. problems, to achieve the effect of easy preparation, low preparation cost, and less amount of solvent
CN102746276AActive Publication Date: 2012-10-24LIVZON PHARM GRP INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LIVZON PHARM GRP INC
Publication Date
2012-10-24

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Abstract

The invention discloses an ilaprazole sodium crystal form and a preparation method thereof. The novel ilaprazole sodium crystal form provided by the invention is easy to prepare, and has advantages of high purity and low impurity content. The preparation method provided by the invention needs low solvent amount, has advantages of low production cost, simple operation and mild reaction condition, is easy to control, and can produce the target product crystalline form doubtlessly and well-repeatedly.
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Description

technical field

[0001] The invention belongs to the field of medicine and relates to a new crystal form of ilaprazole sodium and a preparation method thereof. Background technique

[0002] Ilaprazole belongs to benzimidazoles and is an irreversible proton pump inhibitor. After oral administration, ilaprazole selectively enters gastric parietal cells and is converted into the active metabolite of sulfenamide, which interacts with H + , K + -Sulfhydryl action on ATPase, forming covalent binding of disulfide bonds, irreversibly inhibiting H + , K + -ATPase, produces the effect of inhibiting gastric acid secretion.

[0003] First-generation PPIs have limited clinical application because they can cause delayed gastric emptying, parietal cell swelling, and a significant rebound in gastric acid secretion after drug withdrawal. As one of the new generation of proton pump inhibitors (PPI), ilaprazole has overcome some of the defects of the original similar products to varying de...

Claims

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