14 results about "Peptichemio" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a bifunctional compound with anti-helicobacter pylori and acid inhibition activity, a preparation method of the bifunctional compound and application of the bifunctional compound in preparation of medicines for treating peptic ulcer and helicobacter pylori infection. According to the compound, a potassium ion competitive acid blocker vonoprazan is used as an acid inhibition unit, and rifobetine is used as an anti-helicobacter pylori unit; the two compounds are respectively subjected to covalent modification through linking groups Linker 1 and Linker 2, and then are connected by virtue of a triazole ring to form a series of bifunctional compounds shown as a general formula (I). The compound can simultaneously and synergistically act on two key targets of gastric acid secretion and helicobacter pylori, so that not only is the treatment effect remarkably enhanced, but also better safety is shown due to the fact that the same curative effect can be achieved at a lower dosage.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating peptic ulcer and a preparation method and application thereof. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of sun-dried ginseng, 9-15 parts of roasted rhizoma atractylodis macrocephalae, 9-15 parts of white poria, 3-9 parts of honey-fried licorice root, 9-15 parts of rhizoma pinelliae preparata, 10-20 parts of cuttlebone, 6-12 parts of fructus amomi, 6-12 parts of rhizoma coptidis and 9-15 parts of pericarpium citri reticulatae. Starting from the theory of syndrome differentiation and treatment of traditional Chinese medicine, the traditional Chinese medicine preparation has the functions of tonifying qi and spleen and resolving dampness and descending adverse-rising energy, has a remarkable treatment effect on peptic ulcer, is convenient to take and is easily accepted by patients.

The present invention provides a tegoprazan sugar acid salt and a preparation method therefor, the salt being pharmaceutically usable for gastroesophageal disease, gastroesophageal reflux disease, gastritis, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcer, non-erosive reflux disease (NERD) and the like. The tegoprazan sugar acid salt of the present invention has excellent water solubility and stability of tegoprazan, and thus can be particularly useful as a pharmaceutical injection preparation.

The invention relates to a natural pharmaceutical composition for prevention and treatment of gastric ulcer and a preparation method of the natural pharmaceutical composition. The natural pharmaceutical composition comprises active natural medicinal ingredients. It is composed of turpentine oil, black seed oil, vitamin D and hyaluronic acid. The natural pharmaceutical composition provides a significant synergistic effect, combining anti-inflammatory, antibacterial, and gastroprotective properties, while also ensuring cost-effectiveness and minimal side effects compared to conventional treatments. Beside gastric ulcer is effective in relief of symptoms associated with gastric ulcer. The natural composition has the advantages of accurate curative effects, preparation stability, simplicity and feasibility in process and suitableness for industrial production.

The invention belongs to the field of biological medicine, and particularly relates to preparation and application of dextran for relieving ulcerative colitis. The dextran GS128 is formed by directly catalyzing and synthesizing dextransucrase Gtf128 generated by heterologous expression in vitro by taking sucrose as a substrate, and the product is obtained by ethanol precipitation, centrifugation, dissolution and dialysis. The compound shows high anti-digestion performance in the process of simulating gastrointestinal tract digestion, and can relieve the symptoms of ulcerative colitis by inhibiting oxidative stress, adjusting the balance of proinflammatory / anti-inflammatory factors and improving the colon barrier.

The invention discloses an artificial intelligence assisted peptic ulcer combined hemorrhage endoscopic risk assessment network and model, the assessment network is a classification network, the classification network comprises more than one double-branch module, the double-branch module divides an input feature into two branches to be processed respectively, and the two branches are connected with each other. One branch extracts local features of the image through convolution operation, the other branch extracts global spatial features of the image through depth separation convolution, different normalization methods are adopted for the two branches, the convolution branch adopts batch normalization operation, and the depth separation convolution branch adopts layer normalization operation; a compression-incentive attention module is embedded in the output end of each branch, so that the classification network can adaptively enhance respective important feature channels in the two branches, and then channel splicing is performed to fuse the features of the double branches. The classification network can well perform peptic ulcer combined bleeding endoscopic image feature extraction.

The invention belongs to the technical field of biological medicines, and particularly relates to an imidazo [1, 2-a] pyridine compound as well as a preparation method and application thereof. The structural formula of the imidazo [1, 2-a] pyridine compound is shown in the specification, and R is selected from sodium ions, potassium ions, calcium ions, magnesium ions, lithium ions or ammonium ions; when R is a sodium ion, a potassium ion, an ammonium ion or a lithium ion, n = 2; and when R is a calcium ion or a magnesium ion, n = 1. The imidazo [1, 2-a] pyridine compound provided by the invention shows high solubility, high dissolution rate and excellent biological activity for inhibiting gastric acid secretion, and provides a new choice for treating gastric acid related diseases such as peptic ulcer.

Recombinant blood group antigen-binding adhesin (BabA) can be used in a composition to raise humoral immune response i.e. antibodies, that target conserved structural epitopes in the fucosylated blood group antigen Lewis b (Leb) antigen binding domain in the blood group antigen-binding adhesin (BabA). Such broadly Leb-blocking antibodies can reduce the gastric mucosal attachment of Helicobacter pylori (H. pylori) to human gastric mucosa. This approach can be used for preventing and / or alleviating gastric disease in a subject diagnosed with H. pylori infection, said gastric disease chosen from gastroesophageal reflux disease, chronic active gastritis, peptic ulcer diseases, gastric ulcer disease, gastric cancer gastritis and gastric cancer, in particular gastric cancer. It also becomes possible to identify subjects that carry BabA positive H. pylori infections and subjects that are at risk of developing severe gastric disease, such as peptic ulcer diseases, gastric ulcer disease, gastritis with metaplasia and gastric cancer.

The present application discloses polymorphs of asiaticoside, a preparation method and medical use thereof. The present application firstly proves that asiaticoside has polymorphism, and provides various crystal forms of asiaticoside suitable for being used as a raw material, which can be used for developing asiaticoside preparations with controllable quality. The present application provides a simple, easy and environment-friendly preparation method of the polymorphs of asiaticoside, which is suitable for large-scale production. The polymorphs of asiaticoside or pharmaceutical compositions containing the crystal forms of asiaticoside can be used for preventing and treating diseases including type I interferon disease, peptic ulcer, Parkinson's disease, ulcerative colitis, systemic sclerosis, liver fibrosis, pulmonary fibrosis, renal fibrosis, Alzheimer's disease, depression, diabetic foot ulcer and refractory wound.

The application relates to the medical technical field, in particular to application of 6-mercapto guanine in preparation of a medicine for preventing and / or treating alcoholic gastric ulcer, experimental results show that the 6-mercapto guanine has remarkable curative effect on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, restore animal body weight, and has a good clinical application prospect.

The invention relates to a pharmaceutical composition for preventing or treating peptic ulcer. The pharmaceutical composition comprises a compound shown in a formula I or pharmaceutically acceptable salt and a non-steroidal anti-inflammatory drug.

This invention belongs to the field of biomedical technology, specifically relating to an imidazo[1,2-a]pyridine compound, its preparation method, and its applications. The imidazo[1,2-a]pyridine compound has the following structural formula: [Formula omitted for brevity]. Wherein, R is selected from sodium ions, potassium ions, calcium ions, magnesium ions, lithium ions, or ammonium ions; when R is a sodium ion, potassium ion, ammonium ion, or lithium ion, n=2; when R is a calcium ion or magnesium ion, n=1. The imidazo[1,2-a]pyridine compound provided by this invention exhibits high solubility, high dissolution rate, and excellent bioactivity in inhibiting gastric acid secretion, providing a new option for treating gastric acid-related diseases such as peptic ulcers.

Disclosed in the present invention is a pharmaceutical composition for the prevention or treatment of drug-related peptic ulcer, comprising zastaprazan or a pharmaceutically acceptable salt thereof.