27 results about "Peptichemio" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a bifunctional compound with anti-helicobacter pylori and acid inhibition activity, a preparation method of the bifunctional compound and application of the bifunctional compound in preparation of medicines for treating peptic ulcer and helicobacter pylori infection. According to the compound, a potassium ion competitive acid blocker vonoprazan is used as an acid inhibition unit, and rifobetine is used as an anti-helicobacter pylori unit; the two compounds are respectively subjected to covalent modification through linking groups Linker 1 and Linker 2, and then are connected by virtue of a triazole ring to form a series of bifunctional compounds shown as a general formula (I). The compound can simultaneously and synergistically act on two key targets of gastric acid secretion and helicobacter pylori, so that not only is the treatment effect remarkably enhanced, but also better safety is shown due to the fact that the same curative effect can be achieved at a lower dosage.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine preparation for treating peptic ulcer and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following components in parts by weight: 10 to 15 parts of cassia twig, 10 to 20 parts of radix paeoniae alba, 10 to 20 parts of radix salviae miltiorrhizae, 8 to 12 parts of rhizoma cyperi, 4 to 8 parts of rhizoma chuanxiong, 25 to 35 parts of rhizoma corydalis, 10 to 20 parts of herba artemisiae scopariae, 25 to 35 parts of cortex magnoliae officinalis, 8 to 12 parts of caulis perillae and 2 to 4 parts of liquorice root. According to the invention, theories of dialectical treatment, holism concept and the like are reasonably applied, the compatibility is scientific and reasonable, the prescription is simplified, the preparation process is simple, the efficacy is accurate, the clinical applicability is strong, and the efficacy on peptic ulcer is exact. The traditional Chinese medicine preparation is an innovation of medicines for treating peptic ulcer, and has remarkable economic and social benefits.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating peptic ulcer and a preparation method and application thereof. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of sun-dried ginseng, 9-15 parts of roasted rhizoma atractylodis macrocephalae, 9-15 parts of white poria, 3-9 parts of honey-fried licorice root, 9-15 parts of rhizoma pinelliae preparata, 10-20 parts of cuttlebone, 6-12 parts of fructus amomi, 6-12 parts of rhizoma coptidis and 9-15 parts of pericarpium citri reticulatae. Starting from the theory of syndrome differentiation and treatment of traditional Chinese medicine, the traditional Chinese medicine preparation has the functions of tonifying qi and spleen and resolving dampness and descending adverse-rising energy, has a remarkable treatment effect on peptic ulcer, is convenient to take and is easily accepted by patients.

The present invention provides a tegoprazan sugar acid salt and a preparation method therefor, the salt being pharmaceutically usable for gastroesophageal disease, gastroesophageal reflux disease, gastritis, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcer, non-erosive reflux disease (NERD) and the like. The tegoprazan sugar acid salt of the present invention has excellent water solubility and stability of tegoprazan, and thus can be particularly useful as a pharmaceutical injection preparation.

The invention discloses a rabeprazole pharmaceutical composition as well as a preparation method and application thereof. The invention provides a rabeprazole pharmaceutical composition, the rabeprazole pharmaceutical composition comprises an active pharmaceutical ingredient and an antacid, and the active pharmaceutical ingredient is selected from one or more of rabeprazole, rabeprazole sodium, other pharmaceutically acceptable salt forms, solvates and hydrates thereof. The rabeprazole pharmaceutical composition disclosed by the invention can inhibit the rabeprazole sodium from being damaged by gastric acid, and is small in side effect, rapid in treatment, relatively good in effect and high in patient compliance; the rabeprazole pharmaceutical composition has the advantages that the rabeprazole pharmaceutical composition is simple in preparation process and good in market prospect, and is an excellent medicine for treating peptic ulcer, and a pharmaceutical preparation can be delivered into the stomach by nasal feeding for some patients who cannot be administered by themselves, so that the effect of treating stomach diseases is achieved.

The present invention discloses a pharmaceutical composition for preventing or treating drug-related peptic ulcers, comprising zastaprazan or a pharmaceutically acceptable salt thereof.

The application relates to the medical technical field, in particular to application of zidovudine in preparation of a medicine for preventing and / or treating alcoholic gastric ulcer, and experiment results show that the zidovudine has a remarkable curative effect on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, and restore animal body weight, and has a good clinical application prospect.

A pharmaceutical composition of rabeprazole for treating peptic ulcers, a preparation method therefor and the use thereof. The composition contains a pharmaceutically active ingredient and an antacid, wherein the pharmaceutically active ingredient is selected from one or more of rabeprazole, rabeprazole sodium, and other pharmaceutically acceptable salt forms, solvates and hydrates of rabeprazole.

Provided is a composition of Arctium lappa and Lithospermum erythrorhizon and a method for preparing same. The composition comprises an A. lappa extract and an L. erythrorhizon extract, wherein the A. lappa extract accounts for 90%-10% of the composition, in percentage by weight; the L. erythrorhizon extract accounts for 10%-90% of the composition, in percentage by weight. The composition can be used for preparing a pharmaceutical composition for preventing or treating peptic ulcer or for resisting Helicobacter pylori.

The present invention relates to the field of medical technology, and more particularly to the use of gemcitabine hydrochloride in the preparation of a medicament for preventing and / or treating alcoholic gastric ulcers. Experimental results show that the gemcitabine hydrochloride has significant therapeutic effects on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, and restore animal weight, and has good clinical application prospects.

Disclosed herein are new salts and polymorphs of cethromycin for the treatment of diseases due to infection by bacteria and certain protozoans, including, for example, malaria, Babesosis, Toxoplasmosis, diarrheal disease, respiratory disease, sexually transmitted bacterial infections, and some bioterror bacteria, including, for example, plague, tularemia and post-inhalation anthrax. Also disclosed herein are new salts and polymorphs of cethromycin for the treatment of inflammatory diseases, including, for example, pelvic inflammatory disease, and peptic ulcer disease.

The invention relates to a natural pharmaceutical composition for prevention and treatment of gastric ulcer and a preparation method of the natural pharmaceutical composition. The natural pharmaceutical composition comprises active natural medicinal ingredients. It is composed of turpentine oil, black seed oil, vitamin D and hyaluronic acid. The natural pharmaceutical composition provides a significant synergistic effect, combining anti-inflammatory, antibacterial, and gastroprotective properties, while also ensuring cost-effectiveness and minimal side effects compared to conventional treatments. Beside gastric ulcer is effective in relief of symptoms associated with gastric ulcer. The natural composition has the advantages of accurate curative effects, preparation stability, simplicity and feasibility in process and suitableness for industrial production.

The invention belongs to the field of biological medicine, and particularly relates to preparation and application of dextran for relieving ulcerative colitis. The dextran GS128 is formed by directly catalyzing and synthesizing dextransucrase Gtf128 generated by heterologous expression in vitro by taking sucrose as a substrate, and the product is obtained by ethanol precipitation, centrifugation, dissolution and dialysis. The compound shows high anti-digestion performance in the process of simulating gastrointestinal tract digestion, and can relieve the symptoms of ulcerative colitis by inhibiting oxidative stress, adjusting the balance of proinflammatory / anti-inflammatory factors and improving the colon barrier.

The invention discloses an artificial intelligence assisted peptic ulcer combined hemorrhage endoscopic risk assessment network and model, the assessment network is a classification network, the classification network comprises more than one double-branch module, the double-branch module divides an input feature into two branches to be processed respectively, and the two branches are connected with each other. One branch extracts local features of the image through convolution operation, the other branch extracts global spatial features of the image through depth separation convolution, different normalization methods are adopted for the two branches, the convolution branch adopts batch normalization operation, and the depth separation convolution branch adopts layer normalization operation; a compression-incentive attention module is embedded in the output end of each branch, so that the classification network can adaptively enhance respective important feature channels in the two branches, and then channel splicing is performed to fuse the features of the double branches. The classification network can well perform peptic ulcer combined bleeding endoscopic image feature extraction.

The invention belongs to the technical field of biological medicines, and particularly relates to an imidazo [1, 2-a] pyridine compound as well as a preparation method and application thereof. The structural formula of the imidazo [1, 2-a] pyridine compound is shown in the specification, and R is selected from sodium ions, potassium ions, calcium ions, magnesium ions, lithium ions or ammonium ions; when R is a sodium ion, a potassium ion, an ammonium ion or a lithium ion, n = 2; and when R is a calcium ion or a magnesium ion, n = 1. The imidazo [1, 2-a] pyridine compound provided by the invention shows high solubility, high dissolution rate and excellent biological activity for inhibiting gastric acid secretion, and provides a new choice for treating gastric acid related diseases such as peptic ulcer.

Recombinant blood group antigen-binding adhesin (BabA) can be used in a composition to raise humoral immune response i.e. antibodies, that target conserved structural epitopes in the fucosylated blood group antigen Lewis b (Leb) antigen binding domain in the blood group antigen-binding adhesin (BabA). Such broadly Leb-blocking antibodies can reduce the gastric mucosal attachment of Helicobacter pylori (H. pylori) to human gastric mucosa. This approach can be used for preventing and / or alleviating gastric disease in a subject diagnosed with H. pylori infection, said gastric disease chosen from gastroesophageal reflux disease, chronic active gastritis, peptic ulcer diseases, gastric ulcer disease, gastric cancer gastritis and gastric cancer, in particular gastric cancer. It also becomes possible to identify subjects that carry BabA positive H. pylori infections and subjects that are at risk of developing severe gastric disease, such as peptic ulcer diseases, gastric ulcer disease, gastritis with metaplasia and gastric cancer.

The present application discloses polymorphs of asiaticoside, a preparation method and medical use thereof. The present application firstly proves that asiaticoside has polymorphism, and provides various crystal forms of asiaticoside suitable for being used as a raw material, which can be used for developing asiaticoside preparations with controllable quality. The present application provides a simple, easy and environment-friendly preparation method of the polymorphs of asiaticoside, which is suitable for large-scale production. The polymorphs of asiaticoside or pharmaceutical compositions containing the crystal forms of asiaticoside can be used for preventing and treating diseases including type I interferon disease, peptic ulcer, Parkinson's disease, ulcerative colitis, systemic sclerosis, liver fibrosis, pulmonary fibrosis, renal fibrosis, Alzheimer's disease, depression, diabetic foot ulcer and refractory wound.

The application relates to the medical technical field, in particular to application of 6-mercapto guanine in preparation of a medicine for preventing and / or treating alcoholic gastric ulcer, experimental results show that the 6-mercapto guanine has remarkable curative effect on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, restore animal body weight, and has a good clinical application prospect.

The invention relates to a pharmaceutical composition for preventing or treating peptic ulcer. The pharmaceutical composition comprises a compound shown in a formula I or pharmaceutically acceptable salt and a non-steroidal anti-inflammatory drug.

The present invention relates to a pharmaceutical composition containing ilaprazole or a salt thereof, and a preparation method therefor. The pharmaceutical composition contains or consists of ilaprazole or a salt thereof, and a ilaprazole derivative, wherein the amount of the ilaprazole derivative in the pharmaceutical composition is not higher than 1.3 wt % (less than or equal to 1.3 wt %). The composition can be used for treating peptic ulcer bleeding and stress ulcer and preventing upper gastrointestinal hemorrhage caused by severe diseases.

The invention relates to the field of medicinal chemistry, relates to a crystal of a benzimidazole compound as well as a preparation method and application thereof, and in particular relates to a crystal of a compound as shown in a formula (I) and a preparation method thereof. The crystal of the compound shown in the formula (I) has good stability and can be applied to preparation of drugs for treating peptic ulcer.

This invention belongs to the field of biomedical technology, specifically relating to an imidazo[1,2-a]pyridine compound, its preparation method, and its applications. The imidazo[1,2-a]pyridine compound has the following structural formula: [Formula omitted for brevity]. Wherein, R is selected from sodium ions, potassium ions, calcium ions, magnesium ions, lithium ions, or ammonium ions; when R is a sodium ion, potassium ion, ammonium ion, or lithium ion, n=2; when R is a calcium ion or magnesium ion, n=1. The imidazo[1,2-a]pyridine compound provided by this invention exhibits high solubility, high dissolution rate, and excellent bioactivity in inhibiting gastric acid secretion, providing a new option for treating gastric acid-related diseases such as peptic ulcers.

The invention provides a pharmaceutical composition for treating peptic ulcer as well as pills and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials: 120 to 160 parts of fructus chebulae, 120 to 160 parts of gypsum rubrum powder, 20 to 30 parts of false chinese swertia herb, 25 to 36 parts of travertine, 20 to 25 parts of fructus amomi rotundus, 4 to 8 parts of oxytropis falcate bunge, 60 to 70 parts of Zhaxun cream, 150 to 170 parts of pterocephalus hookeri, 10 to 15 parts of pawpaw, 20 to 28 parts of safflower, 20 to 30 parts of nutmeg, 2 to 6 parts of benzoin, 45 to 56 parts of radix inulae, 18 to 24 parts of agilawood, 20 to 30 parts of pomegranate seed, 20 to 30 parts of clove, 20 to 30 parts of fructus tsaoko, 30 to 40 parts of usnea longissima, 30 to 40 Through reasonable raw material compatibility, the traditional Chinese medicine composition has the effects of strengthening the spleen and stomach, regulating qi and relieving pain, clearing heat and relieving acid, astringing to stop bleeding and promoting tissue regeneration and healing ulcer, and can regulate and control expression of inflammatory cytokines such as TNF-alpha and IL-6 and relieve inflammatory response of peptic ulcer, so that gastric mucosa is protected, healing of gastric ulcer can be promoted, and the curative effect is good. Therefore, an excellent effect of treating the peptic ulcer is achieved.

This disclosure provides methods for the treatment of peptic ulcer disease, comprising administering an effective amount of a formulation comprising an HIV protease inhibitor. The HIV protease inhibitor may comprise amprenavir or its prodrug fosamprenavir, darunavir, ritonavir, saquinavir, or a combination thereof. The formulation may also include a bioadhesive polymer, hydrogel, and / or biocompatible gel.

The invention relates to a novel skeleton compound containing cyclic carbamate and application. The novel compounds (I-1 and II-1) provided by the invention are compounds with novel structures. A biological activity experiment shows that the compound has muscarinic acetylcholine receptor M1 antagonistic activity and can be applied to preparation of drugs for peptic ulcer, irritable bowel syndrome or mental diseases and the like related to muscarinic acetylcholine receptors.

Disclosed in the present invention is a pharmaceutical composition for the prevention or treatment of drug-related peptic ulcer, comprising zastaprazan or a pharmaceutically acceptable salt thereof.