165 results about "Peptichemio" patented technology

The invention relates to an oral medicinal composition formulation for treating peptic ulcer. The composition comprises esomeprazole, antiacid sodium bicarbonate and a medicinally acceptable carrier, wherein the esomeprazole contains an acid-sensitive proton pump inhibitor; and the antiacid sodium bicarbonate can improve the stability of the proton pump inhibitor. The invention also relates to a preparation method of the medicinal composition. Two active ingredients are integrated into one fixed unit formulation, so that response is quick, a medicinal scheme is simplified in the process of treating the peptic ulcer, and the compliance of a patient is improved.

Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+/K+-ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5- alpha ]benzimidazole and 3-substituted imidazo[1,2-d]-1,2,4-thiadiazoles corresponding to the general formula: where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is selected from a wide range, e.g. heterocyclics and carbonyl groups.

The invention discloses a compound or its salt shown in the formula (I) and usage of the compound as a potassium competitive acid blocker or a gastric acid secretion inhibitor. The compound has a proton pump (H+/K+)-ATPase inhibitory effect and can be used for preventing, treating and inhibiting diseases related to gastric acid secretion, such as peptic ulcer, zollinger-ellison syndromes, gastritis, erosive esophagitis, reflux esophagitis and symptomatic gastroesophageal reflux diseases.

The invention discloses a medicine composition for treating peptic ulcer, comprising the following components: 10-20 parts of radix codonopsis pilosulae, 5-15 parts of white atractylodes rhizome, 5-15parts of tuckahoe, 4-12 parts of tuber pinellia, 3-7 parts of rhubarb, 5-15 parts of angelica, 1-5 parts of costusroot, 5-15 parts of tangerine peel, 3-9 parts of villous anomum, 4-12 parts of corydalis tuber, 5-15 parts of salvia miltiorrhiza, 8-16 parts of white peony root, 3-7 parts of rhizoma atractylodis, 4-12 parts of radix bupleuri, 3-9 parts of baikal skullcap root, 3-7 parts of coptis root, 0.5-3 parts of fructus evodiae and 3-7 parts of licorice. The invention also provides a preparation method of the medicine composition, comprising the following steps: weighing each component, grinding, pulverizing, mixing, sieving with a sieve of 100 meshes and preparing various medicament forms which are acceptable in traditional Chinese medicine pharmaceutics. The medicine composition provided by the invention has the characteristics of good curative effect, no toxic or side effect and little possibility of relapse after recovery when being used for treating the peptic ulcer.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia/reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

The invention relates to the field of immunodetection, in particular to a chemiluminescent quantitative determination kit for pepsinogen II and a preparation method of the chemiluminescent quantitative determination kit. The chemiluminescent quantitative determination kit for the pepsinogen II comprises (1) a pepsinogen II antibody coated micropore plate, (2) an HRP-labeled pepsinogen II antibody, (3) series pepsinogen II calibration materials diluted by a calibration material diluent, (4) a luminescent substrate A, (5) a luminescent substrate B and (6) a solid washing liquid. The kit disclosed by the invention is capable of detecting the content of the pepsinogen II in serum; and the level of the pepsinogen II in the serum is in positively relevant to atrophic gastritis and peptic ulcer; in treatment of peptic ulcer, the treatment result can be judged by monitoring the change of the degermed pepsinogen; and the chemiluminescent quantitative determination kit is noninvasive, simple and fast in detection method, high in sensitivity, wide in detection range and the like.

The invention discloses a sodium ilaprazole medicine composition freeze-dried powder injection for treating peptic ulcer, and belongs to the technical field of medicines. The sodium ilaprazole medicine composition freeze-dried powder injection comprises sodium ilaprazole and an excipient, wherein the excipient is low molecular dextran; sodium ilaprazole is a novel crystal compound different from that reported in the prior art, and the X-ray powder diffraction pattern of sodium ilaprazole is measured by utilizing Cu-K alpha rays and shown in Figure 1. Experiments prove that the novel crystal sodium ilaprazole compound is high in purity, liquidity and stability, low in impurity content and hygroscopicity, and safe and reliable in clinical application; the sodium ilaprazole medicine composition freeze-dried powder injection prepared by utilizing the novel crystal sodium ilaprazole compound is high in bioavailability and stability; the stability of the sodium ilaprazole medicine composition freeze-dried powder injection remains high after the sodium ilaprazole medicine composition freeze-dried powder injection is compatible with a solvent; the content of insoluble particles is extremely low. Therefore, the sodium ilaprazole medicine composition freeze-dried powder injection is particularly suitable for clinical application.

The invention provides a composition. The composition is characterized by being prepared from the following ingredients in parts by weight: ginseng roots 1-15, poria cocos 3-25, Chinese yam 5-50, lotus seeds 2-25, coix seeds 3-50, white hyacinth beans 3-25, polished round-grained rice 20-400 or/and oats 20-400. The invention also relates to the application of the composition in health care food or medicines or products having functions of preventing and treating gastric mucosal damage caused by chronic gastritis, gastric ulcer or duodenal ulcer, relieving abdominal pain caused by the chronic gastritis or peptic ulcer and preventing and treating the syndrome of weakness of the spleen and the stomach.

The invention relates to an oral pharmaceutical composition preparation for treating peptic ulcer. The composition contains an acid-sensitive proton pump inhibitor, a gastric mucosa protective agent and a pharmaceutically acceptable carrier, wherein the proton pump inhibitor exists in a stable form. The invention also relates to a preparation method of the pharmaceutical composition. In the preparation method, two medicines are combined in a fixed unit preparation, thereby simplifying the medication scheme and improving the patient compliance.

The invention relates to a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof. The invention particularly discloses a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof in preparing medicines for treating gastroenteropathy, and belongs to the field of life sciences. The method comprises the following steps: extracting medicinal plants with 70-95% ethanol homogenate; and after the extract is concentrated to a certain volume, standing to precipitate, removing a supernatant, dissolving the obtained precipitate with an organic solvent, separating by gel-resin column chromatography, crystallizing and recrystallizing to obtain the Pinostrobin monomer of which the purity is higher than 90%. The Pinostrobin monomer in which different excipients can be added is prepared into any common pharmaceutical formulation. The pharmaceutical preparation has obvious biological activity on peptic ulcer, gastritis, stomachache, gastric evacuation (gasterectasis), alimentary tract tumors and the like caused by Helicobacter pylori infection, and has thecharacteristic of no toxic or side effect.

The invention belongs to the technical field of drugs, and relates to a compound tablet for treating peptic ulcer and a method for preparing the same. In the compound tablet, an anti acid agent (an H2 receptor blocking agent and a proton pump inhibitor) and an united synergic agent of an antibiotic or two types of antibiotics or disunited synergic agent are used as a tablet core. The tablet core comprises main materials and auxiliary materials, wherein the main materials consist of an anti acid agent, a stomach mucous membrane protective agent and one or two types of antibacterial agents; the dosage range of the anti acid agent is between 10 and 40mg, and the cyclodextrin is adopted for coating or self emulsification; the dosage range of each type of antibacterial drug is between 100 and 1,000mg; and the dosage range of the stomach mucous membrane protective agent is between 100 and 500mg. By adopting the reaction of the anti acid agent and the cyclodextrin to prepare a coating matter or for self emulsification, the anti acid agent is treated, and the treated anti acid agent, antibacterial drugs and proper amount of auxiliary materials are pressed into the tablet core, and the tablet core is externally coated with an enteric coating or pressed into the enteric coating. The compound tablet and the method have the advantages of obviously improving the stability and the bioavailability of the anti acid agent and the antibiotics, and simultaneously effectively lowering the irritation of certain antibiotics on stomach.

The present invention provides a food. The food comprises the following raw materials in percentages by weight: 10%-90% of wheat flour, 3%-25% of a traditional Chinese medicinal composition, 0.01%-15% of a swelling agent, 1%-35% of a sweetening agent, 1%-35% of oil, 0.1%-5% of edible salt and 0.001%-10% of essences. The traditional Chinese medicinal composition is characterized by comprising the following raw materials in parts by weight: 1-15 parts of ginsengs, 3-25 parts of poria cocos, 5-50 parts of Chinese yams, 2-25 parts of lotus seeds, 3-50 parts of coix seeds and 3-25 parts of semen lablab album. The food has functions of preventing and treating chronic gastritis, peptic ulcers, chronic diarrhea, functional dyspepsia, ulcerative colitis, spleen and stomach weakness syndromes, abdominal distension or abdominal pains, and inappetence, and benefits qi, strengthens spleen and nourishes stomach.

Disclosed are methods for the prevention or treatment of a disease or infection caused by or associated with H. Pylori in a subject infected by H. Pylori, the method comprising orally administering a halogenated salicylanilide such as niclosamide to the subject. The method may be used for the prevention or treatment of, for example dyspepsia, gastritis, peptic ulcer disease, premalignant gastric lesions, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma.

The invention discloses a preparation method of a medicine for treating peptic ulcers. The method comprises the following steps: (1) weighing raw medicinal materials in parts by weight: 17 to 23 parts of potentilla anserina, 7 to 12 parts of poria cocos, 5 to 9 parts of oriental wormwood, 5 to 9 parts of pogostemon cablin, 5 to 9 parts of raw malt, 3 to 7 parts of mangnolia officinalis, 3 to 7 parts of perilla leaves and 3 to 7 parts of caulis perllae; (2) pulverizing the potentilla anserina to form powder for later use; firstly adding 55-95v/v% (volume per volume) ethyl alcohol into the other medicinal materials except for the potentilla anserina for extracting, filtering to obtain an alcohol extract for later use, decocting filter residue by adding water, combining the alcohol extract with the filter residue, concentrating and then adding the potentilla anserina powder and pharmaceutically acceptable auxiliary materials so as to obtain the medicine. The medicine is less in medicinal flavor according to a specific dosage proportion, and can be used for effectively treating gastric ulcers, duodenal ulcers and erosive gastritis, thereby providing a new medicine selection for clinic treatment of the peptic ulcers. Meanwhile, the pharmacological test proves that the pharmacological activity of the medicine is improved in manners of double alcohol-water extraction and pulverization of the potentilla anserina into medicinal powder, so that the economical utilization of medicinal material resources is realized.

Spinulate hedgehog fungus with sporophore used as material is processed through water decoction for 1-3 times, filtering with filtrate being merged, concentration, addition of enzyme, regulating of temperature and pH value, elimination of protein, straining, alcohol precipitation, filtering to collect precipitate, water dissolving, centrifugation to eliminate dregs, and alcohol precipitation of supernatant to collect spinulate hedgehog fungus polysaccharide. Medicine with spinulate hedgehog fungus polysaccharide as main medicinal component is provided and the medicine may be used in treating chronic atrophic gastritis, superficial gastritis, peptic gastric ulcer, duodenal ampulla ulcer and other gastric diseases and has pain relieving and antiinflammation functions.

A Chinese medicine for treating gastric ulcer, duodenal ulcer and chronic gastritis is prepared from frankincense, peony root, aucklandia root and liquorice root.

The invention discloses a bacterial strain as well as a composition and application, and relates to the technical field of strain separation and application. The Cristinia sp. provided by the invention can be applied to treatment or prevention of liver function impairment and liver function impairment related diseases, alimentary canal mucosal injury and alimentary canal mucosal injury related diseases, diabetes, obesity and obesity related diseases. The inventor verifies that the Cristinia sp. provided by the invention has no toxic or side effect on the kidney and can reduce the weight of the liver; the initial steatohepatitis focus can be treated; fat accumulation of liver cells can be slowed down; AST and ALT in serum can be reduced; and abdominal white fat inflammatory lesion can be reduced. The Cristinia sp. can also repair the digestive tract mucosa, recover the barrier function of the mucosa, and prevent and treat intestinal leakage, peptic ulcer and other diseases caused by barrier function impairment. The Cristinia sp. also has the effects of reducing fasting blood-glucose of a body, regulating insulin level and reducing body fat of mammals, and has the effects of preventing and treating diabetes and improving the metabolic function of obese patients.

Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

The invention discloses 3-pyridinesulfonyl-1-N-heteropyrrole derivatives capable of treating peptic ulcer as well as a preparation method and application of the derivative, and particularly provides compounds as shown in a formula I, or pharmaceutically acceptable salts, isotope replacement forms or stereoisomers thereof. Experimental results show that the compounds (especially the compound 4 andthe compound 5) provided by the invention have an excellent inhibition effect on gastric ulcer, can be used for preparing medicines for preventing and/or treating peptic ulcer (especially gastric ulcer), and show wide application prospects.

The invention relates to the field of microorganisms, in particular to lactobacillus gasseri and application thereof in treatment of peptic ulcer. The lactobacillus gasseri TTYS-839 disclosed by the invention is preserved in the China General Microbiological Culture Collection Center on July 2, 2020, the taxonomic name is lactobacillus gasseri, the preservation number is CGMCC No.20178, and the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No.3, Yard 1, West Beichen Road, Chaoyang District, Beijing. The invention also provides a microbial agent containing the lactobacillus gasseri TTYS-839, the microbial agent is fed to a gastric ulcer rat prepared by an acetic acid wet compress method, the ulcer area and the ulcer volume can be obviously reduced, and the microbial agent has an obvious treatment effect on gastric ulcer.

The invention discloses a traditional Chinese medicine preparation for treating peptic ulcer and a preparation method thereof. The traditional Chinese medicine preparation disclosed by the invention is prepared from the following medicinal materials in parts by weight: 30-47 parts of radix angelicae, 21-29 parts of resina draconis, 22-31 parts of cuttlebone, 13-26 parts of liquorice, 10-21 parts of trichosanthes peel, 13-25 parts of fructus evodiae, 18-29 parts of endothelium corneum gigeriae galli, 20-36 parts of rhizoma corydalis, 10-18 parts of cinnamon, 25-39 parts of corydalis tuber, 2-7 parts of frankincense, 9-18 parts of myrrh, 3-12 parts of clove, 5-17 parts of fructus piperis longi, 6-18 parts of concha arcae, 15-27 parts of dandelion, 11-24 parts of homalomena occulta, 6-17 parts of teasel root, 8-17 parts of rhizoma cyperi, 3-8 parts of nard, 13-24 parts of curcuma aromatica, 6-14 parts of curcuma zedoary, 1-9 parts of rhizoma acori graminei, 3-12 parts of rhizoma atractylodis, and 8-17 parts of gynostemma pentaphylla. The traditional Chinese medicine preparation disclosed by the invention is a pure traditional Chinese medicine prescription and has the advantages of being low in toxic and side effects, good in curative effect and short in treatment course; for treating peptic ulcer, the traditional Chinese medicine preparation is high in curative ratio; furthermore, the traditional Chinese medicine preparation is wide in medicine source and low in cost; and thus, the traditional Chinese medicine preparation is applied to being clinically popularized and applied.

The invention discloses a traditional Chinese medicine for treating peptic ulcer and a preparation method thereof. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 24-39 parts of astragalus root, 21-28 parts of Zhejiang fritillary bulb, 19-31 parts of dried ginger, 11-20 parts of amomum fruit, 13-24 parts of tetradium ruticarpum, 20-38 parts of magnolia bark, 18-27 parts of glycyrrhiza uralensis, 16-29 parts of wolfberry, 11-23 parts of bupleurum root, 15-28 parts of radix paeoniae alba, 1-7 parts of costus root, 9-18 parts of cortex dictamni, 2-9 parts of salvia miltiorrhiza, 11-18 parts of poria cocos, 2-8 parts of angelica sinensis, 3-8 parts of chorion ovi, 3-7 parts of radix curcumae, 5-13 parts of natural indigo, 6-19 parts of borneol, 5-13 parts of pomegranate bark, 9-18 parts of prepared ovate atractylodes, 2-8 parts of rhubarb root, 3-7 parts of coptis root, 1-6 parts of panax pseudo-ginseng, 2-7 parts of pinellia tuber, 3-8 parts of dried tangerine peel and 1-7 parts of citrus aurantium. The traditional Chinese medicine is a pure Chinese traditional medicine prescription, and is low in toxic or side effects, good in treatment effect, short in treatment course and high in cure rate during the treatment of peptic ulcer; the source of the medicinal materials is wide, and the cost is low, so that the traditional Chinese medicine is applicable to clinical popularization and application.