Pharmaceutical composition for treating peptic ulcer as well as pill and application thereof

Abstract

The invention provides a pharmaceutical composition for treating peptic ulcer as well as pills and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials: 120 to 160 parts of fructus chebulae, 120 to 160 parts of gypsum rubrum powder, 20 to 30 parts of false chinese swertia herb, 25 to 36 parts of travertine, 20 to 25 parts of fructus amomi rotundus, 4 to 8 parts of oxytropis falcate bunge, 60 to 70 parts of Zhaxun cream, 150 to 170 parts of pterocephalus hookeri, 10 to 15 parts of pawpaw, 20 to 28 parts of safflower, 20 to 30 parts of nutmeg, 2 to 6 parts of benzoin, 45 to 56 parts of radix inulae, 18 to 24 parts of agilawood, 20 to 30 parts of pomegranate seed, 20 to 30 parts of clove, 20 to 30 parts of fructus tsaoko, 30 to 40 parts of usnea longissima, 30 to 40 Through reasonable raw material compatibility, the traditional Chinese medicine composition has the effects of strengthening the spleen and stomach, regulating qi and relieving pain, clearing heat and relieving acid, astringing to stop bleeding and promoting tissue regeneration and healing ulcer, and can regulate and control expression of inflammatory cytokines such as TNF-alpha and IL-6 and relieve inflammatory response of peptic ulcer, so that gastric mucosa is protected, healing of gastric ulcer can be promoted, and the curative effect is good. Therefore, an excellent effect of treating the peptic ulcer is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a pharmaceutical composition for treating peptic ulcer, a pill thereof and an application thereof. Background Art

[0002] Peptic ulcers, a common digestive system disease, can occur in people of all ages. The esophagus, stomach, duodenum, and the area around the gastrojejunostomy or Meckel's diverticulum, including the gastric mucosa, are common sites of disease, with gastric and duodenal ulcers being the most common. The etiology of this disease is complex, influenced by genetic, environmental, psychological, and dietary factors. Clinical manifestations include cyclical, rhythmic upper abdominal pain accompanied by belching, acid reflux, nausea, and vomiting. Severe cases can lead to complications such as bleeding, perforation, and pyloric obstruction. Currently, Western medicine treatments for peptic ulcers primarily use drugs that inhibit gastric acid secretion, protect the gastric mucosa, and combat Helicobacter pylori. However, these drugs are associated with significant side effects and a high risk of recurrence after discontinuation. Traditional Chinese medicine (TCM) treatments for peptic ulcers offer advantages such as holistic conditioning, minimal side effects, and a low risk of recurrence. However, currently available TCM compositions for peptic ulcers suffer from illogical formulations and uncertain efficacy, resulting in suboptimal results. Summary of the Invention

[0003] In view of this, the present invention proposes a pharmaceutical composition for treating peptic ulcer and its pills and application The technical solution of the present invention is achieved as follows: A pharmaceutical composition for treating peptic ulcer comprises the following raw materials in parts by weight: 150-180 parts of Terminalia chebula fruit, 120-160 parts of calcite powder, 20-30 parts of Swertia japonica, 25-36 parts of travertine, 20-25 parts of cardamom, 4-8 parts of oxytropis falciformis, 60-70 parts of Zhaxun paste, 150-170 parts of Pterocephalus scabra, 10-15 parts of papaya, 20-28 parts of safflower, 20-30 parts of nutmeg, 2-6 parts of benzoin, 45-56 parts of Tibetan woodruff, 18-24 parts of agarwood, 20-30 parts of pomegranate seeds, 20-30 parts of cloves, 20-30 parts of tsaoko, 30-40 parts of usnea longissima, 30-40 parts of iris seeds, 18-20 parts of turnip, 20-26 parts of saussurea oleifera, and 12-18 parts of artemisia capillaris.

[0004] Furthermore, the pharmaceutical composition for treating peptic ulcer comprises the following raw materials in parts by weight: 150 parts of Terminalia chebula, 140 parts of stone powder, 26 parts of Swertia japonica, 25 parts of travertine, 25 parts of cardamom, 4 parts of octupleura falcatum, 65 parts of Zhaxun paste, 170 parts of Pterocephalus scabra, 15 parts of papaya, 28 parts of safflower, 30 parts of nutmeg, 3 parts of benzoin, 50 parts of Tibetan woodruff, 20 parts of agarwood, 30 parts of pomegranate seeds, 25 parts of cloves, 28 parts of tsaoko, 40 parts of long usnea, 35 parts of iris seeds, 18 parts of turnip, 26 parts of saussurea oleifera, and 18 parts of Artemisia capillaris.

[0005] Furthermore, the preparation method of the hanshui stone powder is: after taking hanshui stone and crushing it, add the crushed saltpeter and water to mix, heat and boil for 3 to 4 hours, pour off the water, and then repeatedly wash with water until the solution is clear, then dry it, crush it to obtain powder, and then add milk to stir into a dough, dry it in the shade and crush it to obtain hanshui stone powder.

[0006] Furthermore, the mass ratio of the calcite, saltpeter and water is 1:0.01~0.02:2~4; the mass ratio of the powder to milk is 1:0.4~0.6.

[0007] A pill for treating peptic ulcer is prepared from the pharmaceutical composition of the invention.

[0008] Furthermore, the preparation method of the pills comprises the following steps: S1. crushing travertine and mixing it with calcite powder to obtain mixed powder I; S2. Grinding Terminalia chebula, Swertia japonica, Cardamom, Oxytropis falcatus, Saussurea chinensis, and Artemisia capillaris into a mixed powder II, then adding water to mix evenly, soaking under pressure, and then performing percolation extraction, filtering, collecting the filtrate, adding water to the filter residue and performing percolation extraction 2 to 3 times, combining all the filtrates, filtering again, and concentrating under reduced pressure distillation to an extract I with a relative density of 1.2 to 1.4; S3. Grind Pterocephalus, papaya, safflower, nutmeg, benzoin, Tibetan wood, agarwood, pomegranate seeds, cloves, tsaoko, long usnea, iris seeds, and turnip into mixed powder III, mix the mixed powder III with ethanol solution, perform ultrasonic microwave extraction, filter, and concentrate the filtrate by vacuum distillation to an extract II with a relative density of 1.2-1.4. Dry and grind the extract II to obtain extract powder; S4. Evenly mix the mixed powder I, extract I, extract powder and slag paste, then make pills, dry, polish and seal for storage to obtain pills for treating peptic ulcer.

[0009] Furthermore, the solid-liquid ratio of the mixed powder II to water is 1:5-10 g / mL; the pressurized soaking is performed at a temperature of 30-35° C. and a pressure of 0.3-0.5 MPa for 60-90 min; and the percolation extraction speed is 2-4 mL / min.

[0010] Furthermore, the material-liquid ratio of the mixed powder III to the ethanol solution is 1:15-20 g / mL; and the volume concentration of the ethanol solution is 60%-70%.

[0011] Furthermore, the ultrasonic microwave extraction process is first performed under the conditions of ultrasonic power of 150~200W, microwave power of 200~300W, and temperature of 30~45°C for 90~100min, and then under the conditions of ultrasonic power of 400~500W, microwave power of 350~400W, and temperature of 30~45°C for 60~70min.

[0012] The invention relates to an application of the pharmaceutical composition in preparing medicine for treating peptic ulcer.

[0013] Furthermore, the preparation method of the slag-bearing paste is as follows: according to the slag-bearing and boiling water material-liquid ratio g / mL of 15:8~12, the slag-bearing is stirred and dissolved with boiling water 3~4 times, then filtered, the filtrate is simmered over low heat, and concentrated to obtain the paste until the paste is no longer sticky after cooling.

[0014] Compared with the prior art, the present invention has the following beneficial effects: The Chinese medicinal composition of the present invention has the effects of strengthening the spleen and stomach, regulating qi and relieving pain, clearing away heat and reducing acid, astringing and stopping bleeding, promoting tissue regeneration and healing ulcers through reasonable raw material compatibility. It can regulate the expression levels of inflammatory cytokines such as TNF-α and IL-6, alleviate the inflammatory response of peptic ulcers, thereby protecting the gastric mucosa, and the ulcer inhibition rate reaches more than 82%. It can promote the healing of gastric ulcers, thereby achieving an excellent effect in treating peptic ulcers, and relieving symptoms such as stomach pain, acid reflux, and bloating, with few side effects and high safety.

[0015] In addition, in the process of preparing the pills, the present invention soaks Terminalia chebula, Swertia japonica, Cardamom, Oxytropis falcatus, Saussurea chinensis, and Artemisia capillaris in water under specific conditions and then performs percolation extraction, and performs specific ultrasonic microwave extraction of medicinal ingredients such as Pterocephalus chinensis, papaya, safflower, nutmeg, and benzoin with an ethanol solution. This can retain the active ingredients of each raw material in the pharmaceutical composition, facilitates absorption and utilization, and thus achieves a good effect in treating peptic ulcers. DETAILED DESCRIPTION

[0016] In order to better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention.

[0017] Unless otherwise specified, the experimental methods used in the examples of the present invention are all conventional methods.

[0018] Unless otherwise specified, the materials, reagents, etc. used in the examples of the present invention can be obtained from commercial sources.

[0019] Example 1 A pharmaceutical composition for treating peptic ulcer comprises the following raw materials in parts by weight: 150 parts of Terminalia chebula fruit, 140 parts of calcite powder, 26 parts of Swertia japonica, 25 parts of travertine, 25 parts of cardamom, 4 parts of octupleura falcatum, 65 parts of slag-bone paste, 170 parts of pterygium wilfordii, 15 parts of papaya, 28 parts of safflower, 30 parts of nutmeg, 3 parts of benzoin, 50 parts of Tibetan woodruff, 20 parts of agarwood, 30 parts of pomegranate seeds, 25 parts of cloves, 28 parts of tsaoko, 40 parts of usnea longissima, 35 parts of iris seeds, 18 parts of turnip, 26 parts of saussurea oleifera, and 18 parts of artemisia capillaris.

[0020] The preparation method of quasar powder is as follows: after crushing quasar, add the crushed saltpeter and water, mix well, heat and boil for 4 hours, pour off the water, and then repeatedly wash with water until the solution is clear, then dry, crush to obtain powder, then add milk and stir into a dough, dry in the shade and crush to obtain quasar powder; wherein, the mass ratio of quasar, saltpeter and water is 1:0.02:3, and the mass ratio of powder to milk is 1:0.5.

[0021] A pill for treating peptic ulcer prepared from the above-mentioned pharmaceutical composition, the preparation method of the pill comprising the following steps: S1. crushing travertine and mixing it with calcite powder to obtain mixed powder I; S2, the Terminalia chebula meat, Swertia japonica, cardamom, falcate horny bean, wind flower, Artemisia capillaris powder into a mixed powder II, according to the mixed powder II and water solid-liquid ratio g / mL of 1: 8, the mixed powder II was mixed with water, and then soaked at a temperature of 35 ° C. and a pressure of 0.4 MPa for 90 min, and then percolation extraction was performed at a speed of 3 mL / min, filtered, and the filtrate was collected. According to the solid-liquid ratio of the filter residue to water g / mL of 1: 8, the filter residue was further added with water for percolation extraction 3 times, all the filtrates were combined, filtered again, and concentrated by vacuum distillation to an extract I with a relative density of 1.2; S3. Grind pterygium wilfordii, papaya, safflower, nutmeg, benzoin, Tibetan wood, agarwood, pomegranate seeds, cloves, tsaoko, long usnea, iris seeds, and turnip into mixed powder III. The solid-liquid ratio of mixed powder III to ethanol solution is 1:15 g / mL, wherein the volume concentration of ethanol solution is 70%. After mixing the mixed powder III with the ethanol solution, first perform ultrasonic microwave extraction at an ultrasonic power of 200 W, a microwave power of 200 W, and a temperature of 40°C for 90 min, and then perform ultrasonic microwave extraction at an ultrasonic power of 500 W, a microwave power of 400 W, and a temperature of 40°C for 60 min. Filter, take the filtrate and concentrate it by vacuum distillation to an extract II with a relative density of 1.4, dry the extract II, and grind it to obtain extract powder; S4. Evenly mix the mixed powder I, extract I, extract powder and slag paste, then make pills, dry, polish and seal for storage to obtain pills.

[0022] Example 2 A pharmaceutical composition for treating peptic ulcer comprises the following raw materials in parts by weight: 180 parts of Terminalia chebula fruit, 120 parts of calcite powder, 20 parts of Swertia japonica, 36 parts of travertine, 20 parts of cardamom, 8 parts of octupleura falcatum, 60 parts of Zhaxun paste, 170 parts of pterygium wilfordii, 12 parts of papaya, 26 parts of safflower, 20 parts of nutmeg, 5 parts of benzoin, 56 parts of Tibetan woodruff, 18 parts of agarwood, 20 parts of pomegranate seeds, 30 parts of cloves, 20 parts of tsaoko, 30 parts of usnea longissima, 40 parts of iris seeds, 20 parts of turnip, 20 parts of saussurea oleifera, and 12 parts of artemisia capillaris.

[0023] The preparation method of quasar powder is as follows: after crushing quasar, add the crushed saltpeter and water, mix well, heat and boil for 3 hours, pour off the water, and then repeatedly wash with water until the solution is clear, then dry, crush to obtain powder, then add milk and stir into dough, dry in the shade and crush to obtain quasar powder; wherein, the mass ratio of quasar, saltpeter and water is 1:0.01:2, and the mass ratio of powder to milk is 1:0.4.

[0024] A pill for treating peptic ulcer prepared from the above-mentioned pharmaceutical composition, the preparation method of the pill comprising the following steps: S1. crushing travertine and mixing it with calcite powder to obtain mixed powder I; S2, the Terminalia chebula meat, Swertia japonica, cardamom, falcate horny bean, wind flower, Artemisia capillaris powder into a mixed powder II, according to the mixed powder II and water solid-liquid ratio g / mL of 1:10, the mixed powder II was mixed with water, and then soaked at a temperature of 30 ° C. and a pressure of 0.5 MPa for 80 min, and then percolation extraction was performed at a speed of 4 mL / min, filtered, and the filtrate was collected. According to the solid-liquid ratio of the filter residue to water g / mL of 1:10, the filter residue was further added with water for percolation extraction twice, all the filtrates were combined, filtered again, and concentrated by vacuum distillation to an extract I with a relative density of 1.2; S3. Grind pterygium wilfordii, papaya, safflower, nutmeg, benzoin, Tibetan wood, agarwood, pomegranate seeds, cloves, tsaoko, long usnea, iris seeds, and turnip into mixed powder III. The solid-liquid ratio of mixed powder III to ethanol solution is 1:20 (g / mL), wherein the volume concentration of ethanol solution is 60%. Mix the mixed powder III with the ethanol solution, first perform ultrasonic microwave extraction at an ultrasonic power of 150 W, a microwave power of 300 W, and a temperature of 45°C for 100 min, then perform ultrasonic microwave extraction at an ultrasonic power of 400 W, a microwave power of 350 W, and a temperature of 45°C for 70 min, filter, and concentrate the filtrate by vacuum distillation to an extract II with a relative density of 1.4. Dry the extract II and grind it to obtain extract powder; S4. Evenly mix the mixed powder I, extract I, extract powder and slag paste, then make pills, dry, polish and seal for storage to obtain pills.

[0025] Example 3 A pharmaceutical composition for treating peptic ulcer comprises the following raw materials in parts by weight: 160 parts of Terminalia chebula fruit, 160 parts of calcite powder, 30 parts of Swertia japonica, 30 parts of travertine, 23 parts of cardamom, 6 parts of octupleura falcatum, 70 parts of Zhaxun paste, 160 parts of pterygium wilfordii, 10 parts of papaya, 20 parts of safflower, 24 parts of nutmeg, 6 parts of benzoin, 45 parts of Tibetan woodruff, 24 parts of agarwood, 25 parts of pomegranate seeds, 20 parts of cloves, 30 parts of tsaoko, 36 parts of usnea longissima, 30 parts of iris seeds, 19 parts of turnip, 25 parts of saussurea oleifera, and 16 parts of artemisia capillaris.

[0026] The preparation method of quasar powder is as follows: after crushing quasar, add the crushed saltpeter and water, mix well, heat and boil for 3 hours, pour off the water, and then repeatedly wash with water until the solution is clear, then dry, crush to obtain powder, then add milk and stir into a dough, dry in the shade and crush to obtain quasar powder; wherein, the mass ratio of quasar, saltpeter and water is 1:0.02:4, and the mass ratio of powder to milk is 1:0.6.

[0027] A pill for treating peptic ulcer prepared from the above-mentioned pharmaceutical composition, the preparation method of the pill comprising the following steps: S1. crushing travertine and mixing it with calcite powder to obtain mixed powder I; S2, the Terminalia chebula meat, Swertia japonica, cardamom, falcate horny bean, wind flower, Artemisia capillaris powder into a mixed powder II, according to the mixed powder II and water solid-liquid ratio g / mL of 1:5, the mixed powder II was mixed with water, and then soaked at a temperature of 35 ° C. and a pressure of 0.3 MPa for 60 min, and then percolation extraction was performed at a speed of 2 mL / min, filtered, and the filtrate was collected. According to the solid-liquid ratio of the filter residue to water g / mL of 1:5, the filter residue was further added with water for percolation extraction 3 times, all the filtrates were combined, filtered again, and concentrated by vacuum distillation to an extract I with a relative density of 1.2; S3. Grind pterygium wilfordii, papaya, safflower, nutmeg, benzoin, Tibetan wood, agarwood, pomegranate seeds, cloves, tsaoko, long usnea, iris seeds, and turnip into mixed powder III. The solid-liquid ratio of mixed powder III to ethanol solution is 1:18 (g / mL), wherein the volume concentration of ethanol solution is 65%. Mix the mixed powder III with the ethanol solution, first perform ultrasonic microwave extraction at an ultrasonic power of 200 W, a microwave power of 250 W, and a temperature of 30°C for 90 min, then perform ultrasonic microwave extraction at an ultrasonic power of 450 W, a microwave power of 400 W, and a temperature of 30°C for 60 min, filter, and concentrate the filtrate by vacuum distillation to an extract II with a relative density of 1.4. Dry the extract II and grind it to obtain extract powder; S4. Evenly mix the mixed powder I, extract I, extract powder and slag paste, then make pills, dry, polish and seal for storage to obtain pills.

[0028] Comparative Example 1 Compared with Example 1, this comparative example changes the raw material ratio of the pharmaceutical composition, and the rest is the same as Example 1.

[0029] 1. A pharmaceutical composition for treating peptic ulcer in this comparative example is characterized in that it comprises the following raw materials in parts by weight: 400 parts of Terminalia chebula, 80 parts of stone powder, 60 parts of Swertia japonica, 20 parts of travertine, 10 parts of cardamom, 1 part of Oxytropis falcatus, 40 parts of Zhaxun paste, 120 parts of Pterocephalus herb, 50 parts of papaya, 10 parts of safflower, 50 parts of nutmeg, 1 part of benzoin, 10 parts of Tibetan woodruff, 10 parts of agarwood, 40 parts of pomegranate seeds, 10 parts of cloves, 8 parts of tsaoko, 10 parts of long usnea, 4 parts of iris seeds, 11 parts of turnip, 5 parts of saussurea ovata, and 21 parts of Artemisia capillaris.

[0030] Comparative Example 2 Compared with Example 1, this comparative example does not contain Usnea longissima, Iris iris and Raphanus spinulosa in the pharmaceutical composition, and the rest are the same as Example 1.

[0031] The pharmaceutical composition for treating peptic ulcer in this comparative example comprises the following raw materials in parts by weight: 150 parts of Terminalia chebula fruit, 140 parts of calcite powder, 26 parts of Swertia japonica, 25 parts of travertine, 25 parts of cardamom, 4 parts of octupleura falcatum, 65 parts of Zhaxun paste, 170 parts of Pterocephalus herba, 15 parts of papaya, 28 parts of safflower, 30 parts of nutmeg, 3 parts of benzoin, 50 parts of Tibetan woodruff, 20 parts of agarwood, 30 parts of pomegranate seeds, 25 parts of cloves, 28 parts of tsaoko, 26 parts of saussurea oleifera, and 18 parts of artemisia capillaris.

[0032] Comparative Example 3 Compared with Example 1, this comparative example does not contain Saussurea chinensis and Artemisia capillaris in the pharmaceutical composition, and the rest are the same as Example 1.

[0033] The pharmaceutical composition for treating peptic ulcer in this comparative example comprises the following raw materials in parts by weight: 150 parts of Terminalia chebula fruit, 140 parts of calcite powder, 26 parts of Swertia japonica, 25 parts of travertine, 25 parts of cardamom, 4 parts of octupleura falcatum, 65 parts of Zhaxun paste, 170 parts of Pterocephalus scabra, 15 parts of papaya, 28 parts of safflower, 30 parts of nutmeg, 3 parts of benzoin, 50 parts of Tibetan woodruff, 20 parts of agarwood, 30 parts of pomegranate seeds, 25 parts of cloves, 28 parts of tsaoko, 40 parts of long usnea, 35 parts of iris seeds, and 18 parts of turnip.

[0034] Comparative Example 4 Compared with Example 1, this comparative example changes the preparation process of the pills, and the rest is the same as Example 1.

[0035] The preparation method of the pill for treating peptic ulcer of this comparative example comprises the following steps: S1. crushing travertine and mixing it with calcite powder to obtain mixed powder I; S2. Grind the Terminalia chebula, Swertia japonica, Cardamom, Oxytropis falcatus, Saussurea chinensis, Artemisia capillaris, Pterocephalus chinensis, Papaya, Carthamus tinctorius, Myristica fragrans, Benzoin, Aquilaria sinensis, Pomegranate seeds, Cloves, Amomum villosum, Usnea longissima, Iris ternata, and Brassica rapa into a mixed powder II, wherein the solid-liquid ratio of the mixed powder II to the ethanol solution is 1:15 g / mL, wherein the volume concentration of the ethanol solution is 70%, and the mixed powder II is mixed with the ethanol solution, and then ultrasonically extracted for 150 min under the conditions of an ultrasonic power of 300 W and a temperature of 40°C, filtered, and the filtrate is concentrated by vacuum distillation to an extract II with a relative density of 1.4, and the extract II is dried and pulverized to obtain an extract powder; S4. Evenly mix the mixed powder I, extract powder and slag paste, then make pills, dry, polish and seal for storage to obtain pills.

[0036] Comparative Example 5 Compared with Example 1, this comparative example changes step S2 in the preparation process of the pills, and the rest is the same as Example 1.

[0037] The preparation method of the pill for treating peptic ulcer of this comparative example comprises the following steps: S1. crushing travertine and mixing it with calcite powder to obtain mixed powder I; S2. Grind Terminalia chebula, Swertia japonica, Cardamom, Oxytropis falcatus, Saussurea chinensis, and Artemisia capillaris into a mixed powder II. Add water to the mixed powder II and mix well at a solid-liquid ratio of 1:8 (g / mL). Boil the mixed powder II for 2 h, filter, and collect the filtrate, concentrate it by vacuum distillation to an extract I with a relative density of 1.2. S3. Grind pterygium wilfordii, papaya, safflower, nutmeg, benzoin, Tibetan wood, agarwood, pomegranate seeds, cloves, tsaoko, long usnea, iris seeds, and turnip into mixed powder III. The solid-liquid ratio of mixed powder III to ethanol solution is 1:15 g / mL, wherein the volume concentration of ethanol solution is 70%. After mixing the mixed powder III with the ethanol solution, first perform ultrasonic microwave extraction at an ultrasonic power of 100 W, a microwave power of 200 W, and a temperature of 40°C for 90 min, and then perform ultrasonic microwave extraction at an ultrasonic power of 500 W, a microwave power of 400 W, and a temperature of 40°C for 60 min. The filtrate is concentrated by vacuum distillation to an extract II with a relative density of 1.4. The extract II is dried and pulverized to obtain an extract powder. S4. Evenly mix the mixed powder I, extract I, extract powder and slag paste, then make pills, dry, polish and seal for storage to obtain pills.

[0038] Comparative Example 6 Compared with Example 1, this comparative example changes step S3 in the preparation process of the pills, and the rest is the same as Example 1.

[0039] The preparation method of the pill for treating peptic ulcer of this comparative example comprises the following steps: S1. crushing travertine and mixing it with calcite powder to obtain mixed powder I; S2, the Terminalia chebula meat, Swertia japonica, cardamom, falcate horny bean, wind flower, Artemisia capillaris powder into a mixed powder II, according to the mixed powder II and water solid-liquid ratio g / mL of 1: 8, the mixed powder II was mixed with water, and then soaked at a temperature of 35 ° C. and a pressure of 0.4 MPa for 90 min, and then percolation extraction was performed at a speed of 3 mL / min, filtered, and the filtrate was collected. According to the solid-liquid ratio of the filter residue to water g / mL of 1: 8, the filter residue was further added with water for percolation extraction 3 times, all the filtrates were combined, filtered again, and concentrated by vacuum distillation to an extract I with a relative density of 1.2; S3. Grind pterygium wilfordii, papaya, safflower, nutmeg, benzoin, Tibetan wood, agarwood, pomegranate seeds, cloves, tsaoko, long usnea, iris seeds, and turnip into mixed powder III. The solid-liquid ratio of mixed powder III to ethanol solution is 1:15 (g / mL), wherein the volume concentration of ethanol solution is 70%. Mix the mixed powder III with the ethanol solution, first perform ultrasonic microwave extraction at an ultrasonic power of 600 W, a microwave power of 300 W, and a temperature of 40°C for 30 min, then perform ultrasonic microwave extraction at an ultrasonic power of 100 W, a microwave power of 150 W, and a temperature of 40°C for 120 min, take the filtrate and concentrate it by vacuum distillation to an extract II with a relative density of 1.4, dry the extract II, and grind it to obtain extract powder; S4. Evenly mix the mixed powder I, extract I, extract powder and slag paste, then make pills, dry, polish and seal for storage to obtain pills.

[0040] The therapeutic effects of the pills prepared by the methods of Examples 1-3 and Comparative Examples 1-6 on peptic ulcer were studied.

[0041] A total of 66 SPF male mice aged 6-8 weeks and weighing 20±2g were selected. After adaptive feeding for 1 week, they were fasted for 24 hours before the experiment (water was not allowed). Then, the mice were divided into a normal control group (6) and a model group (60). The normal control group did not receive any treatment. The model group mice were anesthetized by intraperitoneal injection of sodium pentobarbital (50 mg / kg). Then, the stomach was exposed through abdominal incision. 50 μL of glacial acetic acid was evenly applied to the serosal surface of the gastric antrum (avoiding large blood vessels) with a micropipette. After 30 seconds, the mice were washed with normal saline. The model group mice were then randomly divided into 10 groups of 6 mice each, corresponding to the dosing groups of Examples 1-3, Comparative Examples 1-6, and the model group. The pellets prepared in Examples 1-3 and Comparative Examples 1-6 were dissolved in water to prepare a 0.4 g / mL pellet solution. 24 hours after modeling, the pellet solution was administered orally at a rate of 0.2 mL / mouse / day for 14 consecutive days. The model group and the normal control group were gavaged with an equal amount of normal saline. After 14 days of administration, blood was collected from the eyeballs of mice in each group after anesthesia. Serum was centrifuged and TNF-α and IL-6 levels in the serum were determined using an ELISA kit. The entire stomach was quickly removed and rinsed with normal saline. The ulcer area (mm²) was measured using ImageJ, and the ulcer inhibition rate (%) was calculated.

[0042] Ulcer inhibition rate (%) = (mean ulcer area of model group - mean ulcer area of drug-treated group) / mean ulcer area of model group × 100% Table 1 Effect of pills in treating peptic ulcer

[0043] The above results show that the pills of Examples 1-3 of the present invention can reduce the inflammatory reaction of peptic ulcer by regulating the expression of inflammatory cytokines such as TNF-α and IL-6, thereby protecting the gastric mucosa, and have a good inhibitory effect on the peptic ulcer induced by ethanol in mice, with an ulcer inhibition rate of more than 82%, which can promote the healing of gastric ulcer, thereby achieving the effect of excellent treatment of peptic ulcer. Wherein, the effect of the pills prepared by Examples 1-3 of the present invention is better than that of Comparative Examples 1-6. It shows that the present invention can play a good synergistic effect by suitable raw material proportioning, particularly by adding long usnea, iris, turnip, sassafras and artemisia capillaris in the pharmaceutical composition, and by soaking terminalia chebula, swertia, cardamom, falcate osmatophyta, sassafras and artemisia capillaris in water under specific conditions and then performing percolation extraction, by subjecting medicinal ingredients such as pterygium wilfordii, papaya, safflower, nutmeg, benzoin to ethanol solution specific ultrasonic microwave extraction, the active ingredients of each raw material in the pharmaceutical composition can be retained, which is conducive to absorption and utilization, thereby playing a good effect of treating peptic ulcer.

[0044] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A pharmaceutical composition for treating peptic ulcer, characterized in that: The invention comprises the following raw materials in parts by weight: 150-180 parts of Terminalia chebula pulp, 120-160 parts of calcite powder, 20-30 parts of swertia japonica, 25-36 parts of travertine, 20-25 parts of cardamom, 4-8 parts of octupleura falcatum, 60-70 parts of slag-xun paste, 150-170 parts of pterocephala, 10-15 parts of papaya, 20-28 parts of safflower, 20-30 parts of nutmeg, 2-6 parts of benzoin, 45-56 parts of Tibetan woodruff, 18-24 parts of agarwood, 20-30 parts of pomegranate seeds, 20-30 parts of cloves, 20-30 parts of tsaoko, 30-40 parts of long usnea, 30-40 parts of iris seeds, 18-20 parts of turnip, 20-26 parts of saussurea oleifera, and 12-18 parts of artemisia capillaris.

2. The pharmaceutical composition for treating peptic ulcer according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 150 parts of Terminalia chebula fruit, 140 parts of stone powder, 26 parts of Swertia japonica, 25 parts of travertine, 25 parts of cardamom, 4 parts of octupleura falcatum, 65 parts of slag paste, 170 parts of pterygium wilfordii, 15 parts of papaya, 28 parts of safflower, 30 parts of nutmeg, 3 parts of benzoin, 50 parts of Tibetan woodruff, 20 parts of agarwood, 30 parts of pomegranate seeds, 25 parts of cloves, 28 parts of tsaoko, 40 parts of long usnea, 35 parts of iris seeds, 18 parts of turnip, 26 parts of saussurea oleifera, and 18 parts of artemisia capillaris.

3. The pharmaceutical composition for treating peptic ulcer according to claim 1, characterized in that The preparation method of the hanshui stone powder is as follows: after crushing hanshui stone, adding the crushed saltpeter and water to mix evenly, heating and boiling for 3-4 hours, decanting the water, and then repeatedly washing with water until the solution is clear, then drying, crushing to obtain powder, and then adding milk to stir into a dough, drying in the shade and crushing to obtain the hanshui stone powder.

4. The pharmaceutical composition for treating peptic ulcer according to claim 3, characterized in that The mass ratio of the calcite, saltpeter and water is 1:0.01-0.02:2-4; the mass ratio of the powder to milk is 1:0.4-0.

6.

5. A pill for treating peptic ulcer, characterized in that: The pill is prepared from the pharmaceutical composition according to any one of claims 1 to 4.

6. The pill for treating peptic ulcer according to claim 5, characterized in that The preparation method of the pill comprises the following steps: S1. crushing travertine and mixing it with calcite powder to obtain mixed powder I; S2. Grinding Terminalia chebula, Swertia japonica, Cardamom, Oxytropis falcatus, Saussurea chinensis, and Artemisia capillaris into a mixed powder II, then adding water to mix evenly, soaking under pressure, and then performing percolation extraction, filtering, collecting the filtrate, adding water to the filter residue and performing percolation extraction 2 to 3 times, combining all the filtrates, filtering again, and concentrating under reduced pressure distillation to an extract I with a relative density of 1.2 to 1.4; S3. Grind Pterocephalus, papaya, safflower, nutmeg, benzoin, Tibetan wood, agarwood, pomegranate seeds, cloves, tsaoko, long usnea, iris seeds, and turnip into mixed powder III, mix the mixed powder III with ethanol solution, perform ultrasonic microwave extraction, filter, and concentrate the filtrate by vacuum distillation to an extract II with a relative density of 1.2-1.

4. Dry and grind the extract II to obtain extract powder; S4. Evenly mix the mixed powder I, extract I, extract powder and slag paste, then make pills, dry, polish and seal for storage to obtain pills for treating peptic ulcer.

7. The pill for treating peptic ulcer according to claim 6, characterized in that The solid-liquid ratio of the mixed powder II to water is 1:5-10 g / mL; the pressurized soaking is performed at a temperature of 30-35° C. and a pressure of 0.3-0.5 MPa for 60-90 minutes; and the percolation extraction speed is 2-4 mL / min.

8. The pill for treating peptic ulcer according to claim 6, characterized in that The material-liquid ratio of the mixed powder III to the ethanol solution is 1:15-20 g / mL; and the volume concentration of the ethanol solution is 60%-70%.

9. The pill for treating peptic ulcer according to claim 6, characterized in that The ultrasonic microwave extraction process is as follows: first, ultrasonic microwave extraction is performed for 90 to 100 minutes under the conditions of ultrasonic power of 150 to 200 W, microwave power of 200 to 300 W, and temperature of 30 to 45° C.; then, ultrasonic microwave extraction is performed for 60 to 70 minutes under the conditions of ultrasonic power of 400 to 500 W, microwave power of 350 to 400 W, and temperature of 30 to 45° C.

10. Use of the pharmaceutical composition according to any one of claims 1 to 4 in the preparation of a medicament for treating peptic ulcer.

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