The invention discloses a traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection. The traditional Chinese medicine preparation comprises honeysuckle, fructus forsythiae, folium isatidis, mother chrysanthemum, wild buckwheat, semen oroxyli, the root of Chinese pulsatilla, purslane, edible tulip, yellowweed, radix ampelopsis, calculus bovis, eupatorium, mangnolia officinalis, amomum kravanh, immature bitter orange, fevervine, Poria cocos, semen coicis, caulis clematidis armandii, junci medulla, rattletop, gypsum rubrum, bamboo leaf, endive, bark of Indian quassiawood, fimbriate calanthe pseudobulb, dindygulen peperomia herb, Roughhaired Holly Root, natant salvinia herb, pterocephalus hookeri heck, manystem stonecrop leaf and phaenosperma globosa. The traditional Chinese medicine preparation has the effects of clearing away heat and toxic materials and invigorating spleen to eliminate dampness and is mainly used for treating toxin syndromes of recurrent oral ulcer during external infection. By utilizing the theory of traditional Chinese medicine, the overall immunity of the organism is regulated on the basis of the overall concept, the targeting property is high during treatment based on syndrome differentiation, the traditional Chinese medicine preparation has the effects of diminishing inflammation and relieving pain, expansion of the wound surface is avoided, and the drug effect is directly accessed to the lesions. Moreover, the traditional Chinese medicine preparation is safe and effective and difficultly generates drug resistance, and the reoccurrence rate is reduced.