The invention discloses a medicine for treating coronary atherosclerotic heart disease. The medicine is prepared from multiple traditional Chinese medicines including wild chrysanthemum, common selfheal fruit-spike, white peony root, Chinese magnoliavine fruit, tangerine peel, common russianthistle herb, kudzuvine root, hawthorn fruit, barbary wolfberry fruit, American ginseng, notoginseng, cassia seed, corn stigma, twotooth achyranthes root, root-bark of Chinese wolfberry, earthworm, rhubarb, baical skullcap root, Szechuan lovage rhizome, cape jasmine fruit, tuckahoe, magnetite, honeysuckle flower, eucommia bark, coix seed, herb or root of fourleaf peperomia, twig of bretschneider pear, leaf of henon bamboo, ginkgo leaf, Chinese gentian, Chinese arborvitae twig, codonopsis pilosula, glossy privet fruit, peppermint, mulbrry twig, Chinese thorowax root, mulberry fruit, common macrocarpium fruit, tree peony bark, oriental waterplantain rhizome, gambir plant and Chinese yam by performing scientific and reasonable combination according to a 'monarch, minister, assistant and guide' principle, has the effects of facilitating bowel movement to clear away turbidness, supplementing qi and nourishing yin, and removing blood stasis to dredge collaterals, can eliminate blood poison and blood viscosity effectively, and particularly has an obvious curative effect on the coronary atherosclerotic heart disease.