The invention discloses a traditional Chinese medicine preparation for treating systemic lupus erythematosus. The traditional Chinese medicine preparation is prepared from, by weight, 46-51 parts of rushes, 41-59 parts of rhododendron mariae, 33-46 parts of radix knoxiae, 30-42 parts of pokeberry roots, 25-31 parts of rhizoma kaempferiae, 21-30 parts of alpinia katsumadai, 19-27 parts of fritillary bulb, 15-27 parts of antler gelatin, 10-16 parts of Chinese parsnip roots and 8-13 parts of poria cocos. According to the traditional Chinese medicine preparation, the pure natural Chinese herbal medicine is adopted as raw materials, the medicine materials cooperatively act, the traditional Chinese medicine preparation has the effects of removing toxic materials and eliminating patches, tonifying the heart and the spleen, tonifying qi and nourishing yin, warming the kidneys and strengthening yang, strengthening the spleen and soothing the liver, and the like, and the traditional Chinese medicine preparation has a very good curative effect on systemic lupus erythematosus; as clinically tested and proved, the effective rate of the traditional Chinese medicine preparation reaches up to 99%, and the cure rate reaches up to 94.2%.